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Q68W53

- KTHY_RICTY

UniProt

Q68W53 - KTHY_RICTY

Protein

Thymidylate kinase

Gene

tmk

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

    Catalytic activityi

    ATP + dTMP = ADP + dTDP.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi14 – 218ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidylate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dTDP biosynthetic process Source: InterPro
    2. dTTP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-712-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
    Alternative name(s):
    dTMP kinaseUniRule annotation
    Gene namesi
    Name:tmkUniRule annotation
    Ordered Locus Names:RT0679
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 203203Thymidylate kinasePRO_0000155332Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi257363.RT0679.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68W53.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0125.
    HOGENOMiHOG000229078.
    KOiK00943.
    OMAiEPGGCPI.
    OrthoDBiEOG64JFSH.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00165. Thymidylate_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR018095. Thymidylate_kin_CS.
    IPR018094. Thymidylate_kinase.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
    PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68W53-1 [UniParc]FASTAAdd to Basket

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    MNKLTQGKFI TFEGMDGIGK STQSKMLYEY LKSQKIPVIL TREVGGTFVA    50
    EKMREILVHE ELLPMSELLQ AMAARYDHMV RKIIPALKDG YIVICDRFID 100
    STACYQGLEL ENGIDLVYSL HTTLMPSLMP DITFFIDVEP DTAIKRVNSR 150
    NMSNKFDRRR IDFYKKIYSC FQELSHRFPE RIKTIKASHL NPLEVHELIQ 200
    KHL 203
    Length:203
    Mass (Da):23,620
    Last modified:October 11, 2004 - v1
    Checksum:i4752FE4EF6C6ED76
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU04139.1.
    RefSeqiYP_067621.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU04139; AAU04139; RT0679.
    GeneIDi2958763.
    KEGGirty:RT0679.
    PATRICi17910604. VBIRicTyp34752_0698.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU04139.1 .
    RefSeqi YP_067621.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68W53.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0679.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU04139 ; AAU04139 ; RT0679 .
    GeneIDi 2958763.
    KEGGi rty:RT0679.
    PATRICi 17910604. VBIRicTyp34752_0698.

    Phylogenomic databases

    eggNOGi COG0125.
    HOGENOMi HOG000229078.
    KOi K00943.
    OMAi EPGGCPI.
    OrthoDBi EOG64JFSH.

    Enzyme and pathway databases

    BioCyci RTYP257363:GJEQ-712-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00165. Thymidylate_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR018095. Thymidylate_kin_CS.
    IPR018094. Thymidylate_kinase.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00041. DTMP_kinase. 1 hit.
    PROSITEi PS01331. THYMIDYLATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiKTHY_RICTY
    AccessioniPrimary (citable) accession number: Q68W53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3