ID   CART_BOVIN              Reviewed;         116 AA.
AC   Q68RJ9; A4FUF3;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   24-JAN-2024, entry version 97.
DE   RecName: Full=Cocaine- and amphetamine-regulated transcript protein;
DE   Contains:
DE     RecName: Full=CART(1-39);
DE   Contains:
DE     RecName: Full=CART(42-89);
DE   Flags: Precursor;
GN   Name=CARTPT; Synonyms=CART;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15670137; DOI=10.1111/j.1365-2052.2004.01218.x;
RA   Valle E., Moore S.S., Jann O., Williams J.L., Crews D.H., Benkel B.F.;
RT   "The bovine cocaine and amphetamine-regulated transcript locus: gene
RT   characterization and SNP discovery.";
RL   Anim. Genet. 36:74-75(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Satiety factor closely associated with the actions of leptin
CC       and neuropeptide y; this anorectic peptide inhibits both normal and
CC       starvation-induced feeding and completely blocks the feeding response
CC       induced by neuropeptide Y and regulated by leptin in the hypothalamus.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CART family. {ECO:0000305}.
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DR   EMBL; AY603972; AAT99018.1; -; Genomic_DNA.
DR   EMBL; BC114792; AAI14793.1; -; mRNA.
DR   RefSeq; NP_001007821.1; NM_001007820.3.
DR   AlphaFoldDB; Q68RJ9; -.
DR   SMR; Q68RJ9; -.
DR   STRING; 9913.ENSBTAP00000055162; -.
DR   PaxDb; 9913-ENSBTAP00000055162; -.
DR   Ensembl; ENSBTAT00000064119.2; ENSBTAP00000055162.1; ENSBTAG00000047486.2.
DR   GeneID; 493726; -.
DR   KEGG; bta:493726; -.
DR   CTD; 9607; -.
DR   VEuPathDB; HostDB:ENSBTAG00000047486; -.
DR   VGNC; VGNC:26774; CARTPT.
DR   eggNOG; ENOG502S2YU; Eukaryota.
DR   GeneTree; ENSGT00390000018319; -.
DR   HOGENOM; CLU_157363_1_0_1; -.
DR   InParanoid; Q68RJ9; -.
DR   OMA; CNCPRGA; -.
DR   OrthoDB; 3971848at2759; -.
DR   TreeFam; TF332948; -.
DR   Proteomes; UP000009136; Chromosome 20.
DR   Bgee; ENSBTAG00000047486; Expressed in Ammon's horn and 44 other cell types or tissues.
DR   GO; GO:0005615; C:extracellular space; ISS:HGNC-UCL.
DR   GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   GO; GO:0008343; P:adult feeding behavior; ISS:HGNC-UCL.
DR   GO; GO:0009267; P:cellular response to starvation; ISS:HGNC-UCL.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProtKB-KW.
DR   GO; GO:0032922; P:circadian regulation of gene expression; ISS:HGNC-UCL.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:HGNC-UCL.
DR   GO; GO:0001678; P:intracellular glucose homeostasis; ISS:HGNC-UCL.
DR   GO; GO:0032099; P:negative regulation of appetite; ISS:HGNC-UCL.
DR   GO; GO:0045779; P:negative regulation of bone resorption; IEA:Ensembl.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0045777; P:positive regulation of blood pressure; ISS:HGNC-UCL.
DR   GO; GO:0032812; P:positive regulation of epinephrine secretion; ISS:HGNC-UCL.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR   GO; GO:0045860; P:positive regulation of protein kinase activity; ISS:HGNC-UCL.
DR   GO; GO:0051971; P:positive regulation of transmission of nerve impulse; ISS:HGNC-UCL.
DR   CDD; cd22741; CART_CTD-like; 1.
DR   Gene3D; 4.10.40.30; CART, C-terminal domain; 1.
DR   InterPro; IPR009106; CART.
DR   InterPro; IPR036722; CART_C_sf.
DR   PANTHER; PTHR16655; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PROTEIN; 1.
DR   PANTHER; PTHR16655:SF0; COCAINE- AND AMPHETAMINE-REGULATED TRANSCRIPT PROTEIN; 1.
DR   Pfam; PF06373; CART; 1.
DR   SUPFAM; SSF64546; Satiety factor CART (cocaine and amphetamine regulated transcript); 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Neuropeptide;
KW   Neurotransmitter; Obesity; Phosphoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000250"
FT   CHAIN           28..116
FT                   /note="Cocaine- and amphetamine-regulated transcript
FT                   protein"
FT                   /id="PRO_0000256516"
FT   PEPTIDE         28..66
FT                   /note="CART(1-39)"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000256517"
FT   PEPTIDE         69..116
FT                   /note="CART(42-89)"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000256518"
FT   MOD_RES         41
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:P49192"
FT   MOD_RES         48
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P56388"
FT   DISULFID        82..100
FT                   /evidence="ECO:0000250"
FT   DISULFID        88..108
FT                   /evidence="ECO:0000250"
FT   DISULFID        102..115
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   116 AA;  12790 MW;  3664F4DBBE77106E CRC64;
     MESPRLRLLP LLGAALLLLL PLLGALAQED AELQPRALDI YSAVEDASHE KELIEALQEV
     LKKLKSKRIP IYEKKYGQVP MCDAGEQCAV RKGARIGKLC DCPRGTSCNS FLLKCL
//