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Q68VS3

- HEM1_RICTY

UniProt

Q68VS3 - HEM1_RICTY

Protein

5-aminolevulinate synthase

Gene

hemA

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei22 – 221SubstrateBy similarity
    Binding sitei133 – 1331SubstrateBy similarity
    Binding sitei152 – 1521SubstrateBy similarity
    Binding sitei185 – 1851Pyridoxal phosphateBy similarity
    Binding sitei213 – 2131Pyridoxal phosphateBy similarity
    Binding sitei241 – 2411Pyridoxal phosphateBy similarity
    Active sitei244 – 2441By similarity
    Binding sitei273 – 2731Pyridoxal phosphateBy similarity
    Binding sitei274 – 2741Pyridoxal phosphateBy similarity
    Binding sitei359 – 3591SubstrateBy similarity

    GO - Molecular functioni

    1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Heme biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-869-MONOMER.
    UniPathwayiUPA00251; UER00375.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-aminolevulinate synthase (EC:2.3.1.37)
    Alternative name(s):
    5-aminolevulinic acid synthase
    Delta-ALA synthase
    Delta-aminolevulinate synthase
    Gene namesi
    Name:hemA
    Ordered Locus Names:RT0829
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4144145-aminolevulinate synthasePRO_0000280899Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei244 – 2441N6-(pyridoxal phosphate)lysineCurated

    Interactioni

    Protein-protein interaction databases

    STRINGi257363.RT0829.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68VS3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0156.
    HOGENOMiHOG000221020.
    KOiK00643.
    OMAiEEGRYRT.
    OrthoDBiEOG6Q8HZD.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68VS3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSYYDTIFNK HIDKIKSEGR YREFKSLKRQ ADNFPFAEYE DKQIVMWCIN    50
    DYLGMSKHIK VMQASIDALL EYGVGSGGTR NIGGNNISIL ELEKELADLH 100
    SKETALVFTS GFVANDTTLA SLAKIIPDIV FFSDELNHAS IIAGITSSRA 150
    EKYVYRHLDV QHLEKLLQSV DINKPKIIVF ESAYSMDGFF SPIKDIINLA 200
    KKYNALTFID EVHTVGLYGK QGGGISELLD CSNQIDIIQG TLAKAYGTIG 250
    GYITSNYNLI DAIRLTAPGF IFTTSLPPVI STAATHSIRH LKVSNEERIK 300
    HQEVVTKLKN SFEHFNIPYL KNESHIIPII IGDPIKATKV SNMLLNEYGI 350
    YVQHINFPTV PRGTERLRII PTPAHTDKMI NDLSTALVHI FAELDIELSS 400
    TKELNKEVRL HLIA 414
    Length:414
    Mass (Da):46,460
    Last modified:October 11, 2004 - v1
    Checksum:i502930788A98D56D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU04283.1.
    RefSeqiYP_067765.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU04283; AAU04283; RT0829.
    GeneIDi2959058.
    KEGGirty:RT0829.
    PATRICi17910910. VBIRicTyp34752_0846.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU04283.1 .
    RefSeqi YP_067765.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68VS3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0829.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU04283 ; AAU04283 ; RT0829 .
    GeneIDi 2959058.
    KEGGi rty:RT0829.
    PATRICi 17910910. VBIRicTyp34752_0846.

    Phylogenomic databases

    eggNOGi COG0156.
    HOGENOMi HOG000221020.
    KOi K00643.
    OMAi EEGRYRT.
    OrthoDBi EOG6Q8HZD.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00375 .
    BioCyci RTYP257363:GJEQ-869-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiHEM1_RICTY
    AccessioniPrimary (citable) accession number: Q68VS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3