ID   AK_RICTY                Reviewed;         448 AA.
AC   Q68VZ7;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   16-JUN-2009, entry version 35.
DE   RecName: Full=Aspartokinase;
DE            EC=2.7.2.4;
DE   AltName: Full=Aspartate kinase;
GN   Name=lysC; OrderedLocusNames=RT0738;
OS   Rickettsia typhi.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=785;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-144 / Wilmington;
RX   PubMed=15317790; DOI=10.1128/JB.186.17.5842-5855.2004;
RA   McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K.,
RA   Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C.,
RA   Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G.,
RA   Gibbs R.A., Hong C., Yu X.-J., Walker D.H., Weinstock G.M.;
RT   "Complete genome sequence of Rickettsia typhi and comparison with
RT   sequences of other Rickettsiae.";
RL   J. Bacteriol. 186:5842-5855(2004).
CC   -!- CATALYTIC ACTIVITY: ATP + L-aspartate = ADP + 4-phospho-L-
CC       aspartate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC       pathway; tetrahydrodipicolinate from L-aspartate: step 1/4.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 1/3.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 1/5.
CC   -!- SIMILARITY: Belongs to the aspartokinase family.
CC   -!- SIMILARITY: Contains 1 RPE1 insert domain.
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DR   EMBL; AE017197; AAU04195.1; -; Genomic_DNA.
DR   RefSeq; YP_067677.1; -.
DR   GeneID; 2959028; -.
DR   GenomeReviews; AE017197_GR; RT0738.
DR   KEGG; rty:RT0738; -.
DR   HOGENOM; Q68VZ7; -.
DR   OMA; Q68VZ7; AWQLPIL.
DR   BioCyc; RTYP257363:RT0738-MON; -.
DR   BRENDA; 2.7.2.4; 281221.
DR   GO; GO:0004072; F:aspartate kinase activity; IEA:EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004349; F:glutamate 5-kinase activity; IEA:InterPro.
DR   GO; GO:0019877; P:diaminopimelate biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006561; P:proline biosynthetic process; IEA:InterPro.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR001341; Asp_kin_reg.
DR   InterPro; IPR018042; Aspartate_kinase_CS.
DR   InterPro; IPR001057; Glu_5kinase.
DR   Gene3D; G3DSA:3.40.1160.10; Aa_kinase; 1.
DR   Pfam; PF00696; AA_kinase; 1.
DR   PRINTS; PR00474; GLU5KINASE.
DR   TIGRFAMs; TIGR00657; asp_kinases; 1.
DR   PROSITE; PS00324; ASPARTOKINASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; ATP-binding; Complete proteome;
KW   Diaminopimelate biosynthesis; Kinase; Lysine biosynthesis;
KW   Nucleotide-binding; Transferase.
FT   CHAIN         1    448       Aspartokinase.
FT                                /FTId=PRO_0000288721.
FT   DOMAIN      250    296       RPE1 insert.
SQ   SEQUENCE   448 AA;  49936 MW;  80AB560AA9709700 CRC64;
     MALIIQKFGG TSVANIERIK KLVPIIKAEI TKNNQVIVVV SAMAGVTNQL VTLCSEVSSL
     NKISQFAEYD VALSSGEIVT AALLALALQE EEIQAQSLLA WQLPILTNNN HSKALVEFIT
     TDLLEKCLQL KIIPIIAGFQ GINKSNRITT FGRGGSDTTA ALIAAAMKAD RCDIYTDVDG
     IFTADPRIIP NAKRIKEIDF LEMLELASSG AKVLHPRAVE LVMRYKIDMR VLSTFLPNTE
     GTLITSKDTT PLVKSTYMDM EESAKNIKRS TKINIPDDTS GLTYKLPIEL ALQNRYNMEN
     CIIRGITSNK NLLKVSVNTI TLSFLQVANM ITYNNNCIEF MQEIKNNIEY NFITNLTDKN
     NLQTLLTNCK NNKQIQNFTF DTEIATISLI GYGIKNDCKL LEMILSQLTQ DNINVNMMQL
     SEVKITLLIN DKDVEKTISN LYNLFKIS
//