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Protein

Sec-independent protein translocase protein TatA

Gene

tatA

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.UniRule annotation

GO - Molecular functioni

  1. protein transmembrane transporter activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein secretion Source: InterPro
  2. protein transport by the Tat complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-774-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sec-independent protein translocase protein TatAUniRule annotation
Gene namesi
Name:tatAUniRule annotation
Ordered Locus Names:RT0734
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604 Componenti: Chromosome

Subcellular locationi

  1. Cell inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB-HAMAP
  2. TAT protein transport complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5353Sec-independent protein translocase protein TatAPRO_0000278028Add
BLAST

Interactioni

Subunit structurei

The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.UniRule annotation

Protein-protein interaction databases

STRINGi257363.RT0734.

Family & Domainsi

Sequence similaritiesi

Belongs to the TatA/E family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG270103.
HOGENOMiHOG000245363.
KOiK03116.
OMAiWQIFLIL.
OrthoDBiEOG64BQD5.

Family and domain databases

HAMAPiMF_00236. TatA_E.
InterProiIPR003369. TatA/B/E.
IPR006312. TatA/E.
[Graphical view]
PfamiPF02416. MttA_Hcf106. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01411. tatAE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68W01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMSFSHLLI VLLIIFVLFG AGKLPQVMSD LAKGLKAFKE GMKDDGNDND

KNE
Length:53
Mass (Da):5,798
Last modified:October 11, 2004 - v1
Checksum:i41EBCA977FA3C707
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU04191.1.
RefSeqiYP_067673.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU04191; AAU04191; RT0734.
KEGGirty:RT0734.
PATRICi17910720. VBIRicTyp34752_0754.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU04191.1.
RefSeqiYP_067673.1. NC_006142.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257363.RT0734.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU04191; AAU04191; RT0734.
KEGGirty:RT0734.
PATRICi17910720. VBIRicTyp34752_0754.

Phylogenomic databases

eggNOGiNOG270103.
HOGENOMiHOG000245363.
KOiK03116.
OMAiWQIFLIL.
OrthoDBiEOG64BQD5.

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-774-MONOMER.

Family and domain databases

HAMAPiMF_00236. TatA_E.
InterProiIPR003369. TatA/B/E.
IPR006312. TatA/E.
[Graphical view]
PfamiPF02416. MttA_Hcf106. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01411. tatAE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiTATA_RICTY
AccessioniPrimary (citable) accession number: Q68W01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 11, 2004
Last modified: April 29, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.