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Q68WL0

- RHO_RICTY

UniProt

Q68WL0 - RHO_RICTY

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Protein
Transcription termination factor Rho
Gene
rho, RT0513
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei243 – 2431ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi200 – 2056ATP Reviewed prediction
Nucleotide bindingi212 – 2176ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. RNA binding Source: UniProtKB-HAMAP
  3. RNA-dependent ATPase activity Source: InterPro
  4. helicase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA-templated transcription, termination Source: UniProtKB-HAMAP
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Transcription, Transcription regulation, Transcription termination

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-539-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor Rho (EC:3.6.4.-)
Alternative name(s):
ATP-dependent helicase Rho
Gene namesi
Name:rho
Ordered Locus Names:RT0513
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Transcription termination factor RhoUniRule annotation
PRO_0000286653Add
BLAST

Interactioni

Subunit structurei

Homohexamer. The homohexamer assembles into an open ring structure By similarity.

Protein-protein interaction databases

STRINGi257363.RT0513.

Structurei

3D structure databases

ProteinModelPortaliQ68WL0.
SMRiQ68WL0. Positions 30-448.

Family & Domainsi

Sequence similaritiesi

Belongs to the Rho family.

Phylogenomic databases

eggNOGiCOG1158.
HOGENOMiHOG000076952.
KOiK03628.
OMAiQHIAHSI.
OrthoDBiEOG6N681W.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01884. Rho.
InterProiIPR003593. AAA+_ATPase.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR011129. Cold_shock_prot.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR011112. Rho_N.
IPR011113. Rho_RNA-bd.
IPR004665. Term_rho.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF07498. Rho_N. 1 hit.
PF07497. Rho_RNA_bind. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00357. CSP. 1 hit.
SM00959. Rho_N. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF68912. SSF68912. 1 hit.
TIGRFAMsiTIGR00767. rho. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68WL0-1 [UniParc]FASTAAdd to Basket

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MNTTNKQLTE ELNNTESNND HNDFAENNII NLKQLKRKLP EELQVQAEEL    50
KIENISSLLK QELVFAILKK SVEQGGLIVG DGVLEVLPDG FGFLRSPEVN 100
YLAGPDDIYI SPSQIRRFGL RTGDTVEGQI RAPKAGERYF ALLKVNRVNF 150
DDPVNAYHRV HFDNLTPLYP DEKLGLELEN NSKDSKDFST RVIELVAPMG 200
KGQRALIVAP PRTGKTVLLQ NIAHAITTNN PEVFLIVLLI DERPEEVTDM 250
QRSVRGEVVS STFDEPASRH VQLAEMVIEK AKRLVEHKKD VVILVDAITR 300
LARAYNTVVP SSGKVLTGGV DANALQRPKR FFGAARNIEN GGSLTIIGTA 350
LIETGSRMDE VIFEEFKGTG NSEIVLDRKI ADKRIYPAID ITRSGTRKED 400
LLVDKIILNK MWVLRRIIDP MGSSEAIEFL LKKLENTKTN YEFFEMMKSP 450
ERSRNGL 457
Length:457
Mass (Da):51,334
Last modified:May 15, 2007 - v2
Checksum:i83583DC378994916
GO

Sequence cautioni

The sequence AAU03982.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03982.1. Different initiation.
RefSeqiYP_067464.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03982; AAU03982; RT0513.
GeneIDi2959350.
KEGGirty:RT0513.
PATRICi17910266. VBIRicTyp34752_0538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03982.1 . Different initiation.
RefSeqi YP_067464.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68WL0.
SMRi Q68WL0. Positions 30-448.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0513.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03982 ; AAU03982 ; RT0513 .
GeneIDi 2959350.
KEGGi rty:RT0513.
PATRICi 17910266. VBIRicTyp34752_0538.

Phylogenomic databases

eggNOGi COG1158.
HOGENOMi HOG000076952.
KOi K03628.
OMAi QHIAHSI.
OrthoDBi EOG6N681W.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-539-MONOMER.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_01884. Rho.
InterProi IPR003593. AAA+_ATPase.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR011129. Cold_shock_prot.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR011112. Rho_N.
IPR011113. Rho_RNA-bd.
IPR004665. Term_rho.
[Graphical view ]
Pfami PF00006. ATP-synt_ab. 1 hit.
PF07498. Rho_N. 1 hit.
PF07497. Rho_RNA_bind. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM00357. CSP. 1 hit.
SM00959. Rho_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF68912. SSF68912. 1 hit.
TIGRFAMsi TIGR00767. rho. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiRHO_RICTY
AccessioniPrimary (citable) accession number: Q68WL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: May 14, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi