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Reviewed, UniProtKB/Swiss-Prot Q68VY7 (FABG_RICTY)

Last modified November 3, 2009. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    3-oxoacyl-[acyl-carrier-protein] reductase
    EC=1.1.1.100
Alternative name(s):
    3-ketoacyl-acyl carrier protein reductase
Gene names
Name: fabG
Ordered Locus Names: RT0748
OrganismRickettsia typhi [Complete proteome] [HAMAP]
Taxonomic identifier785 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length241 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2412413-oxoacyl-[acyl-carrier-protein] reductase
PRO_0000286634

Regions

Nucleotide binding11 – 3525NADP By similarity

Sites

Active site1481Proton acceptor By similarity
Binding site1351Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68VY7-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 315D2AF9C6543A7D

FASTA24125,892
        10         20         30         40         50         60 
MIDFTGKTSL ITGASGGIGS AIARLLHKLG SKVIISGSNE KKLKLLGNTL KDNYIIEVCN 

        70         80         90        100        110        120 
LANKEECNNL ISKISNLDIL VCNAGITSDT LAIRMKDQDF DKVIDINLKA NFILNREAIK 

       130        140        150        160        170        180 
KMIQKRYGRI INISSIVGIA GNPGQANYCA SKAGLIGMTK SLSYEVATRG ITVNAVAPGF 

       190        200        210        220        230        240 
IKSDMTDKLN EKQREAIVQK IPLGTYGIPE DVAYAVAFLA SNHASYITGQ TLHVNGGMLM 


V 

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References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

AE017197 Genomic DNA. Translation: AAU04205.1.
RefSeqYP_067687.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID2958719.
GenomeReviewsGene locus RT0748 in contig AE017197_GR.
KEGGrty:RT0748.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ68VY7.
OMALANKEEC.

Enzyme and pathway databases

BioCycRTYP257363:RT0748-MON.
BRENDA1.1.1.100. 281221.

Family and domain databases

InterProIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR19410. ADH_short_C2. 1 hit.
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFABG_RICTY
AccessionPrimary (citable) accession number: Q68VY7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2004
Last modified: November 3, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents