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Q68W98

- SECY_RICTY

UniProt

Q68W98 - SECY_RICTY

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Protein
Protein translocase subunit SecY
Gene
secY, RT0631
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently By similarity.UniRule annotation

GO - Biological processi

  1. intracellular protein transmembrane transport Source: UniProtKB-HAMAP
  2. protein targeting Source: UniProtKB-HAMAP
  3. protein transport by the Sec complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-662-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecY
Gene namesi
Name:secY
Ordered Locus Names:RT0631
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721Helical; Reviewed prediction
Add
BLAST
Transmembranei71 – 9121Helical; Reviewed prediction
Add
BLAST
Transmembranei117 – 13721Helical; Reviewed prediction
Add
BLAST
Transmembranei141 – 16121Helical; Reviewed prediction
Add
BLAST
Transmembranei184 – 20421Helical; Reviewed prediction
Add
BLAST
Transmembranei212 – 23221Helical; Reviewed prediction
Add
BLAST
Transmembranei268 – 28821Helical; Reviewed prediction
Add
BLAST
Transmembranei310 – 33021Helical; Reviewed prediction
Add
BLAST
Transmembranei366 – 38621Helical; Reviewed prediction
Add
BLAST
Transmembranei388 – 40821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. intracellular Source: GOC
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Protein translocase subunit SecYUniRule annotation
PRO_0000277282Add
BLAST

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA By similarity.

Protein-protein interaction databases

STRINGi257363.RT0631.

Structurei

3D structure databases

ProteinModelPortaliQ68W98.

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0201.
HOGENOMiHOG000080585.
KOiK03076.
OMAiISINIFY.
OrthoDBiEOG651SWP.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68W98-1 [UniParc]FASTAAdd to Basket

« Hide

MGQNFSKKSS NDLVSRIIFT IFMLIICRIG SFIPIPGIDS IALNSVAEKN    50
QFGILGMFNM LSGGSLGRMS IFALAIMPYI TASIIIQLMS VAYKPLENLK 100
KEGESGKRKI NQLSRYLTVL LASFQAYGVA LSLESMVTNT GPVVILAGFF 150
FRVTTVITLV VGTMLLMWLG EQITQRGIGN GTSLIIFIGI ISGVPSAIIS 200
MFELSRKGAL SPLIAITVCI GVVLLIAIII FFEKAQRKLL VQYPKRQVGN 250
KIYGGEATHM PLKLNTSGVI PPIFASSILL FPTTLANFSN SNSETMSMLS 300
YYLGHGKPVY ILLYVVLIMF FSFFYTAIVF NSEETANNLR KYGAYIPGKR 350
PGKNTSDYFD YILTRLTVIG GLYLSIICVI PELLMNKYVI SLSLGGTSFL 400
IVVNVVLDTM TQIQTYLFSS KYEGLMKKIK LKN 433
Length:433
Mass (Da):47,681
Last modified:October 11, 2004 - v1
Checksum:i25E159B44F948454
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU04094.1.
RefSeqiYP_067576.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU04094; AAU04094; RT0631.
GeneIDi2958744.
KEGGirty:RT0631.
PATRICi17910504. VBIRicTyp34752_0651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU04094.1 .
RefSeqi YP_067576.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68W98.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0631.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU04094 ; AAU04094 ; RT0631 .
GeneIDi 2958744.
KEGGi rty:RT0631.
PATRICi 17910504. VBIRicTyp34752_0651.

Phylogenomic databases

eggNOGi COG0201.
HOGENOMi HOG000080585.
KOi K03076.
OMAi ISINIFY.
OrthoDBi EOG651SWP.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-662-MONOMER.

Family and domain databases

Gene3Di 1.10.3370.10. 1 hit.
HAMAPi MF_01465. SecY.
InterProi IPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR023201. SecY_su_dom.
[Graphical view ]
PANTHERi PTHR10906. PTHR10906. 1 hit.
Pfami PF00344. SecY. 1 hit.
[Graphical view ]
PIRSFi PIRSF004557. SecY. 1 hit.
SUPFAMi SSF103491. SSF103491. 1 hit.
TIGRFAMsi TIGR00967. 3a0501s007. 1 hit.
PROSITEi PS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiSECY_RICTY
AccessioniPrimary (citable) accession number: Q68W98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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