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Protein

Phospholipase A1

Gene
N/A
Organism
Solenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolysis of phosphatidylcholine with phospholipase A1 (EC 3.1.1.32) activity. Has weak hemolytic activity (By similarity).By similarity1 Publication

Catalytic activityi

Phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei167NucleophileBy similarity1
Active sitei195Charge relay systemPROSITE-ProRule annotation1
Active sitei258Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Cytolysis, Hemolysis, Lipid degradation, Lipid metabolism

Protein family/group databases

ESTHERisolin-q68kk0. Phospholipase.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase A1 (EC:3.1.1.32)
Alternative name(s):
Allergen Sol i I
Venom allergen 1
Venom allergen I
Allergen: Sol i 1
OrganismiSolenopsis invicta (Red imported fire ant) (Solenopsis wagneri)
Taxonomic identifieri13686 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataVespoideaFormicidaeMyrmicinaeSolenopsis

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. It exhibits some cross-reactivity with IgE antibodies from patients sensitized to other Hymenoptera venoms.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3481. Sol i 1.0101.
630. Sol i 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PropeptideiPRO_000040192227 – 371 PublicationAdd BLAST11
ChainiPRO_500009378438 – 346Phospholipase A1Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...)Sequence analysis1
Glycosylationi72N-linked (GlcNAc...)Sequence analysis1
Glycosylationi185N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Contains six disulfide bonds.By similarity
N-glycosylated; contains mannose.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed by the venom gland.2 Publications

Structurei

3D structure databases

ProteinModelPortaliQ68KK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013818. Lipase/vitellogenin.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
[Graphical view]
PRINTSiPR00821. TAGLIPASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68KK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKFAAIFVV FFVQCTHLYS LAQARAEPDP GVVEYLKQSC VYGNSSYINV
60 70 80 90 100
YLYNSRFQGK NLGNQQSCQD INASLPVVFI THGFTSSAQV STFKDLANAF
110 120 130 140 150
VQKGHTAFIV DWSEAACTDG LPGVQFAEYN AAASNTYDIG QLMAKYTVDL
160 170 180 190 200
MNKCKIPLNN IQYVGHSLGS HVCGFAAKHV KKLINKTMPY ILALDPADPS
210 220 230 240 250
FGSNKCGERI CKSDAKRIVV FKTSILGIGE NIIGHLLIVF DGGKSQPACS
260 270 280 290 300
WYDVPCSHSE SIVYATGMVS GRCQHLAVPW TAQQRINPIQ WKFWRVFTSN
310 320 330 340
IPAYPTSDTT NCVVLNTNVF KNDNTFEGEY HAFPDCARNL FKCRQQ
Length:346
Mass (Da):38,417
Last modified:October 11, 2004 - v1
Checksum:iB0A88EC6C3D876BF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130N → G AA sequence (PubMed:8588684).Curated1
Sequence conflicti133A → S AA sequence (PubMed:8588684).Curated1
Sequence conflicti154C → W AA sequence (PubMed:8588684).Curated1
Sequence conflicti173C → S AA sequence (PubMed:8588684).Curated1
Sequence conflicti268 – 269MV → VPS AA sequence (PubMed:8588684).Curated2
Sequence conflicti343C → G AA sequence (PubMed:8588684).Curated1
Sequence conflicti346Q → QE AA sequence (PubMed:8588684).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY684998 mRNA. Translation: AAT95008.1.
RefSeqiNP_001291510.1. NM_001304581.1.
XP_011173569.1. XM_011175267.1.

Genome annotation databases

EnsemblMetazoaiXM_011175267.1; XP_011173569.1; LOC105205761.
GeneIDi105205761.
KEGGisoc:105205761.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY684998 mRNA. Translation: AAT95008.1.
RefSeqiNP_001291510.1. NM_001304581.1.
XP_011173569.1. XM_011175267.1.

3D structure databases

ProteinModelPortaliQ68KK0.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3481. Sol i 1.0101.
630. Sol i 1.
ESTHERisolin-q68kk0. Phospholipase.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiXM_011175267.1; XP_011173569.1; LOC105205761.
GeneIDi105205761.
KEGGisoc:105205761.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013818. Lipase/vitellogenin.
IPR000734. TAG_lipase.
[Graphical view]
PANTHERiPTHR11610. PTHR11610. 1 hit.
PfamiPF00151. Lipase. 1 hit.
[Graphical view]
PRINTSiPR00821. TAGLIPASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPA1_SOLIN
AccessioniPrimary (citable) accession number: Q68KK0
Secondary accession number(s): Q9TXF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: October 11, 2004
Last modified: November 30, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.