Q68W53 (KTHY_RICTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidylate kinase
EC=2.7.4.9

Alternative name(s):
dTMP kinase

Gene names

Name:	tmk
Ordered Locus Names:	RT0679

Organism

Rickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]

Taxonomic identifier

257363 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia typhi

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity. HAMAP-Rule MF_00165
Catalytic activity	ATP + dTMP = ADP + dTDP. HAMAP-Rule MF_00165
Sequence similarities	Belongs to the thymidylate kinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dTDP biosynthetic process Inferred from electronic annotation. Source: InterPro dTTP biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP thymidylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 203	203	Thymidylate kinase HAMAP-Rule MF_00165		PRO_0000155332
Regions
	Nucleotide binding	14 – 21	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q68W53 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 4752FE4EF6C6ED76	FASTA	203	23,620
	10 20 30 40 50 60 MNKLTQGKFI TFEGMDGIGK STQSKMLYEY LKSQKIPVIL TREVGGTFVA EKMREILVHE 70 80 90 100 110 120 ELLPMSELLQ AMAARYDHMV RKIIPALKDG YIVICDRFID STACYQGLEL ENGIDLVYSL 130 140 150 160 170 180 HTTLMPSLMP DITFFIDVEP DTAIKRVNSR NMSNKFDRRR IDFYKKIYSC FQELSHRFPE 190 200 RIKTIKASHL NPLEVHELIQ KHL

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017197 Genomic DNA. Translation: AAU04139.1.
RefSeq	YP_067621.1. NC_006142.1.
3D structure databases
ProteinModelPortal	Q68W53.
ModBase	Search...
Protein-protein interaction databases
STRING	257363.RT0679.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAU04139; AAU04139; RT0679.
GeneID	2958763.
KEGG	rty:RT0679.
PATRIC	17910604. VBIRicTyp34752_0698.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0125.
HOGENOM	HOG000229078.
KO	K00943.
OMA	ITLEGPE.
ProtClustDB	PRK00698.
Enzyme and pathway databases
BioCyc	RTYP257363:GJEQ-712-MONOMER.
Family and domain databases
HAMAP	MF_00165. Thymidylate_kinase.
InterPro	IPR027417. P-loop_NTPase. IPR018095. Thymidylate_kin_CS. IPR018094. Thymidylate_kinase. [Graphical view]
PANTHER	PTHR10344. PTHR10344. 1 hit.
SUPFAM	SSF52540. SSF52540. 1 hit.
TIGRFAMs	TIGR00041. DTMP_kinase. 1 hit.
PROSITE	PS01331. THYMIDYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KTHY_RICTY

Accession

Primary (citable) accession number: Q68W53

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	October 11, 2004
Last modified:	May 29, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program