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Q68VM9

- HEMH_RICTY

UniProt

Q68VM9 - HEMH_RICTY

Protein

Ferrochelatase

Gene

hemH

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the ferrous insertion into protoporphyrin IX.UniRule annotation

    Catalytic activityi

    Protoheme + 2 H+ = protoporphyrin + Fe2+.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi188 – 1881IronUniRule annotation
    Metal bindingi268 – 2681IronUniRule annotation

    GO - Molecular functioni

    1. ferrochelatase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. heme biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Heme biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-918-MONOMER.
    UniPathwayiUPA00252; UER00325.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FerrochelataseUniRule annotation (EC:4.99.1.1UniRule annotation)
    Alternative name(s):
    Heme synthaseUniRule annotation
    Protoheme ferro-lyaseUniRule annotation
    Gene namesi
    Name:hemHUniRule annotation
    Ordered Locus Names:RT0876
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342FerrochelatasePRO_0000175195Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi257363.RT0876.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68VM9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ferrochelatase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0276.
    HOGENOMiHOG000060727.
    KOiK01772.
    OMAiNNIFTEY.
    OrthoDBiEOG6XHC5H.

    Family and domain databases

    HAMAPiMF_00323. Ferrochelatase.
    InterProiIPR001015. Ferrochelatase.
    IPR019772. Ferrochelatase_AS.
    [Graphical view]
    PANTHERiPTHR11108. PTHR11108. 1 hit.
    PfamiPF00762. Ferrochelatase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00109. hemH. 1 hit.
    PROSITEiPS00534. FERROCHELATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68VM9-1 [UniParc]FASTAAdd to Basket

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    MKKRIAIVLF NLGGPEDIEY VKPFLFNLFY DKAIINLPNP LRYVIAKIIS    50
    IVRERKSQKI YSLIGRKSYL IQETEKQKLA ITKKLKEILK EDFIIFISMR 100
    YSTPFAKEVI CQIKEYNPSE IILLPLYPQF SSTTTGSSVK NFLQNIDIDI 150
    PIKTICCYPI EEDFIKAHVS IIKEKLYDKN FRILFSAHGL PKRIIKAGDP 200
    YSFQIKETVN KIVKELNIKD LDYKITYQSR VGPIEWLKPS TEYEIELAGK 250
    LKKDIIIVPI SFVSEHVETL VELDIEYKFI ADKYNIQYTR IPTLGTNKIF 300
    INSLTNILIR FINKTDTNLV MSSSSKRICP NKFTKCLCNL IN 342
    Length:342
    Mass (Da):39,758
    Last modified:February 1, 2005 - v2
    Checksum:i29EE43E3DE93E428
    GO

    Sequence cautioni

    The sequence AAU04327.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU04327.1. Different initiation.
    RefSeqiYP_067809.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU04327; AAU04327; RT0876.
    GeneIDi2958508.
    KEGGirty:RT0876.
    PATRICi17911004. VBIRicTyp34752_0891.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017197 Genomic DNA. Translation: AAU04327.1 . Different initiation.
    RefSeqi YP_067809.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q68VM9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0876.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU04327 ; AAU04327 ; RT0876 .
    GeneIDi 2958508.
    KEGGi rty:RT0876.
    PATRICi 17911004. VBIRicTyp34752_0891.

    Phylogenomic databases

    eggNOGi COG0276.
    HOGENOMi HOG000060727.
    KOi K01772.
    OMAi NNIFTEY.
    OrthoDBi EOG6XHC5H.

    Enzyme and pathway databases

    UniPathwayi UPA00252 ; UER00325 .
    BioCyci RTYP257363:GJEQ-918-MONOMER.

    Family and domain databases

    HAMAPi MF_00323. Ferrochelatase.
    InterProi IPR001015. Ferrochelatase.
    IPR019772. Ferrochelatase_AS.
    [Graphical view ]
    PANTHERi PTHR11108. PTHR11108. 1 hit.
    Pfami PF00762. Ferrochelatase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00109. hemH. 1 hit.
    PROSITEi PS00534. FERROCHELATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiHEMH_RICTY
    AccessioniPrimary (citable) accession number: Q68VM9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3