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Protein

Cocaine- and amphetamine-regulated transcript protein

Gene

CARTPT

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide, Neurotransmitter

Names & Taxonomyi

Protein namesi
Recommended name:
Cocaine- and amphetamine-regulated transcript protein
Cleaved into the following 2 chains:
Gene namesi
Name:CARTPT
Synonyms:CART
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 20

Organism-specific databases

VGNCiVGNC:26774 CARTPT

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Obesity

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27By similarityAdd BLAST27
ChainiPRO_000025651628 – 116Cocaine- and amphetamine-regulated transcript proteinAdd BLAST89
PeptideiPRO_000025651728 – 66CART(1-39)By similarityAdd BLAST39
PeptideiPRO_000025651869 – 116CART(42-89)By similarityAdd BLAST48

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphotyrosineBy similarity1
Modified residuei48PhosphoserineBy similarity1
Disulfide bondi82 ↔ 100By similarity
Disulfide bondi88 ↔ 108By similarity
Disulfide bondi102 ↔ 115By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ68RJ9
PRIDEiQ68RJ9

Expressioni

Gene expression databases

BgeeiENSBTAG00000047486

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055162

Structurei

3D structure databases

ProteinModelPortaliQ68RJ9
SMRiQ68RJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CART family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0KJ Eukaryota
ENOG410YRI1 LUCA
GeneTreeiENSGT00390000018319
HOVERGENiHBG018929
InParanoidiQ68RJ9
OMAiFGQVPTC
OrthoDBiEOG091G0Y1C
TreeFamiTF332948

Family and domain databases

Gene3Di4.10.40.30, 1 hit
InterProiView protein in InterPro
IPR009106 CART
IPR036722 CART_C_sf
PANTHERiPTHR16655 PTHR16655, 1 hit
PfamiView protein in Pfam
PF06373 CART, 1 hit
SUPFAMiSSF64546 SSF64546, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68RJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESPRLRLLP LLGAALLLLL PLLGALAQED AELQPRALDI YSAVEDASHE
60 70 80 90 100
KELIEALQEV LKKLKSKRIP IYEKKYGQVP MCDAGEQCAV RKGARIGKLC
110
DCPRGTSCNS FLLKCL
Length:116
Mass (Da):12,790
Last modified:October 11, 2004 - v1
Checksum:i3664F4DBBE77106E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY603972 Genomic DNA Translation: AAT99018.1
BC114792 mRNA Translation: AAI14793.1
RefSeqiNP_001007821.1, NM_001007820.3
UniGeneiBt.20015

Genome annotation databases

EnsembliENSBTAT00000064119; ENSBTAP00000055162; ENSBTAG00000047486
GeneIDi493726
KEGGibta:493726

Similar proteinsi

Entry informationi

Entry nameiCART_BOVIN
AccessioniPrimary (citable) accession number: Q68RJ9
Secondary accession number(s): A4FUF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health