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Q68VV0 (ACON_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aconitate hydratase
Short name=Aconitase
EC=4.2.1.3
Alternative name(s):
Citrate hydro-lyase
Gene names
Name:acnA
Ordered Locus Names:RT0786
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length878 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate By similarity.

Catalytic activity

Citrate = isocitrate.

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.

Sequence similarities

Belongs to the aconitase/IPM isomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 878878Aconitate hydratase
PRO_0000272344

Sites

Metal binding4261Iron-sulfur (4Fe-4S) By similarity
Metal binding4921Iron-sulfur (4Fe-4S) By similarity
Metal binding4951Iron-sulfur (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68VV0 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 7E79B10DA1854EB1

FASTA87897,236
        10         20         30         40         50         60 
MPTVHNSEYI KELLVDNTSY KIYDINKAAS DIGISLNKLP YSLRVLLENV LRTSGNKENL 

        70         80         90        100        110        120 
LVFKEWLKTK KSNTEIDFMP ARVLMQDFTG VPAIVDLAAM RDAMQKIGCN PLKINPLIPV 

       130        140        150        160        170        180 
DLVIDHSVSV DSYGLKESFE QNVQMEMKRN IERYQFLKWG QQAFNNFKVV PPGTGICHQV 

       190        200        210        220        230        240 
NLEYLSKVVW YNDGTAYPDS LVGTDSHTTM VNGLSVLGWG VGGIEAEAAM LGQPLTMIIP 

       250        260        270        280        290        300 
EVIGVKLTGK LEGMATATDL VLTITEMLRR TKVVGKFVEF FGYGLSNLTI SDRATISNMS 

       310        320        330        340        350        360 
PEYGATCGFF PIDQETIKYL EITGRETRQI KLVEKYATEQ NLWYNFEDTQ EYTEVLELDL 

       370        380        390        400        410        420 
STVYSSLAGP KRPQDRVNLS FVESNFKNEL PYFALENQDI DKKYAVANQN YEIGNGDVVI 

       430        440        450        460        470        480 
AAITSCTNTS NPSVMIGAAL LAKKALEHGL NVKPWVKTSL APGSKVVTEY LKISGLDKYL 

       490        500        510        520        530        540 
DALGFNLVGY GCTTCIGNSG SLNPEIENTI NKNRLVVASV LSGNRNFEGR INPLTKASYL 

       550        560        570        580        590        600 
ASPILVVAYA LSGTLNIDLT TTPIGANIYL KDIWPSQKEI DAVIANSINP SMFIEKYADV 

       610        620        630        640        650        660 
FNGTKEWHDL HITTGTNYNW DKNSTYINNP PYFDNICSEN TIKDIKSAKI LAIFGDSITT 

       670        680        690        700        710        720 
DHISPAGSIS KNSPAAKYLI EHNIEPLNFN SYGSRRGNHE VMMRGTFANI RIKNEMCNGV 

       730        740        750        760        770        780 
EGGFTINQLS GVQQTIYDAA MDYQAHDIPL VVFAGKEYGS GSSRDWAAKG PGLLGIKAII 

       790        800        810        820        830        840 
AESFERIHRS NLVGMGILPL TFTGNNTRLS LKLDGSETID IIGLSKNIRP FNLVKCVIKK 

       850        860        870 
QTNEISTIDL ILQIFTENEI NYIKHGSIMQ FVVESLKG

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017197 Genomic DNA. Translation: AAU04242.1.
RefSeqYP_067724.1. NC_006142.1.

3D structure databases

HSSPHSSP built from PDB template 2B3Y based on UniProtKB P21399.
ProteinModelPortalQ68VV0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2958613.
GenomeReviewsGene locus RT0786 in contig AE017197_GR.
KEGGrty:RT0786.
PATRIC17910824. VBIRicTyp34752_0805.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG289738.
OMANADQAGE.
ProtClustDBPRK09277.

Enzyme and pathway databases

BioCycRTYP257363:RT0786-MONOMER.

Family and domain databases

InterProIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR015937. Acoase/IPM_deHydtase.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR006249. Aconitase/Fe_reg_prot_2.
IPR015934. Aconitase/Fe_reg_prot_2/AcnD.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
Gene3DG3DSA:3.30.499.10. Acnase/IPM_dHydase_lsu_aba_1/3. 2 hits.
G3DSA:3.20.19.10. Aconitase/3IPM_dehydase_swvl. 1 hit.
G3DSA:3.40.1060.10. Aconitase/IPMdHydase_lsu_aba_2. 1 hit.
KOK01681.
PANTHERPTHR11670. Aconitase-like_core. 1 hit.
PTHR11670:SF1. Aconitase/Fe_reg_prot_2/AcnD. 1 hit.
PfamPF00330. Aconitase. 1 hit.
PF00694. Aconitase_C. 1 hit.
[Graphical view]
PRINTSPR00415. ACONITASE.
SUPFAMSSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
SSF53732. Aconitase_N. 1 hit.
TIGRFAMsTIGR01341. Aconitase_1. 1 hit.
PROSITEPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACON_RICTY
AccessionPrimary (citable) accession number: Q68VV0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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