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Q68VZ0

- MNME_RICTY

UniProt

Q68VZ0 - MNME_RICTY

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Protein
tRNA modification GTPase MnmE
Gene
mnmE, trmE, RT0745
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm5s2U34 By similarity.UniRule annotation

Cofactori

Binds 1 potassium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201Formyltetrahydrofolate By similarity
Binding sitei79 – 791Formyltetrahydrofolate By similarity
Binding sitei119 – 1191Formyltetrahydrofolate By similarity
Metal bindingi225 – 2251Potassium By similarity
Metal bindingi229 – 2291Magnesium By similarity
Metal bindingi244 – 2441Potassium; via carbonyl oxygen By similarity
Metal bindingi246 – 2461Potassium; via carbonyl oxygen By similarity
Metal bindingi249 – 2491Potassium By similarity
Metal bindingi250 – 2501Magnesium By similarity
Binding sitei445 – 4451Formyltetrahydrofolate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi225 – 2306GTP By similarity
Nucleotide bindingi244 – 2507GTP By similarity
Nucleotide bindingi269 – 2724GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. GTPase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tRNA modification Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-785-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA modification GTPase MnmE (EC:3.6.-.-)
Gene namesi
Name:mnmE
Synonyms:trmE
Ordered Locus Names:RT0745
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445tRNA modification GTPase MnmEUniRule annotation
PRO_0000278005Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity. Heterotetramer of two MnmE and two MnmG subunits By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi257363.RT0745.

Structurei

3D structure databases

ProteinModelPortaliQ68VZ0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini215 – 371157TrmE-type G
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0486.
HOGENOMiHOG000200714.
KOiK03650.
OMAiCAETEWD.
OrthoDBiEOG6DC6K1.

Family and domain databases

Gene3Di1.20.120.430. 3 hits.
3.30.1360.120. 1 hit.
3.40.50.300. 2 hits.
HAMAPiMF_00379. GTPase_MnmE.
InterProiIPR018948. GTP-bd_TrmE_N.
IPR006073. GTP_binding_domain.
IPR004520. GTPase_MnmE.
IPR025867. GTPase_MnmE_C_dom.
IPR008144. Guanylate_kin-like.
IPR027368. MnmE_dom2.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PfamiPF12631. GTPase_Cys_C. 1 hit.
PF01926. MMR_HSR1. 1 hit.
PF10396. TrmE_N. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00450. mnmE_trmE_thdF. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51709. G_TRME. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68VZ0-1 [UniParc]FASTAAdd to Basket

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METIFAQSSA FGKAGVAVFR ISGPKSLEVL QLLTGRKDFK PRLMYYQQII    50
SPETNELIDN AMVVYFKLPN SFTGEDVVEI HTHGSKAISI MLINTLLNID 100
DIRLAEAGEF TKRAFLNNKF DLTAAEGIAD LINAETIMQH RQAVRQANGG 150
LEELYNNWRN QLLKIIALLE AYLDFPDEDI PDSILNDVNN THKNIVNEIS 200
NYLNDNRRGE LLNNGLKLAI IGPPNTGKSS LLNFLMQRNI AIVSNIAGTT 250
RDIIEGHLDI GGYPIILQDT AGIRAESTDI IEREGIKRAI NSAKTANIKI 300
IMFDAEKLDL SINNDIIDLI DENTIVIINK IDLIEPSQIF PIEKKYKCLR 350
VSVKNNIALS SILKNIENIA ENIAGFTETP YITNQRHRHY LKQALSHLMA 400
FNLDNDLVLA TEDMRMTARC IGLITGVINV EEILNEIFKN FCIGK 445
Length:445
Mass (Da):49,892
Last modified:October 11, 2004 - v1
Checksum:i3E700EAC12F31B55
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU04202.1.
RefSeqiYP_067684.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU04202; AAU04202; RT0745.
GeneIDi2958546.
KEGGirty:RT0745.
PATRICi17910742. VBIRicTyp34752_0765.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU04202.1 .
RefSeqi YP_067684.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68VZ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0745.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU04202 ; AAU04202 ; RT0745 .
GeneIDi 2958546.
KEGGi rty:RT0745.
PATRICi 17910742. VBIRicTyp34752_0765.

Phylogenomic databases

eggNOGi COG0486.
HOGENOMi HOG000200714.
KOi K03650.
OMAi CAETEWD.
OrthoDBi EOG6DC6K1.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-785-MONOMER.

Family and domain databases

Gene3Di 1.20.120.430. 3 hits.
3.30.1360.120. 1 hit.
3.40.50.300. 2 hits.
HAMAPi MF_00379. GTPase_MnmE.
InterProi IPR018948. GTP-bd_TrmE_N.
IPR006073. GTP_binding_domain.
IPR004520. GTPase_MnmE.
IPR025867. GTPase_MnmE_C_dom.
IPR008144. Guanylate_kin-like.
IPR027368. MnmE_dom2.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR027266. TrmE/GcvT_dom1.
[Graphical view ]
Pfami PF12631. GTPase_Cys_C. 1 hit.
PF01926. MMR_HSR1. 1 hit.
PF10396. TrmE_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
TIGRFAMsi TIGR00450. mnmE_trmE_thdF. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51709. G_TRME. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiMNME_RICTY
AccessioniPrimary (citable) accession number: Q68VZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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