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Q68SN8

- FCRL5_MOUSE

UniProt

Q68SN8 - FCRL5_MOUSE

Protein

Fc receptor-like protein 5

Gene

Fcrl5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. negative regulation of B cell receptor signaling pathway Source: MGI
    2. negative regulation of release of sequestered calcium ion into cytosol Source: MGI

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fc receptor-like protein 5
    Short name:
    FcR-like protein 5
    Short name:
    FcRL5
    Alternative name(s):
    BXMAS1-like protein 2
    Short name:
    mBXMH2
    Fc receptor homolog 3
    Short name:
    FcRH3
    Short name:
    moFcRH3
    CD_antigen: CD307e
    Gene namesi
    Name:Fcrl5
    Synonyms:Fcrh3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:3053558. Fcrl5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: MGI
    3. receptor complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 596570Fc receptor-like protein 5PRO_0000331641Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi55 ↔ 99PROSITE-ProRule annotation
    Disulfide bondi137 ↔ 181PROSITE-ProRule annotation
    Disulfide bondi228 ↔ 277PROSITE-ProRule annotation
    Glycosylationi324 – 3241N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi325 ↔ 373PROSITE-ProRule annotation
    Disulfide bondi419 ↔ 466PROSITE-ProRule annotation
    Glycosylationi436 – 4361N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein tyrosine kinases.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ68SN8.
    PRIDEiQ68SN8.

    PTM databases

    PhosphoSiteiQ68SN8.

    Expressioni

    Tissue specificityi

    Preferentially expressed in marginal zone B cells.1 Publication

    Gene expression databases

    ArrayExpressiQ68SN8.
    BgeeiQ68SN8.
    GenevestigatoriQ68SN8.

    Interactioni

    Subunit structurei

    Interacts with PTPN6, PTPN11, SYK and ZAP70.By similarity

    Protein-protein interaction databases

    DIPiDIP-60955N.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68SN8.
    SMRiQ68SN8. Positions 33-482.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 496470ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini518 – 59679CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei497 – 51721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 11582Ig-like C2-type 1Add
    BLAST
    Domaini106 – 19994Ig-like C2-type 2Add
    BLAST
    Domaini207 – 29488Ig-like C2-type 3Add
    BLAST
    Domaini296 – 38489Ig-like C2-type 4Add
    BLAST
    Domaini398 – 48386Ig-like C2-type 5Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG151212.
    GeneTreeiENSGT00560000076958.
    HOGENOMiHOG000036945.
    HOVERGENiHBG074073.
    InParanoidiQ68SN8.

    Family and domain databases

    Gene3Di2.60.40.10. 5 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    SM00408. IGc2. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q68SN8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGSFSPCVV FTQMWLTLLV VTPVNGQHEA AQQSVVSLQP PWTTFFRGEV    50
    VTLTCYRFGF SVPQKTKWYQ KRKTVKQTPG ALVIKAHTLK VHESGEYWCQ 100
    ADSLLPSMHV NVEFSEDFLV LQAPPAVFEG DSVVLRCYAK KGIEAETLTF 150
    YKDGKALTLH PQSSEFYIHR ANLKDNGQYK CTSKKKWSFG SLYTSNTVVV 200
    QVQELFPRPV LRARPSHPID GSPVTLTCQT QLSAQKSDAR LQFCFFRNLQ 250
    LLGSGCSRSS EFHIPAIWTE ESKRYQCKAE TVNSQVSKQS TAFIIPVQRA 300
    SARFQTHIIP ASKLVFEGQL LLLNCSVKGV PGPLKFSWYK KDMLNKETKI 350
    LKSSNAEFKI SQVNISDAGE YYCEANNSRR SFVSRAFPIT IKVPVSQPVL 400
    TLSTGKTQAL EGDLMTLHCQ SQRGSPCILY EFFYENVSLG NSSILSGGGA 450
    YFNFSMSTER SGNYYCTADN GLGAQCSEAI RISIFDMTKN RSVPMAAGIT 500
    VGLLIMAVGV FLFYCWFSRK AGGKPTSDDS RNPSDSEPQE PTYYNVPACI 550
    ELQPVYSNEP EENVIYTEVR RTQPRQKHAD QESESPRSRC QMAEKK 596
    Length:596
    Mass (Da):66,779
    Last modified:July 27, 2011 - v3
    Checksum:i3EF9C7E4728461B4
    GO
    Isoform 2 (identifier: Q68SN8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         29-116: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:508
    Mass (Da):56,709
    Checksum:i9E86672E7DDC03ED
    GO

