Q68WL3 (KCY_RICTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidylate kinase
Short name=CK
EC=2.7.4.25

Alternative name(s):
Cytidine monophosphate kinase
Short name=CMP kinase

Gene names

Name:	cmk
Ordered Locus Names:	RT0509

Organism

Rickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]

Taxonomic identifier

257363 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia typhi

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (d)CMP = ADP + (d)CDP. HAMAP-Rule MF_00238
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP cytidylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 219	219	Cytidylate kinase HAMAP-Rule MF_00238		PRO_0000131967
Regions
	Nucleotide binding	21 – 29	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q68WL3 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 4B6D963183883660	FASTA	219	24,348
	10 20 30 40 50 60 MVDLKTKAFD IAQNFTISLD GPAASGKGTI GLILAKKFAL KYFQSSIVYR QLAFNCIHQQ 70 80 90 100 110 120 IDITDIDAVI ALSQELKLDN NIDLENEDIG DIASKIAVIS EVRNNLNHNL INLVKTTPRI 130 140 150 160 170 180 IMEGRDIGTV VAPDADLKIF ITASPYVRAV RRYNQLQAKG KTCILDEIIQ QIILRDKRDK 190 200 210 ERKVGPLLPA LGAFIIDTSK LSAIEVVEEV TNYIKNKIT

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017197 Genomic DNA. Translation: AAU03979.1.
RefSeq	YP_067461.1. NC_006142.1.
3D structure databases
ProteinModelPortal	Q68WL3.
ModBase	Search...
Protein-protein interaction databases
STRING	257363.RT0509.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAU03979; AAU03979; RT0509.
GeneID	2959043.
KEGG	rty:RT0509.
PATRIC	17910258. VBIRicTyp34752_0535.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0283.
HOGENOM	HOG000242849.
KO	K00945.
OMA	HIDTGAM.
ProtClustDB	PRK00023.
Enzyme and pathway databases
BioCyc	RTYP257363:GJEQ-534-MONOMER.
Family and domain databases
HAMAP	MF_00238. Cytidyl_kinase_type1.
InterPro	IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kinase_dom. [Graphical view]
PANTHER	PTHR21299:SF2. PTHR21299:SF2. 1 hit.
Pfam	PF02224. Cytidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00017. cmk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KCY_RICTY

Accession

Primary (citable) accession number: Q68WL3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program