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Q68VV3

- NUOH_RICTY

UniProt

Q68VV3 - NUOH_RICTY

Protein

NADH-quinone oxidoreductase subunit H

Gene

nuoH

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.UniRule annotation

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.UniRule annotation

    GO - Molecular functioni

    1. NADH dehydrogenase (quinone) activity Source: UniProtKB-EC
    2. quinone binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD, Ubiquinone

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-823-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit HUniRule annotation (EC:1.6.99.5UniRule annotation)
    Alternative name(s):
    NADH dehydrogenase I subunit HUniRule annotation
    NDH-1 subunit HUniRule annotation
    Gene namesi
    Name:nuoHUniRule annotation
    Ordered Locus Names:RT0783
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 339339NADH-quinone oxidoreductase subunit HPRO_0000240108Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi257363.RT0783.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021HelicalUniRule annotationAdd
    BLAST
    Transmembranei50 – 7021HelicalUniRule annotationAdd
    BLAST
    Transmembranei82 – 10221HelicalUniRule annotationAdd
    BLAST
    Transmembranei115 – 13521HelicalUniRule annotationAdd
    BLAST
    Transmembranei155 – 17521HelicalUniRule annotationAdd
    BLAST
    Transmembranei187 – 20721HelicalUniRule annotationAdd
    BLAST
    Transmembranei235 – 25521HelicalUniRule annotationAdd
    BLAST
    Transmembranei275 – 29521HelicalUniRule annotationAdd
    BLAST
    Transmembranei311 – 33121HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 1 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1005.
    HOGENOMiHOG000228276.
    KOiK00337.
    OMAiWGLLQSF.
    OrthoDBiEOG6B62B4.

    Family and domain databases

    HAMAPiMF_01350. NDH1_NuoH.
    InterProiIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
    IPR018086. NADH_UbQ_OxRdtase_su1_CS.
    [Graphical view]
    PANTHERiPTHR11432. PTHR11432. 1 hit.
    PfamiPF00146. NADHdh. 1 hit.
    [Graphical view]
    PROSITEiPS00667. COMPLEX1_ND1_1. 1 hit.
    PS00668. COMPLEX1_ND1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68VV3-1 [UniParc]FASTAAdd to Basket

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    MIELFYEYMF PLTVIALKVV AITIPLILCV AYLTYAERRV IGLMQLRRGP    50
    NVVGPFGLLQ PIADAVKLLF KEPIIPTNAD KILFILAPII TFVLSLIGWA 100
    VIPFAKGVVL ADINVGVLYI LAISSLSVYG IIIAGWASNS KYAFLGAIRS 150
    SAQMISYEVS IGLVIVTVLL TTGTLNLSRI IEAQKTLPWW IDLMLLPMSI 200
    VFFISVLAET NRLPFDLPEA ESELVAGYNV EYSSMGFALF FLGEYANMIL 250
    VSAMTTTFFL GGYLPPFNLP FLDCIPGFFW FVLKVMLLLF CFLWIRATLP 300
    RYRYDQLMRL GWKVFLPLTL FGVVLVSSVL FYTDNLPSV 339
    Length:339
    Mass (Da):37,923
    Last modified:October 11, 2004 - v1
    Checksum:iAD523832338F154D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU04239.1.
    RefSeqiYP_067721.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU04239; AAU04239; RT0783.
    GeneIDi2958566.
    KEGGirty:RT0783.
    PATRICi17910818. VBIRicTyp34752_0802.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU04239.1 .
    RefSeqi YP_067721.1. NC_006142.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0783.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU04239 ; AAU04239 ; RT0783 .
    GeneIDi 2958566.
    KEGGi rty:RT0783.
    PATRICi 17910818. VBIRicTyp34752_0802.

    Phylogenomic databases

    eggNOGi COG1005.
    HOGENOMi HOG000228276.
    KOi K00337.
    OMAi WGLLQSF.
    OrthoDBi EOG6B62B4.

    Enzyme and pathway databases

    BioCyci RTYP257363:GJEQ-823-MONOMER.

    Family and domain databases

    HAMAPi MF_01350. NDH1_NuoH.
    InterProi IPR001694. NADH_UbQ_OxRdtase_su1/FPO.
    IPR018086. NADH_UbQ_OxRdtase_su1_CS.
    [Graphical view ]
    PANTHERi PTHR11432. PTHR11432. 1 hit.
    Pfami PF00146. NADHdh. 1 hit.
    [Graphical view ]
    PROSITEi PS00667. COMPLEX1_ND1_1. 1 hit.
    PS00668. COMPLEX1_ND1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiNUOH_RICTY
    AccessioniPrimary (citable) accession number: Q68VV3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3