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Protein

Transcription termination factor Rho

Gene

rho

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei243ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi200 – 205ATPUniRule annotation6
Nucleotide bindingi212 – 217ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Transcription, Transcription regulation, Transcription termination

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor RhoUniRule annotation (EC:3.6.4.-UniRule annotation)
Alternative name(s):
ATP-dependent helicase RhoUniRule annotation
Gene namesi
Name:rhoUniRule annotation
Ordered Locus Names:RT0513
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000000604 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002866531 – 457Transcription termination factor RhoAdd BLAST457

Interactioni

Subunit structurei

Homohexamer. The homohexamer assembles into an open ring structure.UniRule annotation

Protein-protein interaction databases

STRINGi257363.RT0513.

Structurei

3D structure databases

ProteinModelPortaliQ68WL0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rho family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C4P. Bacteria.
COG1158. LUCA.
HOGENOMiHOG000076952.
KOiK03628.
OMAiFLRAPDY.
OrthoDBiPOG091H05EO.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01884. Rho. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR011129. Cold_shock_prot.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR011112. Rho_N.
IPR011113. Rho_RNA-bd.
IPR004665. Term_rho.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF07498. Rho_N. 1 hit.
PF07497. Rho_RNA_bind. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00357. CSP. 1 hit.
SM00959. Rho_N. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF68912. SSF68912. 1 hit.
TIGRFAMsiTIGR00767. rho. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68WL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTTNKQLTE ELNNTESNND HNDFAENNII NLKQLKRKLP EELQVQAEEL
60 70 80 90 100
KIENISSLLK QELVFAILKK SVEQGGLIVG DGVLEVLPDG FGFLRSPEVN
110 120 130 140 150
YLAGPDDIYI SPSQIRRFGL RTGDTVEGQI RAPKAGERYF ALLKVNRVNF
160 170 180 190 200
DDPVNAYHRV HFDNLTPLYP DEKLGLELEN NSKDSKDFST RVIELVAPMG
210 220 230 240 250
KGQRALIVAP PRTGKTVLLQ NIAHAITTNN PEVFLIVLLI DERPEEVTDM
260 270 280 290 300
QRSVRGEVVS STFDEPASRH VQLAEMVIEK AKRLVEHKKD VVILVDAITR
310 320 330 340 350
LARAYNTVVP SSGKVLTGGV DANALQRPKR FFGAARNIEN GGSLTIIGTA
360 370 380 390 400
LIETGSRMDE VIFEEFKGTG NSEIVLDRKI ADKRIYPAID ITRSGTRKED
410 420 430 440 450
LLVDKIILNK MWVLRRIIDP MGSSEAIEFL LKKLENTKTN YEFFEMMKSP

ERSRNGL
Length:457
Mass (Da):51,334
Last modified:May 15, 2007 - v2
Checksum:i83583DC378994916
GO

Sequence cautioni

The sequence AAU03982 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03982.1. Different initiation.
RefSeqiWP_014419441.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03982; AAU03982; RT0513.
KEGGirty:RT0513.
PATRICi17910266. VBIRicTyp34752_0538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03982.1. Different initiation.
RefSeqiWP_014419441.1. NC_006142.1.

3D structure databases

ProteinModelPortaliQ68WL0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257363.RT0513.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU03982; AAU03982; RT0513.
KEGGirty:RT0513.
PATRICi17910266. VBIRicTyp34752_0538.

Phylogenomic databases

eggNOGiENOG4105C4P. Bacteria.
COG1158. LUCA.
HOGENOMiHOG000076952.
KOiK03628.
OMAiFLRAPDY.
OrthoDBiPOG091H05EO.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01884. Rho. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR011129. Cold_shock_prot.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR011112. Rho_N.
IPR011113. Rho_RNA-bd.
IPR004665. Term_rho.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF07498. Rho_N. 1 hit.
PF07497. Rho_RNA_bind. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00357. CSP. 1 hit.
SM00959. Rho_N. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF68912. SSF68912. 1 hit.
TIGRFAMsiTIGR00767. rho. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRHO_RICTY
AccessioniPrimary (citable) accession number: Q68WL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 2, 2016
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.