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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei134L-tryptophanUniRule annotation1
Binding sitei186ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 12ATPUniRule annotation3
Nucleotide bindingi18 – 19ATPUniRule annotation2
Nucleotide bindingi146 – 148ATPUniRule annotation3
Nucleotide bindingi195 – 199ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRTYP257363:G1G0L-462-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:RT0455
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002748521 – 330Tryptophan--tRNA ligaseAdd BLAST330

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi257363.RT0455

Structurei

3D structure databases

ProteinModelPortaliQ68WR2
SMRiQ68WR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 19"HIGH" regionUniRule annotation9
Motifi195 – 199"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
HOGENOMiHOG000059940
KOiK01867
OMAiQRMTQFK
OrthoDBiPOG091H00I9

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit

Sequencei

Sequence statusi: Complete.

Q68WR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTVLSGVQ TTGALHLGNY LGSIKNWVKM QEEYNCFFFL ADLHAITIDI
60 70 80 90 100
KTSELNNSIM EVLAIYLAAG LNPDKVTIFA QSMVKEHAEL SWLLNCVTPL
110 120 130 140 150
GWLKRMTQFK DKAGSDQCKA CLGLFAYPIL MAADILIYKA DIVPVGEDQK
160 170 180 190 200
QHLELTRDIA EVINRRFDKE ILKVPDILIS ETGTRIMSLR NGLKKMSKSD
210 220 230 240 250
IADFSRINLK DSNDLIYQKI KKAKTDHLSF ISYDKKTRPE ISNLLDIYKS
260 270 280 290 300
LSKESMEKII NNYQNQGFAK FKEDLAEIII TNLQPIRDKC LELMNDKEYL
310 320 330
LKILHKGAEK AKIRASETVN EVKKQFGFII
Length:330
Mass (Da):37,661
Last modified:October 11, 2004 - v1
Checksum:i71AEB3676A2C1ACF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA Translation: AAU03930.1
RefSeqiWP_011190913.1, NC_006142.1

Genome annotation databases

EnsemblBacteriaiAAU03930; AAU03930; RT0455
KEGGirty:RT0455

Similar proteinsi

Entry informationi

Entry nameiSYW_RICTY
AccessioniPrimary (citable) accession number: Q68WR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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