Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q68RJ9

- CART_BOVIN

UniProt

Q68RJ9 - CART_BOVIN

Protein

Cocaine- and amphetamine-regulated transcript protein

Gene

CARTPT

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus.By similarity

    GO - Biological processi

    1. activation of MAPKK activity Source: HGNC
    2. adult feeding behavior Source: HGNC
    3. cellular glucose homeostasis Source: HGNC
    4. cellular response to starvation Source: HGNC
    5. circadian regulation of gene expression Source: HGNC
    6. G-protein coupled receptor signaling pathway Source: HGNC
    7. negative regulation of appetite Source: HGNC
    8. negative regulation of bone resorption Source: Ensembl
    9. neuropeptide signaling pathway Source: UniProtKB-KW
    10. positive regulation of blood pressure Source: HGNC
    11. positive regulation of epinephrine secretion Source: HGNC
    12. positive regulation of transmission of nerve impulse Source: HGNC
    13. synaptic transmission Source: UniProtKB-KW

    Keywords - Molecular functioni

    Neuropeptide, Neurotransmitter

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cocaine- and amphetamine-regulated transcript protein
    Cleaved into the following 2 chains:
    Gene namesi
    Name:CARTPT
    Synonyms:CART
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 20

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular space Source: HGNC
    2. secretory granule Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Keywords - Diseasei

    Obesity

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727By similarityAdd
    BLAST
    Chaini28 – 11689Cocaine- and amphetamine-regulated transcript proteinPRO_0000256516Add
    BLAST
    Peptidei28 – 6639CART(1-39)By similarityPRO_0000256517Add
    BLAST
    Peptidei69 – 11648CART(42-89)By similarityPRO_0000256518Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi82 ↔ 100By similarity
    Disulfide bondi88 ↔ 108By similarity
    Disulfide bondi102 ↔ 115By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Structurei

    3D structure databases

    ProteinModelPortaliQ68RJ9.
    SMRiQ68RJ9. Positions 76-116.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CART family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    GeneTreeiENSGT00390000018319.
    HOVERGENiHBG018929.
    OMAiSHEKELP.
    OrthoDBiEOG7JDR0T.
    TreeFamiTF332948.

    Family and domain databases

    Gene3Di4.10.40.30. 1 hit.
    InterProiIPR009106. CART.
    [Graphical view]
    PANTHERiPTHR16655. PTHR16655. 1 hit.
    PfamiPF06373. CART. 1 hit.
    [Graphical view]
    SUPFAMiSSF64546. SSF64546. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q68RJ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESPRLRLLP LLGAALLLLL PLLGALAQED AELQPRALDI YSAVEDASHE    50
    KELIEALQEV LKKLKSKRIP IYEKKYGQVP MCDAGEQCAV RKGARIGKLC 100
    DCPRGTSCNS FLLKCL 116
    Length:116
    Mass (Da):12,790
    Last modified:October 11, 2004 - v1
    Checksum:i3664F4DBBE77106E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY603972 Genomic DNA. Translation: AAT99018.1.
    BC114792 mRNA. Translation: AAI14793.1.
    RefSeqiNP_001007821.1. NM_001007820.3.
    UniGeneiBt.20015.

    Genome annotation databases

    EnsembliENSBTAT00000064119; ENSBTAP00000055162; ENSBTAG00000047486.
    GeneIDi493726.
    KEGGibta:493726.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY603972 Genomic DNA. Translation: AAT99018.1 .
    BC114792 mRNA. Translation: AAI14793.1 .
    RefSeqi NP_001007821.1. NM_001007820.3.
    UniGenei Bt.20015.

    3D structure databases

    ProteinModelPortali Q68RJ9.
    SMRi Q68RJ9. Positions 76-116.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000064119 ; ENSBTAP00000055162 ; ENSBTAG00000047486 .
    GeneIDi 493726.
    KEGGi bta:493726.

    Organism-specific databases

    CTDi 9607.

    Phylogenomic databases

    GeneTreei ENSGT00390000018319.
    HOVERGENi HBG018929.
    OMAi SHEKELP.
    OrthoDBi EOG7JDR0T.
    TreeFami TF332948.

    Miscellaneous databases

    NextBioi 20865469.

    Family and domain databases

    Gene3Di 4.10.40.30. 1 hit.
    InterProi IPR009106. CART.
    [Graphical view ]
    PANTHERi PTHR16655. PTHR16655. 1 hit.
    Pfami PF06373. CART. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64546. SSF64546. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The bovine cocaine and amphetamine-regulated transcript locus: gene characterization and SNP discovery."
      Valle E., Moore S.S., Jann O., Williams J.L., Crews D.H., Benkel B.F.
      Anim. Genet. 36:74-75(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Hypothalamus.

    Entry informationi

    Entry nameiCART_BOVIN
    AccessioniPrimary (citable) accession number: Q68RJ9
    Secondary accession number(s): A4FUF3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3