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Protein

Fc receptor-like protein 5

Gene

Fcrl5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. negative regulation of B cell receptor signaling pathway Source: MGI
  2. negative regulation of release of sequestered calcium ion into cytosol Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Fc receptor-like protein 5
Short name:
FcR-like protein 5
Short name:
FcRL5
Alternative name(s):
BXMAS1-like protein 2
Short name:
mBXMH2
Fc receptor homolog 3
Short name:
FcRH3
Short name:
moFcRH3
CD_antigen: CD307e
Gene namesi
Name:Fcrl5
Synonyms:Fcrh3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:3053558. Fcrl5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 496470ExtracellularSequence AnalysisAdd
BLAST
Transmembranei497 – 51721HelicalSequence AnalysisAdd
BLAST
Topological domaini518 – 59679CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: MGI
  3. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 596570Fc receptor-like protein 5PRO_0000331641Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi55 ↔ 99PROSITE-ProRule annotation
Disulfide bondi137 ↔ 181PROSITE-ProRule annotation
Disulfide bondi228 ↔ 277PROSITE-ProRule annotation
Glycosylationi324 – 3241N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi325 ↔ 373PROSITE-ProRule annotation
Disulfide bondi419 ↔ 466PROSITE-ProRule annotation
Glycosylationi436 – 4361N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein tyrosine kinases.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ68SN8.
PRIDEiQ68SN8.

PTM databases

PhosphoSiteiQ68SN8.

Expressioni

Tissue specificityi

Preferentially expressed in marginal zone B cells.1 Publication

Gene expression databases

BgeeiQ68SN8.
ExpressionAtlasiQ68SN8. baseline and differential.
GenevestigatoriQ68SN8.

Interactioni

Subunit structurei

Interacts with PTPN6, PTPN11, SYK and ZAP70.By similarity

Protein-protein interaction databases

DIPiDIP-60955N.

Structurei

3D structure databases

SMRiQ68SN8. Positions 33-482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 11582Ig-like C2-type 1Add
BLAST
Domaini106 – 19994Ig-like C2-type 2Add
BLAST
Domaini207 – 29488Ig-like C2-type 3Add
BLAST
Domaini296 – 38489Ig-like C2-type 4Add
BLAST
Domaini398 – 48386Ig-like C2-type 5Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG151212.
GeneTreeiENSGT00760000119130.
HOGENOMiHOG000036945.
HOVERGENiHBG074073.
InParanoidiQ68SN8.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q68SN8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGSFSPCVV FTQMWLTLLV VTPVNGQHEA AQQSVVSLQP PWTTFFRGEV
60 70 80 90 100
VTLTCYRFGF SVPQKTKWYQ KRKTVKQTPG ALVIKAHTLK VHESGEYWCQ
110 120 130 140 150
ADSLLPSMHV NVEFSEDFLV LQAPPAVFEG DSVVLRCYAK KGIEAETLTF
160 170 180 190 200
YKDGKALTLH PQSSEFYIHR ANLKDNGQYK CTSKKKWSFG SLYTSNTVVV
210 220 230 240 250
QVQELFPRPV LRARPSHPID GSPVTLTCQT QLSAQKSDAR LQFCFFRNLQ
260 270 280 290 300
LLGSGCSRSS EFHIPAIWTE ESKRYQCKAE TVNSQVSKQS TAFIIPVQRA
310 320 330 340 350
SARFQTHIIP ASKLVFEGQL LLLNCSVKGV PGPLKFSWYK KDMLNKETKI
360 370 380 390 400
LKSSNAEFKI SQVNISDAGE YYCEANNSRR SFVSRAFPIT IKVPVSQPVL
410 420 430 440 450
TLSTGKTQAL EGDLMTLHCQ SQRGSPCILY EFFYENVSLG NSSILSGGGA
460 470 480 490 500
YFNFSMSTER SGNYYCTADN GLGAQCSEAI RISIFDMTKN RSVPMAAGIT
510 520 530 540 550
VGLLIMAVGV FLFYCWFSRK AGGKPTSDDS RNPSDSEPQE PTYYNVPACI
560 570 580 590
ELQPVYSNEP EENVIYTEVR RTQPRQKHAD QESESPRSRC QMAEKK
Length:596
Mass (Da):66,779
Last modified:July 27, 2011 - v3
Checksum:i3EF9C7E4728461B4
GO
Isoform 2 (identifier: Q68SN8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-116: Missing.

Note: No experimental confirmation available.

