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Q68VV2

- NUOG_RICTY

UniProt

Q68VV2 - NUOG_RICTY

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Protein

NADH-quinone oxidoreductase subunit G

Gene

nuoG

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).By similarity

Catalytic activityi

NADH + quinone = NAD+ + quinol.

Cofactori

Protein has several cofactor binding sites:
  • [2Fe-2S] clusterBy similarityNote: Binds 1 [2Fe-2S] cluster per subunit.By similarity
  • [4Fe-4S] clusterBy similarityNote: Binds 2 [4Fe-4S] clusters per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi34 – 341Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi45 – 451Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi48 – 481Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi62 – 621Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi94 – 941Iron-sulfur 2 (4Fe-4S); via pros nitrogenBy similarity
Metal bindingi98 – 981Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi101 – 1011Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi107 – 1071Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi146 – 1461Iron-sulfur 3 (4Fe-4S)By similarity
Metal bindingi149 – 1491Iron-sulfur 3 (4Fe-4S)By similarity
Metal bindingi152 – 1521Iron-sulfur 3 (4Fe-4S)By similarity
Metal bindingi196 – 1961Iron-sulfur 3 (4Fe-4S)By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. electron carrier activity Source: InterPro
  4. metal ion binding Source: UniProtKB-KW
  5. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  6. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP synthesis coupled electron transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-824-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit G (EC:1.6.99.5)
Alternative name(s):
NADH dehydrogenase I subunit G
NDH-1 subunit G
Gene namesi
Name:nuoG
Ordered Locus Names:RT0784
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 675675NADH-quinone oxidoreductase subunit GPRO_0000287844Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0784.

Structurei

3D structure databases

ProteinModelPortaliQ68VV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 78782Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST
Domaini215 – 271574Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the complex I 75 kDa subunit family.Curated
Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
Contains 1 4Fe-4S Mo/W bis-MGD-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1034.
HOGENOMiHOG000031442.
KOiK00336.
OMAiGAMTLIQ.
OrthoDBiEOG6CVV7G.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR012675. Beta-grasp_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR000283. NADH_UbQ_OxRdtase_75kDa_su_CS.
IPR010228. NADH_UbQ_OxRdtase_Gsu.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
IPR015405. NuoG_C.
[Graphical view]
PfamiPF09326. DUF1982. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SMARTiSM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SUPFAMiSSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR01973. NuoG. 1 hit.
PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00641. COMPLEX1_75K_1. 1 hit.
PS00642. COMPLEX1_75K_2. 1 hit.
PS00643. COMPLEX1_75K_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68VV2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKLIIDGSE IEISEGSTVY QACIQAGKQI PHFCYHARLK IAGNCRMCLV
60 70 80 90 100
EIEKSQKPVA SCAMPVSNGM VIHTDTSMVK KAREGVMEFL LINHPLDCPI
110 120 130 140 150
CDQGGECDLQ DQAFRYGKGT NRFHENKRSI KDKYMGPLIK TAMTRCIQCT
160 170 180 190 200
RCIRFANDIA GIEEIGAINR GEHMEVTSYL EQTLDSEISG NMIDICPVGA
210 220 230 240 250
LNSKPYAFKA RKWELKHTAS IGVHDAEGSN IRIDSRADEI MRILPSVNEA
260 270 280 290 300
INEAWISDKN RFCYDGLKYQ RLDHPYIRKN GKLVEVSWSE ALKTIMDKIK
310 320 330 340 350
SVKPEKIAAI AGSIVSVEAM FMLKILLQKL GSNNYTVNQF NYKIDTSERG
360 370 380 390 400
NYLFNTTIVG VEKADLCLLI GANIRQIAPI LNSRIGRRVR IGALKVVRIG
410 420 430 440 450
IGHNQTYKIH DLGNDIKIIE DLAVGTHEYT KAFKEAKYPM IIVGDGVYGR
460 470 480 490 500
DDGYALLSLI HKVVDKYNMM RDDWQGFNIL HNHASIVGGL DIGFNTAIKF
510 520 530 540 550
EGVKLAYLLG ADAIPFDKLK SAFIIYQGHH GDVGAMSADV ILPSAAYTEQ
560 570 580 590 600
SGIYVNLEGR PQIAQKAVSP VGRAKEDIEI IKEIAGYLKI DIGMDNLQEV
610 620 630 640 650
RIRLAKEYNI FANIDKITAN RFTQFISIDK LSQEPIAARP INYYMTDVIS
660 670
KNSVTMAKCV EAKEERKRDV AKVFY
Length:675
Mass (Da):75,554
Last modified:October 11, 2004 - v1
Checksum:i037650EB4680CF4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU04240.1.
RefSeqiYP_067722.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU04240; AAU04240; RT0784.
GeneIDi2958618.
KEGGirty:RT0784.
PATRICi17910820. VBIRicTyp34752_0803.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU04240.1 .
RefSeqi YP_067722.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68VV2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0784.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU04240 ; AAU04240 ; RT0784 .
GeneIDi 2958618.
KEGGi rty:RT0784.
PATRICi 17910820. VBIRicTyp34752_0803.

Phylogenomic databases

eggNOGi COG1034.
HOGENOMi HOG000031442.
KOi K00336.
OMAi GAMTLIQ.
OrthoDBi EOG6CVV7G.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-824-MONOMER.

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR012675. Beta-grasp_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR000283. NADH_UbQ_OxRdtase_75kDa_su_CS.
IPR010228. NADH_UbQ_OxRdtase_Gsu.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
IPR015405. NuoG_C.
[Graphical view ]
Pfami PF09326. DUF1982. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view ]
SMARTi SM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view ]
SUPFAMi SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR01973. NuoG. 1 hit.
PROSITEi PS51085. 2FE2S_FER_2. 1 hit.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00641. COMPLEX1_75K_1. 1 hit.
PS00642. COMPLEX1_75K_2. 1 hit.
PS00643. COMPLEX1_75K_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiNUOG_RICTY
AccessioniPrimary (citable) accession number: Q68VV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2004
Last modified: November 26, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3