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Q68WL0

- RHO_RICTY

UniProt

Q68WL0 - RHO_RICTY

Protein

Transcription termination factor Rho

Gene

rho

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (15 May 2007)
      Previous versions | rss
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    Functioni

    Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei243 – 2431ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi200 – 2056ATPUniRule annotation
    Nucleotide bindingi212 – 2176ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. helicase activity Source: UniProtKB-HAMAP
    3. RNA binding Source: UniProtKB-HAMAP
    4. RNA-dependent ATPase activity Source: InterPro

    GO - Biological processi

    1. DNA-templated transcription, termination Source: UniProtKB-HAMAP
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Biological processi

    Transcription, Transcription regulation, Transcription termination

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-539-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription termination factor RhoUniRule annotation (EC:3.6.4.-UniRule annotation)
    Alternative name(s):
    ATP-dependent helicase RhoUniRule annotation
    Gene namesi
    Name:rhoUniRule annotation
    Ordered Locus Names:RT0513
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 457457Transcription termination factor RhoPRO_0000286653Add
    BLAST

    Interactioni

    Subunit structurei

    Homohexamer. The homohexamer assembles into an open ring structure.UniRule annotation

    Protein-protein interaction databases

    STRINGi257363.RT0513.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68WL0.
    SMRiQ68WL0. Positions 30-448.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Rho family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1158.
    HOGENOMiHOG000076952.
    KOiK03628.
    OMAiQHIAHSI.
    OrthoDBiEOG6N681W.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_01884. Rho.
    InterProiIPR003593. AAA+_ATPase.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR011129. Cold_shock_prot.
    IPR012340. NA-bd_OB-fold.
    IPR027417. P-loop_NTPase.
    IPR011112. Rho_N.
    IPR011113. Rho_RNA-bd.
    IPR004665. Term_rho.
    [Graphical view]
    PfamiPF00006. ATP-synt_ab. 1 hit.
    PF07498. Rho_N. 1 hit.
    PF07497. Rho_RNA_bind. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM00357. CSP. 1 hit.
    SM00959. Rho_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF68912. SSF68912. 1 hit.
    TIGRFAMsiTIGR00767. rho. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q68WL0-1 [UniParc]FASTAAdd to Basket

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    MNTTNKQLTE ELNNTESNND HNDFAENNII NLKQLKRKLP EELQVQAEEL    50
    KIENISSLLK QELVFAILKK SVEQGGLIVG DGVLEVLPDG FGFLRSPEVN 100
    YLAGPDDIYI SPSQIRRFGL RTGDTVEGQI RAPKAGERYF ALLKVNRVNF 150
    DDPVNAYHRV HFDNLTPLYP DEKLGLELEN NSKDSKDFST RVIELVAPMG 200
    KGQRALIVAP PRTGKTVLLQ NIAHAITTNN PEVFLIVLLI DERPEEVTDM 250
    QRSVRGEVVS STFDEPASRH VQLAEMVIEK AKRLVEHKKD VVILVDAITR 300
    LARAYNTVVP SSGKVLTGGV DANALQRPKR FFGAARNIEN GGSLTIIGTA 350
    LIETGSRMDE VIFEEFKGTG NSEIVLDRKI ADKRIYPAID ITRSGTRKED 400
    LLVDKIILNK MWVLRRIIDP MGSSEAIEFL LKKLENTKTN YEFFEMMKSP 450
    ERSRNGL 457
    Length:457
    Mass (Da):51,334
    Last modified:May 15, 2007 - v2
    Checksum:i83583DC378994916
    GO

    Sequence cautioni

    The sequence AAU03982.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03982.1. Different initiation.
    RefSeqiYP_067464.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU03982; AAU03982; RT0513.
    GeneIDi2959350.
    KEGGirty:RT0513.
    PATRICi17910266. VBIRicTyp34752_0538.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU03982.1 . Different initiation.
    RefSeqi YP_067464.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68WL0.
    SMRi Q68WL0. Positions 30-448.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0513.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU03982 ; AAU03982 ; RT0513 .
    GeneIDi 2959350.
    KEGGi rty:RT0513.
    PATRICi 17910266. VBIRicTyp34752_0538.

    Phylogenomic databases

    eggNOGi COG1158.
    HOGENOMi HOG000076952.
    KOi K03628.
    OMAi QHIAHSI.
    OrthoDBi EOG6N681W.

    Enzyme and pathway databases

    BioCyci RTYP257363:GJEQ-539-MONOMER.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_01884. Rho.
    InterProi IPR003593. AAA+_ATPase.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR011129. Cold_shock_prot.
    IPR012340. NA-bd_OB-fold.
    IPR027417. P-loop_NTPase.
    IPR011112. Rho_N.
    IPR011113. Rho_RNA-bd.
    IPR004665. Term_rho.
    [Graphical view ]
    Pfami PF00006. ATP-synt_ab. 1 hit.
    PF07498. Rho_N. 1 hit.
    PF07497. Rho_RNA_bind. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM00357. CSP. 1 hit.
    SM00959. Rho_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF68912. SSF68912. 1 hit.
    TIGRFAMsi TIGR00767. rho. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiRHO_RICTY
    AccessioniPrimary (citable) accession number: Q68WL0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3