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Protein

Ferrochelatase

Gene

hemH

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ferrous insertion into protoporphyrin IX.UniRule annotation

Catalytic activityi

Protoheme + 2 H+ = protoporphyrin + Fe2+.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi188 – 1881IronUniRule annotation
Metal bindingi268 – 2681IronUniRule annotation

GO - Molecular functioni

  1. ferrochelatase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. heme biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-918-MONOMER.
UniPathwayiUPA00252; UER00325.

Names & Taxonomyi

Protein namesi
Recommended name:
FerrochelataseUniRule annotation (EC:4.99.1.1UniRule annotation)
Alternative name(s):
Heme synthaseUniRule annotation
Protoheme ferro-lyaseUniRule annotation
Gene namesi
Name:hemHUniRule annotation
Ordered Locus Names:RT0876
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342FerrochelatasePRO_0000175195Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0876.

Structurei

3D structure databases

ProteinModelPortaliQ68VM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ferrochelatase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0276.
HOGENOMiHOG000060727.
KOiK01772.
OMAiYRYYNEV.
OrthoDBiEOG6XHC5H.

Family and domain databases

HAMAPiMF_00323. Ferrochelatase.
InterProiIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.
PROSITEiPS00534. FERROCHELATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68VM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKRIAIVLF NLGGPEDIEY VKPFLFNLFY DKAIINLPNP LRYVIAKIIS
60 70 80 90 100
IVRERKSQKI YSLIGRKSYL IQETEKQKLA ITKKLKEILK EDFIIFISMR
110 120 130 140 150
YSTPFAKEVI CQIKEYNPSE IILLPLYPQF SSTTTGSSVK NFLQNIDIDI
160 170 180 190 200
PIKTICCYPI EEDFIKAHVS IIKEKLYDKN FRILFSAHGL PKRIIKAGDP
210 220 230 240 250
YSFQIKETVN KIVKELNIKD LDYKITYQSR VGPIEWLKPS TEYEIELAGK
260 270 280 290 300
LKKDIIIVPI SFVSEHVETL VELDIEYKFI ADKYNIQYTR IPTLGTNKIF
310 320 330 340
INSLTNILIR FINKTDTNLV MSSSSKRICP NKFTKCLCNL IN
Length:342
Mass (Da):39,758
Last modified:February 1, 2005 - v2
Checksum:i29EE43E3DE93E428
GO

Sequence cautioni

The sequence AAU04327.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU04327.1. Different initiation.
RefSeqiYP_067809.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU04327; AAU04327; RT0876.
KEGGirty:RT0876.
PATRICi17911004. VBIRicTyp34752_0891.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017197 Genomic DNA. Translation: AAU04327.1. Different initiation.
RefSeqiYP_067809.1. NC_006142.1.

3D structure databases

ProteinModelPortaliQ68VM9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257363.RT0876.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU04327; AAU04327; RT0876.
KEGGirty:RT0876.
PATRICi17911004. VBIRicTyp34752_0891.

Phylogenomic databases

eggNOGiCOG0276.
HOGENOMiHOG000060727.
KOiK01772.
OMAiYRYYNEV.
OrthoDBiEOG6XHC5H.

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325.
BioCyciRTYP257363:GJEQ-918-MONOMER.

Family and domain databases

HAMAPiMF_00323. Ferrochelatase.
InterProiIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.
PROSITEiPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiHEMH_RICTY
AccessioniPrimary (citable) accession number: Q68VM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: April 29, 2015
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.