Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q68VS3

- HEM1_RICTY

UniProt

Q68VS3 - HEM1_RICTY

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

5-aminolevulinate synthase

Gene

hemA

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactori

Pyridoxal phosphate.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei22 – 221SubstrateBy similarity
Binding sitei133 – 1331SubstrateBy similarity
Binding sitei152 – 1521SubstrateBy similarity
Binding sitei185 – 1851Pyridoxal phosphateBy similarity
Binding sitei213 – 2131Pyridoxal phosphateBy similarity
Binding sitei241 – 2411Pyridoxal phosphateBy similarity
Active sitei244 – 2441By similarity
Binding sitei273 – 2731Pyridoxal phosphateBy similarity
Binding sitei274 – 2741Pyridoxal phosphateBy similarity
Binding sitei359 – 3591SubstrateBy similarity

GO - Molecular functioni

  1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Heme biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-869-MONOMER.
UniPathwayiUPA00251; UER00375.

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase (EC:2.3.1.37)
Alternative name(s):
5-aminolevulinic acid synthase
Delta-ALA synthase
Delta-aminolevulinate synthase
Gene namesi
Name:hemA
Ordered Locus Names:RT0829
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4144145-aminolevulinate synthasePRO_0000280899Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei244 – 2441N6-(pyridoxal phosphate)lysineCurated

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0829.

Structurei

3D structure databases

ProteinModelPortaliQ68VS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0156.
HOGENOMiHOG000221020.
KOiK00643.
OMAiEEGRYRT.
OrthoDBiEOG6Q8HZD.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68VS3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSYYDTIFNK HIDKIKSEGR YREFKSLKRQ ADNFPFAEYE DKQIVMWCIN
60 70 80 90 100
DYLGMSKHIK VMQASIDALL EYGVGSGGTR NIGGNNISIL ELEKELADLH
110 120 130 140 150
SKETALVFTS GFVANDTTLA SLAKIIPDIV FFSDELNHAS IIAGITSSRA
160 170 180 190 200
EKYVYRHLDV QHLEKLLQSV DINKPKIIVF ESAYSMDGFF SPIKDIINLA
210 220 230 240 250
KKYNALTFID EVHTVGLYGK QGGGISELLD CSNQIDIIQG TLAKAYGTIG
260 270 280 290 300
GYITSNYNLI DAIRLTAPGF IFTTSLPPVI STAATHSIRH LKVSNEERIK
310 320 330 340 350
HQEVVTKLKN SFEHFNIPYL KNESHIIPII IGDPIKATKV SNMLLNEYGI
360 370 380 390 400
YVQHINFPTV PRGTERLRII PTPAHTDKMI NDLSTALVHI FAELDIELSS
410
TKELNKEVRL HLIA
Length:414
Mass (Da):46,460
Last modified:October 11, 2004 - v1
Checksum:i502930788A98D56D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU04283.1.
RefSeqiYP_067765.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU04283; AAU04283; RT0829.
GeneIDi2959058.
KEGGirty:RT0829.
PATRICi17910910. VBIRicTyp34752_0846.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU04283.1 .
RefSeqi YP_067765.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68VS3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0829.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU04283 ; AAU04283 ; RT0829 .
GeneIDi 2959058.
KEGGi rty:RT0829.
PATRICi 17910910. VBIRicTyp34752_0846.

Phylogenomic databases

eggNOGi COG0156.
HOGENOMi HOG000221020.
KOi K00643.
OMAi EEGRYRT.
OrthoDBi EOG6Q8HZD.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00375 .
BioCyci RTYP257363:GJEQ-869-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiHEM1_RICTY
AccessioniPrimary (citable) accession number: Q68VS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 11, 2004
Last modified: October 1, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3