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Q68SN8 (FCRL5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fc receptor-like protein 5

Short name=FcR-like protein 5
Short name=FcRL5
Alternative name(s):
BXMAS1-like protein 2
Short name=mBXMH2
Fc receptor homolog 3
Short name=FcRH3
Short name=moFcRH3
CD_antigen=CD307e
Gene names
Name:Fcrl5
Synonyms:Fcrh3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length596 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Interacts with PTPN6, PTPN11, SYK and ZAP70 By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity.

Tissue specificity

Preferentially expressed in marginal zone B cells. Ref.1

Post-translational modification

Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein tyrosine kinases By similarity.

Sequence similarities

Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

Caution

It is uncertain whether Met-1 or Met-14 is the initiator.

Sequence caution

The sequence AAO20873.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q68SN8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q68SN8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     29-116: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 596570Fc receptor-like protein 5
PRO_0000331641

Regions

Topological domain27 – 496470Extracellular Potential
Transmembrane497 – 51721Helical; Potential
Topological domain518 – 59679Cytoplasmic Potential
Domain34 – 11582Ig-like C2-type 1
Domain106 – 19994Ig-like C2-type 2
Domain207 – 29488Ig-like C2-type 3
Domain296 – 38489Ig-like C2-type 4
Domain398 – 48386Ig-like C2-type 5

Amino acid modifications

Glycosylation3241N-linked (GlcNAc...) Potential
Glycosylation4361N-linked (GlcNAc...) Potential
Disulfide bond55 ↔ 99 By similarity
Disulfide bond137 ↔ 181 By similarity
Disulfide bond228 ↔ 277 By similarity
Disulfide bond325 ↔ 373 By similarity
Disulfide bond419 ↔ 466 By similarity

Natural variations

Alternative sequence29 – 11688Missing in isoform 2.
VSP_033309

Experimental info

Sequence conflict161 – 1633PQS → HQ in AAS91578. Ref.1
Sequence conflict161 – 1633PQS → HQ in AAO20873. Ref.2
Sequence conflict1661F → L in BAC40954. Ref.3
Sequence conflict1671Y → S in AAS91578. Ref.1
Sequence conflict1671Y → S in AAO20873. Ref.2
Sequence conflict1701R → H in BAC40954. Ref.3
Sequence conflict1991V → R in AAS91578. Ref.1
Sequence conflict1991V → R in AAO20873. Ref.2
Sequence conflict2731K → R in AAS91578. Ref.1
Sequence conflict2731K → R in AAO20873. Ref.2
Sequence conflict2871S → R in AAS91578. Ref.1
Sequence conflict2871S → R in AAO20873. Ref.2
Sequence conflict2871S → R in BAC40954. Ref.3
Sequence conflict3461K → E in AAS91578. Ref.1
Sequence conflict3461K → E in AAO20873. Ref.2
Sequence conflict3721Y → H in AAS91578. Ref.1
Sequence conflict3721Y → H in AAO20873. Ref.2
Sequence conflict3731C → R in BAC40954. Ref.3
Sequence conflict3761N → T in AAS91578. Ref.1
Sequence conflict3761N → T in AAO20873. Ref.2
Sequence conflict3761N → T in BAC40954. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 3EF9C7E4728461B4

FASTA59666,779
        10         20         30         40         50         60 
MSGSFSPCVV FTQMWLTLLV VTPVNGQHEA AQQSVVSLQP PWTTFFRGEV VTLTCYRFGF 

        70         80         90        100        110        120 
SVPQKTKWYQ KRKTVKQTPG ALVIKAHTLK VHESGEYWCQ ADSLLPSMHV NVEFSEDFLV 

       130        140        150        160        170        180 
LQAPPAVFEG DSVVLRCYAK KGIEAETLTF YKDGKALTLH PQSSEFYIHR ANLKDNGQYK 

       190        200        210        220        230        240 
CTSKKKWSFG SLYTSNTVVV QVQELFPRPV LRARPSHPID GSPVTLTCQT QLSAQKSDAR 

       250        260        270        280        290        300 
LQFCFFRNLQ LLGSGCSRSS EFHIPAIWTE ESKRYQCKAE TVNSQVSKQS TAFIIPVQRA 

       310        320        330        340        350        360 
SARFQTHIIP ASKLVFEGQL LLLNCSVKGV PGPLKFSWYK KDMLNKETKI LKSSNAEFKI 

       370        380        390        400        410        420 
SQVNISDAGE YYCEANNSRR SFVSRAFPIT IKVPVSQPVL TLSTGKTQAL EGDLMTLHCQ 

       430        440        450        460        470        480 
SQRGSPCILY EFFYENVSLG NSSILSGGGA YFNFSMSTER SGNYYCTADN GLGAQCSEAI 

       490        500        510        520        530        540 
RISIFDMTKN RSVPMAAGIT VGLLIMAVGV FLFYCWFSRK AGGKPTSDDS RNPSDSEPQE 

       550        560        570        580        590 
PTYYNVPACI ELQPVYSNEP EENVIYTEVR RTQPRQKHAD QESESPRSRC QMAEKK 

« Hide

Isoform 2 [UniParc].

Checksum: 9E86672E7DDC03ED
Show »

FASTA50856,709

References

« Hide 'large scale' references
[1]"Differential B cell expression of mouse Fc receptor homologs."
Davis R.S., Stephan R.P., Chen C.-C., Dennis G. Jr., Cooper M.D.
Int. Immunol. 16:1343-1353(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
Strain: BALB/c.
Tissue: Spleen.
[2]"Molecular cloning of mouse BXMAS1 homologs; homologous to IgFc receptor."
Nakayama Y., Maher S.E., Weissman S.M., Bothwell A.L.M.
Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: C57BL/6J.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: NOD.
Tissue: Spleen.
[4]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY506558 mRNA. Translation: AAS91578.1.
AY158090 mRNA. Translation: AAO20873.1. Different initiation.
AK089756 mRNA. Translation: BAC40954.1.
AC163618 Genomic DNA. No translation available.
CCDSCCDS50943.1. [Q68SN8-1]
CCDS50944.1. [Q68SN8-2]
RefSeqNP_001106709.1. NM_001113238.1. [Q68SN8-2]
NP_899045.3. NM_183222.3. [Q68SN8-1]
UniGeneMm.331122.

3D structure databases

ProteinModelPortalQ68SN8.
SMRQ68SN8. Positions 33-482.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ68SN8.

Proteomic databases

PaxDbQ68SN8.
PRIDEQ68SN8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000049926; ENSMUSP00000050151; ENSMUSG00000048031. [Q68SN8-1]
ENSMUST00000166297; ENSMUSP00000131176; ENSMUSG00000048031. [Q68SN8-2]
GeneID329693.
KEGGmmu:329693.
UCSCuc008psf.1. mouse. [Q68SN8-2]
uc012crg.1. mouse. [Q68SN8-1]

Organism-specific databases

CTD83416.
MGIMGI:3053558. Fcrl5.

Phylogenomic databases

eggNOGNOG151212.
GeneTreeENSGT00560000076958.
HOGENOMHOG000036945.
HOVERGENHBG074073.
InParanoidQ68SN8.

Gene expression databases

ArrayExpressQ68SN8.
BgeeQ68SN8.
GenevestigatorQ68SN8.

Family and domain databases

Gene3D2.60.40.10. 5 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
SMARTSM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio398903.
PROQ68SN8.
SOURCESearch...

Entry information

Entry nameFCRL5_MOUSE
AccessionPrimary (citable) accession number: Q68SN8
Secondary accession number(s): E9QLI5, Q80WN2, Q8BJA5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 79 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot