Reviewed, UniProtKB/Swiss-Prot Q68VZ7 (AK_RICTY)

Names and origin

Protein names

Recommended name:
    Aspartokinase
    EC=2.7.2.4
Alternative name(s):
    Aspartate kinase

Gene names

Name:	lysC
Ordered Locus Names:	RT0738

Organism

Rickettsia typhi [Complete proteome] [HAMAP]

Taxonomic identifier

785 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-aspartate = ADP + 4-phospho-L-aspartate.
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4. Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3. Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.
Sequence similarities	Belongs to the aspartokinase family. Contains 1 RPE1 insert domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW aspartate kinase activity Inferred from electronic annotation. Source: EC glutamate 5-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	Aspartokinase		PRO_0000288721
Regions
	Domain	250 – 296	47	RPE1 insert

Sequences

	Sequence		Length	Mass (Da)
	Q68VZ7-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 80AB560AA9709700	FASTA	448	49,936
	10 20 30 40 50 60 MALIIQKFGG TSVANIERIK KLVPIIKAEI TKNNQVIVVV SAMAGVTNQL VTLCSEVSSL 70 80 90 100 110 120 NKISQFAEYD VALSSGEIVT AALLALALQE EEIQAQSLLA WQLPILTNNN HSKALVEFIT 130 140 150 160 170 180 TDLLEKCLQL KIIPIIAGFQ GINKSNRITT FGRGGSDTTA ALIAAAMKAD RCDIYTDVDG 190 200 210 220 230 240 IFTADPRIIP NAKRIKEIDF LEMLELASSG AKVLHPRAVE LVMRYKIDMR VLSTFLPNTE 250 260 270 280 290 300 GTLITSKDTT PLVKSTYMDM EESAKNIKRS TKINIPDDTS GLTYKLPIEL ALQNRYNMEN 310 320 330 340 350 360 CIIRGITSNK NLLKVSVNTI TLSFLQVANM ITYNNNCIEF MQEIKNNIEY NFITNLTDKN 370 380 390 400 410 420 NLQTLLTNCK NNKQIQNFTF DTEIATISLI GYGIKNDCKL LEMILSQLTQ DNINVNMMQL 430 440 SEVKITLLIN DKDVEKTISN LYNLFKIS

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017197 Genomic DNA. Translation: AAU04195.1.
RefSeq	YP_067677.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2959028.
GenomeReviews	Gene locus RT0738 in contig AE017197_GR.
KEGG	rty:RT0738.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q68VZ7.
OMA	AWQLPIL.
Enzyme and pathway databases
BioCyc	RTYP257363:RT0738-MON.
BRENDA	2.7.2.4. 281221.
Family and domain databases
InterPro	IPR001048. Asp/Glu/Uridylate_kinase. IPR001341. Asp_kin_reg. IPR018042. Aspartate_kinase_CS. IPR001057. Glu_5kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PRINTS	PR00474. GLU5KINASE.
TIGRFAMs	TIGR00657. asp_kinases. 1 hit.
PROSITE	PS00324. ASPARTOKINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AK_RICTY

Accession

Primary (citable) accession number: Q68VZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	October 11, 2004
Last modified:	November 3, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)