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Protein

Dual specificity phosphatase DUPD1

Gene

DUPD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei147Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciZFISH:G66-32777-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity phosphatase DUPD1 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Dual specificity phosphatase 27
Gene namesi
Name:DUPD1
Synonyms:DUSP27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23481. DUPD1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188716.
ENSG00000281660.
PharmGKBiPA134959776.

Polymorphism and mutation databases

BioMutaiDUPD1.
DMDMi74748317.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002958771 – 220Dual specificity phosphatase DUPD1Add BLAST220

Proteomic databases

PaxDbiQ68J44.
PeptideAtlasiQ68J44.
PRIDEiQ68J44.

PTM databases

DEPODiQ68J44.
iPTMnetiQ68J44.
PhosphoSitePlusiQ68J44.

Expressioni

Tissue specificityi

Skeletal muscle, liver and adipose tissue.1 Publication

Gene expression databases

BgeeiENSG00000188716.
CleanExiHS_DUPD1.
HS_DUSP27.

Organism-specific databases

HPAiHPA042964.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

IntActiQ68J44. 5 interactors.
STRINGi9606.ENSP00000340609.

Structurei

Secondary structure

1220
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi38 – 47Combined sources10
Beta strandi54 – 59Combined sources6
Beta strandi62 – 65Combined sources4
Helixi67 – 71Combined sources5
Helixi73 – 78Combined sources6
Beta strandi83 – 86Combined sources4
Helixi97 – 100Combined sources4
Turni101 – 103Combined sources3
Beta strandi107 – 110Combined sources4
Helixi121 – 124Combined sources4
Helixi125 – 136Combined sources12
Beta strandi143 – 146Combined sources4
Beta strandi148 – 152Combined sources5
Helixi153 – 165Combined sources13
Helixi170 – 178Combined sources9
Helixi187 – 205Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Y96X-ray2.38A/B2-220[»]
ProteinModelPortaliQ68J44.
SMRiQ68J44.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 201Tyrosine-protein phosphataseAdd BLAST148

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni146 – 153Substrate bindingCurated8

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000233767.
HOVERGENiHBG001524.
InParanoidiQ68J44.
KOiK14165.
OMAiCDEVYPR.
OrthoDBiEOG091G0249.
PhylomeDBiQ68J44.
TreeFamiTF105128.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68J44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSGEVKTSL KNAYSSAKRL SPKMEEEGEE EDYCTPGAFE LERLFWKGSP
60 70 80 90 100
QYTHVNEVWP KLYIGDEATA LDRYRLQKAG FTHVLNAAHG RWNVDTGPDY
110 120 130 140 150
YRDMDIQYHG VEADDLPTFD LSVFFYPAAA FIDRALSDDH SKILVHCVMG
160 170 180 190 200
RSRSATLVLA YLMIHKDMTL VDAIQQVAKN RCVLPNRGFL KQLRELDKQL
210 220
VQQRRRSQRQ DGEEEDGREL
Length:220
Mass (Da):25,336
Last modified:October 11, 2004 - v1
Checksum:iA4DA1E37FD39D5A3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05175766D → N.Corresponds to variant rs11594934dbSNPEnsembl.1
Natural variantiVAR_033376137S → R.Corresponds to variant rs16931938dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY686755 mRNA. Translation: AAT94288.1.
BC137321 mRNA. Translation: AAI37322.1.
BC137322 mRNA. Translation: AAI37323.1.
CCDSiCCDS31223.1.
RefSeqiNP_001003892.1. NM_001003892.1.
XP_011538049.1. XM_011539747.2.
UniGeneiHs.535090.

Genome annotation databases

EnsembliENST00000338487; ENSP00000340609; ENSG00000188716.
ENST00000625469; ENSP00000487404; ENSG00000281660.
GeneIDi338599.
KEGGihsa:338599.
UCSCiuc001jwq.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY686755 mRNA. Translation: AAT94288.1.
BC137321 mRNA. Translation: AAI37322.1.
BC137322 mRNA. Translation: AAI37323.1.
CCDSiCCDS31223.1.
RefSeqiNP_001003892.1. NM_001003892.1.
XP_011538049.1. XM_011539747.2.
UniGeneiHs.535090.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Y96X-ray2.38A/B2-220[»]
ProteinModelPortaliQ68J44.
SMRiQ68J44.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ68J44. 5 interactors.
STRINGi9606.ENSP00000340609.

PTM databases

DEPODiQ68J44.
iPTMnetiQ68J44.
PhosphoSitePlusiQ68J44.

Polymorphism and mutation databases

BioMutaiDUPD1.
DMDMi74748317.

Proteomic databases

PaxDbiQ68J44.
PeptideAtlasiQ68J44.
PRIDEiQ68J44.

Protocols and materials databases

DNASUi338599.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338487; ENSP00000340609; ENSG00000188716.
ENST00000625469; ENSP00000487404; ENSG00000281660.
GeneIDi338599.
KEGGihsa:338599.
UCSCiuc001jwq.1. human.

Organism-specific databases

CTDi338599.
GeneCardsiDUPD1.
HGNCiHGNC:23481. DUPD1.
HPAiHPA042964.
neXtProtiNX_Q68J44.
OpenTargetsiENSG00000188716.
ENSG00000281660.
PharmGKBiPA134959776.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000233767.
HOVERGENiHBG001524.
InParanoidiQ68J44.
KOiK14165.
OMAiCDEVYPR.
OrthoDBiEOG091G0249.
PhylomeDBiQ68J44.
TreeFamiTF105128.

Enzyme and pathway databases

BioCyciZFISH:G66-32777-MONOMER.

Miscellaneous databases

GenomeRNAii338599.
PROiQ68J44.

Gene expression databases

BgeeiENSG00000188716.
CleanExiHS_DUPD1.
HS_DUSP27.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR020405. Atypical_DUSP_famA.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDUPD1_HUMAN
AccessioniPrimary (citable) accession number: Q68J44
Secondary accession number(s): B2RP93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 11, 2004
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.