SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q68WP6

- ISCS_RICTY

UniProt

Q68WP6 - ISCS_RICTY

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cysteine desulfurase IscS

Gene
iscS, RT0473
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins By similarity.UniRule annotation

Catalytic activityi

L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei334 – 3341Cysteine persulfide intermediate By similarity

GO - Molecular functioni

  1. cysteine desulfurase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. cysteine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-495-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine desulfurase IscS (EC:2.8.1.7)
Gene namesi
Name:iscS
Ordered Locus Names:RT0473
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Cysteine desulfurase IscSUniRule annotationPRO_0000277975Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei211 – 2111N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors By similarity.

Protein-protein interaction databases

STRINGi257363.RT0473.

Structurei

3D structure databases

ProteinModelPortaliQ68WP6.
SMRiQ68WP6. Positions 9-398.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1104.
HOGENOMiHOG000017510.
KOiK04487.
OMAiWGWEAEA.
OrthoDBiEOG62RSBK.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_00331. Cys_desulf_IscS.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR010240. Cys_deSase.
IPR016454. Cysteine_dSase_NifS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF005572. NifS. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR02006. IscS. 1 hit.
PROSITEiPS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68WP6-1 [UniParc]FASTAAdd to Basket

« Hide

MNQQLKNLTL PIYMDYQSTT PIDPRVMEAM LPYFTTKFGN PHSRSHSFGW    50
EAENAVENAR SMIAKLIGAD SKEIIFTSGA TESNNLVIKG IAKFYGNKKN 100
HIITLVSEHK CVLNACRYLE QEGIKITYLP IKPNGIIDLE ILKNAITDQT 150
LLVSVMAVNN EIGVIQPLRE IGKICRERSV FFHSDIAQGF GKIPINVNEY 200
NIDLASISGH KIYGPKGIGA LYIRKKPRVR VTPLINGGGQ ERGMRSGTLP 250
TPLIVGFGIA AEISYNEMEK DAQHVNYLFD RFLNNIYSRI PEVYLNGDKD 300
QRYKGNLNLS FAGVEGESII LAIKDLAVSS GSACTSASLE PSYVLRSIGI 350
SEELAHTSIR FGIGRFTTEQ EIDYAVNLIC SKIDKLRKLS PLWEMMQEGI 400
DLKKIKWTAH 410
Length:410
Mass (Da):45,761
Last modified:October 11, 2004 - v1
Checksum:i053978B04BA24782
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03946.1.
RefSeqiWP_011190929.1. NC_006142.1.
YP_067428.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03946; AAU03946; RT0473.
GeneIDi2958830.
KEGGirty:RT0473.
PATRICi17910188. VBIRicTyp34752_0502.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03946.1 .
RefSeqi WP_011190929.1. NC_006142.1.
YP_067428.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68WP6.
SMRi Q68WP6. Positions 9-398.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0473.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03946 ; AAU03946 ; RT0473 .
GeneIDi 2958830.
KEGGi rty:RT0473.
PATRICi 17910188. VBIRicTyp34752_0502.

Phylogenomic databases

eggNOGi COG1104.
HOGENOMi HOG000017510.
KOi K04487.
OMAi WGWEAEA.
OrthoDBi EOG62RSBK.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-495-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_00331. Cys_desulf_IscS.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR020578. Aminotrans_V_PyrdxlP_BS.
IPR010240. Cys_deSase.
IPR016454. Cysteine_dSase_NifS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF005572. NifS. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR02006. IscS. 1 hit.
PROSITEi PS00595. AA_TRANSFER_CLASS_5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiISCS_RICTY
AccessioniPrimary (citable) accession number: Q68WP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 11, 2004
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi