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Q68WJ7

- NUON_RICTY

UniProt

Q68WJ7 - NUON_RICTY

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Protein
NADH-quinone oxidoreductase subunit N
Gene
nuoN, RT0526
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  2. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP synthesis coupled electron transport Source: InterPro
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-552-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit N (EC:1.6.99.5)
Alternative name(s):
NADH dehydrogenase I subunit N
NDH-1 subunit N
Gene namesi
Name:nuoN
Ordered Locus Names:RT0526
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221Helical; Reviewed prediction
Add
BLAST
Transmembranei30 – 5021Helical; Reviewed prediction
Add
BLAST
Transmembranei62 – 8221Helical; Reviewed prediction
Add
BLAST
Transmembranei93 – 11321Helical; Reviewed prediction
Add
BLAST
Transmembranei118 – 13821Helical; Reviewed prediction
Add
BLAST
Transmembranei153 – 17321Helical; Reviewed prediction
Add
BLAST
Transmembranei196 – 21621Helical; Reviewed prediction
Add
BLAST
Transmembranei235 – 25521Helical; Reviewed prediction
Add
BLAST
Transmembranei261 – 28121Helical; Reviewed prediction
Add
BLAST
Transmembranei290 – 31021Helical; Reviewed prediction
Add
BLAST
Transmembranei319 – 33921Helical; Reviewed prediction
Add
BLAST
Transmembranei361 – 38121Helical; Reviewed prediction
Add
BLAST
Transmembranei397 – 41721Helical; Reviewed prediction
Add
BLAST
Transmembranei438 – 45821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458NADH-quinone oxidoreductase subunit NUniRule annotation
PRO_0000272333Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.

Protein-protein interaction databases

STRINGi257363.RT0526.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1007.
HOGENOMiHOG000010703.
KOiK00343.
OMAiIDKLSWI.
OrthoDBiEOG64JFNZ.

Family and domain databases

HAMAPiMF_00445. NDH1_NuoN_1.
InterProiIPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01770. NDH_I_N. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68WJ7-1 [UniParc]FASTAAdd to Basket

« Hide

MLLILPEITL TLIALLGQCF ALMIPNKNKI IYNIVILLCI ISIFLTFKYS    50
SYEGIWHSFA TGINIGISKS IVLLFTIVSL IIYRDYSNLI GEAIKFEFIT 100
LILLSIVGIF VAISSRNFLL LFCGMELTAL TSYALAGFKL DDIQSSEGAL 150
KYFILGSLVT CLSLFGISFI YGFGGSIQFE DILHQLNNNS EIKPGLIIGI 200
VLFLSSIFFK LASSPLHFWI PDVYEGSPIS SITYFTSAAK IGMVIVLFNI 250
SKLIIGNYYP INYNLIKIIA ILSMLFGAFG AIQQTSLKRL MAYSTILNIG 300
YVLIGVILPN QEGYKAALLY ILIYAVVSIG FFTCLIMLFG KDVDKASFKT 350
IQGIAETHKT IAALISIVMF SMIGIPPLTG FFGKYYLFYQ AINKQEFTLA 400
YCGIFTSVVA AFYYLKVVKA MYFSKKNSII KLPIQYGLLL INYLVLVFLL 450
FGSFIILF 458
Length:458
Mass (Da):51,036
Last modified:October 11, 2004 - v1
Checksum:i38151D913207A51A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03995.1.
RefSeqiYP_067477.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03995; AAU03995; RT0526.
GeneIDi2958745.
KEGGirty:RT0526.
PATRICi17910290. VBIRicTyp34752_0550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU03995.1 .
RefSeqi YP_067477.1. NC_006142.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0526.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03995 ; AAU03995 ; RT0526 .
GeneIDi 2958745.
KEGGi rty:RT0526.
PATRICi 17910290. VBIRicTyp34752_0550.

Phylogenomic databases

eggNOGi COG1007.
HOGENOMi HOG000010703.
KOi K00343.
OMAi IDKLSWI.
OrthoDBi EOG64JFNZ.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-552-MONOMER.

Family and domain databases

HAMAPi MF_00445. NDH1_NuoN_1.
InterProi IPR010096. NADH-Q_OxRdtase_suN/2.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
[Graphical view ]
Pfami PF00361. Oxidored_q1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01770. NDH_I_N. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiNUON_RICTY
AccessioniPrimary (citable) accession number: Q68WJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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