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Q68V26

- Q68V26_MOUSE

UniProt

Q68V26 - Q68V26_MOUSE

Protein
Submitted name:

Voltage-gated sodium channel alpha subunit Nav1.3

Gene

Scn3a

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. potassium channel activity Source: UniProtKB-KW
    2. voltage-gated sodium channel activity Source: RefGenome

    GO - Biological processi

    1. membrane depolarization during action potential Source: RefGenome
    2. neuronal action potential Source: RefGenome
    3. sodium ion transmembrane transport Source: RefGenome

    Keywords - Molecular functioni

    Ion channel, Potassium channelSAAS annotation, Voltage-gated channelSAAS annotation

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Voltage-gated sodium channel alpha subunit Nav1.3Imported
    Gene namesi
    Name:Scn3aImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:98249. Scn3a.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. membrane Source: MGI
    3. plasma membrane Source: RefGenome
    4. voltage-gated sodium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    ArrayExpressiQ68V26.
    BgeeiQ68V26.
    GenevestigatoriQ68V26.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ68V26.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000231755.
    InParanoidiQ68V26.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR028808. Na_channel_a3su.
    [Graphical view]
    PANTHERiPTHR10037:SF200. PTHR10037:SF200. 1 hit.
    PfamiPF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.

    Sequencei

    Sequence statusi: Fragment.

    Q68V26-1 [UniParc]FASTAAdd to Basket

    « Hide

    QKKKFGGQDI FMTEEQKKYY NAMKKLGSKK PQKPIPRPAN KFQGMVFDFV    50
    TRQVFDISIM ILICLNMVTM MVETDDQSKY MTLVLSRINL VFIVLFTGEF 100
    LLKLISLRYY YFTIGWNIFD FVVVILSIVG MFLAELIEKY FVSPTLFRVI 150
    RLARIGRILR LIKGAKGIRT LLFALMMSLP ALFNIGLLLF LVMFIYAIFG 200
    MSNFAYVKKE AGIDDMFNFE 220
    Length:220
    Mass (Da):25,603
    Last modified:October 11, 2004 - v1
    Checksum:i321C149A098F54DA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei220 – 2201Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ810517 mRNA. Translation: CAH17961.1.
    UniGeneiMm.330256.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ810517 mRNA. Translation: CAH17961.1 .
    UniGenei Mm.330256.

    3D structure databases

    ProteinModelPortali Q68V26.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q68V26.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:98249. Scn3a.

    Phylogenomic databases

    HOGENOMi HOG000231755.
    InParanoidi Q68V26.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q68V26.
    Bgeei Q68V26.
    Genevestigatori Q68V26.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR028808. Na_channel_a3su.
    [Graphical view ]
    PANTHERi PTHR10037:SF200. PTHR10037:SF200. 1 hit.
    Pfami PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    ProtoNeti Search...

    Publicationsi

    1. "Expression pattern of neuronal and skeletal muscle voltage-gated sodium channels in the developing mouse heart."
      Haufe V., Camacho J.A., Guenther B., Dumaine R., Bollensdorff C., Segond von Banchet G., Benndorf K., Zimmer T.
      Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BALB/cImported.
      Tissue: HeartImported.

    Entry informationi

    Entry nameiQ68V26_MOUSE
    AccessioniPrimary (citable) accession number: Q68V26
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)