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Q68WR3

- HEM3_RICTY

UniProt

Q68WR3 - HEM3_RICTY

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Protein
Porphobilinogen deaminase
Gene
hemC, RT0453
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps By similarity.UniRule annotation

Catalytic activityi

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.UniRule annotation

Cofactori

Binds 1 dipyrromethane group covalently By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. hydroxymethylbilane synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. peptidyl-pyrromethane cofactor linkage Source: InterPro
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Porphyrin biosynthesis

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-475-MONOMER.
UniPathwayiUPA00251; UER00319.

Names & Taxonomyi

Protein namesi
Recommended name:
Porphobilinogen deaminase (EC:2.5.1.61)
Short name:
PBG
Alternative name(s):
Hydroxymethylbilane synthase
Short name:
HMBS
Pre-uroporphyrinogen synthase
Gene namesi
Name:hemC
Ordered Locus Names:RT0453
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Porphobilinogen deaminaseUniRule annotation
PRO_0000142983Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei242 – 2421S-(dipyrrolylmethanemethyl)cysteine By similarity

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi257363.RT0453.

Structurei

3D structure databases

ProteinModelPortaliQ68WR3.

Family & Domainsi

Sequence similaritiesi

Belongs to the HMBS family.

Phylogenomic databases

eggNOGiCOG0181.
HOGENOMiHOG000228587.
KOiK01749.
OMAiGAICIES.
OrthoDBiEOG6HB9Z6.

Family and domain databases

Gene3Di3.30.160.40. 1 hit.
HAMAPiMF_00260. Porphobil_deam.
InterProiIPR000860. 4pyrrol_synth_OHMeBilane_synth.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view]
PANTHERiPTHR11557. PTHR11557. 1 hit.
PfamiPF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
[Graphical view]
PIRSFiPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSiPR00151. PORPHBDMNASE.
SUPFAMiSSF54782. SSF54782. 1 hit.
TIGRFAMsiTIGR00212. hemC. 1 hit.
PROSITEiPS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68WR3-1 [UniParc]FASTAAdd to Basket

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MINSIRIGTR NSTLALIQTN LVIAQIKQFF PDINCEIVPI ITSGDLIQNK    50
PLYDIGGKAL FLKEIEQALL DKKIDLAVHS LKDIPGRIPV DLVIAAVLER 100
EDPRDVLVCL NYKSIETLPQ NAVIGSSAVR RKAFIKKIRP DLNIKVFRGN 150
VDSRIKKLMT GEVDATILSY AGLKRLNAFN KKYCHLIEYS QILPCVGQGV 200
IAVEIRKDDN AMFNICNQIN HIPTFELIKP ERAFLEHLDA NCSTPIGAYS 250
QYLDAYNIQT DFMLGKLDCN KIIFQTEITN INTSRECGIK AAKMMLAQQ 299
Length:299
Mass (Da):33,561
Last modified:October 11, 2004 - v1
Checksum:i0DC81A31938FAABE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03929.1.
RefSeqiYP_067411.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03929; AAU03929; RT0453.
GeneIDi2959104.
KEGGirty:RT0453.
PATRICi17910146. VBIRicTyp34752_0484.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03929.1 .
RefSeqi YP_067411.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68WR3.
ModBasei Search...

Protein-protein interaction databases

STRINGi 257363.RT0453.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03929 ; AAU03929 ; RT0453 .
GeneIDi 2959104.
KEGGi rty:RT0453.
PATRICi 17910146. VBIRicTyp34752_0484.

Phylogenomic databases

eggNOGi COG0181.
HOGENOMi HOG000228587.
KOi K01749.
OMAi GAICIES.
OrthoDBi EOG6HB9Z6.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00319 .
BioCyci RTYP257363:GJEQ-475-MONOMER.

Family and domain databases

Gene3Di 3.30.160.40. 1 hit.
HAMAPi MF_00260. Porphobil_deam.
InterProi IPR000860. 4pyrrol_synth_OHMeBilane_synth.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view ]
PANTHERi PTHR11557. PTHR11557. 1 hit.
Pfami PF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSi PR00151. PORPHBDMNASE.
SUPFAMi SSF54782. SSF54782. 1 hit.
TIGRFAMsi TIGR00212. hemC. 1 hit.
PROSITEi PS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiHEM3_RICTY
AccessioniPrimary (citable) accession number: Q68WR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethane group By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi