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Protein

Tetraspanin-5

Gene

Tspan5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44.By similarity

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: RGD
  • cell proliferation Source: RGD
  • cell surface receptor signaling pathway Source: GO_Central
  • positive regulation of Notch signaling pathway Source: Ensembl
  • protein localization to plasma membrane Source: Ensembl
  • protein maturation Source: Ensembl

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-5
Short name:
Tspan-5
Alternative name(s):
Transmembrane 4 superfamily member 9
Gene namesi
Name:Tspan5
Synonyms:Tm4sf9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1303176 Tspan5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 61ExtracellularSequence analysisAdd BLAST23
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 92CytoplasmicSequence analysis10
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Topological domaini114 – 232ExtracellularSequence analysisAdd BLAST119
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Topological domaini254 – 268CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192451 – 268Tetraspanin-5Add BLAST268

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ68VK5

PTM databases

PhosphoSitePlusiQ68VK5

Expressioni

Gene expression databases

BgeeiENSRNOG00000015913
GenevisibleiQ68VK5 RN

Interactioni

Subunit structurei

Interacts with ADAM10.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ68VK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137851
HOGENOMiHOG000230652
HOVERGENiHBG108605
InParanoidiQ68VK5
KOiK17345
OMAiFNIIFWF
OrthoDBiEOG091G0CHZ
PhylomeDBiQ68VK5
TreeFamiTF313002

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q68VK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGKHYKGPE VSCCIKYFIF GFNVIFWFLG ITFLGIGLWA WNEKGVLSNI
60 70 80 90 100
SSITDLGGFD PVWLFLVVGG VMFILGFAGC IGALRENTFL LKFFSVFLGI
110 120 130 140 150
IFFLELTAGV LAFVFKDWIK DQLYFFINNN IRAYRDDIDL QNLIDFTQEY
160 170 180 190 200
WQCCGAFGAD DWNLNIYFNC TDSNASRERC GVPFSCCTKD PAEDVINTQC
210 220 230 240 250
GYDARQKPEV DQQIVIYTKG CVPQFEKWLQ DNLTIVAGIF IGIALLQIFG
260
ICLAQNLVSD IEAVRASW
Length:268
Mass (Da):30,337
Last modified:May 15, 2007 - v2
Checksum:i7F4480BD0FA6192D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142N → S in AAQ11226 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF540877 mRNA Translation: AAQ11226.1
BC100135 mRNA Translation: AAI00136.1
RefSeqiNP_001004090.2, NM_001004090.2
UniGeneiRn.98240

Genome annotation databases

EnsembliENSRNOT00000021381; ENSRNOP00000021381; ENSRNOG00000015913
GeneIDi362048
KEGGirno:362048

Similar proteinsi

Entry informationi

Entry nameiTSN5_RAT
AccessioniPrimary (citable) accession number: Q68VK5
Secondary accession number(s): Q498N9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 15, 2007
Last modified: May 23, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health