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Q68WL0 (RHO_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription termination factor Rho

EC=3.6.4.-
Alternative name(s):
ATP-dependent helicase Rho
Gene names
Name:rho
Ordered Locus Names:RT0513
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template By similarity. HAMAP-Rule MF_01884

Subunit structure

Homohexamer. The homohexamer assembles into an open ring structure By similarity.

Sequence similarities

Belongs to the Rho family.

Sequence caution

The sequence AAU03982.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457Transcription termination factor Rho HAMAP-Rule MF_01884
PRO_0000286653

Regions

Nucleotide binding200 – 2056ATP Potential
Nucleotide binding212 – 2176ATP By similarity

Sites

Binding site2431ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68WL0 [UniParc].

Last modified May 15, 2007. Version 2.
Checksum: 83583DC378994916

FASTA45751,334
        10         20         30         40         50         60 
MNTTNKQLTE ELNNTESNND HNDFAENNII NLKQLKRKLP EELQVQAEEL KIENISSLLK 

        70         80         90        100        110        120 
QELVFAILKK SVEQGGLIVG DGVLEVLPDG FGFLRSPEVN YLAGPDDIYI SPSQIRRFGL 

       130        140        150        160        170        180 
RTGDTVEGQI RAPKAGERYF ALLKVNRVNF DDPVNAYHRV HFDNLTPLYP DEKLGLELEN 

       190        200        210        220        230        240 
NSKDSKDFST RVIELVAPMG KGQRALIVAP PRTGKTVLLQ NIAHAITTNN PEVFLIVLLI 

       250        260        270        280        290        300 
DERPEEVTDM QRSVRGEVVS STFDEPASRH VQLAEMVIEK AKRLVEHKKD VVILVDAITR 

       310        320        330        340        350        360 
LARAYNTVVP SSGKVLTGGV DANALQRPKR FFGAARNIEN GGSLTIIGTA LIETGSRMDE 

       370        380        390        400        410        420 
VIFEEFKGTG NSEIVLDRKI ADKRIYPAID ITRSGTRKED LLVDKIILNK MWVLRRIIDP 

       430        440        450 
MGSSEAIEFL LKKLENTKTN YEFFEMMKSP ERSRNGL 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU03982.1. Different initiation.
RefSeqYP_067464.1. NC_006142.1.

3D structure databases

ProteinModelPortalQ68WL0.
SMRQ68WL0. Positions 30-448.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0513.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU03982; AAU03982; RT0513.
GeneID2959350.
KEGGrty:RT0513.
PATRIC17910266. VBIRicTyp34752_0538.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1158.
HOGENOMHOG000076952.
KOK03628.
OMAQHIAHSI.
OrthoDBEOG6N681W.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-539-MONOMER.

Family and domain databases

Gene3D2.40.50.140. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_01884. Rho.
InterProIPR003593. AAA+_ATPase.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR011129. Cold_shock_prot.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR011112. Rho_N.
IPR011113. Rho_RNA-bd.
IPR004665. Term_rho.
[Graphical view]
PfamPF00006. ATP-synt_ab. 1 hit.
PF07498. Rho_N. 1 hit.
PF07497. Rho_RNA_bind. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
SM00357. CSP. 1 hit.
SM00959. Rho_N. 1 hit.
[Graphical view]
SUPFAMSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF68912. SSF68912. 1 hit.
TIGRFAMsTIGR00767. rho. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRHO_RICTY
AccessionPrimary (citable) accession number: Q68WL0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: May 14, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names