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Q68VV3

- NUOH_RICTY

UniProt

Q68VV3 - NUOH_RICTY

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Protein

NADH-quinone oxidoreductase subunit H

Gene
nuoH, RT0783
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone By similarity.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (quinone) activity Source: UniProtKB-EC
  2. quinone binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-823-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit H (EC:1.6.99.5)
Alternative name(s):
NADH dehydrogenase I subunit H
NDH-1 subunit H
Gene namesi
Name:nuoH
Ordered Locus Names:RT0783
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3021Helical; Reviewed predictionAdd
BLAST
Transmembranei50 – 7021Helical; Reviewed predictionAdd
BLAST
Transmembranei82 – 10221Helical; Reviewed predictionAdd
BLAST
Transmembranei115 – 13521Helical; Reviewed predictionAdd
BLAST
Transmembranei155 – 17521Helical; Reviewed predictionAdd
BLAST
Transmembranei187 – 20721Helical; Reviewed predictionAdd
BLAST
Transmembranei235 – 25521Helical; Reviewed predictionAdd
BLAST
Transmembranei275 – 29521Helical; Reviewed predictionAdd
BLAST
Transmembranei311 – 33121Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339NADH-quinone oxidoreductase subunit HUniRule annotationPRO_0000240108Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.

Protein-protein interaction databases

STRINGi257363.RT0783.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1005.
HOGENOMiHOG000228276.
KOiK00337.
OMAiWGLLQSF.
OrthoDBiEOG6B62B4.

Family and domain databases

HAMAPiMF_01350. NDH1_NuoH.
InterProiIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view]
PANTHERiPTHR11432. PTHR11432. 1 hit.
PfamiPF00146. NADHdh. 1 hit.
[Graphical view]
PROSITEiPS00667. COMPLEX1_ND1_1. 1 hit.
PS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68VV3-1 [UniParc]FASTAAdd to Basket

« Hide

MIELFYEYMF PLTVIALKVV AITIPLILCV AYLTYAERRV IGLMQLRRGP    50
NVVGPFGLLQ PIADAVKLLF KEPIIPTNAD KILFILAPII TFVLSLIGWA 100
VIPFAKGVVL ADINVGVLYI LAISSLSVYG IIIAGWASNS KYAFLGAIRS 150
SAQMISYEVS IGLVIVTVLL TTGTLNLSRI IEAQKTLPWW IDLMLLPMSI 200
VFFISVLAET NRLPFDLPEA ESELVAGYNV EYSSMGFALF FLGEYANMIL 250
VSAMTTTFFL GGYLPPFNLP FLDCIPGFFW FVLKVMLLLF CFLWIRATLP 300
RYRYDQLMRL GWKVFLPLTL FGVVLVSSVL FYTDNLPSV 339
Length:339
Mass (Da):37,923
Last modified:October 11, 2004 - v1
Checksum:iAD523832338F154D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU04239.1.
RefSeqiYP_067721.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU04239; AAU04239; RT0783.
GeneIDi2958566.
KEGGirty:RT0783.
PATRICi17910818. VBIRicTyp34752_0802.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU04239.1 .
RefSeqi YP_067721.1. NC_006142.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0783.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU04239 ; AAU04239 ; RT0783 .
GeneIDi 2958566.
KEGGi rty:RT0783.
PATRICi 17910818. VBIRicTyp34752_0802.

Phylogenomic databases

eggNOGi COG1005.
HOGENOMi HOG000228276.
KOi K00337.
OMAi WGLLQSF.
OrthoDBi EOG6B62B4.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-823-MONOMER.

Family and domain databases

HAMAPi MF_01350. NDH1_NuoH.
InterProi IPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view ]
PANTHERi PTHR11432. PTHR11432. 1 hit.
Pfami PF00146. NADHdh. 1 hit.
[Graphical view ]
PROSITEi PS00667. COMPLEX1_ND1_1. 1 hit.
PS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiNUOH_RICTY
AccessioniPrimary (citable) accession number: Q68VV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi