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Q68W45 (CLPX_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP-dependent Clp protease ATP-binding subunit ClpX
Gene names
Name:clpX
Ordered Locus Names:RT0687
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group ›

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP By similarity. HAMAP-Rule MF_00175

Subunit structure

Heterodimer of ClpP and ClpX By similarity.

Sequence similarities

Belongs to the ClpX chaperone family.

Ontologies

Keywords
   DomainZinc-finger
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionChaperone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: HAMAP

nucleoside-triphosphatase activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 425425ATP-dependent Clp protease ATP-binding subunit ClpX HAMAP-Rule MF_00175
PRO_0000160414

Regions

Zinc finger12 – 3726C4-type HAMAP-Rule MF_00175
Nucleotide binding116 – 1238ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q68W45 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: BA6D79DDF6033B69

FASTA42547,010
        10         20         30         40         50         60 
MVVDADKKEL ICSFCSKKQH EVKKLIAGPA VFICDECIDL CTDIMKEESK VALKQITASI 

        70         80         90        100        110        120 
PTPQKICKIL NDYVVGQDKA KKILAVAVYN HYKRLEYVQS GNNDVELNKS NILLIGPTGS 

       130        140        150        160        170        180 
GKTLLAQTLA KILDVPFTMA DATSLTEAGY VGEDVENILL RLLISAEFNI AKAQKGIIYI 

       190        200        210        220        230        240 
DEVDKIARKS DNPSITRDVS GEGVQQALLK IMEGTVASVP PQGGRKHPQQ DFVQLDTSNI 

       250        260        270        280        290        300 
LFICGGAFMG IDRIIRSRTN HSSIGFAANI NIDKEKNNNE VLKSLEIEDL TKFGLIPEFI 

       310        320        330        340        350        360 
GRLPIVTTLE ELDKESLITI LTKPKNAIVK QYQKQFELDD AELVIEYSAL EAIAEKALVK 

       370        380        390        400        410        420 
KTGARGLRSI LEHLLLDSMY KVAELKKQRV TLTKEVVDGL IEPVMTSIIS TKLNKKQQMI 


EDIPA

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References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017197 Genomic DNA. Translation: AAU04147.1.
RefSeqYP_067629.1. NC_006142.1.

3D structure databases

ProteinModelPortalQ68W45.
SMRQ68W45. Positions 8-48.
ModBaseSearch...

Protein-protein interaction databases

STRING257363.RT0687.

Proteomic databases

PRIDEQ68W45.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU04147; AAU04147; RT0687.
GeneID2958902.
KEGGrty:RT0687.
PATRIC17910620. VBIRicTyp34752_0706.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1219.
HOGENOMHOG000010093.
KOK03544.
OMASDLELEH.
ProtClustDBPRK05342.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-721-MONOMER.

Family and domain databases

HAMAPMF_00175. ClpX.
InterProIPR003593. AAA+_ATPase.
IPR013093. ATPase_AAA-2.
IPR019489. Clp_ATPase_C.
IPR004487. Clp_protease_ATP-bd_su_ClpX.
IPR010603. Znf_CppX_C4.
[Graphical view]
PANTHERPTHR11262:SF4. PTHR11262:SF4. 1 hit.
PfamPF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
PF06689. zf-C4_ClpX. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SM00994. zf-C4_ClpX. 1 hit.
[Graphical view]
TIGRFAMsTIGR00382. clpX. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCLPX_RICTY
AccessionPrimary (citable) accession number: Q68W45
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 11, 2004
Last modified: May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names

SIMILARITY comments

Index of protein domains and families

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