Reviewed, UniProtKB/Swiss-Prot Q68J44 (DUPD1_HUMAN)

Names and origin

Protein names

Recommended name:
    Dual specificity phosphatase DUPD1
    EC=3.1.3.48
    EC=3.1.3.16
Alternative name(s):
    Dual specificity phosphatase 27

Gene names

Name:	DUPD1
Synonyms:	DUSP27

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Cytoplasm Ref.1.
Tissue specificity	Skeletal muscle, liver and adipose tissue. Ref.1
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein amino acid dephosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 220	220	Dual specificity phosphatase DUPD1		PRO_0000295877
Regions
	Domain	54 – 201	148	Tyrosine-protein phosphatase
Sites
	Active site	147	1	Phosphocysteine intermediate By similarity
Natural variations
	Natural variant	66	1	D → N: dbSNP rs11594934.		VAR_051757
	Natural variant	137	1	S → R: dbSNP rs16931938.		VAR_033376

Sequences

	Sequence		Length	Mass (Da)
	Q68J44-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: A4DA1E37FD39D5A3	FASTA	220	25,336
	10 20 30 40 50 60 MTSGEVKTSL KNAYSSAKRL SPKMEEEGEE EDYCTPGAFE LERLFWKGSP QYTHVNEVWP 70 80 90 100 110 120 KLYIGDEATA LDRYRLQKAG FTHVLNAAHG RWNVDTGPDY YRDMDIQYHG VEADDLPTFD 130 140 150 160 170 180 LSVFFYPAAA FIDRALSDDH SKILVHCVMG RSRSATLVLA YLMIHKDMTL VDAIQQVAKN 190 200 210 220 RCVLPNRGFL KQLRELDKQL VQQRRRSQRQ DGEEEDGREL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of DUSP27, a novel dual-specific protein phosphatase." Friedberg I., Nika K., Tautz L., Saito K., Cerignoli F., Friedberg I., Godzik A., Mustelin T. FEBS Lett. 581:2527-2533(2007) [PubMed: 17498703] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY686755 mRNA. Translation: AAT94288.1. BC137321 mRNA. Translation: AAI37322.1. BC137322 mRNA. Translation: AAI37323.1.
IPI	IPI00456156.
RefSeq	NP_001003892.1.
UniGene	Hs.535090
3D structure databases
HSSP	HSSP built from PDB template 1VHR based on UniProtKB P51452.
SMR	Q68J44. Positions 40-205.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q68J44. 2 interactions.
Proteomic databases
PRIDE	Q68J44.
Genome annotation databases
Ensembl	ENST00000338487; ENSP00000340609; ENSG00000188716; Homo sapiens. [Genome view]
GeneID	338599.
KEGG	hsa:338599.
UCSC	uc001jwq.1. human.
Organism-specific databases
CTD	338599.
GeneCards	GC10M076467.
HGNC	HGNC:23481. DUPD1.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18608.
HOGENOM	HBG717377.
HOVERGEN	Q68J44.
InParanoid	Q68J44.
OMA	HSKILVH.
OrthoDB	EOG9DBX09.
Enzyme and pathway databases
BRENDA	3.1.3.16. 247. 3.1.3.48. 247.
Gene expression databases
ArrayExpress	Q68J44.
CleanEx	HS_DUPD1. HS_DUSP27.
Genevestigator	Q68J44.
Family and domain databases
InterPro	IPR000387. Dual-sp/Tyr_phosphatase. IPR020417. Dual-sp_phosphatase. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020405. Dual-sp_phosphatase_famA. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR016130. Tyr_Pase_AS. [Graphical view]
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PRINTS	PR01908. ADSPHPHTASE. PR01909. ADSPHPHTASEA.
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	97059.

Entry information

Entry name

DUPD1_HUMAN

Accession

Primary (citable) accession number: Q68J44
Secondary accession number(s): B2RP93

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	October 11, 2004
Last modified:	January 19, 2010
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.