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Reviewed, UniProtKB/Swiss-Prot Q68J44 (DUPD1_HUMAN)

Last modified January 19, 2010. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Dual specificity phosphatase DUPD1
    EC=3.1.3.48
    EC=3.1.3.16
Alternative name(s):
    Dual specificity phosphatase 27
Gene names
Name: DUPD1
Synonyms: DUSP27
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

A phosphoprotein + H2O = a protein + phosphate.

Subcellular location

Cytoplasm Ref.1.

Tissue specificity

Skeletal muscle, liver and adipose tissue. Ref.1

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityPolymorphism
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processprotein amino acid dephosphorylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: EC

protein tyrosine/serine/threonine phosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 220220Dual specificity phosphatase DUPD1
PRO_0000295877

Regions

Domain54 – 201148Tyrosine-protein phosphatase

Sites

Active site1471Phosphocysteine intermediate By similarity

Natural variations

Natural variant661D → N: dbSNP rs11594934.
VAR_051757
Natural variant1371S → R: dbSNP rs16931938.
VAR_033376

Sequences

Sequence LengthMass (Da)Tools
Q68J44-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: A4DA1E37FD39D5A3

FASTA22025,336
        10         20         30         40         50         60 
MTSGEVKTSL KNAYSSAKRL SPKMEEEGEE EDYCTPGAFE LERLFWKGSP QYTHVNEVWP 

        70         80         90        100        110        120 
KLYIGDEATA LDRYRLQKAG FTHVLNAAHG RWNVDTGPDY YRDMDIQYHG VEADDLPTFD 

       130        140        150        160        170        180 
LSVFFYPAAA FIDRALSDDH SKILVHCVMG RSRSATLVLA YLMIHKDMTL VDAIQQVAKN 

       190        200        210        220 
RCVLPNRGFL KQLRELDKQL VQQRRRSQRQ DGEEEDGREL 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of DUSP27, a novel dual-specific protein phosphatase."
Friedberg I., Nika K., Tautz L., Saito K., Cerignoli F., Friedberg I., Godzik A., Mustelin T.
FEBS Lett. 581:2527-2533(2007) [PubMed: 17498703] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY686755 mRNA. Translation: AAT94288.1.
BC137321 mRNA. Translation: AAI37322.1.
BC137322 mRNA. Translation: AAI37323.1.
IPIIPI00456156.
RefSeqNP_001003892.1.
UniGeneHs.535090

3D structure databases

HSSPHSSP built from PDB template 1VHR based on UniProtKB P51452.
SMRQ68J44. Positions 40-205.
ModBaseSearch...

Protein-protein interaction databases

IntActQ68J44. 2 interactions.

Proteomic databases

PRIDEQ68J44.

Genome annotation databases

EnsemblENST00000338487; ENSP00000340609; ENSG00000188716; Homo sapiens. [Genome view]
GeneID338599.
KEGGhsa:338599.
UCSCuc001jwq.1. human.

Organism-specific databases

CTD338599.
GeneCardsGC10M076467.
HGNCHGNC:23481. DUPD1.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG18608.
HOGENOMHBG717377.
HOVERGENQ68J44.
InParanoidQ68J44.
OMAHSKILVH.
OrthoDBEOG9DBX09.

Enzyme and pathway databases

BRENDA3.1.3.16. 247.
3.1.3.48. 247.

Gene expression databases

ArrayExpressQ68J44.
CleanExHS_DUPD1.
HS_DUSP27.
GenevestigatorQ68J44.

Family and domain databases

InterProIPR000387. Dual-sp/Tyr_phosphatase.
IPR020417. Dual-sp_phosphatase.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020405. Dual-sp_phosphatase_famA.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSPR01908. ADSPHPHTASE.
PR01909. ADSPHPHTASEA.
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio97059.

Entry information

Entry nameDUPD1_HUMAN
AccessionPrimary (citable) accession number: Q68J44
Secondary accession number(s): B2RP93
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 11, 2004
Last modified: January 19, 2010
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents