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Q68WH7 (FAD3_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative fatty acid oxidation complex trifunctional enzyme

Including the following 2 domains:

  1. 3-hydroxyacyl-CoA dehydrogenase
    EC=1.1.1.35
  2. Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase
    EC=4.2.1.17
    EC=5.3.3.8
Gene names
Ordered Locus Names:RT0547
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length720 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.

(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.

(3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA.

Sequence similarities

In the N-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 720720Putative fatty acid oxidation complex trifunctional enzyme
PRO_0000285699

Regions

Region1 – 3843843-hydroxyacyl-CoA dehydrogenase
Region453 – 720268Enoyl-CoA hydratase/isomerase

Sequences

Sequence LengthMass (Da)Tools
Q68WH7 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 969CD34D859084C6

FASTA72081,410
        10         20         30         40         50         60 
MQNEIKKVCV IGAGVMGSGI AALIANSSHR VVLLDILDKD SNDPNKIVKN AVKNLHRQKL 

        70         80         90        100        110        120 
PPLSYPDKVN FITIGNLEHD LDLIKECNLV IEVIVEKLDI KHQLYNKIIP YLKEDTIIAS 

       130        140        150        160        170        180 
NTSTLPLKKL KENLPNNIKS RFIITHFFNP PRYMELVELI IDNTIKDEVI EKISVFLTKI 

       190        200        210        220        230        240 
LGKTIIKCND TPGFIANRVG CFLLELVAHK AIAQNLDFVT IDQIFSRCLG LPNTGIFGLY 

       250        260        270        280        290        300 
DLIGHDVMKL ISSSLLSALP KSDDYHRIYF NTKVFDKMIE HNLIGRKGEG GFYRLSVSNG 

       310        320        330        340        350        360 
KKIKEVINIS DLSYHPVQKV DISFNNLDEL LASDSIYSKF FSEIITEFYI YLTSLVPSVT 

       370        380        390        400        410        420 
NNIYDIDATM KLGYSWHYGP FELLTIAVKN GWNSIIKNAD LMNISLPKYL ASKEYQKIDK 

       430        440        450        460        470        480 
QKFNSKKDFL QESTIVLAND SANLIHYCEN LIFVITTKMN TLNHNVFYLL QEAVSKAENY 

       490        500        510        520        530        540 
GKNLYIFPQG NNFSAGADLK LILSYIQDGN FDNLENLLKL GQQTMRYLKY SSVHIISCAR 

       550        560        570        580        590        600 
GVALGGGCEL LLNSSYIVAN QELNAGLIEF GVGLIPGWSG VTEMFARSNG DKTKLIRNIK 

       610        620        630        640        650        660 
NIIEQNKTSS ADYFKADYDV SNMQVNMNKH YILDEALKLN VSNKIVSIPH KIALPKINIV 

       670        680        690        700        710        720 
SEIDTSKYND LQNKVLNKFQ NIIDKHNEIS EAELLTYERE IFLELAKEPQ TIEKLHAIVG 

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References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU04015.1.
RefSeqYP_067497.1. NC_006142.1.

3D structure databases

ProteinModelPortalQ68WH7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0547.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU04015; AAU04015; RT0547.
GeneID2958739.
KEGGrty:RT0547.
PATRIC17910330. VBIRicTyp34752_0569.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1250.
HOGENOMHOG000264370.
KOK01782.
OMARANCIEP.
OrthoDBEOG6B8XF5.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-576-MONOMER.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
3.90.226.10. 1 hit.
InterProIPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 2 hits.
SSF52096. SSF52096. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFAD3_RICTY
AccessionPrimary (citable) accession number: Q68WH7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names