Q68WL0 (RHO_RICTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription termination factor Rho
EC=3.6.4.-

Alternative name(s):
ATP-dependent helicase Rho

Gene names

Name:	rho
Ordered Locus Names:	RT0513

Organism

Rickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]

Taxonomic identifier

257363 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia typhi

Protein attributes

Sequence length	457 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template By similarity. HAMAP-Rule MF_01884
Subunit structure	Homohexamer. The homohexamer assembles into an open ring structure By similarity.
Sequence similarities	Belongs to the Rho family.
Sequence caution	The sequence AAU03982.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Transcription termination
Ligand	ATP-binding Nucleotide-binding RNA-binding
Molecular function	Helicase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA-dependent transcription, termination Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP RNA binding Inferred from electronic annotation. Source: HAMAP RNA-dependent ATPase activity Inferred from electronic annotation. Source: InterPro helicase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 457	457	Transcription termination factor Rho HAMAP-Rule MF_01884		PRO_0000286653
Regions
	Nucleotide binding	200 – 205	6	ATP Potential
	Nucleotide binding	212 – 217	6	ATP By similarity
Sites
	Binding site	243	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q68WL0 [UniParc]. Last modified May 15, 2007. Version 2. Checksum: 83583DC378994916	FASTA	457	51,334
	10 20 30 40 50 60 MNTTNKQLTE ELNNTESNND HNDFAENNII NLKQLKRKLP EELQVQAEEL KIENISSLLK 70 80 90 100 110 120 QELVFAILKK SVEQGGLIVG DGVLEVLPDG FGFLRSPEVN YLAGPDDIYI SPSQIRRFGL 130 140 150 160 170 180 RTGDTVEGQI RAPKAGERYF ALLKVNRVNF DDPVNAYHRV HFDNLTPLYP DEKLGLELEN 190 200 210 220 230 240 NSKDSKDFST RVIELVAPMG KGQRALIVAP PRTGKTVLLQ NIAHAITTNN PEVFLIVLLI 250 260 270 280 290 300 DERPEEVTDM QRSVRGEVVS STFDEPASRH VQLAEMVIEK AKRLVEHKKD VVILVDAITR 310 320 330 340 350 360 LARAYNTVVP SSGKVLTGGV DANALQRPKR FFGAARNIEN GGSLTIIGTA LIETGSRMDE 370 380 390 400 410 420 VIFEEFKGTG NSEIVLDRKI ADKRIYPAID ITRSGTRKED LLVDKIILNK MWVLRRIIDP 430 440 450 MGSSEAIEFL LKKLENTKTN YEFFEMMKSP ERSRNGL

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017197 Genomic DNA. Translation: AAU03982.1. Different initiation.
RefSeq	YP_067464.1. NC_006142.1.
3D structure databases
ProteinModelPortal	Q68WL0.
SMR	Q68WL0. Positions 30-448.
ModBase	Search...
Protein-protein interaction databases
STRING	257363.RT0513.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAU03982; AAU03982; RT0513.
GeneID	2959350.
KEGG	rty:RT0513.
PATRIC	17910266. VBIRicTyp34752_0538.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1158.
HOGENOM	HOG000076952.
KO	K03628.
OMA	FGFLRAP.
ProtClustDB	PRK09376.
Enzyme and pathway databases
BioCyc	RTYP257363:GJEQ-539-MONOMER.
Family and domain databases
Gene3D	2.40.50.140. 1 hit.
HAMAP	MF_01884. Rho.
InterPro	IPR003593. AAA+_ATPase. IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd. IPR011129. Cold_shock_prot. IPR012340. NA-bd_OB-fold. IPR011112. Rho_N. IPR011113. Rho_RNA-bd. IPR004665. Term_rho. [Graphical view]
Pfam	PF00006. ATP-synt_ab. 1 hit. PF07498. Rho_N. 1 hit. PF07497. Rho_RNA_bind. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. SM00357. CSP. 1 hit. SM00959. Rho_N. 1 hit. [Graphical view]
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit. SSF68912. Rho_N. 1 hit.
TIGRFAMs	TIGR00767. rho. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RHO_RICTY

Accession

Primary (citable) accession number: Q68WL0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	May 15, 2007
Last modified:	May 1, 2013
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program