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Q68VS6 (FTSK_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA translocase FtsK
Gene names
Name:ftsK
Ordered Locus Names:RT0811
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length740 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif By similarity.

Subunit structure

Homohexamer. Forms a ring that surrounds DNA By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity. Note: Located at the septum By similarity.

Domain

Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase By similarity.

Sequence similarities

Belongs to the FtsK/SpoIIIE/SftA family.

Contains 1 FtsK domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 740740DNA translocase FtsK
PRO_0000280968

Regions

Transmembrane16 – 3621Helical; Potential
Transmembrane63 – 8321Helical; Potential
Transmembrane93 – 11321Helical; Potential
Transmembrane115 – 13521Helical; Potential
Transmembrane144 – 16421Helical; Potential
Transmembrane167 – 18721Helical; Potential
Topological domain188 – 740553Cytoplasmic Potential
Domain382 – 601220FtsK
Nucleotide binding402 – 4076ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68VS6 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 8AAF71DEC71AA9BE

FASTA74082,552
        10         20         30         40         50         60 
MILYYINKIL SNNKVQAFIL WIIGLAIVIV LISYNIDDPS FNSVTTEYPS NLIGIAGAYL 

        70         80         90        100        110        120 
SDFLYQFFGL TAFIIPLACF VWGRNCWHER YRSVFIRIFV VLLALISSST LLSKIKLEFI 

       130        140        150        160        170        180 
PASAGGAVGI IVSNFCERFI NQLYLLFQTF VILVVLLEIK LISISNVLIK LSKFLTNLIL 

       190        200        210        220        230        240 
SFFNYIFPRL SLITIQNNDK LNITSFYQKP ASKKVTFTEE ASLIPTNPIK CFIKPVCTKI 

       250        260        270        280        290        300 
SQNKIAALPP ISLLCDPKNN HVKGASSSEL KQKAEELLTV LNDFGVKGHI ININQGPVVT 

       310        320        330        340        350        360 
QYEFEPAAGT KTSRVVGLSD DIARSLSALS TRIAVIPGKN VLGIELPNKQ REFFCLKELI 

       370        380        390        400        410        420 
ETPEYQDKSI LLPLVLGKDL AGKPLIADLA RMPHLLVAGT TGSGKSVGIN AMIVSLLYRY 

       430        440        450        460        470        480 
TPEECRFIMI DPKMLELSAY DGIPHLLTPV VTEPSKAVIA LKWAVKEMEN RYRMMSNIGV 

       490        500        510        520        530        540 
KNIAGYNEKI LEAVKENRVI ERPIQTGFDP ETGKPIYETV TMNMAKLPYI VVIVDEMADL 

       550        560        570        580        590        600 
MLVSGKDIEM LIQRLAQMAR AAGIHIIMAT QRPSVDVITG VIKANFPSRI SFKVTSKIDS 

       610        620        630        640        650        660 
RTILGEQGSE QLLGMGDMLF MGNTSKISRV HGPFVNEAEI TKITEYLKET SMPVYISEVT 

       670        680        690        700        710        720 
EQPEENYSSI DIVDGSIDEV LYKKAVQIVR NERKASISYI QRSLRIGYNK AANLVEKMEK 

       730        740 
DGIVSPPNHT GKREILLPEM 

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References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU04266.1.
RefSeqYP_067748.1. NC_006142.1.

3D structure databases

ProteinModelPortalQ68VS6.
SMRQ68VS6. Positions 248-660.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0811.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU04266; AAU04266; RT0811.
GeneID2958865.
KEGGrty:RT0811.
PATRIC17910872. VBIRicTyp34752_0828.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1674.
HOGENOMHOG000010003.
KOK03466.
OMAPNKEREI.
OrthoDBEOG6S52GD.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-851-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR002543. Cell_div_FtsK/SpoIIIE.
IPR018541. DNA_translocase_Ftsk_gamma.
IPR025199. DUF4117.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF13491. DUF4117. 1 hit.
PF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS50901. FTSK. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTSK_RICTY
AccessionPrimary (citable) accession number: Q68VS6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 11, 2004
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names