Q68WQ3 (TLCC_RICTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ADP,ATP carrier protein 3

Alternative name(s):
ADP/ATP translocase 3

Gene names

Name:	tlcC
Synonyms:	tlc3
Ordered Locus Names:	RT0464

Organism

Rickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]

Taxonomic identifier

257363 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia typhi

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the ADP/ATP translocase tlc family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP:ADP antiporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 501	501	ADP,ATP carrier protein 3		PRO_0000286474
Regions
	Transmembrane	23 – 43	21	Helical; Potential
	Transmembrane	59 – 79	21	Helical; Potential
	Transmembrane	90 – 110	21	Helical; Potential
	Transmembrane	146 – 166	21	Helical; Potential
	Transmembrane	183 – 203	21	Helical; Potential
	Transmembrane	227 – 247	21	Helical; Potential
	Transmembrane	293 – 313	21	Helical; Potential
	Transmembrane	326 – 346	21	Helical; Potential
	Transmembrane	361 – 381	21	Helical; Potential
	Transmembrane	383 – 403	21	Helical; Potential
	Transmembrane	446 – 466	21	Helical; Potential
	Transmembrane	470 – 490	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q68WQ3 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 5145AEB78D2B2F23	FASTA	501	57,193
	10 20 30 40 50 60 MLPPKIFFEK FKEIIWPIER KELKLFIPMA LMMLCILFNF GALRSIKDSL VVPSMGAEII 70 80 90 100 110 120 SFLKLWLVLP SCVIFTVLYV KLSNKLNFEY IFYSIVGTFL LFFLLFAYII YPNQDIYHPN 130 140 150 160 170 180 DAMINNLIAS YPNLKWFIKI GSKWSYALMY IFSELWSAVV INLMFWQFAN HIFDTAKAKR 190 200 210 220 230 240 FYPVLGMIGN IGLIIAGSVL VFFSSGQYII DSELLTDSFN SSSCNSIILQ PIISIIVTAG 250 260 270 280 290 300 IIAMFLFRII NRFILTNAIN VLDVKKAAAR TKTKLALIES IKLIIHSKYI GRIALLIICY 310 320 330 340 350 360 GLLINIVEGP WKAKIKELHP NTIDYVNFMG MFNIWMGISC VTFMIIGSNI LRRLGWLISA 370 380 390 400 410 420 LLTPIMLSIT GFIFFIFIIF IEEIGTCFGD FNLLYVAIIV GAIQNILSKS SKYSLFDSTK 430 440 450 460 470 480 EMAYIPLSLE LRTKGKAAVE VIGTKFGKSL GAFIQSLIFI IIPTATFDSI IIYLLVIFIV 490 500 MMNLWIWNII KLNKEYIKLC K

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017197 Genomic DNA. Translation: AAU03939.1.
RefSeq	YP_067421.1. NC_006142.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	257363.RT0464.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAU03939; AAU03939; RT0464.
GeneID	2958702.
KEGG	rty:RT0464.
PATRIC	17910170. VBIRicTyp34752_0495.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3202.
HOGENOM	HOG000238123.
OMA	RLGWLIS.
ProtClustDB	CLSK870724.
Enzyme and pathway databases
BioCyc	RTYP257363:GJEQ-486-MONOMER.
Family and domain databases
InterPro	IPR004667. ADP_ATP_car. [Graphical view]
Pfam	PF03219. TLC. 1 hit. [Graphical view]
TIGRFAMs	TIGR00769. AAA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TLCC_RICTY

Accession

Primary (citable) accession number: Q68WQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program