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Protein
Submitted name:

Voltage-gated sodium channel alpha subunit Nav1.3

Gene

Scn3a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channelSAAS annotation, Voltage-gated channelSAAS annotation

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Submitted name:
Voltage-gated sodium channel alpha subunit Nav1.3Imported
Gene namesi
Name:Scn3aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98249. Scn3a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei54 – 7219HelicalSequence analysisAdd
BLAST
Transmembranei84 – 10219HelicalSequence analysisAdd
BLAST
Transmembranei109 – 13426HelicalSequence analysisAdd
BLAST
Transmembranei171 – 19929HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: MGI
  • membrane Source: MGI
  • plasma membrane Source: GO_Central
  • voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ68V26.

Expressioni

Gene expression databases

BgeeiQ68V26.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097647.

Chemistry

BindingDBiQ68V26.

Structurei

3D structure databases

ProteinModelPortaliQ68V26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 218166Ion_transInterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410XNP6. LUCA.
KOG2301. Eukaryota.
HOGENOMiHOG000231755.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR028325. VG_K_chnl.
[Graphical view]
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.

Sequencei

Sequence statusi: Fragment.

Q68V26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QKKKFGGQDI FMTEEQKKYY NAMKKLGSKK PQKPIPRPAN KFQGMVFDFV
60 70 80 90 100
TRQVFDISIM ILICLNMVTM MVETDDQSKY MTLVLSRINL VFIVLFTGEF
110 120 130 140 150
LLKLISLRYY YFTIGWNIFD FVVVILSIVG MFLAELIEKY FVSPTLFRVI
160 170 180 190 200
RLARIGRILR LIKGAKGIRT LLFALMMSLP ALFNIGLLLF LVMFIYAIFG
210 220
MSNFAYVKKE AGIDDMFNFE
Length:220
Mass (Da):25,603
Last modified:October 11, 2004 - v1
Checksum:i321C149A098F54DA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei220 – 2201Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ810517 mRNA. Translation: CAH17961.1.
UniGeneiMm.330256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ810517 mRNA. Translation: CAH17961.1.
UniGeneiMm.330256.

3D structure databases

ProteinModelPortaliQ68V26.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097647.

Chemistry

BindingDBiQ68V26.

Proteomic databases

PaxDbiQ68V26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:98249. Scn3a.

Phylogenomic databases

eggNOGiENOG410XNP6. LUCA.
KOG2301. Eukaryota.
HOGENOMiHOG000231755.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ68V26.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR028325. VG_K_chnl.
[Graphical view]
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
ProtoNetiSearch...

Publicationsi

  1. "Expression pattern of neuronal and skeletal muscle voltage-gated sodium channels in the developing mouse heart."
    Haufe V., Camacho J.A., Guenther B., Dumaine R., Bollensdorff C., Segond von Banchet G., Benndorf K., Zimmer T.
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/cImported.
    Tissue: HeartImported.

Entry informationi

Entry nameiQ68V26_MOUSE
AccessioniPrimary (citable) accession number: Q68V26
Entry historyi
Integrated into UniProtKB/TrEMBL: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 20, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.