Q68WD4 (PTH_RICTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-tRNA hydrolase
Short name=PTH
EC=3.1.1.29

Gene names

Name:	pth
Ordered Locus Names:	RT0593

Organism

Rickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]

Taxonomic identifier

257363 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia typhi

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity. HAMAP-Rule MF_00083
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP-Rule MF_00083
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the PTH family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Peptidyl-tRNA hydrolase HAMAP-Rule MF_00083		PRO_0000187806

Sequences

	Sequence		Length	Mass (Da)
	Q68WD4 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: E883C0F496FCE7E9	FASTA	185	21,000
	10 20 30 40 50 60 MILVIGLGNP GIVYQYTRHN IGFIAIERIA NKYHLSFSTK QKFNCKIAEA IIDRQKICFI 70 80 90 100 110 120 KPTTYMNLSG KSVILVKTYY NINYEKVFVI HDDIDLEIGR IKFKTGGSNG GHNGLKSIDS 130 140 150 160 170 180 IIGSHYNRIR IGIGRPQNNH DVADYVLSNF SESEYKTVMQ SIDNVANNFG LILEHKLAEF KNKIV

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017197 Genomic DNA. Translation: AAU04058.1.
RefSeq	YP_067540.1. NC_006142.1.
3D structure databases
ProteinModelPortal	Q68WD4.
ModBase	Search...
Protein-protein interaction databases
STRING	257363.RT0593.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAU04058; AAU04058; RT0593.
GeneID	2959396.
KEGG	rty:RT0593.
PATRIC	17910426. VBIRicTyp34752_0614.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0193.
HOGENOM	HOG000004797.
KO	K01056.
OMA	IKFKTGG.
ProtClustDB	PRK05426.
Enzyme and pathway databases
BioCyc	RTYP257363:GJEQ-623-MONOMER.
Family and domain databases
Gene3D	3.40.50.1470. 1 hit.
HAMAP	MF_00083. Pept_tRNA_hydro_bact.
InterPro	IPR001328. Pept_tRNA_hydro. IPR018171. Pept_tRNA_hydro_CS. [Graphical view]
PANTHER	PTHR17224. PTHR17224. 1 hit.
Pfam	PF01195. Pept_tRNA_hydro. 1 hit. [Graphical view]
SUPFAM	SSF53178. Pept_tRNA_hydro. 1 hit.
TIGRFAMs	TIGR00447. pth. 1 hit.
PROSITE	PS01195. PEPT_TRNA_HYDROL_1. 1 hit. PS01196. PEPT_TRNA_HYDROL_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTH_RICTY

Accession

Primary (citable) accession number: Q68WD4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program