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Q68RJ9 (CART_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cocaine- and amphetamine-regulated transcript protein

Cleaved into the following 2 chains:

  1. CART(1-39)
  2. CART(42-89)
Gene names
Name:CARTPT
Synonyms:CART
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length116 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus By similarity.

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the CART family.

Ontologies

Keywords
   Cellular componentSecreted
   DiseaseObesity
   DomainSignal
   Molecular functionNeuropeptide
Neurotransmitter
   PTMCleavage on pair of basic residues
Disulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from sequence or structural similarity. Source: HGNC

activation of MAPKK activity

Inferred from sequence or structural similarity. Source: HGNC

adult feeding behavior

Inferred from sequence or structural similarity. Source: HGNC

cellular glucose homeostasis

Inferred from sequence or structural similarity. Source: HGNC

cellular response to starvation

Inferred from sequence or structural similarity. Source: HGNC

circadian regulation of gene expression

Inferred from sequence or structural similarity. Source: HGNC

negative regulation of appetite

Inferred from sequence or structural similarity. Source: HGNC

negative regulation of bone resorption

Inferred from electronic annotation. Source: Ensembl

neuropeptide signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of blood pressure

Inferred from sequence or structural similarity. Source: HGNC

positive regulation of epinephrine secretion

Inferred from sequence or structural similarity. Source: HGNC

positive regulation of transmission of nerve impulse

Inferred from sequence or structural similarity. Source: HGNC

synaptic transmission

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from sequence or structural similarity. Source: HGNC

secretory granule

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 By similarity
Chain28 – 11689Cocaine- and amphetamine-regulated transcript protein
PRO_0000256516
Peptide28 – 6639CART(1-39) By similarity
PRO_0000256517
Peptide69 – 11648CART(42-89) By similarity
PRO_0000256518

Amino acid modifications

Disulfide bond82 ↔ 100 By similarity
Disulfide bond88 ↔ 108 By similarity
Disulfide bond102 ↔ 115 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68RJ9 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 3664F4DBBE77106E

FASTA11612,790
        10         20         30         40         50         60 
MESPRLRLLP LLGAALLLLL PLLGALAQED AELQPRALDI YSAVEDASHE KELIEALQEV 

        70         80         90        100        110 
LKKLKSKRIP IYEKKYGQVP MCDAGEQCAV RKGARIGKLC DCPRGTSCNS FLLKCL 

« Hide

References

« Hide 'large scale' references
[1]"The bovine cocaine and amphetamine-regulated transcript locus: gene characterization and SNP discovery."
Valle E., Moore S.S., Jann O., Williams J.L., Crews D.H., Benkel B.F.
Anim. Genet. 36:74-75(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Hypothalamus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY603972 Genomic DNA. Translation: AAT99018.1.
BC114792 mRNA. Translation: AAI14793.1.
RefSeqNP_001007821.1. NM_001007820.3.
UniGeneBt.20015.

3D structure databases

ProteinModelPortalQ68RJ9.
SMRQ68RJ9. Positions 76-116.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000064119; ENSBTAP00000055162; ENSBTAG00000047486.
GeneID493726.
KEGGbta:493726.

Organism-specific databases

CTD9607.

Phylogenomic databases

GeneTreeENSGT00390000018319.
HOVERGENHBG018929.
OMASHEKELP.
OrthoDBEOG7JDR0T.
TreeFamTF332948.

Family and domain databases

Gene3D4.10.40.30. 1 hit.
InterProIPR009106. CART.
[Graphical view]
PANTHERPTHR16655. PTHR16655. 1 hit.
PfamPF06373. CART. 1 hit.
[Graphical view]
SUPFAMSSF64546. SSF64546. 1 hit.
ProtoNetSearch...

Other

NextBio20865469.

Entry information

Entry nameCART_BOVIN
AccessionPrimary (citable) accession number: Q68RJ9
Secondary accession number(s): A4FUF3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 11, 2004
Last modified: February 19, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families