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Protein

NADH-quinone oxidoreductase subunit N

Gene

nuoN

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + a quinone = NAD+ + a quinol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit NUniRule annotation (EC:1.6.5.11UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit NUniRule annotation
NDH-1 subunit NUniRule annotation
Gene namesi
Name:nuoNUniRule annotation
Ordered Locus Names:RT0526
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000000604 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalUniRule annotationAdd BLAST21
Transmembranei30 – 50HelicalUniRule annotationAdd BLAST21
Transmembranei62 – 82HelicalUniRule annotationAdd BLAST21
Transmembranei93 – 113HelicalUniRule annotationAdd BLAST21
Transmembranei118 – 138HelicalUniRule annotationAdd BLAST21
Transmembranei153 – 173HelicalUniRule annotationAdd BLAST21
Transmembranei196 – 216HelicalUniRule annotationAdd BLAST21
Transmembranei235 – 255HelicalUniRule annotationAdd BLAST21
Transmembranei261 – 281HelicalUniRule annotationAdd BLAST21
Transmembranei290 – 310HelicalUniRule annotationAdd BLAST21
Transmembranei319 – 339HelicalUniRule annotationAdd BLAST21
Transmembranei361 – 381HelicalUniRule annotationAdd BLAST21
Transmembranei397 – 417HelicalUniRule annotationAdd BLAST21
Transmembranei438 – 458HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002723331 – 458NADH-quinone oxidoreductase subunit NAdd BLAST458

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi257363.RT0526.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 2 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CNR. Bacteria.
COG1007. LUCA.
HOGENOMiHOG000010703.
KOiK00343.
OMAiISHIGYA.
OrthoDBiPOG091H0B2L.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1. 1 hit.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68WJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLILPEITL TLIALLGQCF ALMIPNKNKI IYNIVILLCI ISIFLTFKYS
60 70 80 90 100
SYEGIWHSFA TGINIGISKS IVLLFTIVSL IIYRDYSNLI GEAIKFEFIT
110 120 130 140 150
LILLSIVGIF VAISSRNFLL LFCGMELTAL TSYALAGFKL DDIQSSEGAL
160 170 180 190 200
KYFILGSLVT CLSLFGISFI YGFGGSIQFE DILHQLNNNS EIKPGLIIGI
210 220 230 240 250
VLFLSSIFFK LASSPLHFWI PDVYEGSPIS SITYFTSAAK IGMVIVLFNI
260 270 280 290 300
SKLIIGNYYP INYNLIKIIA ILSMLFGAFG AIQQTSLKRL MAYSTILNIG
310 320 330 340 350
YVLIGVILPN QEGYKAALLY ILIYAVVSIG FFTCLIMLFG KDVDKASFKT
360 370 380 390 400
IQGIAETHKT IAALISIVMF SMIGIPPLTG FFGKYYLFYQ AINKQEFTLA
410 420 430 440 450
YCGIFTSVVA AFYYLKVVKA MYFSKKNSII KLPIQYGLLL INYLVLVFLL

FGSFIILF
Length:458
Mass (Da):51,036
Last modified:October 11, 2004 - v1
Checksum:i38151D913207A51A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03995.1.
RefSeqiWP_011190976.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03995; AAU03995; RT0526.
KEGGirty:RT0526.
PATRICi17910290. VBIRicTyp34752_0550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU03995.1.
RefSeqiWP_011190976.1. NC_006142.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257363.RT0526.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU03995; AAU03995; RT0526.
KEGGirty:RT0526.
PATRICi17910290. VBIRicTyp34752_0550.

Phylogenomic databases

eggNOGiENOG4105CNR. Bacteria.
COG1007. LUCA.
HOGENOMiHOG000010703.
KOiK00343.
OMAiISHIGYA.
OrthoDBiPOG091H0B2L.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1. 1 hit.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF00361. Proton_antipo_M. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNUON_RICTY
AccessioniPrimary (citable) accession number: Q68WJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.