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Q68J44

- DUPD1_HUMAN

UniProt

Q68J44 - DUPD1_HUMAN

Protein

Dual specificity phosphatase DUPD1

Gene

DUPD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei147 – 1471Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein dephosphorylation Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity phosphatase DUPD1 (EC:3.1.3.16, EC:3.1.3.48)
    Alternative name(s):
    Dual specificity phosphatase 27
    Gene namesi
    Name:DUPD1
    Synonyms:DUSP27
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:23481. DUPD1.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134959776.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 220220Dual specificity phosphatase DUPD1PRO_0000295877Add
    BLAST

    Proteomic databases

    PaxDbiQ68J44.
    PRIDEiQ68J44.

    PTM databases

    PhosphoSiteiQ68J44.

    Expressioni

    Tissue specificityi

    Skeletal muscle, liver and adipose tissue.1 Publication

    Gene expression databases

    BgeeiQ68J44.
    CleanExiHS_DUPD1.
    HS_DUSP27.
    GenevestigatoriQ68J44.

    Organism-specific databases

    HPAiHPA042964.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    STRINGi9606.ENSP00000340609.

    Structurei

    Secondary structure

    1
    220
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi38 – 4710
    Beta strandi54 – 596
    Beta strandi62 – 654
    Helixi67 – 715
    Helixi73 – 786
    Beta strandi83 – 864
    Helixi97 – 1004
    Turni101 – 1033
    Beta strandi107 – 1104
    Helixi121 – 1244
    Helixi125 – 13612
    Beta strandi143 – 1464
    Beta strandi148 – 1525
    Helixi153 – 16513
    Helixi170 – 1789
    Helixi187 – 20519

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2Y96X-ray2.38A/B2-220[»]
    ProteinModelPortaliQ68J44.
    SMRiQ68J44. Positions 32-206.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini54 – 201148Tyrosine-protein phosphataseAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni146 – 1538Substrate bindingCurated

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    HOGENOMiHOG000233767.
    HOVERGENiHBG001524.
    InParanoidiQ68J44.
    KOiK14165.
    OMAiYLMIHKD.
    OrthoDBiEOG7CZK7N.
    PhylomeDBiQ68J44.
    TreeFamiTF105128.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR020417. Atypical_DUSP.
    IPR020405. Atypical_DUSP_famA.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    PRINTSiPR01908. ADSPHPHTASE.
    PR01909. ADSPHPHTASEA.
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q68J44-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSGEVKTSL KNAYSSAKRL SPKMEEEGEE EDYCTPGAFE LERLFWKGSP    50
    QYTHVNEVWP KLYIGDEATA LDRYRLQKAG FTHVLNAAHG RWNVDTGPDY 100
    YRDMDIQYHG VEADDLPTFD LSVFFYPAAA FIDRALSDDH SKILVHCVMG 150
    RSRSATLVLA YLMIHKDMTL VDAIQQVAKN RCVLPNRGFL KQLRELDKQL 200
    VQQRRRSQRQ DGEEEDGREL 220
    Length:220
    Mass (Da):25,336
    Last modified:October 11, 2004 - v1
    Checksum:iA4DA1E37FD39D5A3
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti66 – 661D → N.
    Corresponds to variant rs11594934 [ dbSNP | Ensembl ].
    VAR_051757
    Natural varianti137 – 1371S → R.
    Corresponds to variant rs16931938 [ dbSNP | Ensembl ].
    VAR_033376

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY686755 mRNA. Translation: AAT94288.1.
    BC137321 mRNA. Translation: AAI37322.1.
    BC137322 mRNA. Translation: AAI37323.1.
    CCDSiCCDS31223.1.
    RefSeqiNP_001003892.1. NM_001003892.1.
    XP_005269819.1. XM_005269762.1.
    UniGeneiHs.535090.

    Genome annotation databases

    EnsembliENST00000338487; ENSP00000340609; ENSG00000188716.
    GeneIDi338599.
    KEGGihsa:338599.
    UCSCiuc001jwq.1. human.

    Polymorphism databases

    DMDMi74748317.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY686755 mRNA. Translation: AAT94288.1 .
    BC137321 mRNA. Translation: AAI37322.1 .
    BC137322 mRNA. Translation: AAI37323.1 .
    CCDSi CCDS31223.1.
    RefSeqi NP_001003892.1. NM_001003892.1.
    XP_005269819.1. XM_005269762.1.
    UniGenei Hs.535090.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2Y96 X-ray 2.38 A/B 2-220 [» ]
    ProteinModelPortali Q68J44.
    SMRi Q68J44. Positions 32-206.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000340609.

    PTM databases

    PhosphoSitei Q68J44.

    Polymorphism databases

    DMDMi 74748317.

    Proteomic databases

    PaxDbi Q68J44.
    PRIDEi Q68J44.

    Protocols and materials databases

    DNASUi 338599.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338487 ; ENSP00000340609 ; ENSG00000188716 .
    GeneIDi 338599.
    KEGGi hsa:338599.
    UCSCi uc001jwq.1. human.

    Organism-specific databases

    CTDi 338599.
    GeneCardsi GC10M076797.
    HGNCi HGNC:23481. DUPD1.
    HPAi HPA042964.
    neXtProti NX_Q68J44.
    PharmGKBi PA134959776.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2453.
    HOGENOMi HOG000233767.
    HOVERGENi HBG001524.
    InParanoidi Q68J44.
    KOi K14165.
    OMAi YLMIHKD.
    OrthoDBi EOG7CZK7N.
    PhylomeDBi Q68J44.
    TreeFami TF105128.

    Miscellaneous databases

    GenomeRNAii 338599.
    NextBioi 97059.
    PROi Q68J44.

    Gene expression databases

    Bgeei Q68J44.
    CleanExi HS_DUPD1.
    HS_DUSP27.
    Genevestigatori Q68J44.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR020417. Atypical_DUSP.
    IPR020405. Atypical_DUSP_famA.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    PRINTSi PR01908. ADSPHPHTASE.
    PR01909. ADSPHPHTASEA.
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of DUSP27, a novel dual-specific protein phosphatase."
      Friedberg I., Nika K., Tautz L., Saito K., Cerignoli F., Friedberg I., Godzik A., Mustelin T.
      FEBS Lett. 581:2527-2533(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Structure of human dual-specificity phosphatase 27 at 2.38 A resolution."
      Lountos G.T., Tropea J.E., Waugh D.S.
      Acta Crystallogr. D 67:471-479(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.38 ANGSTROMS) IN COMPLEX WITH SULFATE, SUBUNIT.

    Entry informationi

    Entry nameiDUPD1_HUMAN
    AccessioniPrimary (citable) accession number: Q68J44
    Secondary accession number(s): B2RP93
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3