Q68W38 (LOLD_RICTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipoprotein-releasing system ATP-binding protein LolD
EC=3.6.3.-

Gene names

Name:	lolD
Ordered Locus Names:	RT0695

Organism

Rickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]

Taxonomic identifier

257363 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia typhi

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner By similarity.
Subunit structure	The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE) By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family. [View classification] Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro lipoprotein transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 221	221	Lipoprotein-releasing system ATP-binding protein LolD		PRO_0000260198
Regions
	Domain	6 – 220	215	ABC transporter
	Nucleotide binding	42 – 49	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q68W38 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 9B293B7F449F1C29	FASTA	221	24,812
	10 20 30 40 50 60 MNNTVLILKK ISKHYKQGNT IVKVLDDLNL TANEGELIAI IGSSGSGKST LLHIAGLLDK 70 80 90 100 110 120 PTNGQVIIPN SKYKKYHLIR LYYLGFIYQQ HHLLKDFTAL ENVIIPRLIR GLDQKEAIRD 130 140 150 160 170 180 ATKILDDLGL EKKLYNMPGE LSGGEQQRVA IARSLINKPR IILADEPTGN LDPKSTNEVF 190 200 210 220 NLFLKVAQKQ NTTVIMVTHN HELAHKMDKL YNLKNGLLNI A

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017197 Genomic DNA. Translation: AAU04154.1.
RefSeq	YP_067636.1. NC_006142.1.
3D structure databases
ProteinModelPortal	Q68W38.
ModBase	Search...
Protein-protein interaction databases
STRING	257363.RT0695.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAU04154; AAU04154; RT0695.
GeneID	2958968.
KEGG	rty:RT0695.
PATRIC	17910636. VBIRicTyp34752_0713.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1136.
KO	K09810.
OMA	ELAHKMD.
ProtClustDB	CLSK871039.
Enzyme and pathway databases
BioCyc	RTYP257363:GJEQ-729-MONOMER.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR015854. ABC_transpr_LolD. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
SUPFAM	SSF52540. SSF52540. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51244. LOLD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LOLD_RICTY

Accession

Primary (citable) accession number: Q68W38

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	October 11, 2004
Last modified:	May 29, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program