    Sequence cautioni

    The sequence AAO20873.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti161 – 1633PQS → HQ in AAS91578. (PubMed:15302849)Curated
    Sequence conflicti161 – 1633PQS → HQ in AAO20873. 1 PublicationCurated
    Sequence conflicti166 – 1661F → L in BAC40954. (PubMed:16141072)Curated
    Sequence conflicti167 – 1671Y → S in AAS91578. (PubMed:15302849)Curated
    Sequence conflicti167 – 1671Y → S in AAO20873. 1 PublicationCurated
    Sequence conflicti170 – 1701R → H in BAC40954. (PubMed:16141072)Curated
    Sequence conflicti199 – 1991V → R in AAS91578. (PubMed:15302849)Curated
    Sequence conflicti199 – 1991V → R in AAO20873. 1 PublicationCurated
    Sequence conflicti273 – 2731K → R in AAS91578. (PubMed:15302849)Curated
    Sequence conflicti273 – 2731K → R in AAO20873. 1 PublicationCurated
    Sequence conflicti287 – 2871S → R in AAS91578. (PubMed:15302849)Curated
    Sequence conflicti287 – 2871S → R in AAO20873. 1 PublicationCurated
    Sequence conflicti287 – 2871S → R in BAC40954. (PubMed:16141072)Curated
    Sequence conflicti346 – 3461K → E in AAS91578. (PubMed:15302849)Curated
    Sequence conflicti346 – 3461K → E in AAO20873. 1 PublicationCurated
    Sequence conflicti372 – 3721Y → H in AAS91578. (PubMed:15302849)Curated
    Sequence conflicti372 – 3721Y → H in AAO20873. 1 PublicationCurated
    Sequence conflicti373 – 3731C → R in BAC40954. (PubMed:16141072)Curated
    Sequence conflicti376 – 3761N → T in AAS91578. (PubMed:15302849)Curated
    Sequence conflicti376 – 3761N → T in AAO20873. 1 PublicationCurated
    Sequence conflicti376 – 3761N → T in BAC40954. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei29 – 11688Missing in isoform 2. 1 PublicationVSP_033309Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY506558 mRNA. Translation: AAS91578.1.
    AY158090 mRNA. Translation: AAO20873.1. Different initiation.
    AK089756 mRNA. Translation: BAC40954.1.
    AC163618 Genomic DNA. No translation available.
    CCDSiCCDS50943.1. [Q68SN8-1]
    CCDS50944.1. [Q68SN8-2]
    RefSeqiNP_001106709.1. NM_001113238.1. [Q68SN8-2]
    NP_899045.3. NM_183222.3. [Q68SN8-1]
    UniGeneiMm.331122.

    Genome annotation databases

    EnsembliENSMUST00000049926; ENSMUSP00000050151; ENSMUSG00000048031. [Q68SN8-1]
    ENSMUST00000166297; ENSMUSP00000131176; ENSMUSG00000048031. [Q68SN8-2]
    GeneIDi329693.
    KEGGimmu:329693.
    UCSCiuc008psf.1. mouse. [Q68SN8-2]
    uc012crg.1. mouse. [Q68SN8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY506558 mRNA. Translation: AAS91578.1 .
    AY158090 mRNA. Translation: AAO20873.1 . Different initiation.
    AK089756 mRNA. Translation: BAC40954.1 .
    AC163618 Genomic DNA. No translation available.
    CCDSi CCDS50943.1. [Q68SN8-1 ]
    CCDS50944.1. [Q68SN8-2 ]
    RefSeqi NP_001106709.1. NM_001113238.1. [Q68SN8-2 ]
    NP_899045.3. NM_183222.3. [Q68SN8-1 ]
    UniGenei Mm.331122.

    3D structure databases

    ProteinModelPortali Q68SN8.
    SMRi Q68SN8. Positions 33-482.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60955N.

    PTM databases

    PhosphoSitei Q68SN8.

    Proteomic databases

    PaxDbi Q68SN8.
    PRIDEi Q68SN8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049926 ; ENSMUSP00000050151 ; ENSMUSG00000048031 . [Q68SN8-1 ]
    ENSMUST00000166297 ; ENSMUSP00000131176 ; ENSMUSG00000048031 . [Q68SN8-2 ]
    GeneIDi 329693.
    KEGGi mmu:329693.
    UCSCi uc008psf.1. mouse. [Q68SN8-2 ]
    uc012crg.1. mouse. [Q68SN8-1 ]

    Organism-specific databases

    CTDi 83416.
    MGIi MGI:3053558. Fcrl5.

    Phylogenomic databases

    eggNOGi NOG151212.
    GeneTreei ENSGT00560000076958.
    HOGENOMi HOG000036945.
    HOVERGENi HBG074073.
    InParanoidi Q68SN8.

    Miscellaneous databases

    NextBioi 398903.
    PROi Q68SN8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q68SN8.
    Bgeei Q68SN8.
    Genevestigatori Q68SN8.

    Family and domain databases

    Gene3Di 2.60.40.10. 5 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    SM00408. IGc2. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential B cell expression of mouse Fc receptor homologs."
      Davis R.S., Stephan R.P., Chen C.-C., Dennis G. Jr., Cooper M.D.
      Int. Immunol. 16:1343-1353(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Strain: BALB/c.
      Tissue: Spleen.
    2. "Molecular cloning of mouse BXMAS1 homologs; homologous to IgFc receptor."
      Nakayama Y., Maher S.E., Weissman S.M., Bothwell A.L.M.
      Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: NOD.
      Tissue: Spleen.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiFCRL5_MOUSE
    AccessioniPrimary (citable) accession number: Q68SN8
    Secondary accession number(s): E9QLI5, Q80WN2, Q8BJA5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 80 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3