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Q68VS6

- FTSK_RICTY

UniProt

Q68VS6 - FTSK_RICTY

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Protein
DNA translocase FtsK
Gene
ftsK, RT0811
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi402 – 4076ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. nucleoside-triphosphatase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. chromosome segregation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-851-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA translocase FtsK
Gene namesi
Name:ftsK
Ordered Locus Names:RT0811
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Cell inner membrane; Multi-pass membrane protein By similarity
Note: Located at the septum By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621Helical; Reviewed prediction
Add
BLAST
Transmembranei63 – 8321Helical; Reviewed prediction
Add
BLAST
Transmembranei93 – 11321Helical; Reviewed prediction
Add
BLAST
Transmembranei115 – 13521Helical; Reviewed prediction
Add
BLAST
Transmembranei144 – 16421Helical; Reviewed prediction
Add
BLAST
Transmembranei167 – 18721Helical; Reviewed prediction
Add
BLAST
Topological domaini188 – 740553Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 740740DNA translocase FtsK
PRO_0000280968Add
BLAST

Interactioni

Subunit structurei

Homohexamer. Forms a ring that surrounds DNA By similarity.

Protein-protein interaction databases

STRINGi257363.RT0811.

Structurei

3D structure databases

ProteinModelPortaliQ68VS6.
SMRiQ68VS6. Positions 248-660.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini382 – 601220FtsK
Add
BLAST

Domaini

Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase By similarity.

Sequence similaritiesi

Belongs to the FtsK/SpoIIIE/SftA family.
Contains 1 FtsK domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1674.
HOGENOMiHOG000010003.
KOiK03466.
OMAiPNKEREI.
OrthoDBiEOG6S52GD.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR025199. DUF4117.
IPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13491. DUF4117. 1 hit.
PF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50901. FTSK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68VS6-1 [UniParc]FASTAAdd to Basket

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MILYYINKIL SNNKVQAFIL WIIGLAIVIV LISYNIDDPS FNSVTTEYPS    50
NLIGIAGAYL SDFLYQFFGL TAFIIPLACF VWGRNCWHER YRSVFIRIFV 100
VLLALISSST LLSKIKLEFI PASAGGAVGI IVSNFCERFI NQLYLLFQTF 150
VILVVLLEIK LISISNVLIK LSKFLTNLIL SFFNYIFPRL SLITIQNNDK 200
LNITSFYQKP ASKKVTFTEE ASLIPTNPIK CFIKPVCTKI SQNKIAALPP 250
ISLLCDPKNN HVKGASSSEL KQKAEELLTV LNDFGVKGHI ININQGPVVT 300
QYEFEPAAGT KTSRVVGLSD DIARSLSALS TRIAVIPGKN VLGIELPNKQ 350
REFFCLKELI ETPEYQDKSI LLPLVLGKDL AGKPLIADLA RMPHLLVAGT 400
TGSGKSVGIN AMIVSLLYRY TPEECRFIMI DPKMLELSAY DGIPHLLTPV 450
VTEPSKAVIA LKWAVKEMEN RYRMMSNIGV KNIAGYNEKI LEAVKENRVI 500
ERPIQTGFDP ETGKPIYETV TMNMAKLPYI VVIVDEMADL MLVSGKDIEM 550
LIQRLAQMAR AAGIHIIMAT QRPSVDVITG VIKANFPSRI SFKVTSKIDS 600
RTILGEQGSE QLLGMGDMLF MGNTSKISRV HGPFVNEAEI TKITEYLKET 650
SMPVYISEVT EQPEENYSSI DIVDGSIDEV LYKKAVQIVR NERKASISYI 700
QRSLRIGYNK AANLVEKMEK DGIVSPPNHT GKREILLPEM 740
Length:740
Mass (Da):82,552
Last modified:October 11, 2004 - v1
Checksum:i8AAF71DEC71AA9BE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU04266.1.
RefSeqiYP_067748.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU04266; AAU04266; RT0811.
GeneIDi2958865.
KEGGirty:RT0811.
PATRICi17910872. VBIRicTyp34752_0828.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU04266.1 .
RefSeqi YP_067748.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68VS6.
SMRi Q68VS6. Positions 248-660.
ModBasei Search...

Protein-protein interaction databases

STRINGi 257363.RT0811.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU04266 ; AAU04266 ; RT0811 .
GeneIDi 2958865.
KEGGi rty:RT0811.
PATRICi 17910872. VBIRicTyp34752_0828.

Phylogenomic databases

eggNOGi COG1674.
HOGENOMi HOG000010003.
KOi K03466.
OMAi PNKEREI.
OrthoDBi EOG6S52GD.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-851-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR025199. DUF4117.
IPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF13491. DUF4117. 1 hit.
PF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS50901. FTSK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiFTSK_RICTY
AccessioniPrimary (citable) accession number: Q68VS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 11, 2004
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi