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Protein

Putative fatty acid oxidation complex trifunctional enzyme

Gene

RT0547

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.
(3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA.

GO - Molecular functioni

  1. 3-hydroxyacyl-CoA dehydrogenase activity Source: UniProtKB-EC
  2. coenzyme binding Source: InterPro
  3. dodecenoyl-CoA delta-isomerase activity Source: UniProtKB-EC
  4. enoyl-CoA hydratase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Lyase, Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-576-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative fatty acid oxidation complex trifunctional enzyme
Including the following 2 domains:
3-hydroxyacyl-CoA dehydrogenase (EC:1.1.1.35)
Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase (EC:4.2.1.17, EC:5.3.3.8)
Gene namesi
Ordered Locus Names:RT0547
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 720720Putative fatty acid oxidation complex trifunctional enzymePRO_0000285699Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0547.

Structurei

3D structure databases

ProteinModelPortaliQ68WH7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 3843843-hydroxyacyl-CoA dehydrogenaseAdd
BLAST
Regioni453 – 720268Enoyl-CoA hydratase/isomeraseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.Curated
In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.Curated

Phylogenomic databases

eggNOGiCOG1250.
HOGENOMiHOG000264370.
KOiK01782.
OMAiMRWGFGW.
OrthoDBiEOG6B8XF5.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
3.90.226.10. 1 hit.
InterProiIPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 2 hits.
SSF52096. SSF52096. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68WH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNEIKKVCV IGAGVMGSGI AALIANSSHR VVLLDILDKD SNDPNKIVKN
60 70 80 90 100
AVKNLHRQKL PPLSYPDKVN FITIGNLEHD LDLIKECNLV IEVIVEKLDI
110 120 130 140 150
KHQLYNKIIP YLKEDTIIAS NTSTLPLKKL KENLPNNIKS RFIITHFFNP
160 170 180 190 200
PRYMELVELI IDNTIKDEVI EKISVFLTKI LGKTIIKCND TPGFIANRVG
210 220 230 240 250
CFLLELVAHK AIAQNLDFVT IDQIFSRCLG LPNTGIFGLY DLIGHDVMKL
260 270 280 290 300
ISSSLLSALP KSDDYHRIYF NTKVFDKMIE HNLIGRKGEG GFYRLSVSNG
310 320 330 340 350
KKIKEVINIS DLSYHPVQKV DISFNNLDEL LASDSIYSKF FSEIITEFYI
360 370 380 390 400
YLTSLVPSVT NNIYDIDATM KLGYSWHYGP FELLTIAVKN GWNSIIKNAD
410 420 430 440 450
LMNISLPKYL ASKEYQKIDK QKFNSKKDFL QESTIVLAND SANLIHYCEN
460 470 480 490 500
LIFVITTKMN TLNHNVFYLL QEAVSKAENY GKNLYIFPQG NNFSAGADLK
510 520 530 540 550
LILSYIQDGN FDNLENLLKL GQQTMRYLKY SSVHIISCAR GVALGGGCEL
560 570 580 590 600
LLNSSYIVAN QELNAGLIEF GVGLIPGWSG VTEMFARSNG DKTKLIRNIK
610 620 630 640 650
NIIEQNKTSS ADYFKADYDV SNMQVNMNKH YILDEALKLN VSNKIVSIPH
660 670 680 690 700
KIALPKINIV SEIDTSKYND LQNKVLNKFQ NIIDKHNEIS EAELLTYERE
710 720
IFLELAKEPQ TIEKLHAIVG
Length:720
Mass (Da):81,410
Last modified:October 11, 2004 - v1
Checksum:i969CD34D859084C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU04015.1.
RefSeqiYP_067497.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU04015; AAU04015; RT0547.
GeneIDi2958739.
KEGGirty:RT0547.
PATRICi17910330. VBIRicTyp34752_0569.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU04015.1.
RefSeqiYP_067497.1. NC_006142.1.

3D structure databases

ProteinModelPortaliQ68WH7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257363.RT0547.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU04015; AAU04015; RT0547.
GeneIDi2958739.
KEGGirty:RT0547.
PATRICi17910330. VBIRicTyp34752_0569.

Phylogenomic databases

eggNOGiCOG1250.
HOGENOMiHOG000264370.
KOiK01782.
OMAiMRWGFGW.
OrthoDBiEOG6B8XF5.

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-576-MONOMER.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
3.90.226.10. 1 hit.
InterProiIPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 2 hits.
SSF52096. SSF52096. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiFAD3_RICTY
AccessioniPrimary (citable) accession number: Q68WH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 11, 2004
Last modified: January 7, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.