Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q68W53

- KTHY_RICTY

UniProt

Q68W53 - KTHY_RICTY

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Thymidylate kinase

Gene

tmk

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 218ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidylate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTDP biosynthetic process Source: InterPro
  2. dTTP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-712-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:RT0679
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Thymidylate kinasePRO_0000155332Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0679.

Structurei

3D structure databases

ProteinModelPortaliQ68W53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0125.
HOGENOMiHOG000229078.
KOiK00943.
OMAiEPGGCPI.
OrthoDBiEOG64JFSH.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68W53-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKLTQGKFI TFEGMDGIGK STQSKMLYEY LKSQKIPVIL TREVGGTFVA
60 70 80 90 100
EKMREILVHE ELLPMSELLQ AMAARYDHMV RKIIPALKDG YIVICDRFID
110 120 130 140 150
STACYQGLEL ENGIDLVYSL HTTLMPSLMP DITFFIDVEP DTAIKRVNSR
160 170 180 190 200
NMSNKFDRRR IDFYKKIYSC FQELSHRFPE RIKTIKASHL NPLEVHELIQ

KHL
Length:203
Mass (Da):23,620
Last modified:October 11, 2004 - v1
Checksum:i4752FE4EF6C6ED76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU04139.1.
RefSeqiYP_067621.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU04139; AAU04139; RT0679.
GeneIDi2958763.
KEGGirty:RT0679.
PATRICi17910604. VBIRicTyp34752_0698.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU04139.1 .
RefSeqi YP_067621.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68W53.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0679.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU04139 ; AAU04139 ; RT0679 .
GeneIDi 2958763.
KEGGi rty:RT0679.
PATRICi 17910604. VBIRicTyp34752_0698.

Phylogenomic databases

eggNOGi COG0125.
HOGENOMi HOG000229078.
KOi K00943.
OMAi EPGGCPI.
OrthoDBi EOG64JFSH.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-712-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00165. Thymidylate_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00041. DTMP_kinase. 1 hit.
PROSITEi PS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiKTHY_RICTY
AccessioniPrimary (citable) accession number: Q68W53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: October 11, 2004
Last modified: October 1, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3