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Q68W66

- RSMA_RICTY

UniProt

Q68W66 - RSMA_RICTY

Protein

Ribosomal RNA small subunit methyltransferase A

Gene

rsmA

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.UniRule annotation

    Catalytic activityi

    4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei23 – 231S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
    Binding sitei25 – 251S-adenosyl-L-methionine; via amide nitrogenUniRule annotation
    Binding sitei50 – 501S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
    Binding sitei72 – 721S-adenosyl-L-methionineUniRule annotation
    Binding sitei97 – 971S-adenosyl-L-methionineUniRule annotation
    Binding sitei116 – 1161S-adenosyl-L-methionineUniRule annotation

    GO - Molecular functioni

    1. 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity Source: UniProtKB-EC
    2. RNA binding Source: UniProtKB-KW
    3. rRNA (adenine-N6,N6-)-dimethyltransferase activity Source: InterPro

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    RNA-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-698-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal RNA small subunit methyltransferase AUniRule annotation (EC:2.1.1.182UniRule annotation)
    Alternative name(s):
    16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferaseUniRule annotation
    16S rRNA dimethyladenosine transferaseUniRule annotation
    16S rRNA dimethylaseUniRule annotation
    S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferaseUniRule annotation
    Gene namesi
    Name:rsmAUniRule annotation
    Synonyms:ksgAUniRule annotation
    Ordered Locus Names:RT0666
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 268268Ribosomal RNA small subunit methyltransferase APRO_0000101596Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi257363.RT0666.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68W66.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0030.
    HOGENOMiHOG000227961.
    KOiK02528.
    OMAiKMLRQSV.
    OrthoDBiEOG66F08Z.

    Family and domain databases

    Gene3Di1.10.8.100. 1 hit.
    3.40.50.150. 1 hit.
    HAMAPiMF_00607. 16SrRNA_methyltr_A.
    InterProiIPR023165. rRNA_Ade_diMease-like.
    IPR020596. rRNA_Ade_Mease_Trfase_CS.
    IPR001737. rRNA_Ade_methylase_transferase.
    IPR020598. rRNA_Ade_methylase_Trfase_N.
    IPR011530. rRNA_adenine_dimethylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR11727. PTHR11727. 1 hit.
    PfamiPF00398. RrnaAD. 1 hit.
    [Graphical view]
    SMARTiSM00650. rADc. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00755. ksgA. 1 hit.
    PROSITEiPS01131. RRNA_A_DIMETH. 1 hit.
    PS51689. SAM_RNA_A_N6_MT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68W66-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPSIAKHAA SHQINPLKKH GQNFIFDSSL CDKIIRASNI SENSKVIEIG    50
    PGVGGLTRSI LHKNPKSLTV IEIDERCIPL LNEIQGYYPN LNIIKQDVLK 100
    INLTDLIYDK VTVISNLPYH IGTELVIRLL KEAKLITNMI LMLQKEVVER 150
    ICAMPSTKAY GRLSVICQIV AKVEKCFDVA PTAFYPHPKV YSAIVKIIPL 200
    ENPPSIALIN KVEQITKLVF AGRRKMIKSS LRNLVPNIHE VLTQLKINNN 250
    DRAENLTPKD YLRIAMQL 268
    Length:268
    Mass (Da):30,159
    Last modified:October 11, 2004 - v1
    Checksum:i0060DB172444B909
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU04126.1.
    RefSeqiYP_067608.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU04126; AAU04126; RT0666.
    GeneIDi2958653.
    KEGGirty:RT0666.
    PATRICi17910574. VBIRicTyp34752_0683.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU04126.1 .
    RefSeqi YP_067608.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68W66.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0666.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU04126 ; AAU04126 ; RT0666 .
    GeneIDi 2958653.
    KEGGi rty:RT0666.
    PATRICi 17910574. VBIRicTyp34752_0683.

    Phylogenomic databases

    eggNOGi COG0030.
    HOGENOMi HOG000227961.
    KOi K02528.
    OMAi KMLRQSV.
    OrthoDBi EOG66F08Z.

    Enzyme and pathway databases

    BioCyci RTYP257363:GJEQ-698-MONOMER.

    Family and domain databases

    Gene3Di 1.10.8.100. 1 hit.
    3.40.50.150. 1 hit.
    HAMAPi MF_00607. 16SrRNA_methyltr_A.
    InterProi IPR023165. rRNA_Ade_diMease-like.
    IPR020596. rRNA_Ade_Mease_Trfase_CS.
    IPR001737. rRNA_Ade_methylase_transferase.
    IPR020598. rRNA_Ade_methylase_Trfase_N.
    IPR011530. rRNA_adenine_dimethylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR11727. PTHR11727. 1 hit.
    Pfami PF00398. RrnaAD. 1 hit.
    [Graphical view ]
    SMARTi SM00650. rADc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00755. ksgA. 1 hit.
    PROSITEi PS01131. RRNA_A_DIMETH. 1 hit.
    PS51689. SAM_RNA_A_N6_MT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiRSMA_RICTY
    AccessioniPrimary (citable) accession number: Q68W66
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3