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Protein

Transcription termination factor Rho

Gene

rho

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei243 – 2431ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi200 – 2056ATPUniRule annotation
Nucleotide bindingi212 – 2176ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. helicase activity Source: UniProtKB-HAMAP
  3. RNA binding Source: UniProtKB-HAMAP
  4. RNA-dependent ATPase activity Source: InterPro

GO - Biological processi

  1. DNA-templated transcription, termination Source: UniProtKB-HAMAP
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Transcription, Transcription regulation, Transcription termination

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-539-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor RhoUniRule annotation (EC:3.6.4.-UniRule annotation)
Alternative name(s):
ATP-dependent helicase RhoUniRule annotation
Gene namesi
Name:rhoUniRule annotation
Ordered Locus Names:RT0513
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Transcription termination factor RhoPRO_0000286653Add
BLAST

Interactioni

Subunit structurei

Homohexamer. The homohexamer assembles into an open ring structure.UniRule annotation

Protein-protein interaction databases

STRINGi257363.RT0513.

Structurei

3D structure databases

ProteinModelPortaliQ68WL0.
SMRiQ68WL0. Positions 30-448.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rho family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1158.
HOGENOMiHOG000076952.
KOiK03628.
OMAiDYNYLPG.
OrthoDBiEOG6N681W.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01884. Rho.
InterProiIPR003593. AAA+_ATPase.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR011129. Cold_shock_prot.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR011112. Rho_N.
IPR011113. Rho_RNA-bd.
IPR004665. Term_rho.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF07498. Rho_N. 1 hit.
PF07497. Rho_RNA_bind. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00357. CSP. 1 hit.
SM00959. Rho_N. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF68912. SSF68912. 1 hit.
TIGRFAMsiTIGR00767. rho. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68WL0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTTNKQLTE ELNNTESNND HNDFAENNII NLKQLKRKLP EELQVQAEEL
60 70 80 90 100
KIENISSLLK QELVFAILKK SVEQGGLIVG DGVLEVLPDG FGFLRSPEVN
110 120 130 140 150
YLAGPDDIYI SPSQIRRFGL RTGDTVEGQI RAPKAGERYF ALLKVNRVNF
160 170 180 190 200
DDPVNAYHRV HFDNLTPLYP DEKLGLELEN NSKDSKDFST RVIELVAPMG
210 220 230 240 250
KGQRALIVAP PRTGKTVLLQ NIAHAITTNN PEVFLIVLLI DERPEEVTDM
260 270 280 290 300
QRSVRGEVVS STFDEPASRH VQLAEMVIEK AKRLVEHKKD VVILVDAITR
310 320 330 340 350
LARAYNTVVP SSGKVLTGGV DANALQRPKR FFGAARNIEN GGSLTIIGTA
360 370 380 390 400
LIETGSRMDE VIFEEFKGTG NSEIVLDRKI ADKRIYPAID ITRSGTRKED
410 420 430 440 450
LLVDKIILNK MWVLRRIIDP MGSSEAIEFL LKKLENTKTN YEFFEMMKSP

ERSRNGL
Length:457
Mass (Da):51,334
Last modified:May 15, 2007 - v2
Checksum:i83583DC378994916
GO

Sequence cautioni

The sequence AAU03982.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03982.1. Different initiation.
RefSeqiYP_067464.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03982; AAU03982; RT0513.
GeneIDi2959350.
KEGGirty:RT0513.
PATRICi17910266. VBIRicTyp34752_0538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03982.1. Different initiation.
RefSeqiYP_067464.1. NC_006142.1.

3D structure databases

ProteinModelPortaliQ68WL0.
SMRiQ68WL0. Positions 30-448.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257363.RT0513.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU03982; AAU03982; RT0513.
GeneIDi2959350.
KEGGirty:RT0513.
PATRICi17910266. VBIRicTyp34752_0538.

Phylogenomic databases

eggNOGiCOG1158.
HOGENOMiHOG000076952.
KOiK03628.
OMAiDYNYLPG.
OrthoDBiEOG6N681W.

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-539-MONOMER.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01884. Rho.
InterProiIPR003593. AAA+_ATPase.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR011129. Cold_shock_prot.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR011112. Rho_N.
IPR011113. Rho_RNA-bd.
IPR004665. Term_rho.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF07498. Rho_N. 1 hit.
PF07497. Rho_RNA_bind. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00357. CSP. 1 hit.
SM00959. Rho_N. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF68912. SSF68912. 1 hit.
TIGRFAMsiTIGR00767. rho. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiRHO_RICTY
AccessioniPrimary (citable) accession number: Q68WL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: January 7, 2015
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.