Reviewed, UniProtKB/Swiss-Prot Q68VT0 (PLD_RICTY)

Names and origin

Protein names

Recommended name:
    Phospholipase D
      Short name=PLD
    EC=3.1.4.4
Alternative name(s):
    Choline phosphatase

Gene names

Name:	pld
Ordered Locus Names:	RT0807

Organism

Rickettsia typhi [Complete proteome] [HAMAP]

Taxonomic identifier

785 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Could be a virulence factor By similarity.
Catalytic activity	A phosphatidylcholine + H2O = choline + a phosphatidate.
Subunit structure	Homodimer By similarity.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the phospholipase D family. Contains 1 PLD phosphodiesterase domain.

Ontologies

Keywords
Biological process	Lipid degradation Virulence
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAPE-specific phospholipase D activity Inferred from electronic annotation. Source: EC phospholipase D activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 204	182	Phospholipase D		PRO_0000274785
Regions
	Domain	142 – 169	28	PLD phosphodiesterase
Sites
	Active site	147	1	Potential
	Active site	149	1	Potential
	Active site	154	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q68VT0-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 028CDDBACBB5ACEA	FASTA	204	23,027
	10 20 30 40 50 60 MKSKNNKFIA MSIPFILGTA LGIYVESTYY FTSIINQKSF ALPDTQIKHY SIPELSRRNV 70 80 90 100 110 120 STCFTPPAGC TKFIVQQLEK AEESIYMQAY GMSDSLITTA LINAQMRGVK VKILLDRSNL 130 140 150 160 170 180 KQKFSKLYEL QQAKIDVGID TVPGIAHNKV IIIDKKKVIT GSFNFTVAAD KRNAENVILI 190 200 EDQQLAESYL QNWFSRKASN SVHF

References

[1]

"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE017197 Genomic DNA. Translation: AAU04262.1.
RefSeq	YP_067744.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2958807.
GenomeReviews	Gene locus RT0807 in contig AE017197_GR.
KEGG	rty:RT0807.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q68VT0.
OMA	TVPGIAH.
Enzyme and pathway databases
BioCyc	RTYP257363:RT0807-MON.
BRENDA	3.1.4.4. 281221.
Family and domain databases
InterPro	IPR001736. PLipase_D/transphosphatidylase. [Graphical view]
SMART	SM00155. PLDc. 1 hit. [Graphical view]
PROSITE	PS50035. PLD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PLD_RICTY

Accession

Primary (citable) accession number: Q68VT0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	October 11, 2004
Last modified:	November 3, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)