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Protein

Glutamate--tRNA ligase 2

Gene

gltX2

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei242ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRTYP257363:G1G0L-618-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 2UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 2UniRule annotation
Short name:
GluRS 2UniRule annotation
Gene namesi
Name:gltX2UniRule annotation
Ordered Locus Names:RT0614
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000000604 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001196431 – 469Glutamate--tRNA ligase 2Add BLAST469

Proteomic databases

PRIDEiQ68WB4

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi257363.RT0614

Structurei

3D structure databases

ProteinModelPortaliQ68WB4
SMRiQ68WB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 20"HIGH" regionUniRule annotationAdd BLAST11
Motifi239 – 243"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q68WB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNIITRFAP SPTGFLHIGS ARTALFNYLF ARHNNGKFFL RIEDTDKKRS
60 70 80 90 100
TKEAIAAIFS GLKWLGINWD GEVIFQSKRN SLYKEAALKL LKEGKAYYCF
110 120 130 140 150
TKQEEIARQR QQALKDKKHF IFNSEWRDKG PSTYPADIKP VIRLKVPREG
160 170 180 190 200
SITIHDTLQG DIVIENSHID DMILIRADGT ATYMLAVIVD DHDMGITHII
210 220 230 240 250
RGDDHLTNAA RQIAIYHAFG YEVPNMTHIP LIHGADGTKL SKRHGALGVE
260 270 280 290 300
AYKDMGYLPE SLCNYLLRLG WSHGDDEIIS MNQAIEWFNL DSLGKSPSKL
310 320 330 340 350
DFAKMNSINS HYLRMLDNDS LTSKTVAILK QNYKISEKEV SYIKQAMPSL
360 370 380 390 400
IVRSATLIDL AQLAYIYLVD SPMIYNQDAK EVIKNCDKDL IKQIIANLNK
410 420 430 440 450
LEQFDKECIQ NKFKEIAIYN GLKLNDIMRP VRALITGMTA SPSIFEIAET
460
LGKENILKRL NIIYYNLNF
Length:469
Mass (Da):53,447
Last modified:October 11, 2004 - v1
Checksum:iB6EE33BFF5549861
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA Translation: AAU04078.1
RefSeqiWP_011191058.1, NC_006142.1

Genome annotation databases

EnsemblBacteriaiAAU04078; AAU04078; RT0614
KEGGirty:RT0614

Similar proteinsi

Entry informationi

Entry nameiSYE2_RICTY
AccessioniPrimary (citable) accession number: Q68WB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health