Q68W05 (GLRX2_RICTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable monothiol glutaredoxin-2

Gene names

Name:	grxC2
Synonyms:	grlA
Ordered Locus Names:	RT0730

Organism

Rickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]

Taxonomic identifier

257363 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	111 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the glutaredoxin family. Monothiol subfamily. Contains 1 glutaredoxin domain.

Ontologies

Keywords
Domain	Redox-active center
Ligand	2Fe-2S Iron Iron-sulfur Metal-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Molecular function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 111	111	Probable monothiol glutaredoxin-2		PRO_0000288733
Regions
	Domain	7 – 109	103	Glutaredoxin
	Region	86 – 87	2	Glutathione binding By similarity
Sites
	Metal binding	32	1	Iron-sulfur (2Fe-2S); shared with dimeric partner By similarity
	Binding site	24	1	Glutathione By similarity
	Binding site	61	1	Glutathione By similarity
	Binding site	73	1	Glutathione; via amide nitrogen and carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q68W05 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 29A88F606B8A05E1	FASTA	111	12,637
	10 20 30 40 50 60 MMENKNLKFI QNAIKKNKVV LFMKGTKEMP ACGFSGTVVA ILNKLGVEFS DINVLFDTSL 70 80 90 100 110 REDLKKFSDW PTFPQLYING ELVGGCDIVK ELYQNGELEK MLKDETKLIK N

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017197 Genomic DNA. Translation: AAU04187.1.
RefSeq	YP_067669.1. NC_006142.1.
3D structure databases
HSSP	HSSP built from PDB template 1WIK based on UniProtKB Q9CQM9.
ProteinModelPortal	Q68W05.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2959258.
GenomeReviews	Gene locus RT0730 in contig AE017197_GR.
KEGG	rty:RT0730.
PATRIC	17910712. VBIRicTyp34752_0750.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG728471.
OMA	NGELEKM.
ProtClustDB	CLSK2484244.
Enzyme and pathway databases
BioCyc	RTYP257363:RT0730-MONOMER.
Family and domain databases
InterPro	IPR002109. Glutaredoxin. IPR014434. Monothiol_GRX. IPR004480. Monothiol_GRX-rel. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K07390.
PANTHER	PTHR10293. Glutredox-rel. 1 hit.
Pfam	PF00462. Glutaredoxin. 1 hit. [Graphical view]
PIRSF	PIRSF005894. Monothiol_GRX. 1 hit.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMs	TIGR00365. TIGR00365. 1 hit.
PROSITE	PS51354. GLUTAREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLRX2_RICTY

Accession

Primary (citable) accession number: Q68W05

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program