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Q68WS8 (LON_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lon protease

EC=3.4.21.53
Alternative name(s):
ATP-dependent protease La
Gene names
Name:lon
Ordered Locus Names:RT0437
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length784 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner By similarity. HAMAP-Rule MF_01973

Catalytic activity

Hydrolysis of proteins in presence of ATP. HAMAP-Rule MF_01973

Subunit structure

Homohexamer. Organized in a ring with a central cavity By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01973.

Induction

By heat shock By similarity. HAMAP-Rule MF_01973

Sequence similarities

Belongs to the peptidase S16 family.

Contains 1 Lon domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 784784Lon protease HAMAP-Rule MF_01973
PRO_0000280894

Regions

Domain6 – 203198Lon
Nucleotide binding356 – 3638ATP By similarity

Sites

Active site6791 By similarity
Active site7221 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68WS8 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 1475B928B9428BC7

FASTA78488,102
        10         20         30         40         50         60 
MNKKSLPLMA LRDMVLFPGV IAPIFVGRKK SLQALSRTTI SEENNTKYIL VTLQKKFDQE 

        70         80         90        100        110        120 
NPSKHELYNT AILAKIIQIV KLPNNTAKIL IEAVARVKLS DIKDEESFEA NYEIIPDEEI 

       130        140        150        160        170        180 
LDMHNMRSLV DNAVQLFNKY AMNDKKVNTE IIETINKEIS NKTNFINIIN ILASHLITSL 

       190        200        210        220        230        240 
ETKQQLLEET SPVKRITTVI TTLTSNIVNS ETEHALQQRV RKQIEKTQRD YYLHEQMKAI 

       250        260        270        280        290        300 
QKELDEDKSE LADIEKKIKS LKLSKEAKEK AESEFKKLRA MNQMSAESGV TRNYLETLLS 

       310        320        330        340        350        360 
LPWGKYDNSK IDINQAEKIL NRDHFGLEKV KERIIEYLAV LQRSNKIRGP ILCLIGPPGV 

       370        380        390        400        410        420 
GKTSLVKSIA EGMGRKYAKF SLGGVRDEAE IRGHRKTYLG SMPGKILGQL KKVKTSNPVM 

       430        440        450        460        470        480 
LLDEIDKMSS DFRGDPASAL LEVLDPEQNS HFVDHYLEVE YDLSNVVFIA TANSHDLPRA 

       490        500        510        520        530        540 
LSDRMEKIYI SGYVEEEKLQ IAKNYLVPKQ FKVHKIKKDE ITISEDAILD LIRYYTKESG 

       550        560        570        580        590        600 
VRALEREICA LTRKALKQIL ADNTVKNISI DSNNLEEFLG AKKYNFGLVE KEDQIGSTTG 

       610        620        630        640        650        660 
LAYTEVGGEL LTIEALAFSG KGEIKTTGKL GDVMKESAMA AYSCFRSRAP NFGLKYDNYK 

       670        680        690        700        710        720 
DFDIHIHVPA GAIPKDGPSA GCALFTTIVS LMTKIPVHRT VAMTGEITLR GNVLPIGGLK 

       730        740        750        760        770        780 
EKLLAASRGG IKTVLIPEEN VKDLKDIPPN IKENLEIISV SNIDQVLKHA LVEMPINKGL 


SYDL 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU03914.1.
RefSeqYP_067396.1. NC_006142.1.

3D structure databases

ProteinModelPortalQ68WS8.
SMRQ68WS8. Positions 594-775.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0437.

Protein family/group databases

MEROPSS16.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU03914; AAU03914; RT0437.
GeneID2958989.
KEGGrty:RT0437.
PATRIC17910112. VBIRicTyp34752_0468.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0466.
HOGENOMHOG000261410.
KOK01338.
OMANATGRKY.
OrthoDBEOG6XHC23.
ProtClustDBCLSK870932.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-459-MONOMER.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_01973. lon_bact.
InterProIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027543. Lon_bac.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR003111. Pept_S16_N.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERPTHR10046. PTHR10046. 1 hit.
PfamPF00004. AAA. 1 hit.
PF02190. LON. 1 hit.
PF05362. Lon_C. 1 hit.
[Graphical view]
PIRSFPIRSF001174. Lon_proteas. 1 hit.
SMARTSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsTIGR00763. lon. 1 hit.
PROSITEPS01046. LON_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLON_RICTY
AccessionPrimary (citable) accession number: Q68WS8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names

Peptidase families

Classification of peptidase families and list of entries