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Protein

ADP,ATP carrier protein 3

Gene

tlcC

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein 3
Alternative name(s):
ADP/ATP translocase 3
Gene namesi
Name:tlcC
Synonyms:tlc3
Ordered Locus Names:RT0464
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000000604 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Transmembranei361 – 381HelicalSequence analysisAdd BLAST21
Transmembranei383 – 403HelicalSequence analysisAdd BLAST21
Transmembranei446 – 466HelicalSequence analysisAdd BLAST21
Transmembranei470 – 490HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002864741 – 501ADP,ATP carrier protein 3Add BLAST501

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0464.

Family & Domainsi

Sequence similaritiesi

Belongs to the ADP/ATP translocase tlc family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107G2R. Bacteria.
COG3202. LUCA.
HOGENOMiHOG000238123.
OMAiISHKERS.
OrthoDBiPOG091H0NNH.

Family and domain databases

InterProiIPR004667. ADP_ATP_car.
[Graphical view]
PANTHERiPTHR31187. PTHR31187. 1 hit.
PfamiPF03219. TLC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00769. AAA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68WQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPPKIFFEK FKEIIWPIER KELKLFIPMA LMMLCILFNF GALRSIKDSL
60 70 80 90 100
VVPSMGAEII SFLKLWLVLP SCVIFTVLYV KLSNKLNFEY IFYSIVGTFL
110 120 130 140 150
LFFLLFAYII YPNQDIYHPN DAMINNLIAS YPNLKWFIKI GSKWSYALMY
160 170 180 190 200
IFSELWSAVV INLMFWQFAN HIFDTAKAKR FYPVLGMIGN IGLIIAGSVL
210 220 230 240 250
VFFSSGQYII DSELLTDSFN SSSCNSIILQ PIISIIVTAG IIAMFLFRII
260 270 280 290 300
NRFILTNAIN VLDVKKAAAR TKTKLALIES IKLIIHSKYI GRIALLIICY
310 320 330 340 350
GLLINIVEGP WKAKIKELHP NTIDYVNFMG MFNIWMGISC VTFMIIGSNI
360 370 380 390 400
LRRLGWLISA LLTPIMLSIT GFIFFIFIIF IEEIGTCFGD FNLLYVAIIV
410 420 430 440 450
GAIQNILSKS SKYSLFDSTK EMAYIPLSLE LRTKGKAAVE VIGTKFGKSL
460 470 480 490 500
GAFIQSLIFI IIPTATFDSI IIYLLVIFIV MMNLWIWNII KLNKEYIKLC

K
Length:501
Mass (Da):57,193
Last modified:October 11, 2004 - v1
Checksum:i5145AEB78D2B2F23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03939.1.
RefSeqiWP_011190922.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03939; AAU03939; RT0464.
KEGGirty:RT0464.
PATRICi17910170. VBIRicTyp34752_0495.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03939.1.
RefSeqiWP_011190922.1. NC_006142.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257363.RT0464.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU03939; AAU03939; RT0464.
KEGGirty:RT0464.
PATRICi17910170. VBIRicTyp34752_0495.

Phylogenomic databases

eggNOGiENOG4107G2R. Bacteria.
COG3202. LUCA.
HOGENOMiHOG000238123.
OMAiISHKERS.
OrthoDBiPOG091H0NNH.

Family and domain databases

InterProiIPR004667. ADP_ATP_car.
[Graphical view]
PANTHERiPTHR31187. PTHR31187. 1 hit.
PfamiPF03219. TLC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00769. AAA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTLCC_RICTY
AccessioniPrimary (citable) accession number: Q68WQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.