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Q68VM9 (HEMH_RICTY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferrochelatase

EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:RT0876
OrganismRickettsia typhi (strain ATCC VR-144 / Wilmington) [Complete proteome] [HAMAP]
Taxonomic identifier257363 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP-Rule MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP-Rule MF_00323

Pathway

Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP-Rule MF_00323

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Sequence caution

The sequence AAU04327.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionferrochelatase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342Ferrochelatase HAMAP-Rule MF_00323
PRO_0000175195

Sites

Metal binding1881Iron By similarity
Metal binding2681Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68VM9 [UniParc].

Last modified February 1, 2005. Version 2.
Checksum: 29EE43E3DE93E428

FASTA34239,758
        10         20         30         40         50         60 
MKKRIAIVLF NLGGPEDIEY VKPFLFNLFY DKAIINLPNP LRYVIAKIIS IVRERKSQKI 

        70         80         90        100        110        120 
YSLIGRKSYL IQETEKQKLA ITKKLKEILK EDFIIFISMR YSTPFAKEVI CQIKEYNPSE 

       130        140        150        160        170        180 
IILLPLYPQF SSTTTGSSVK NFLQNIDIDI PIKTICCYPI EEDFIKAHVS IIKEKLYDKN 

       190        200        210        220        230        240 
FRILFSAHGL PKRIIKAGDP YSFQIKETVN KIVKELNIKD LDYKITYQSR VGPIEWLKPS 

       250        260        270        280        290        300 
TEYEIELAGK LKKDIIIVPI SFVSEHVETL VELDIEYKFI ADKYNIQYTR IPTLGTNKIF 

       310        320        330        340 
INSLTNILIR FINKTDTNLV MSSSSKRICP NKFTKCLCNL IN 

« Hide

References

[1]"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae."
McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. expand/collapse author list , Hong C., Yu X.-J., Walker D.H., Weinstock G.M.
J. Bacteriol. 186:5842-5855(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017197 Genomic DNA. Translation: AAU04327.1. Different initiation.
RefSeqYP_067809.1. NC_006142.1.

3D structure databases

ProteinModelPortalQ68VM9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257363.RT0876.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU04327; AAU04327; RT0876.
GeneID2958508.
KEGGrty:RT0876.
PATRIC17911004. VBIRicTyp34752_0891.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHOG000060727.
KOK01772.
OMANNIFTEY.
OrthoDBEOG6XHC5H.

Enzyme and pathway databases

BioCycRTYP257363:GJEQ-918-MONOMER.
UniPathwayUPA00252; UER00325.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
PANTHERPTHR11108. PTHR11108. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. hemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_RICTY
AccessionPrimary (citable) accession number: Q68VM9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia typhi

Rickettsia typhi (strain Wilmington): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways