Reviewed,
UniProtKB/Swiss-Prot Q68WH7 (FAD3_RICTY)
Last modified
January 19, 2010.
Version 38.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Putative fatty acid oxidation complex trifunctional enzyme Including the following 2 domains: 1- Recommended name: 3-hydroxyacyl-CoA dehydrogenase EC=1.1.1.35 2- Recommended name: Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase EC=4.2.1.17 EC=5.3.3.8 | ||
| Gene names |
| ||
| Organism | Rickettsia typhi [Complete proteome] [HAMAP] | ||
| Taxonomic identifier | 785 [NCBI] | ||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group |
Protein attributes
| Sequence length | 720 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH. (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O. (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA. |
| Sequence similarities | In the N-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Fatty acid metabolism Lipid metabolism |
| Ligand | NAD |
| Molecular function | Isomerase Lyase Oxidoreductase |
| Technical term | Complete proteome Multifunctional enzyme |
| Gene Ontology (GO) | |
| Biological process | fatty acid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 3-hydroxyacyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: EC coenzyme bindingInferred from electronic annotation. Source: InterPro dodecenoyl-CoA delta-isomerase activityInferred from electronic annotation. Source: EC enoyl-CoA hydratase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. Weinstock G.M.J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE017197 Genomic DNA. Translation: AAU04015.1. |
| RefSeq | YP_067497.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 3HDH based on UniProtKB P00348. |
| SMR | Q68WH7. Positions 457-718. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2958739. |
| GenomeReviews | Gene locus RT0547 in contig AE017197_GR. |
| KEGG | rty:RT0547. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG729334. |
| OMA | FRTLDVV. |
Enzyme and pathway databases | |
| BioCyc | RTYP257363:RT0547-MONOMER. |
| BRENDA | 1.1.1.35. 281221. 4.2.1.17. 281221. 5.3.3.8. 281221. |
Family and domain databases | |
| InterPro | IPR006176. 3-OHacyl-CoA_DH_NAD-bd. IPR006108. 3HC_DH_C. IPR008927. 6-PGluconate_DH_C-like. IPR001753. Crotonase_core. IPR013328. DH_multihelical. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit. |
| Pfam | PF00725. 3HCDH. 1 hit. PF02737. 3HCDH_N. 1 hit. PF00378. ECH. 1 hit. [Graphical view] |
| PROSITE | PS00067. 3HCDH. False negative. PS00166. ENOYL_COA_HYDRATASE. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FAD3_RICTY | ||||||||
| Accession | Primary (citable) accession number: Q68WH7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Rickettsia typhi Rickettsia typhi (strain Wilmington): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


