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Q68WQ3 (TLCC_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ADP,ATP carrier protein 3
Alternative name(s):
ADP/ATP translocase 3
Gene names
Name:tlcC
Synonyms:tlc3
Ordered Locus Names:RT0464
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length501 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ADP/ATP translocase tlc family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP:ADP antiporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 501501ADP,ATP carrier protein 3
PRO_0000286474

Regions

Transmembrane23 – 4321Helical; Potential
Transmembrane59 – 7921Helical; Potential
Transmembrane90 – 11021Helical; Potential
Transmembrane146 – 16621Helical; Potential
Transmembrane183 – 20321Helical; Potential
Transmembrane227 – 24721Helical; Potential
Transmembrane293 – 31321Helical; Potential
Transmembrane326 – 34621Helical; Potential
Transmembrane361 – 38121Helical; Potential
Transmembrane383 – 40321Helical; Potential
Transmembrane446 – 46621Helical; Potential
Transmembrane470 – 49021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q68WQ3 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 5145AEB78D2B2F23

FASTA50157,193
        10         20         30         40         50         60 
MLPPKIFFEK FKEIIWPIER KELKLFIPMA LMMLCILFNF GALRSIKDSL VVPSMGAEII 

        70         80         90        100        110        120 
SFLKLWLVLP SCVIFTVLYV KLSNKLNFEY IFYSIVGTFL LFFLLFAYII YPNQDIYHPN 

       130        140        150        160        170        180 
DAMINNLIAS YPNLKWFIKI GSKWSYALMY IFSELWSAVV INLMFWQFAN HIFDTAKAKR 

       190        200        210        220        230        240 
FYPVLGMIGN IGLIIAGSVL VFFSSGQYII DSELLTDSFN SSSCNSIILQ PIISIIVTAG 

       250        260        270        280        290        300 
IIAMFLFRII NRFILTNAIN VLDVKKAAAR TKTKLALIES IKLIIHSKYI GRIALLIICY 

       310        320        330        340        350        360 
GLLINIVEGP WKAKIKELHP NTIDYVNFMG MFNIWMGISC VTFMIIGSNI LRRLGWLISA 

       370        380        390        400        410        420 
LLTPIMLSIT GFIFFIFIIF IEEIGTCFGD FNLLYVAIIV GAIQNILSKS SKYSLFDSTK 

       430        440        450        460        470        480 
EMAYIPLSLE LRTKGKAAVE VIGTKFGKSL GAFIQSLIFI IIPTATFDSI IIYLLVIFIV 

       490        500 
MMNLWIWNII KLNKEYIKLC K 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU03939.1.
RefSeqYP_067421.1. NC_006142.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0464.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU03939; AAU03939; RT0464.
GeneID2958702.
KEGGrty:RT0464.
PATRIC17910170. VBIRicTyp34752_0495.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3202.
HOGENOMHOG000238123.
OMAHPNTIDY.
OrthoDBEOG6BCSND.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-486-MONOMER.

Family and domain databases

InterProIPR004667. ADP_ATP_car.
[Graphical view]
PfamPF03219. TLC. 1 hit.
[Graphical view]
TIGRFAMsTIGR00769. AAA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTLCC_RICTY
AccessionPrimary (citable) accession number: Q68WQ3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names