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Q68W45

- CLPX_RICTY

UniProt

Q68W45 - CLPX_RICTY

Protein

ATP-dependent Clp protease ATP-binding subunit ClpX

Gene

clpX

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri12 – 3726C4-typeUniRule annotationAdd
    BLAST
    Nucleotide bindingi117 – 1248ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. nucleoside-triphosphatase activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein folding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-721-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotation
    Gene namesi
    Name:clpXUniRule annotation
    Ordered Locus Names:RT0687
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425ATP-dependent Clp protease ATP-binding subunit ClpXPRO_0000160414Add
    BLAST

    Proteomic databases

    PRIDEiQ68W45.

    Interactioni

    Subunit structurei

    Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

    Protein-protein interaction databases

    STRINGi257363.RT0687.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68W45.
    SMRiQ68W45. Positions 8-48.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ClpX chaperone family.UniRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri12 – 3726C4-typeUniRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1219.
    HOGENOMiHOG000010093.
    KOiK03544.
    OMAiKLFSMEG.
    OrthoDBiEOG625JZK.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_00175. ClpX.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR004487. Clp_protease_ATP-bd_su_ClpX.
    IPR027417. P-loop_NTPase.
    IPR010603. Znf_CppX_C4.
    [Graphical view]
    PfamiPF07724. AAA_2. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    PF06689. zf-C4_ClpX. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM01086. ClpB_D2-small. 1 hit.
    SM00994. zf-C4_ClpX. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00382. clpX. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q68W45-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVDADKKEL ICSFCSKKQH EVKKLIAGPA VFICDECIDL CTDIMKEESK    50
    VALKQITASI PTPQKICKIL NDYVVGQDKA KKILAVAVYN HYKRLEYVQS 100
    GNNDVELNKS NILLIGPTGS GKTLLAQTLA KILDVPFTMA DATSLTEAGY 150
    VGEDVENILL RLLISAEFNI AKAQKGIIYI DEVDKIARKS DNPSITRDVS 200
    GEGVQQALLK IMEGTVASVP PQGGRKHPQQ DFVQLDTSNI LFICGGAFMG 250
    IDRIIRSRTN HSSIGFAANI NIDKEKNNNE VLKSLEIEDL TKFGLIPEFI 300
    GRLPIVTTLE ELDKESLITI LTKPKNAIVK QYQKQFELDD AELVIEYSAL 350
    EAIAEKALVK KTGARGLRSI LEHLLLDSMY KVAELKKQRV TLTKEVVDGL 400
    IEPVMTSIIS TKLNKKQQMI EDIPA 425
    Length:425
    Mass (Da):47,010
    Last modified:October 11, 2004 - v1
    Checksum:iBA6D79DDF6033B69
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU04147.1.
    RefSeqiYP_067629.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU04147; AAU04147; RT0687.
    GeneIDi2958902.
    KEGGirty:RT0687.
    PATRICi17910620. VBIRicTyp34752_0706.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU04147.1 .
    RefSeqi YP_067629.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68W45.
    SMRi Q68W45. Positions 8-48.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0687.

    Proteomic databases

    PRIDEi Q68W45.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU04147 ; AAU04147 ; RT0687 .
    GeneIDi 2958902.
    KEGGi rty:RT0687.
    PATRICi 17910620. VBIRicTyp34752_0706.

    Phylogenomic databases

    eggNOGi COG1219.
    HOGENOMi HOG000010093.
    KOi K03544.
    OMAi KLFSMEG.
    OrthoDBi EOG625JZK.

    Enzyme and pathway databases

    BioCyci RTYP257363:GJEQ-721-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_00175. ClpX.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR004487. Clp_protease_ATP-bd_su_ClpX.
    IPR027417. P-loop_NTPase.
    IPR010603. Znf_CppX_C4.
    [Graphical view ]
    Pfami PF07724. AAA_2. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    PF06689. zf-C4_ClpX. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM01086. ClpB_D2-small. 1 hit.
    SM00994. zf-C4_ClpX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00382. clpX. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiCLPX_RICTY
    AccessioniPrimary (citable) accession number: Q68W45
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3