Q68WK5 (IF3_RICTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Translation initiation factor IF-3

Gene names

Name:	infC
Ordered Locus Names:	RT0518

Organism

Rickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]

Taxonomic identifier

257363 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia typhi

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins By similarity. HAMAP-Rule MF_00080
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the IF-3 family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Molecular function	Initiation factor
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	translation initiation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Translation initiation factor IF-3 HAMAP-Rule MF_00080		PRO_0000177569

Sequences

	Sequence		Length	Mass (Da)
	Q68WK5 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: BA74292A4834590B	FASTA	185	21,676
	10 20 30 40 50 60 MYLFVNIIWR NFISKNNLPK ANREIRAREV RLVDENSEMH GVVNIREALD MAERAGLDLV 70 80 90 100 110 120 EISPNAVPPV CKILDFGKFK YENKKRLHEA RKKQKIVVLK EMKFKPNISI GDFETKLRKI 130 140 150 160 170 180 KEFLKDGDKV KISLWFKGRE ILHKEVGHEL FKRIELALEG LIKIDQHAKM EGKQMIMIIS PDIKV

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017197 Genomic DNA. Translation: AAU03987.1.
RefSeq	YP_067469.1. NC_006142.1.
3D structure databases
ProteinModelPortal	Q68WK5.
SMR	Q68WK5. Positions 20-92.
ModBase	Search...
Protein-protein interaction databases
STRING	257363.RT0518.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAU03987; AAU03987; RT0518.
GeneID	2959044.
KEGG	rty:RT0518.
PATRIC	17910276. VBIRicTyp34752_0543.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0290.
HOGENOM	HOG000035157.
KO	K02520.
OMA	HDYQTKV.
ProtClustDB	PRK00028.
Enzyme and pathway databases
BioCyc	RTYP257363:GJEQ-544-MONOMER.
Family and domain databases
Gene3D	3.10.20.80. 1 hit.
HAMAP	MF_00080. IF-3.
InterPro	IPR019813. Translation_initiation_fac3_CS. IPR001288. Translation_initiation_fac_3. IPR019815. Translation_initiation_fac_3_C. IPR019814. Translation_initiation_fac_3_N. [Graphical view]
PANTHER	PTHR10938. PTHR10938. 1 hit.
Pfam	PF00707. IF3_C. 1 hit. PF05198. IF3_N. 1 hit. [Graphical view]
SUPFAM	SSF54364. IF3. 1 hit. SSF55200. IF3. 1 hit.
TIGRFAMs	TIGR00168. infC. 1 hit.
PROSITE	PS00938. IF3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IF3_RICTY

Accession

Primary (citable) accession number: Q68WK5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program