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Q68RJ9

- CART_BOVIN

UniProt

Q68RJ9 - CART_BOVIN

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Protein
Cocaine- and amphetamine-regulated transcript protein
Gene
CARTPT, CART
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus By similarity.

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: HGNC
  2. activation of MAPKK activity Source: HGNC
  3. adult feeding behavior Source: HGNC
  4. cellular glucose homeostasis Source: HGNC
  5. cellular response to starvation Source: HGNC
  6. circadian regulation of gene expression Source: HGNC
  7. negative regulation of appetite Source: HGNC
  8. negative regulation of bone resorption Source: Ensembl
  9. neuropeptide signaling pathway Source: UniProtKB-KW
  10. positive regulation of blood pressure Source: HGNC
  11. positive regulation of epinephrine secretion Source: HGNC
  12. positive regulation of transmission of nerve impulse Source: HGNC
  13. synaptic transmission Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide, Neurotransmitter

Names & Taxonomyi

Protein namesi
Recommended name:
Cocaine- and amphetamine-regulated transcript protein
Cleaved into the following 2 chains:
Gene namesi
Name:CARTPT
Synonyms:CART
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 20

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular space Source: HGNC
  2. secretory granule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Obesity

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 By similarity
Add
BLAST
Chaini28 – 11689Cocaine- and amphetamine-regulated transcript protein
PRO_0000256516Add
BLAST
Peptidei28 – 6639CART(1-39) By similarity
PRO_0000256517Add
BLAST
Peptidei69 – 11648CART(42-89) By similarity
PRO_0000256518Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi82 ↔ 100 By similarity
Disulfide bondi88 ↔ 108 By similarity
Disulfide bondi102 ↔ 115 By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ68RJ9.
SMRiQ68RJ9. Positions 76-116.

Family & Domainsi

Sequence similaritiesi

Belongs to the CART family.

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000018319.
HOVERGENiHBG018929.
OMAiSHEKELP.
OrthoDBiEOG7JDR0T.
TreeFamiTF332948.

Family and domain databases

Gene3Di4.10.40.30. 1 hit.
InterProiIPR009106. CART.
[Graphical view]
PANTHERiPTHR16655. PTHR16655. 1 hit.
PfamiPF06373. CART. 1 hit.
[Graphical view]
SUPFAMiSSF64546. SSF64546. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68RJ9-1 [UniParc]FASTAAdd to Basket

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MESPRLRLLP LLGAALLLLL PLLGALAQED AELQPRALDI YSAVEDASHE    50
KELIEALQEV LKKLKSKRIP IYEKKYGQVP MCDAGEQCAV RKGARIGKLC 100
DCPRGTSCNS FLLKCL 116
Length:116
Mass (Da):12,790
Last modified:October 11, 2004 - v1
Checksum:i3664F4DBBE77106E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY603972 Genomic DNA. Translation: AAT99018.1.
BC114792 mRNA. Translation: AAI14793.1.
RefSeqiNP_001007821.1. NM_001007820.3.
UniGeneiBt.20015.

Genome annotation databases

EnsembliENSBTAT00000064119; ENSBTAP00000055162; ENSBTAG00000047486.
GeneIDi493726.
KEGGibta:493726.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY603972 Genomic DNA. Translation: AAT99018.1 .
BC114792 mRNA. Translation: AAI14793.1 .
RefSeqi NP_001007821.1. NM_001007820.3.
UniGenei Bt.20015.

3D structure databases

ProteinModelPortali Q68RJ9.
SMRi Q68RJ9. Positions 76-116.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000064119 ; ENSBTAP00000055162 ; ENSBTAG00000047486 .
GeneIDi 493726.
KEGGi bta:493726.

Organism-specific databases

CTDi 9607.

Phylogenomic databases

GeneTreei ENSGT00390000018319.
HOVERGENi HBG018929.
OMAi SHEKELP.
OrthoDBi EOG7JDR0T.
TreeFami TF332948.

Miscellaneous databases

NextBioi 20865469.

Family and domain databases

Gene3Di 4.10.40.30. 1 hit.
InterProi IPR009106. CART.
[Graphical view ]
PANTHERi PTHR16655. PTHR16655. 1 hit.
Pfami PF06373. CART. 1 hit.
[Graphical view ]
SUPFAMi SSF64546. SSF64546. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The bovine cocaine and amphetamine-regulated transcript locus: gene characterization and SNP discovery."
    Valle E., Moore S.S., Jann O., Williams J.L., Crews D.H., Benkel B.F.
    Anim. Genet. 36:74-75(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiCART_BOVIN
AccessioniPrimary (citable) accession number: Q68RJ9
Secondary accession number(s): A4FUF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 11, 2004
Last modified: February 19, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi