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Q68WD8

- DNAA_RICTY

UniProt

Q68WD8 - DNAA_RICTY

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Protein
Chromosomal replication initiator protein DnaA
Gene
dnaA, RT0589
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi168 – 1758ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA replication origin binding Source: UniProtKB-HAMAP
  3. nucleoside-triphosphatase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. DNA replication initiation Source: UniProtKB-HAMAP
  2. regulation of DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-619-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaA
Gene namesi
Name:dnaA
Ordered Locus Names:RT0589
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463Chromosomal replication initiator protein DnaAUniRule annotation
PRO_0000114248Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0589.

Structurei

3D structure databases

ProteinModelPortaliQ68WD8.

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.

Phylogenomic databases

eggNOGiCOG0593.
HOGENOMiHOG000235660.
KOiK02313.
OMAiLPHEPRQ.
OrthoDBiEOG689HR1.

Family and domain databases

Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013159. DnaA_C.
IPR013317. DnaA_Hda.
IPR024633. DnaA_N_dom.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PF11638. DnaA_N. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68WD8-1 [UniParc]FASTAAdd to Basket

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MSTNQIPLTD QGDNYVNVWS YVAQDLYNHY GETLYNSWFS KVNFIESSLN    50
TVILCAPTNF IRDWIKSKYA MVILQLFQHY NNAIKSIEII TKEVPGTTQT 100
VIELPTKTFS NISNSALNSE NTISTLDLRF TFDNFVVGAP NELAYAAARA 150
VAESSGAVFE SNPLFLYGGV GLGKTHLMHA IGWYIKQNNP SRKVIYMSAE 200
KFMYQFVKAL RNKEVILFKE KFRSVDVLMI DDIQFICGKD STQEEFFHTF 250
NTLIDNNRQM VISCDRSPSD LDNIEDRIKS RLGWGLVADV HSTTYELRLG 300
ILESKIEQMN VKIPKDVINF LASKIVSNVR ELEGALNKVI AHSNFTLKAI 350
TLENTQNILR DLLRSNERII TVEDIQKKVA NRYNIKLSDM YSSRRLREVA 400
RPRQIAMYLS KILTPKSLAD IGKKFGKKDH TTVMHAIKKV EELLENDIEL 450
REEINLLMKI LQN 463
Length:463
Mass (Da):53,050
Last modified:October 11, 2004 - v1
Checksum:i4ECCE1C474171366
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU04054.1.
RefSeqiYP_067536.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU04054; AAU04054; RT0589.
GeneIDi2959355.
KEGGirty:RT0589.
PATRICi17910414. VBIRicTyp34752_0608.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU04054.1 .
RefSeqi YP_067536.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68WD8.
ModBasei Search...

Protein-protein interaction databases

STRINGi 257363.RT0589.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU04054 ; AAU04054 ; RT0589 .
GeneIDi 2959355.
KEGGi rty:RT0589.
PATRICi 17910414. VBIRicTyp34752_0608.

Phylogenomic databases

eggNOGi COG0593.
HOGENOMi HOG000235660.
KOi K02313.
OMAi LPHEPRQ.
OrthoDBi EOG689HR1.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-619-MONOMER.

Family and domain databases

Gene3Di 1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00377. DnaA_bact.
InterProi IPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013159. DnaA_C.
IPR013317. DnaA_Hda.
IPR024633. DnaA_N_dom.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view ]
Pfami PF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PF11638. DnaA_N. 1 hit.
[Graphical view ]
PRINTSi PR00051. DNAA.
SMARTi SM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00362. DnaA. 1 hit.
PROSITEi PS01008. DNAA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiDNAA_RICTY
AccessioniPrimary (citable) accession number: Q68WD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi