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Q68WS8

- LON_RICTY

UniProt

Q68WS8 - LON_RICTY

Protein

Lon protease

Gene

lon

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.UniRule annotation

    Catalytic activityi

    Hydrolysis of proteins in presence of ATP.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei679 – 6791UniRule annotation
    Active sitei722 – 7221UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi356 – 3638ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. ATP-dependent peptidase activity Source: UniProtKB-HAMAP
    3. sequence-specific DNA binding Source: UniProtKB-HAMAP
    4. serine-type endopeptidase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular response to stress Source: UniProtKB-HAMAP
    2. misfolded or incompletely synthesized protein catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-459-MONOMER.

    Protein family/group databases

    MEROPSiS16.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lon proteaseUniRule annotation (EC:3.4.21.53UniRule annotation)
    Alternative name(s):
    ATP-dependent protease LaUniRule annotation
    Gene namesi
    Name:lonUniRule annotation
    Ordered Locus Names:RT0437
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 784784Lon proteasePRO_0000280894Add
    BLAST

    Expressioni

    Inductioni

    By heat shock.UniRule annotation

    Interactioni

    Subunit structurei

    Homohexamer. Organized in a ring with a central cavity.UniRule annotation

    Protein-protein interaction databases

    STRINGi257363.RT0437.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68WS8.
    SMRiQ68WS8. Positions 594-775.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 203198LonUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S16 family.UniRule annotation
    Contains 1 Lon domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0466.
    HOGENOMiHOG000261410.
    KOiK01338.
    OMAiITEYTEL.
    OrthoDBiEOG6XHC23.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_01973. lon_bact.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR027543. Lon_bac.
    IPR004815. Lon_bac/euk-typ.
    IPR027065. Lon_Prtase.
    IPR027417. P-loop_NTPase.
    IPR008269. Pept_S16_C.
    IPR003111. Pept_S16_N.
    IPR008268. Peptidase_S16_AS.
    IPR015947. PUA-like_domain.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view]
    PANTHERiPTHR10046. PTHR10046. 1 hit.
    PfamiPF00004. AAA. 1 hit.
    PF02190. LON. 1 hit.
    PF05362. Lon_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001174. Lon_proteas. 1 hit.
    SMARTiSM00382. AAA. 1 hit.
    SM00464. LON. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF54211. SSF54211. 1 hit.
    SSF88697. SSF88697. 1 hit.
    TIGRFAMsiTIGR00763. lon. 1 hit.
    PROSITEiPS01046. LON_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68WS8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKKSLPLMA LRDMVLFPGV IAPIFVGRKK SLQALSRTTI SEENNTKYIL    50
    VTLQKKFDQE NPSKHELYNT AILAKIIQIV KLPNNTAKIL IEAVARVKLS 100
    DIKDEESFEA NYEIIPDEEI LDMHNMRSLV DNAVQLFNKY AMNDKKVNTE 150
    IIETINKEIS NKTNFINIIN ILASHLITSL ETKQQLLEET SPVKRITTVI 200
    TTLTSNIVNS ETEHALQQRV RKQIEKTQRD YYLHEQMKAI QKELDEDKSE 250
    LADIEKKIKS LKLSKEAKEK AESEFKKLRA MNQMSAESGV TRNYLETLLS 300
    LPWGKYDNSK IDINQAEKIL NRDHFGLEKV KERIIEYLAV LQRSNKIRGP 350
    ILCLIGPPGV GKTSLVKSIA EGMGRKYAKF SLGGVRDEAE IRGHRKTYLG 400
    SMPGKILGQL KKVKTSNPVM LLDEIDKMSS DFRGDPASAL LEVLDPEQNS 450
    HFVDHYLEVE YDLSNVVFIA TANSHDLPRA LSDRMEKIYI SGYVEEEKLQ 500
    IAKNYLVPKQ FKVHKIKKDE ITISEDAILD LIRYYTKESG VRALEREICA 550
    LTRKALKQIL ADNTVKNISI DSNNLEEFLG AKKYNFGLVE KEDQIGSTTG 600
    LAYTEVGGEL LTIEALAFSG KGEIKTTGKL GDVMKESAMA AYSCFRSRAP 650
    NFGLKYDNYK DFDIHIHVPA GAIPKDGPSA GCALFTTIVS LMTKIPVHRT 700
    VAMTGEITLR GNVLPIGGLK EKLLAASRGG IKTVLIPEEN VKDLKDIPPN 750
    IKENLEIISV SNIDQVLKHA LVEMPINKGL SYDL 784
    Length:784
    Mass (Da):88,102
    Last modified:October 11, 2004 - v1
    Checksum:i1475B928B9428BC7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03914.1.
    RefSeqiYP_067396.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU03914; AAU03914; RT0437.
    GeneIDi2958989.
    KEGGirty:RT0437.
    PATRICi17910112. VBIRicTyp34752_0468.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03914.1 .
    RefSeqi YP_067396.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68WS8.
    SMRi Q68WS8. Positions 594-775.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0437.

    Protein family/group databases

    MEROPSi S16.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU03914 ; AAU03914 ; RT0437 .
    GeneIDi 2958989.
    KEGGi rty:RT0437.
    PATRICi 17910112. VBIRicTyp34752_0468.

    Phylogenomic databases

    eggNOGi COG0466.
    HOGENOMi HOG000261410.
    KOi K01338.
    OMAi ITEYTEL.
    OrthoDBi EOG6XHC23.

    Enzyme and pathway databases

    BioCyci RTYP257363:GJEQ-459-MONOMER.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_01973. lon_bact.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR027543. Lon_bac.
    IPR004815. Lon_bac/euk-typ.
    IPR027065. Lon_Prtase.
    IPR027417. P-loop_NTPase.
    IPR008269. Pept_S16_C.
    IPR003111. Pept_S16_N.
    IPR008268. Peptidase_S16_AS.
    IPR015947. PUA-like_domain.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view ]
    PANTHERi PTHR10046. PTHR10046. 1 hit.
    Pfami PF00004. AAA. 1 hit.
    PF02190. LON. 1 hit.
    PF05362. Lon_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001174. Lon_proteas. 1 hit.
    SMARTi SM00382. AAA. 1 hit.
    SM00464. LON. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF54211. SSF54211. 1 hit.
    SSF88697. SSF88697. 1 hit.
    TIGRFAMsi TIGR00763. lon. 1 hit.
    PROSITEi PS01046. LON_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiLON_RICTY
    AccessioniPrimary (citable) accession number: Q68WS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3