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Q68W98

- SECY_RICTY

UniProt

Q68W98 - SECY_RICTY

Protein

Protein translocase subunit SecY

Gene

secY

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.UniRule annotation

    GO - Biological processi

    1. intracellular protein transmembrane transport Source: UniProtKB-HAMAP
    2. protein targeting Source: UniProtKB-HAMAP
    3. protein transport by the Sec complex Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-662-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein translocase subunit SecYUniRule annotation
    Gene namesi
    Name:secYUniRule annotation
    Ordered Locus Names:RT0631
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. intracellular Source: GOC
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 433433Protein translocase subunit SecYPRO_0000277282Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.UniRule annotation

    Protein-protein interaction databases

    STRINGi257363.RT0631.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68W98.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalUniRule annotationAdd
    BLAST
    Transmembranei71 – 9121HelicalUniRule annotationAdd
    BLAST
    Transmembranei117 – 13721HelicalUniRule annotationAdd
    BLAST
    Transmembranei141 – 16121HelicalUniRule annotationAdd
    BLAST
    Transmembranei184 – 20421HelicalUniRule annotationAdd
    BLAST
    Transmembranei212 – 23221HelicalUniRule annotationAdd
    BLAST
    Transmembranei268 – 28821HelicalUniRule annotationAdd
    BLAST
    Transmembranei310 – 33021HelicalUniRule annotationAdd
    BLAST
    Transmembranei366 – 38621HelicalUniRule annotationAdd
    BLAST
    Transmembranei388 – 40821HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SecY/SEC61-alpha family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0201.
    HOGENOMiHOG000080585.
    KOiK03076.
    OMAiISINIFY.
    OrthoDBiEOG651SWP.

    Family and domain databases

    Gene3Di1.10.3370.10. 1 hit.
    HAMAPiMF_01465. SecY.
    InterProiIPR026593. SecY.
    IPR002208. SecY/SEC61-alpha.
    IPR023201. SecY_su_dom.
    [Graphical view]
    PANTHERiPTHR10906. PTHR10906. 1 hit.
    PfamiPF00344. SecY. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004557. SecY. 1 hit.
    SUPFAMiSSF103491. SSF103491. 1 hit.
    TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
    PROSITEiPS00755. SECY_1. 1 hit.
    PS00756. SECY_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68W98-1 [UniParc]FASTAAdd to Basket

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    MGQNFSKKSS NDLVSRIIFT IFMLIICRIG SFIPIPGIDS IALNSVAEKN    50
    QFGILGMFNM LSGGSLGRMS IFALAIMPYI TASIIIQLMS VAYKPLENLK 100
    KEGESGKRKI NQLSRYLTVL LASFQAYGVA LSLESMVTNT GPVVILAGFF 150
    FRVTTVITLV VGTMLLMWLG EQITQRGIGN GTSLIIFIGI ISGVPSAIIS 200
    MFELSRKGAL SPLIAITVCI GVVLLIAIII FFEKAQRKLL VQYPKRQVGN 250
    KIYGGEATHM PLKLNTSGVI PPIFASSILL FPTTLANFSN SNSETMSMLS 300
    YYLGHGKPVY ILLYVVLIMF FSFFYTAIVF NSEETANNLR KYGAYIPGKR 350
    PGKNTSDYFD YILTRLTVIG GLYLSIICVI PELLMNKYVI SLSLGGTSFL 400
    IVVNVVLDTM TQIQTYLFSS KYEGLMKKIK LKN 433
    Length:433
    Mass (Da):47,681
    Last modified:October 11, 2004 - v1
    Checksum:i25E159B44F948454
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU04094.1.
    RefSeqiYP_067576.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU04094; AAU04094; RT0631.
    GeneIDi2958744.
    KEGGirty:RT0631.
    PATRICi17910504. VBIRicTyp34752_0651.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU04094.1 .
    RefSeqi YP_067576.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68W98.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0631.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU04094 ; AAU04094 ; RT0631 .
    GeneIDi 2958744.
    KEGGi rty:RT0631.
    PATRICi 17910504. VBIRicTyp34752_0651.

    Phylogenomic databases

    eggNOGi COG0201.
    HOGENOMi HOG000080585.
    KOi K03076.
    OMAi ISINIFY.
    OrthoDBi EOG651SWP.

    Enzyme and pathway databases

    BioCyci RTYP257363:GJEQ-662-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3370.10. 1 hit.
    HAMAPi MF_01465. SecY.
    InterProi IPR026593. SecY.
    IPR002208. SecY/SEC61-alpha.
    IPR023201. SecY_su_dom.
    [Graphical view ]
    PANTHERi PTHR10906. PTHR10906. 1 hit.
    Pfami PF00344. SecY. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004557. SecY. 1 hit.
    SUPFAMi SSF103491. SSF103491. 1 hit.
    TIGRFAMsi TIGR00967. 3a0501s007. 1 hit.
    PROSITEi PS00755. SECY_1. 1 hit.
    PS00756. SECY_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiSECY_RICTY
    AccessioniPrimary (citable) accession number: Q68W98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3