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Q68VS6

- FTSK_RICTY

UniProt

Q68VS6 - FTSK_RICTY

Protein

DNA translocase FtsK

Gene

ftsK

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi402 – 4076ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW
    3. nucleoside-triphosphatase activity Source: InterPro

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. chromosome segregation Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division, Chromosome partition

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-851-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA translocase FtsK
    Gene namesi
    Name:ftsK
    Ordered Locus Names:RT0811
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    Subcellular locationi

    Cell inner membrane By similarity; Multi-pass membrane protein By similarity
    Note: Located at the septum.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 740740DNA translocase FtsKPRO_0000280968Add
    BLAST

    Interactioni

    Subunit structurei

    Homohexamer. Forms a ring that surrounds DNA By similarity.By similarity

    Protein-protein interaction databases

    STRINGi257363.RT0811.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68VS6.
    SMRiQ68VS6. Positions 248-660.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini188 – 740553CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei63 – 8321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei93 – 11321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei115 – 13521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei144 – 16421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei167 – 18721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini382 – 601220FtsKPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase By similarity.By similarity

    Sequence similaritiesi

    Belongs to the FtsK/SpoIIIE/SftA family.Curated
    Contains 1 FtsK domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1674.
    HOGENOMiHOG000010003.
    KOiK03466.
    OMAiPNKEREI.
    OrthoDBiEOG6S52GD.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR025199. DUF4117.
    IPR002543. FtsK_dom.
    IPR018541. Ftsk_gamma.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF13491. DUF4117. 1 hit.
    PF09397. Ftsk_gamma. 1 hit.
    PF01580. FtsK_SpoIIIE. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM00843. Ftsk_gamma. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS50901. FTSK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68VS6-1 [UniParc]FASTAAdd to Basket

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    MILYYINKIL SNNKVQAFIL WIIGLAIVIV LISYNIDDPS FNSVTTEYPS    50
    NLIGIAGAYL SDFLYQFFGL TAFIIPLACF VWGRNCWHER YRSVFIRIFV 100
    VLLALISSST LLSKIKLEFI PASAGGAVGI IVSNFCERFI NQLYLLFQTF 150
    VILVVLLEIK LISISNVLIK LSKFLTNLIL SFFNYIFPRL SLITIQNNDK 200
    LNITSFYQKP ASKKVTFTEE ASLIPTNPIK CFIKPVCTKI SQNKIAALPP 250
    ISLLCDPKNN HVKGASSSEL KQKAEELLTV LNDFGVKGHI ININQGPVVT 300
    QYEFEPAAGT KTSRVVGLSD DIARSLSALS TRIAVIPGKN VLGIELPNKQ 350
    REFFCLKELI ETPEYQDKSI LLPLVLGKDL AGKPLIADLA RMPHLLVAGT 400
    TGSGKSVGIN AMIVSLLYRY TPEECRFIMI DPKMLELSAY DGIPHLLTPV 450
    VTEPSKAVIA LKWAVKEMEN RYRMMSNIGV KNIAGYNEKI LEAVKENRVI 500
    ERPIQTGFDP ETGKPIYETV TMNMAKLPYI VVIVDEMADL MLVSGKDIEM 550
    LIQRLAQMAR AAGIHIIMAT QRPSVDVITG VIKANFPSRI SFKVTSKIDS 600
    RTILGEQGSE QLLGMGDMLF MGNTSKISRV HGPFVNEAEI TKITEYLKET 650
    SMPVYISEVT EQPEENYSSI DIVDGSIDEV LYKKAVQIVR NERKASISYI 700
    QRSLRIGYNK AANLVEKMEK DGIVSPPNHT GKREILLPEM 740
    Length:740
    Mass (Da):82,552
    Last modified:October 11, 2004 - v1
    Checksum:i8AAF71DEC71AA9BE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU04266.1.
    RefSeqiYP_067748.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU04266; AAU04266; RT0811.
    GeneIDi2958865.
    KEGGirty:RT0811.
    PATRICi17910872. VBIRicTyp34752_0828.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU04266.1 .
    RefSeqi YP_067748.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68VS6.
    SMRi Q68VS6. Positions 248-660.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0811.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU04266 ; AAU04266 ; RT0811 .
    GeneIDi 2958865.
    KEGGi rty:RT0811.
    PATRICi 17910872. VBIRicTyp34752_0828.

    Phylogenomic databases

    eggNOGi COG1674.
    HOGENOMi HOG000010003.
    KOi K03466.
    OMAi PNKEREI.
    OrthoDBi EOG6S52GD.

    Enzyme and pathway databases

    BioCyci RTYP257363:GJEQ-851-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR025199. DUF4117.
    IPR002543. FtsK_dom.
    IPR018541. Ftsk_gamma.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF13491. DUF4117. 1 hit.
    PF09397. Ftsk_gamma. 1 hit.
    PF01580. FtsK_SpoIIIE. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM00843. Ftsk_gamma. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS50901. FTSK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiFTSK_RICTY
    AccessioniPrimary (citable) accession number: Q68VS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3