Reviewed, UniProtKB/Swiss-Prot Q68WT3 (TRXB_RICTY)

Names and origin

Protein names

Recommended name:
    Thioredoxin reductase
      Short name=TRXR
    EC=1.8.1.9

Gene names

Name:	trxB
Ordered Locus Names:	RT0432

Organism

Rickettsia typhi [Complete proteome] [HAMAP]

Taxonomic identifier

785 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.
Cofactor	Binds 1 FAD per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Miscellaneous	The active site is a redox-active disulfide bond.
Sequence similarities	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Redox-active center
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW removal of superoxide radicals Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro thioredoxin-disulfide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Thioredoxin reductase		PRO_0000274792
Regions
	Nucleotide binding	34 – 41	8	FAD By similarity
	Nucleotide binding	281 – 290	10	FAD By similarity
Amino acid modifications
	Disulfide bond	135 ↔ 138		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q68WT3-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: C1D1EB4A96A5DE49	FASTA	310	33,699
	10 20 30 40 50 60 MKITTKVLII GSGPAGLSAA IYTARSSLKP ILINGMQPGG QLTMTTDVEN YPGFAKTIQG 70 80 90 100 110 120 PWLMEQMSIQ AKNVGTEIIN DYVERVDLSK RPFKIFTGTG NKYEADSIII CTGAESKWLG 130 140 150 160 170 180 ITSEQEFRGF GVSSCAICDG FFFKNQDIVV VGGGNSALEE ALYLTNHANK VTVVHRRNSF 190 200 210 220 230 240 RAEKILQDRL FKNPKISVIW DHVIDEIVGS NQPKTVTGVK IKNVYTNEIN LVNCSGVFIA 250 260 270 280 290 300 IGHTPNTTLF NGQIAIDDDN YIITQTGSTR TSVEGVFAAG DVQDKIYRQA ITAAASGCMA 310 ALEVAKFLNK

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017197 Genomic DNA. Translation: AAU03909.1.
RefSeq	YP_067391.1.
3D structure databases
HSSP	HSSP built from PDB template 1TRB based on UniProtKB P0A9P4.
SMR	Q68WT3. Positions 4-310.
ModBase	Search...
Genome annotation databases
GeneID	2958952.
GenomeReviews	Gene locus RT0432 in contig AE017197_GR.
KEGG	rty:RT0432.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG669726.
OMA	HCKLLIL.
Enzyme and pathway databases
BioCyc	RTYP257363:RT0432-MONOMER.
BRENDA	1.8.1.9. 281221.
Family and domain databases
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR008255. Pyr_nucl-diS_OxRdtase_2_AS. IPR001327. Pyr_OxRdtase_NAD_bd. IPR000103. Pyridine_nuc-diS_OxRdtase_2. IPR005982. Thioredox_Rdtase. [Graphical view]
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00469. PNDRDTASEII.
TIGRFAMs	TIGR01292. TRX_reduct. 1 hit.
PROSITE	PS00573. PYRIDINE_REDOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRXB_RICTY

Accession

Primary (citable) accession number: Q68WT3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	October 11, 2004
Last modified:	February 9, 2010
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)