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Q68WR3

- HEM3_RICTY

UniProt

Q68WR3 - HEM3_RICTY

Protein

Porphobilinogen deaminase

Gene

hemC

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.UniRule annotation

    Catalytic activityi

    4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.UniRule annotation

    Cofactori

    Binds 1 dipyrromethane group covalently.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. hydroxymethylbilane synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptidyl-pyrromethane cofactor linkage Source: InterPro
    2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-475-MONOMER.
    UniPathwayiUPA00251; UER00319.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Porphobilinogen deaminaseUniRule annotation (EC:2.5.1.61UniRule annotation)
    Short name:
    PBGUniRule annotation
    Alternative name(s):
    Hydroxymethylbilane synthaseUniRule annotation
    Short name:
    HMBSUniRule annotation
    Pre-uroporphyrinogen synthaseUniRule annotation
    Gene namesi
    Name:hemCUniRule annotation
    Ordered Locus Names:RT0453
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Porphobilinogen deaminasePRO_0000142983Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei242 – 2421S-(dipyrrolylmethanemethyl)cysteineUniRule annotation

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi257363.RT0453.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68WR3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HMBS family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0181.
    HOGENOMiHOG000228587.
    KOiK01749.
    OMAiGAICIES.
    OrthoDBiEOG6HB9Z6.

    Family and domain databases

    Gene3Di3.30.160.40. 1 hit.
    HAMAPiMF_00260. Porphobil_deam.
    InterProiIPR000860. 4pyrrol_synth_OHMeBilane_synth.
    IPR022419. Porphobilin_deaminase_cofac_BS.
    IPR022417. Porphobilin_deaminase_N.
    IPR022418. Porphobilinogen_deaminase_C.
    [Graphical view]
    PANTHERiPTHR11557. PTHR11557. 1 hit.
    PfamiPF01379. Porphobil_deam. 1 hit.
    PF03900. Porphobil_deamC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
    PRINTSiPR00151. PORPHBDMNASE.
    SUPFAMiSSF54782. SSF54782. 1 hit.
    TIGRFAMsiTIGR00212. hemC. 1 hit.
    PROSITEiPS00533. PORPHOBILINOGEN_DEAM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68WR3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MINSIRIGTR NSTLALIQTN LVIAQIKQFF PDINCEIVPI ITSGDLIQNK    50
    PLYDIGGKAL FLKEIEQALL DKKIDLAVHS LKDIPGRIPV DLVIAAVLER 100
    EDPRDVLVCL NYKSIETLPQ NAVIGSSAVR RKAFIKKIRP DLNIKVFRGN 150
    VDSRIKKLMT GEVDATILSY AGLKRLNAFN KKYCHLIEYS QILPCVGQGV 200
    IAVEIRKDDN AMFNICNQIN HIPTFELIKP ERAFLEHLDA NCSTPIGAYS 250
    QYLDAYNIQT DFMLGKLDCN KIIFQTEITN INTSRECGIK AAKMMLAQQ 299
    Length:299
    Mass (Da):33,561
    Last modified:October 11, 2004 - v1
    Checksum:i0DC81A31938FAABE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03929.1.
    RefSeqiYP_067411.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU03929; AAU03929; RT0453.
    GeneIDi2959104.
    KEGGirty:RT0453.
    PATRICi17910146. VBIRicTyp34752_0484.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03929.1 .
    RefSeqi YP_067411.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68WR3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0453.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU03929 ; AAU03929 ; RT0453 .
    GeneIDi 2959104.
    KEGGi rty:RT0453.
    PATRICi 17910146. VBIRicTyp34752_0484.

    Phylogenomic databases

    eggNOGi COG0181.
    HOGENOMi HOG000228587.
    KOi K01749.
    OMAi GAICIES.
    OrthoDBi EOG6HB9Z6.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00319 .
    BioCyci RTYP257363:GJEQ-475-MONOMER.

    Family and domain databases

    Gene3Di 3.30.160.40. 1 hit.
    HAMAPi MF_00260. Porphobil_deam.
    InterProi IPR000860. 4pyrrol_synth_OHMeBilane_synth.
    IPR022419. Porphobilin_deaminase_cofac_BS.
    IPR022417. Porphobilin_deaminase_N.
    IPR022418. Porphobilinogen_deaminase_C.
    [Graphical view ]
    PANTHERi PTHR11557. PTHR11557. 1 hit.
    Pfami PF01379. Porphobil_deam. 1 hit.
    PF03900. Porphobil_deamC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
    PRINTSi PR00151. PORPHBDMNASE.
    SUPFAMi SSF54782. SSF54782. 1 hit.
    TIGRFAMsi TIGR00212. hemC. 1 hit.
    PROSITEi PS00533. PORPHOBILINOGEN_DEAM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiHEM3_RICTY
    AccessioniPrimary (citable) accession number: Q68WR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The porphobilinogen subunits are added to the dipyrromethane group.UniRule annotation

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3