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Protein

Putative fatty acid oxidation complex trifunctional enzyme

Gene

RT0547

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.
A (3Z)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA.
A (3E)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Lyase, Multifunctional enzyme, Oxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandNAD

Enzyme and pathway databases

BioCyciRTYP257363:G1G0L-553-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative fatty acid oxidation complex trifunctional enzyme
Including the following 2 domains:
3-hydroxyacyl-CoA dehydrogenase (EC:1.1.1.35)
Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase (EC:4.2.1.17, EC:5.3.3.8)
Gene namesi
Ordered Locus Names:RT0547
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000000604 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002856991 – 720Putative fatty acid oxidation complex trifunctional enzymeAdd BLAST720

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0547

Structurei

3D structure databases

ProteinModelPortaliQ68WH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 3843-hydroxyacyl-CoA dehydrogenaseAdd BLAST384
Regioni453 – 720Enoyl-CoA hydratase/isomeraseAdd BLAST268

Sequence similaritiesi

In the N-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.Curated
In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.Curated

Phylogenomic databases

eggNOGiENOG4105DYT Bacteria
COG1024 LUCA
COG1250 LUCA
HOGENOMiHOG000264370
KOiK01782
OMAiGQGFYKK
OrthoDBiPOG091H0NDD

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR006176 3-OHacyl-CoA_DH_NAD-bd
IPR006108 3HC_DH_C
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR029045 ClpP/crotonase-like_dom_sf
IPR032259 HIBYL-CoA-H
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00725 3HCDH, 1 hit
PF02737 3HCDH_N, 1 hit
PF16113 ECH_2, 1 hit
SUPFAMiSSF48179 SSF48179, 2 hits
SSF51735 SSF51735, 1 hit
SSF52096 SSF52096, 1 hit

Sequencei

Sequence statusi: Complete.

Q68WH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNEIKKVCV IGAGVMGSGI AALIANSSHR VVLLDILDKD SNDPNKIVKN
60 70 80 90 100
AVKNLHRQKL PPLSYPDKVN FITIGNLEHD LDLIKECNLV IEVIVEKLDI
110 120 130 140 150
KHQLYNKIIP YLKEDTIIAS NTSTLPLKKL KENLPNNIKS RFIITHFFNP
160 170 180 190 200
PRYMELVELI IDNTIKDEVI EKISVFLTKI LGKTIIKCND TPGFIANRVG
210 220 230 240 250
CFLLELVAHK AIAQNLDFVT IDQIFSRCLG LPNTGIFGLY DLIGHDVMKL
260 270 280 290 300
ISSSLLSALP KSDDYHRIYF NTKVFDKMIE HNLIGRKGEG GFYRLSVSNG
310 320 330 340 350
KKIKEVINIS DLSYHPVQKV DISFNNLDEL LASDSIYSKF FSEIITEFYI
360 370 380 390 400
YLTSLVPSVT NNIYDIDATM KLGYSWHYGP FELLTIAVKN GWNSIIKNAD
410 420 430 440 450
LMNISLPKYL ASKEYQKIDK QKFNSKKDFL QESTIVLAND SANLIHYCEN
460 470 480 490 500
LIFVITTKMN TLNHNVFYLL QEAVSKAENY GKNLYIFPQG NNFSAGADLK
510 520 530 540 550
LILSYIQDGN FDNLENLLKL GQQTMRYLKY SSVHIISCAR GVALGGGCEL
560 570 580 590 600
LLNSSYIVAN QELNAGLIEF GVGLIPGWSG VTEMFARSNG DKTKLIRNIK
610 620 630 640 650
NIIEQNKTSS ADYFKADYDV SNMQVNMNKH YILDEALKLN VSNKIVSIPH
660 670 680 690 700
KIALPKINIV SEIDTSKYND LQNKVLNKFQ NIIDKHNEIS EAELLTYERE
710 720
IFLELAKEPQ TIEKLHAIVG
Length:720
Mass (Da):81,410
Last modified:October 11, 2004 - v1
Checksum:i969CD34D859084C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA Translation: AAU04015.1
RefSeqiWP_011190996.1, NC_006142.1

Genome annotation databases

EnsemblBacteriaiAAU04015; AAU04015; RT0547
KEGGirty:RT0547

Similar proteinsi

Entry informationi

Entry nameiFAD3_RICTY
AccessioniPrimary (citable) accession number: Q68WH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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