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Protein

Dual specificity phosphatase DUPD1

Gene

DUPD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei147 – 1471Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity phosphatase DUPD1 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Dual specificity phosphatase 27
Gene namesi
Name:DUPD1
Synonyms:DUSP27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 1, Chromosome 10

Organism-specific databases

HGNCiHGNC:23481. DUPD1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134959776.

Polymorphism and mutation databases

BioMutaiDUPD1.
DMDMi74748317.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Dual specificity phosphatase DUPD1PRO_0000295877Add
BLAST

Proteomic databases

PaxDbiQ68J44.
PRIDEiQ68J44.

PTM databases

DEPODiQ68J44.
PhosphoSiteiQ68J44.

Expressioni

Tissue specificityi

Skeletal muscle, liver and adipose tissue.1 Publication

Gene expression databases

BgeeiQ68J44.
CleanExiHS_DUPD1.
HS_DUSP27.

Organism-specific databases

HPAiHPA042964.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000340609.

Structurei

Secondary structure

1
220
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi38 – 4710Combined sources
Beta strandi54 – 596Combined sources
Beta strandi62 – 654Combined sources
Helixi67 – 715Combined sources
Helixi73 – 786Combined sources
Beta strandi83 – 864Combined sources
Helixi97 – 1004Combined sources
Turni101 – 1033Combined sources
Beta strandi107 – 1104Combined sources
Helixi121 – 1244Combined sources
Helixi125 – 13612Combined sources
Beta strandi143 – 1464Combined sources
Beta strandi148 – 1525Combined sources
Helixi153 – 16513Combined sources
Helixi170 – 1789Combined sources
Helixi187 – 20519Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Y96X-ray2.38A/B2-220[»]
ProteinModelPortaliQ68J44.
SMRiQ68J44. Positions 32-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 201148Tyrosine-protein phosphataseAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni146 – 1538Substrate bindingCurated

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000233767.
HOVERGENiHBG001524.
InParanoidiQ68J44.
KOiK14165.
OMAiRRAECAI.
OrthoDBiEOG7CZK7N.
PhylomeDBiQ68J44.
TreeFamiTF105128.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68J44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSGEVKTSL KNAYSSAKRL SPKMEEEGEE EDYCTPGAFE LERLFWKGSP
60 70 80 90 100
QYTHVNEVWP KLYIGDEATA LDRYRLQKAG FTHVLNAAHG RWNVDTGPDY
110 120 130 140 150
YRDMDIQYHG VEADDLPTFD LSVFFYPAAA FIDRALSDDH SKILVHCVMG
160 170 180 190 200
RSRSATLVLA YLMIHKDMTL VDAIQQVAKN RCVLPNRGFL KQLRELDKQL
210 220
VQQRRRSQRQ DGEEEDGREL
Length:220
Mass (Da):25,336
Last modified:October 11, 2004 - v1
Checksum:iA4DA1E37FD39D5A3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti66 – 661D → N.
Corresponds to variant rs11594934 [ dbSNP | Ensembl ].
VAR_051757
Natural varianti137 – 1371S → R.
Corresponds to variant rs16931938 [ dbSNP | Ensembl ].
VAR_033376

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY686755 mRNA. Translation: AAT94288.1.
BC137321 mRNA. Translation: AAI37322.1.
BC137322 mRNA. Translation: AAI37323.1.
CCDSiCCDS31223.1.
RefSeqiNP_001003892.1. NM_001003892.1.
XP_005269819.1. XM_005269762.2.
XP_011538049.1. XM_011539747.1.
XP_011547079.1. XM_011548777.1.
UniGeneiHs.535090.

Genome annotation databases

EnsembliENST00000338487; ENSP00000340609; ENSG00000188716.
ENST00000625469; ENSP00000487404; ENSG00000281660.
GeneIDi338599.
KEGGihsa:338599.
UCSCiuc001jwq.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY686755 mRNA. Translation: AAT94288.1.
BC137321 mRNA. Translation: AAI37322.1.
BC137322 mRNA. Translation: AAI37323.1.
CCDSiCCDS31223.1.
RefSeqiNP_001003892.1. NM_001003892.1.
XP_005269819.1. XM_005269762.2.
XP_011538049.1. XM_011539747.1.
XP_011547079.1. XM_011548777.1.
UniGeneiHs.535090.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Y96X-ray2.38A/B2-220[»]
ProteinModelPortaliQ68J44.
SMRiQ68J44. Positions 32-206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000340609.

PTM databases

DEPODiQ68J44.
PhosphoSiteiQ68J44.

Polymorphism and mutation databases

BioMutaiDUPD1.
DMDMi74748317.

Proteomic databases

PaxDbiQ68J44.
PRIDEiQ68J44.

Protocols and materials databases

DNASUi338599.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338487; ENSP00000340609; ENSG00000188716.
ENST00000625469; ENSP00000487404; ENSG00000281660.
GeneIDi338599.
KEGGihsa:338599.
UCSCiuc001jwq.1. human.

Organism-specific databases

CTDi338599.
GeneCardsiGC10M076797.
HGNCiHGNC:23481. DUPD1.
HPAiHPA042964.
neXtProtiNX_Q68J44.
PharmGKBiPA134959776.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000233767.
HOVERGENiHBG001524.
InParanoidiQ68J44.
KOiK14165.
OMAiRRAECAI.
OrthoDBiEOG7CZK7N.
PhylomeDBiQ68J44.
TreeFamiTF105128.

Miscellaneous databases

GenomeRNAii338599.
NextBioi97059.
PROiQ68J44.

Gene expression databases

BgeeiQ68J44.
CleanExiHS_DUPD1.
HS_DUSP27.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of DUSP27, a novel dual-specific protein phosphatase."
    Friedberg I., Nika K., Tautz L., Saito K., Cerignoli F., Friedberg I., Godzik A., Mustelin T.
    FEBS Lett. 581:2527-2533(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Structure of human dual-specificity phosphatase 27 at 2.38 A resolution."
    Lountos G.T., Tropea J.E., Waugh D.S.
    Acta Crystallogr. D 67:471-479(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.38 ANGSTROMS) IN COMPLEX WITH SULFATE, SUBUNIT.

Entry informationi

Entry nameiDUPD1_HUMAN
AccessioniPrimary (citable) accession number: Q68J44
Secondary accession number(s): B2RP93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 11, 2004
Last modified: July 22, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.