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Q68WH7

- FAD3_RICTY

UniProt

Q68WH7 - FAD3_RICTY

Protein

Putative fatty acid oxidation complex trifunctional enzyme

Gene

RT0547

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.
    (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.
    (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA.

    GO - Molecular functioni

    1. 3-hydroxyacyl-CoA dehydrogenase activity Source: UniProtKB-EC
    2. coenzyme binding Source: InterPro
    3. dodecenoyl-CoA delta-isomerase activity Source: UniProtKB-EC
    4. enoyl-CoA hydratase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, Lyase, Oxidoreductase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-576-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative fatty acid oxidation complex trifunctional enzyme
    Including the following 2 domains:
    3-hydroxyacyl-CoA dehydrogenase (EC:1.1.1.35)
    Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase (EC:4.2.1.17, EC:5.3.3.8)
    Gene namesi
    Ordered Locus Names:RT0547
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 720720Putative fatty acid oxidation complex trifunctional enzymePRO_0000285699Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi257363.RT0547.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68WH7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 3843843-hydroxyacyl-CoA dehydrogenaseAdd
    BLAST
    Regioni453 – 720268Enoyl-CoA hydratase/isomeraseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.Curated
    In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.Curated

    Phylogenomic databases

    eggNOGiCOG1250.
    HOGENOMiHOG000264370.
    KOiK01782.
    OMAiRANCIEP.
    OrthoDBiEOG6B8XF5.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    3.90.226.10. 1 hit.
    InterProiIPR006176. 3-OHacyl-CoA_DH_NAD-bd.
    IPR006108. 3HC_DH_C.
    IPR008927. 6-PGluconate_DH_C-like.
    IPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    IPR013328. DH_multihelical.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00725. 3HCDH. 1 hit.
    PF02737. 3HCDH_N. 1 hit.
    PF00378. ECH. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 2 hits.
    SSF52096. SSF52096. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q68WH7-1 [UniParc]FASTAAdd to Basket

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    MQNEIKKVCV IGAGVMGSGI AALIANSSHR VVLLDILDKD SNDPNKIVKN    50
    AVKNLHRQKL PPLSYPDKVN FITIGNLEHD LDLIKECNLV IEVIVEKLDI 100
    KHQLYNKIIP YLKEDTIIAS NTSTLPLKKL KENLPNNIKS RFIITHFFNP 150
    PRYMELVELI IDNTIKDEVI EKISVFLTKI LGKTIIKCND TPGFIANRVG 200
    CFLLELVAHK AIAQNLDFVT IDQIFSRCLG LPNTGIFGLY DLIGHDVMKL 250
    ISSSLLSALP KSDDYHRIYF NTKVFDKMIE HNLIGRKGEG GFYRLSVSNG 300
    KKIKEVINIS DLSYHPVQKV DISFNNLDEL LASDSIYSKF FSEIITEFYI 350
    YLTSLVPSVT NNIYDIDATM KLGYSWHYGP FELLTIAVKN GWNSIIKNAD 400
    LMNISLPKYL ASKEYQKIDK QKFNSKKDFL QESTIVLAND SANLIHYCEN 450
    LIFVITTKMN TLNHNVFYLL QEAVSKAENY GKNLYIFPQG NNFSAGADLK 500
    LILSYIQDGN FDNLENLLKL GQQTMRYLKY SSVHIISCAR GVALGGGCEL 550
    LLNSSYIVAN QELNAGLIEF GVGLIPGWSG VTEMFARSNG DKTKLIRNIK 600
    NIIEQNKTSS ADYFKADYDV SNMQVNMNKH YILDEALKLN VSNKIVSIPH 650
    KIALPKINIV SEIDTSKYND LQNKVLNKFQ NIIDKHNEIS EAELLTYERE 700
    IFLELAKEPQ TIEKLHAIVG 720
    Length:720
    Mass (Da):81,410
    Last modified:October 11, 2004 - v1
    Checksum:i969CD34D859084C6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU04015.1.
    RefSeqiYP_067497.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU04015; AAU04015; RT0547.
    GeneIDi2958739.
    KEGGirty:RT0547.
    PATRICi17910330. VBIRicTyp34752_0569.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU04015.1 .
    RefSeqi YP_067497.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68WH7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0547.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU04015 ; AAU04015 ; RT0547 .
    GeneIDi 2958739.
    KEGGi rty:RT0547.
    PATRICi 17910330. VBIRicTyp34752_0569.

    Phylogenomic databases

    eggNOGi COG1250.
    HOGENOMi HOG000264370.
    KOi K01782.
    OMAi RANCIEP.
    OrthoDBi EOG6B8XF5.

    Enzyme and pathway databases

    BioCyci RTYP257363:GJEQ-576-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    3.90.226.10. 1 hit.
    InterProi IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
    IPR006108. 3HC_DH_C.
    IPR008927. 6-PGluconate_DH_C-like.
    IPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    IPR013328. DH_multihelical.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00725. 3HCDH. 1 hit.
    PF02737. 3HCDH_N. 1 hit.
    PF00378. ECH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 2 hits.
    SSF52096. SSF52096. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiFAD3_RICTY
    AccessioniPrimary (citable) accession number: Q68WH7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3