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Q68WS6 (IDI2_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Isopentenyl-diphosphate delta-isomerase

Short name=IPP isomerase
EC=5.3.3.2
Alternative name(s):
Isopentenyl pyrophosphate isomerase
Gene names
Name:fni
Ordered Locus Names:RT0439
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) By similarity. HAMAP-Rule MF_00354

Catalytic activity

Isopentenyl diphosphate = dimethylallyl diphosphate. HAMAP-Rule MF_00354

Cofactor

FMN By similarity. HAMAP-Rule MF_00354

NADPH By similarity. HAMAP-Rule MF_00354

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00354.

Sequence similarities

Belongs to the IPP isomerase type 2 family.

Ontologies

Keywords
   Biological processIsoprene biosynthesis
   Cellular componentCytoplasm
   LigandFlavoprotein
FMN
NADP
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processisoprenoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionFMN binding

Inferred from electronic annotation. Source: InterPro

isopentenyl-diphosphate delta-isomerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

oxidoreductase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342Isopentenyl-diphosphate delta-isomerase HAMAP-Rule MF_00354
PRO_0000229509

Sequences

Sequence LengthMass (Da)Tools
Q68WS6 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: E973A10B89332FB4

FASTA34237,359
        10         20         30         40         50         60 
MLEEQNSDIE RKQDHIEINL KQNVNSTLKS GLASIKFIHN ALPEINYDNI DTTTTFLGKY 

        70         80         90        100        110        120 
MKAPILISSM TGGTTRAKDI NYRLAQAAQK SGIAMGLGSM RILLTKPDTI KTFTVRHVAP 

       130        140        150        160        170        180 
DIPLLANIGA VQLNYGVTPK ECQYLIDTIK ADALILHLNV LHELTQPEGN RNWENLLPKI 

       190        200        210        220        230        240 
KEVINYLSVP VIIKEVGYGL SKQVAKKLIK VGVKVLDIAG SGGTSWSQVE AYRAKNSMQN 

       250        260        270        280        290        300 
RIASSFINWG ITTLDSLKML REVSKDITLI ASGGLQSGID GAKAIRMGAN IFGLAGQLLK 

       310        320        330        340 
AADIAESLVS EEIQLIIEQL KITMLCTGSC TLKDLAKAEI ML 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU03916.1.
RefSeqYP_067398.1. NC_006142.1.

3D structure databases

ProteinModelPortalQ68WS6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0439.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU03916; AAU03916; RT0439.
GeneID2959042.
KEGGrty:RT0439.
PATRIC17910116. VBIRicTyp34752_0470.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1304.
HOGENOMHOG000072126.
KOK01823.
OMAFEFPFYI.
OrthoDBEOG62C9GJ.
ProtClustDBPRK05437.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-461-MONOMER.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00354. Idi_2.
InterProIPR013785. Aldolase_TIM.
IPR000262. FMN-dep_DH.
IPR011179. IPdP_isomerase.
[Graphical view]
PANTHERPTHR10578:SF3. PTHR10578:SF3. 1 hit.
PfamPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFPIRSF003314. IPP_isomerase. 1 hit.
TIGRFAMsTIGR02151. IPP_isom_2. 1 hit.
ProtoNetSearch...

Entry information

Entry nameIDI2_RICTY
AccessionPrimary (citable) accession number: Q68WS6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names