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Q68VM9

- HEMH_RICTY

UniProt

Q68VM9 - HEMH_RICTY

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Protein

Ferrochelatase

Gene

hemH

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the ferrous insertion into protoporphyrin IX.UniRule annotation

Catalytic activityi

Protoheme + 2 H+ = protoporphyrin + Fe2+.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi188 – 1881IronUniRule annotation
Metal bindingi268 – 2681IronUniRule annotation

GO - Molecular functioni

  1. ferrochelatase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. heme biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-918-MONOMER.
UniPathwayiUPA00252; UER00325.

Names & Taxonomyi

Protein namesi
Recommended name:
FerrochelataseUniRule annotation (EC:4.99.1.1UniRule annotation)
Alternative name(s):
Heme synthaseUniRule annotation
Protoheme ferro-lyaseUniRule annotation
Gene namesi
Name:hemHUniRule annotation
Ordered Locus Names:RT0876
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342FerrochelatasePRO_0000175195Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0876.

Structurei

3D structure databases

ProteinModelPortaliQ68VM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ferrochelatase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0276.
HOGENOMiHOG000060727.
KOiK01772.
OMAiNNIFTEY.
OrthoDBiEOG6XHC5H.

Family and domain databases

HAMAPiMF_00323. Ferrochelatase.
InterProiIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.
PROSITEiPS00534. FERROCHELATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68VM9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKRIAIVLF NLGGPEDIEY VKPFLFNLFY DKAIINLPNP LRYVIAKIIS
60 70 80 90 100
IVRERKSQKI YSLIGRKSYL IQETEKQKLA ITKKLKEILK EDFIIFISMR
110 120 130 140 150
YSTPFAKEVI CQIKEYNPSE IILLPLYPQF SSTTTGSSVK NFLQNIDIDI
160 170 180 190 200
PIKTICCYPI EEDFIKAHVS IIKEKLYDKN FRILFSAHGL PKRIIKAGDP
210 220 230 240 250
YSFQIKETVN KIVKELNIKD LDYKITYQSR VGPIEWLKPS TEYEIELAGK
260 270 280 290 300
LKKDIIIVPI SFVSEHVETL VELDIEYKFI ADKYNIQYTR IPTLGTNKIF
310 320 330 340
INSLTNILIR FINKTDTNLV MSSSSKRICP NKFTKCLCNL IN
Length:342
Mass (Da):39,758
Last modified:February 1, 2005 - v2
Checksum:i29EE43E3DE93E428
GO

Sequence cautioni

The sequence AAU04327.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU04327.1. Different initiation.
RefSeqiYP_067809.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU04327; AAU04327; RT0876.
GeneIDi2958508.
KEGGirty:RT0876.
PATRICi17911004. VBIRicTyp34752_0891.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017197 Genomic DNA. Translation: AAU04327.1 . Different initiation.
RefSeqi YP_067809.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q68VM9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0876.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU04327 ; AAU04327 ; RT0876 .
GeneIDi 2958508.
KEGGi rty:RT0876.
PATRICi 17911004. VBIRicTyp34752_0891.

Phylogenomic databases

eggNOGi COG0276.
HOGENOMi HOG000060727.
KOi K01772.
OMAi NNIFTEY.
OrthoDBi EOG6XHC5H.

Enzyme and pathway databases

UniPathwayi UPA00252 ; UER00325 .
BioCyci RTYP257363:GJEQ-918-MONOMER.

Family and domain databases

HAMAPi MF_00323. Ferrochelatase.
InterProi IPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view ]
PANTHERi PTHR11108. PTHR11108. 1 hit.
Pfami PF00762. Ferrochelatase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00109. hemH. 1 hit.
PROSITEi PS00534. FERROCHELATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiHEMH_RICTY
AccessioniPrimary (citable) accession number: Q68VM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: October 29, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3