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Protein

Tetraspanin-5

Gene

Tspan5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • cell adhesion Source: RGD
  • cell proliferation Source: RGD
  • establishment of protein localization to plasma membrane Source: Ensembl
  • positive regulation of Notch signaling pathway Source: Ensembl
  • protein maturation Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-5
Short name:
Tspan-5
Alternative name(s):
Transmembrane 4 superfamily member 9
Gene namesi
Name:Tspan5
Synonyms:Tm4sf9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1303176. Tspan5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717CytoplasmicSequence analysisAdd
BLAST
Transmembranei18 – 3821HelicalSequence analysisAdd
BLAST
Topological domaini39 – 6123ExtracellularSequence analysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence analysisAdd
BLAST
Topological domaini83 – 9210CytoplasmicSequence analysis
Transmembranei93 – 11321HelicalSequence analysisAdd
BLAST
Topological domaini114 – 232119ExtracellularSequence analysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence analysisAdd
BLAST
Topological domaini254 – 26815CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: RGD
  • plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Tetraspanin-5PRO_0000219245Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi49 – 491N-linked (GlcNAc...)Sequence analysis
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence analysis
Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence analysis
Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ68VK5.
PRIDEiQ68VK5.

PTM databases

PhosphoSiteiQ68VK5.

Expressioni

Gene expression databases

GenevisibleiQ68VK5. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021381.

Structurei

3D structure databases

ProteinModelPortaliQ68VK5.
SMRiQ68VK5. Positions 113-162.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230652.
HOVERGENiHBG108605.
InParanoidiQ68VK5.
KOiK17345.
OMAiIYIKGCV.
OrthoDBiEOG73FQNF.
PhylomeDBiQ68VK5.
TreeFamiTF313002.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68VK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGKHYKGPE VSCCIKYFIF GFNVIFWFLG ITFLGIGLWA WNEKGVLSNI
60 70 80 90 100
SSITDLGGFD PVWLFLVVGG VMFILGFAGC IGALRENTFL LKFFSVFLGI
110 120 130 140 150
IFFLELTAGV LAFVFKDWIK DQLYFFINNN IRAYRDDIDL QNLIDFTQEY
160 170 180 190 200
WQCCGAFGAD DWNLNIYFNC TDSNASRERC GVPFSCCTKD PAEDVINTQC
210 220 230 240 250
GYDARQKPEV DQQIVIYTKG CVPQFEKWLQ DNLTIVAGIF IGIALLQIFG
260
ICLAQNLVSD IEAVRASW
Length:268
Mass (Da):30,337
Last modified:May 15, 2007 - v2
Checksum:i7F4480BD0FA6192D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti142 – 1421N → S in AAQ11226 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF540877 mRNA. Translation: AAQ11226.1.
BC100135 mRNA. Translation: AAI00136.1.
RefSeqiNP_001004090.2. NM_001004090.2.
UniGeneiRn.98240.

Genome annotation databases

EnsembliENSRNOT00000021381; ENSRNOP00000021381; ENSRNOG00000015913.
GeneIDi362048.
KEGGirno:362048.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF540877 mRNA. Translation: AAQ11226.1.
BC100135 mRNA. Translation: AAI00136.1.
RefSeqiNP_001004090.2. NM_001004090.2.
UniGeneiRn.98240.

3D structure databases

ProteinModelPortaliQ68VK5.
SMRiQ68VK5. Positions 113-162.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021381.

PTM databases

PhosphoSiteiQ68VK5.

Proteomic databases

PaxDbiQ68VK5.
PRIDEiQ68VK5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021381; ENSRNOP00000021381; ENSRNOG00000015913.
GeneIDi362048.
KEGGirno:362048.

Organism-specific databases

CTDi10098.
RGDi1303176. Tspan5.

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230652.
HOVERGENiHBG108605.
InParanoidiQ68VK5.
KOiK17345.
OMAiIYIKGCV.
OrthoDBiEOG73FQNF.
PhylomeDBiQ68VK5.
TreeFamiTF313002.

Miscellaneous databases

NextBioi678502.
PROiQ68VK5.

Gene expression databases

GenevisibleiQ68VK5. RN.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Tetraspanin-5 is upregulated after lesion in the hippocampus."
    Braeuer A.U., Savaskan N.E., Ninnemann O., Nitsch R.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiTSN5_RAT
AccessioniPrimary (citable) accession number: Q68VK5
Secondary accession number(s): Q498N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 15, 2007
Last modified: May 11, 2016
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.