Show »
Length:508
Mass (Da):56,709
Checksum:i9E86672E7DDC03ED
GO

Sequence cautioni

The sequence AAO20873.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti161 – 1633PQS → HQ in AAS91578 (PubMed:15302849).Curated
Sequence conflicti161 – 1633PQS → HQ in AAO20873 (Ref. 2) Curated
Sequence conflicti166 – 1661F → L in BAC40954 (PubMed:16141072).Curated
Sequence conflicti167 – 1671Y → S in AAS91578 (PubMed:15302849).Curated
Sequence conflicti167 – 1671Y → S in AAO20873 (Ref. 2) Curated
Sequence conflicti170 – 1701R → H in BAC40954 (PubMed:16141072).Curated
Sequence conflicti199 – 1991V → R in AAS91578 (PubMed:15302849).Curated
Sequence conflicti199 – 1991V → R in AAO20873 (Ref. 2) Curated
Sequence conflicti273 – 2731K → R in AAS91578 (PubMed:15302849).Curated
Sequence conflicti273 – 2731K → R in AAO20873 (Ref. 2) Curated
Sequence conflicti287 – 2871S → R in AAS91578 (PubMed:15302849).Curated
Sequence conflicti287 – 2871S → R in AAO20873 (Ref. 2) Curated
Sequence conflicti287 – 2871S → R in BAC40954 (PubMed:16141072).Curated
Sequence conflicti346 – 3461K → E in AAS91578 (PubMed:15302849).Curated
Sequence conflicti346 – 3461K → E in AAO20873 (Ref. 2) Curated
Sequence conflicti372 – 3721Y → H in AAS91578 (PubMed:15302849).Curated
Sequence conflicti372 – 3721Y → H in AAO20873 (Ref. 2) Curated
Sequence conflicti373 – 3731C → R in BAC40954 (PubMed:16141072).Curated
Sequence conflicti376 – 3761N → T in AAS91578 (PubMed:15302849).Curated
Sequence conflicti376 – 3761N → T in AAO20873 (Ref. 2) Curated
Sequence conflicti376 – 3761N → T in BAC40954 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei29 – 11688Missing in isoform 2. 1 PublicationVSP_033309Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY506558 mRNA. Translation: AAS91578.1.
AY158090 mRNA. Translation: AAO20873.1. Different initiation.
AK089756 mRNA. Translation: BAC40954.1.
AC163618 Genomic DNA. No translation available.
CCDSiCCDS50943.1. [Q68SN8-1]
CCDS50944.1. [Q68SN8-2]
RefSeqiNP_001106709.1. NM_001113238.1. [Q68SN8-2]
NP_899045.3. NM_183222.3. [Q68SN8-1]
UniGeneiMm.331122.

Genome annotation databases

EnsembliENSMUST00000049926; ENSMUSP00000050151; ENSMUSG00000048031. [Q68SN8-1]
ENSMUST00000166297; ENSMUSP00000131176; ENSMUSG00000048031. [Q68SN8-2]
ENSMUST00000193229; ENSMUSP00000141311; ENSMUSG00000048031. [Q68SN8-2]
ENSMUST00000194102; ENSMUSP00000142210; ENSMUSG00000048031. [Q68SN8-1]
GeneIDi329693.
KEGGimmu:329693.
UCSCiuc008psf.1. mouse. [Q68SN8-2]
uc012crg.1. mouse. [Q68SN8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY506558 mRNA. Translation: AAS91578.1.
AY158090 mRNA. Translation: AAO20873.1. Different initiation.
AK089756 mRNA. Translation: BAC40954.1.
AC163618 Genomic DNA. No translation available.
CCDSiCCDS50943.1. [Q68SN8-1]
CCDS50944.1. [Q68SN8-2]
RefSeqiNP_001106709.1. NM_001113238.1. [Q68SN8-2]
NP_899045.3. NM_183222.3. [Q68SN8-1]
UniGeneiMm.331122.

3D structure databases

SMRiQ68SN8. Positions 33-482.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60955N.

PTM databases

PhosphoSiteiQ68SN8.

Proteomic databases

PaxDbiQ68SN8.
PRIDEiQ68SN8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049926; ENSMUSP00000050151; ENSMUSG00000048031. [Q68SN8-1]
ENSMUST00000166297; ENSMUSP00000131176; ENSMUSG00000048031. [Q68SN8-2]
ENSMUST00000193229; ENSMUSP00000141311; ENSMUSG00000048031. [Q68SN8-2]
ENSMUST00000194102; ENSMUSP00000142210; ENSMUSG00000048031. [Q68SN8-1]
GeneIDi329693.
KEGGimmu:329693.
UCSCiuc008psf.1. mouse. [Q68SN8-2]
uc012crg.1. mouse. [Q68SN8-1]

Organism-specific databases

CTDi83416.
MGIiMGI:3053558. Fcrl5.

Phylogenomic databases

eggNOGiNOG151212.
GeneTreeiENSGT00760000119130.
HOGENOMiHOG000036945.
HOVERGENiHBG074073.
InParanoidiQ68SN8.

Miscellaneous databases

NextBioi398903.
PROiQ68SN8.
SOURCEiSearch...

Gene expression databases

BgeeiQ68SN8.
ExpressionAtlasiQ68SN8. baseline and differential.
GenevestigatoriQ68SN8.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differential B cell expression of mouse Fc receptor homologs."
    Davis R.S., Stephan R.P., Chen C.-C., Dennis G. Jr., Cooper M.D.
    Int. Immunol. 16:1343-1353(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Spleen.
  2. "Molecular cloning of mouse BXMAS1 homologs; homologous to IgFc receptor."
    Nakayama Y., Maher S.E., Weissman S.M., Bothwell A.L.M.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: NOD.
    Tissue: Spleen.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiFCRL5_MOUSE
AccessioniPrimary (citable) accession number: Q68SN8
Secondary accession number(s): E9QLI5, Q80WN2, Q8BJA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 27, 2011
Last modified: April 1, 2015
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-14 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.