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Q68VV2 (NUOG_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit G

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit G
NDH-1 subunit G
Gene names
Name:nuoG
Ordered Locus Names:RT0784
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length675 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.

Catalytic activity

NADH + quinone = NAD+ + quinol.

Cofactor

Binds 1 2Fe-2S cluster per subunit By similarity.

Binds 2 4Fe-4S clusters per subunit By similarity.

Sequence similarities

Belongs to the complex I 75 kDa subunit family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S Mo/W bis-MGD-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 675675NADH-quinone oxidoreductase subunit G
PRO_0000287844

Regions

Domain1 – 78782Fe-2S ferredoxin-type
Domain215 – 271574Fe-4S Mo/W bis-MGD-type

Sites

Metal binding341Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding451Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding481Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding621Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding941Iron-sulfur 2 (4Fe-4S); via pros nitrogen By similarity
Metal binding981Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1011Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1071Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1461Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1491Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1521Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1961Iron-sulfur 3 (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68VV2 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 037650EB4680CF4F

FASTA67575,554
        10         20         30         40         50         60 
MIKLIIDGSE IEISEGSTVY QACIQAGKQI PHFCYHARLK IAGNCRMCLV EIEKSQKPVA 

        70         80         90        100        110        120 
SCAMPVSNGM VIHTDTSMVK KAREGVMEFL LINHPLDCPI CDQGGECDLQ DQAFRYGKGT 

       130        140        150        160        170        180 
NRFHENKRSI KDKYMGPLIK TAMTRCIQCT RCIRFANDIA GIEEIGAINR GEHMEVTSYL 

       190        200        210        220        230        240 
EQTLDSEISG NMIDICPVGA LNSKPYAFKA RKWELKHTAS IGVHDAEGSN IRIDSRADEI 

       250        260        270        280        290        300 
MRILPSVNEA INEAWISDKN RFCYDGLKYQ RLDHPYIRKN GKLVEVSWSE ALKTIMDKIK 

       310        320        330        340        350        360 
SVKPEKIAAI AGSIVSVEAM FMLKILLQKL GSNNYTVNQF NYKIDTSERG NYLFNTTIVG 

       370        380        390        400        410        420 
VEKADLCLLI GANIRQIAPI LNSRIGRRVR IGALKVVRIG IGHNQTYKIH DLGNDIKIIE 

       430        440        450        460        470        480 
DLAVGTHEYT KAFKEAKYPM IIVGDGVYGR DDGYALLSLI HKVVDKYNMM RDDWQGFNIL 

       490        500        510        520        530        540 
HNHASIVGGL DIGFNTAIKF EGVKLAYLLG ADAIPFDKLK SAFIIYQGHH GDVGAMSADV 

       550        560        570        580        590        600 
ILPSAAYTEQ SGIYVNLEGR PQIAQKAVSP VGRAKEDIEI IKEIAGYLKI DIGMDNLQEV 

       610        620        630        640        650        660 
RIRLAKEYNI FANIDKITAN RFTQFISIDK LSQEPIAARP INYYMTDVIS KNSVTMAKCV 

       670 
EAKEERKRDV AKVFY 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU04240.1.
RefSeqYP_067722.1. NC_006142.1.

3D structure databases

ProteinModelPortalQ68VV2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0784.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU04240; AAU04240; RT0784.
GeneID2958618.
KEGGrty:RT0784.
PATRIC17910820. VBIRicTyp34752_0803.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1034.
HOGENOMHOG000031442.
KOK00336.
OMAGAMTLIQ.
OrthoDBEOG6CVV7G.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-824-MONOMER.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR012675. Beta-grasp_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR000283. NADH_UbQ_OxRdtase_75kDa_su_CS.
IPR010228. NADH_UbQ_OxRdtase_Gsu.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
IPR015405. NuoG_C.
[Graphical view]
PfamPF09326. DUF1982. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SMARTSM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SUPFAMSSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR01973. NuoG. 1 hit.
PROSITEPS51085. 2FE2S_FER_2. 1 hit.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00641. COMPLEX1_75K_1. 1 hit.
PS00642. COMPLEX1_75K_2. 1 hit.
PS00643. COMPLEX1_75K_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUOG_RICTY
AccessionPrimary (citable) accession number: Q68VV2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names