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Protein

Protein translocase subunit SecY

Gene

secY

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-662-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecYUniRule annotation
Gene namesi
Name:secYUniRule annotation
Ordered Locus Names:RT0631
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalUniRule annotationAdd
BLAST
Transmembranei71 – 9121HelicalUniRule annotationAdd
BLAST
Transmembranei117 – 13721HelicalUniRule annotationAdd
BLAST
Transmembranei141 – 16121HelicalUniRule annotationAdd
BLAST
Transmembranei184 – 20421HelicalUniRule annotationAdd
BLAST
Transmembranei212 – 23221HelicalUniRule annotationAdd
BLAST
Transmembranei268 – 28821HelicalUniRule annotationAdd
BLAST
Transmembranei310 – 33021HelicalUniRule annotationAdd
BLAST
Transmembranei366 – 38621HelicalUniRule annotationAdd
BLAST
Transmembranei388 – 40821HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Protein translocase subunit SecYPRO_0000277282Add
BLAST

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.UniRule annotation

Protein-protein interaction databases

STRINGi257363.RT0631.

Structurei

3D structure databases

ProteinModelPortaliQ68W98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0201.
HOGENOMiHOG000080585.
KOiK03076.
OMAiQTYVISQ.
OrthoDBiEOG651SWP.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68W98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQNFSKKSS NDLVSRIIFT IFMLIICRIG SFIPIPGIDS IALNSVAEKN
60 70 80 90 100
QFGILGMFNM LSGGSLGRMS IFALAIMPYI TASIIIQLMS VAYKPLENLK
110 120 130 140 150
KEGESGKRKI NQLSRYLTVL LASFQAYGVA LSLESMVTNT GPVVILAGFF
160 170 180 190 200
FRVTTVITLV VGTMLLMWLG EQITQRGIGN GTSLIIFIGI ISGVPSAIIS
210 220 230 240 250
MFELSRKGAL SPLIAITVCI GVVLLIAIII FFEKAQRKLL VQYPKRQVGN
260 270 280 290 300
KIYGGEATHM PLKLNTSGVI PPIFASSILL FPTTLANFSN SNSETMSMLS
310 320 330 340 350
YYLGHGKPVY ILLYVVLIMF FSFFYTAIVF NSEETANNLR KYGAYIPGKR
360 370 380 390 400
PGKNTSDYFD YILTRLTVIG GLYLSIICVI PELLMNKYVI SLSLGGTSFL
410 420 430
IVVNVVLDTM TQIQTYLFSS KYEGLMKKIK LKN
Length:433
Mass (Da):47,681
Last modified:October 11, 2004 - v1
Checksum:i25E159B44F948454
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU04094.1.
RefSeqiWP_011191073.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU04094; AAU04094; RT0631.
KEGGirty:RT0631.
PATRICi17910504. VBIRicTyp34752_0651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU04094.1.
RefSeqiWP_011191073.1. NC_006142.1.

3D structure databases

ProteinModelPortaliQ68W98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257363.RT0631.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU04094; AAU04094; RT0631.
KEGGirty:RT0631.
PATRICi17910504. VBIRicTyp34752_0651.

Phylogenomic databases

eggNOGiCOG0201.
HOGENOMiHOG000080585.
KOiK03076.
OMAiQTYVISQ.
OrthoDBiEOG651SWP.

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-662-MONOMER.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiSECY_RICTY
AccessioniPrimary (citable) accession number: Q68W98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 11, 2004
Last modified: July 22, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.