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Q68W53 (KTHY_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidylate kinase

EC=2.7.4.9
Alternative name(s):
dTMP kinase
Gene names
Name:tmk
Ordered Locus Names:RT0679
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length203 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity. HAMAP-Rule MF_00165

Catalytic activity

ATP + dTMP = ADP + dTDP. HAMAP-Rule MF_00165

Sequence similarities

Belongs to the thymidylate kinase family.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processdTDP biosynthetic process

Inferred from electronic annotation. Source: InterPro

dTTP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

thymidylate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 203203Thymidylate kinase HAMAP-Rule MF_00165
PRO_0000155332

Regions

Nucleotide binding14 – 218ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q68W53 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 4752FE4EF6C6ED76

FASTA20323,620
        10         20         30         40         50         60 
MNKLTQGKFI TFEGMDGIGK STQSKMLYEY LKSQKIPVIL TREVGGTFVA EKMREILVHE 

        70         80         90        100        110        120 
ELLPMSELLQ AMAARYDHMV RKIIPALKDG YIVICDRFID STACYQGLEL ENGIDLVYSL 

       130        140        150        160        170        180 
HTTLMPSLMP DITFFIDVEP DTAIKRVNSR NMSNKFDRRR IDFYKKIYSC FQELSHRFPE 

       190        200 
RIKTIKASHL NPLEVHELIQ KHL 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU04139.1.
RefSeqYP_067621.1. NC_006142.1.

3D structure databases

ProteinModelPortalQ68W53.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0679.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU04139; AAU04139; RT0679.
GeneID2958763.
KEGGrty:RT0679.
PATRIC17910604. VBIRicTyp34752_0698.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0125.
HOGENOMHOG000229078.
KOK00943.
OMAEPGGCPI.
OrthoDBEOG64JFSH.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-712-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00165. Thymidylate_kinase.
InterProIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00041. DTMP_kinase. 1 hit.
PROSITEPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKTHY_RICTY
AccessionPrimary (citable) accession number: Q68W53
Entry history
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names