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Reviewed, UniProtKB/Swiss-Prot Q68VS3 (HEM1_RICTY)

Last modified February 9, 2010. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    5-aminolevulinate synthase
    EC=2.3.1.37
Alternative name(s):
    5-aminolevulinic acid synthase
    Delta-aminolevulinate synthase
    Delta-ALA synthase
Gene names
Name: hemA
Ordered Locus Names: RT0829
OrganismRickettsia typhi [Complete proteome] [HAMAP]
Taxonomic identifier785 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length414 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.

Sequence similarities

Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4144145-aminolevulinate synthase
PRO_0000280899

Amino acid modifications

Modified residue2441N6-(pyridoxal phosphate)lysine Probable

Sequences

Sequence LengthMass (Da)Tools
Q68VS3-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 502930788A98D56D

FASTA41446,460
        10         20         30         40         50         60 
MSYYDTIFNK HIDKIKSEGR YREFKSLKRQ ADNFPFAEYE DKQIVMWCIN DYLGMSKHIK 

        70         80         90        100        110        120 
VMQASIDALL EYGVGSGGTR NIGGNNISIL ELEKELADLH SKETALVFTS GFVANDTTLA 

       130        140        150        160        170        180 
SLAKIIPDIV FFSDELNHAS IIAGITSSRA EKYVYRHLDV QHLEKLLQSV DINKPKIIVF 

       190        200        210        220        230        240 
ESAYSMDGFF SPIKDIINLA KKYNALTFID EVHTVGLYGK QGGGISELLD CSNQIDIIQG 

       250        260        270        280        290        300 
TLAKAYGTIG GYITSNYNLI DAIRLTAPGF IFTTSLPPVI STAATHSIRH LKVSNEERIK 

       310        320        330        340        350        360 
HQEVVTKLKN SFEHFNIPYL KNESHIIPII IGDPIKATKV SNMLLNEYGI YVQHINFPTV 

       370        380        390        400        410 
PRGTERLRII PTPAHTDKMI NDLSTALVHI FAELDIELSS TKELNKEVRL HLIA 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU04283.1.
RefSeqYP_067765.1.

3D structure databases

HSSPHSSP built from PDB template 2BWN based on UniProtKB P18079.
SMRQ68VS3. Positions 4-391.
ModBaseSearch...

Genome annotation databases

GeneID2959058.
GenomeReviewsGene locus RT0829 in contig AE017197_GR.
KEGGrty:RT0829.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649839.
OMAVMDSTTH.

Enzyme and pathway databases

BioCycRTYP257363:RT0829-MONOMER.
BRENDA2.3.1.37. 281221.

Family and domain databases

InterProIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PfamPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
TIGRFAMsTIGR01821. 5aminolev_synth. 1 hit.
PROSITEPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEM1_RICTY
AccessionPrimary (citable) accession number: Q68VS3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 11, 2004
Last modified: February 9, 2010
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents