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Q68J44 (DUPD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity phosphatase DUPD1

EC=3.1.3.16
EC=3.1.3.48
Alternative name(s):
Dual specificity phosphatase 27
Gene names
Name:DUPD1
Synonyms:DUSP27
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Homodimer. Ref.3

Subcellular location

Cytoplasm Ref.1.

Tissue specificity

Skeletal muscle, liver and adipose tissue. Ref.1

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityPolymorphism
   Molecular functionHydrolase
Protein phosphatase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpeptidyl-tyrosine dephosphorylation

Inferred from electronic annotation. Source: GOC

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

protein tyrosine/serine/threonine phosphatase activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 220220Dual specificity phosphatase DUPD1
PRO_0000295877

Regions

Domain54 – 201148Tyrosine-protein phosphatase
Region146 – 1538Substrate binding Probable

Sites

Active site1471Phosphocysteine intermediate By similarity

Natural variations

Natural variant661D → N.
Corresponds to variant rs11594934 [ dbSNP | Ensembl ].
VAR_051757
Natural variant1371S → R.
Corresponds to variant rs16931938 [ dbSNP | Ensembl ].
VAR_033376

Secondary structure

.............................. 220
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q68J44 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: A4DA1E37FD39D5A3

FASTA22025,336
        10         20         30         40         50         60 
MTSGEVKTSL KNAYSSAKRL SPKMEEEGEE EDYCTPGAFE LERLFWKGSP QYTHVNEVWP 

        70         80         90        100        110        120 
KLYIGDEATA LDRYRLQKAG FTHVLNAAHG RWNVDTGPDY YRDMDIQYHG VEADDLPTFD 

       130        140        150        160        170        180 
LSVFFYPAAA FIDRALSDDH SKILVHCVMG RSRSATLVLA YLMIHKDMTL VDAIQQVAKN 

       190        200        210        220 
RCVLPNRGFL KQLRELDKQL VQQRRRSQRQ DGEEEDGREL 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of DUSP27, a novel dual-specific protein phosphatase."
Friedberg I., Nika K., Tautz L., Saito K., Cerignoli F., Friedberg I., Godzik A., Mustelin T.
FEBS Lett. 581:2527-2533(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Structure of human dual-specificity phosphatase 27 at 2.38 A resolution."
Lountos G.T., Tropea J.E., Waugh D.S.
Acta Crystallogr. D 67:471-479(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.38 ANGSTROMS) IN COMPLEX WITH SULFATE, SUBUNIT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY686755 mRNA. Translation: AAT94288.1.
BC137321 mRNA. Translation: AAI37322.1.
BC137322 mRNA. Translation: AAI37323.1.
RefSeqNP_001003892.1. NM_001003892.1.
XP_005269819.1. XM_005269762.1.
XP_005269820.1. XM_005269763.1.
UniGeneHs.535090.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2Y96X-ray2.38A/B2-220[»]
ProteinModelPortalQ68J44.
SMRQ68J44. Positions 32-206.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000340609.

PTM databases

PhosphoSiteQ68J44.

Polymorphism databases

DMDM74748317.

Proteomic databases

PaxDbQ68J44.
PRIDEQ68J44.

Protocols and materials databases

DNASU338599.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000338487; ENSP00000340609; ENSG00000188716.
GeneID338599.
KEGGhsa:338599.
UCSCuc001jwq.1. human.

Organism-specific databases

CTD338599.
GeneCardsGC10M076797.
HGNCHGNC:23481. DUPD1.
HPAHPA042964.
neXtProtNX_Q68J44.
PharmGKBPA134959776.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2453.
HOGENOMHOG000233767.
HOVERGENHBG001524.
InParanoidQ68J44.
KOK14165.
OMAYLMIHKD.
OrthoDBEOG7CZK7N.
TreeFamTF105128.

Gene expression databases

BgeeQ68J44.
CleanExHS_DUPD1.
HS_DUSP27.
GenevestigatorQ68J44.

Family and domain databases

InterProIPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSPR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi338599.
NextBio97059.
PROQ68J44.

Entry information

Entry nameDUPD1_HUMAN
AccessionPrimary (citable) accession number: Q68J44
Secondary accession number(s): B2RP93
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 11, 2004
Last modified: February 19, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM