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Protein

Dual specificity phosphatase DUPD1

Gene

DUPD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.1 Publication
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.1 Publication

Kineticsi

kcat is 0.330 sec(-1) for para-nitrophenylphosphate.1 Publication
  1. KM=1.02 mM for para-nitrophenylphosphate (at pH 5.5)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Active sitei147Phosphocysteine intermediatePROSITE-ProRule annotation1

    GO - Molecular functioni

    • protein homodimerization activity Source: UniProtKB
    • protein tyrosine/serine/threonine phosphatase activity Source: UniProtKB
    • protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    • protein dephosphorylation Source: UniProtKB

    Keywordsi

    Molecular functionHydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity phosphatase DUPD1Curated (EC:3.1.3.161 Publication, EC:3.1.3.481 Publication)
    Alternative name(s):
    Dual specificity phosphatase 272 Publications
    Gene namesi
    Name:DUPD1Imported
    Synonyms:DUSP272 Publications
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 10

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000188716.5.
    HGNCiHGNC:23481. DUPD1.

    Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    OpenTargetsiENSG00000188716.
    PharmGKBiPA134959776.

    Polymorphism and mutation databases

    BioMutaiDUPD1.
    DMDMi74748317.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00002958771 – 220Dual specificity phosphatase DUPD1Add BLAST220

    Proteomic databases

    EPDiQ68J44.
    PaxDbiQ68J44.
    PeptideAtlasiQ68J44.
    PRIDEiQ68J44.

    PTM databases

    DEPODiQ68J44.
    iPTMnetiQ68J44.
    PhosphoSitePlusiQ68J44.

    Expressioni

    Gene expression databases

    BgeeiENSG00000188716.
    CleanExiHS_DUPD1.
    HS_DUSP27.

    Organism-specific databases

    HPAiHPA042964.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ASPAP453814EBI-1054321,EBI-750475

    GO - Molecular functioni

    • protein homodimerization activity Source: UniProtKB

    Protein-protein interaction databases

    BioGridi130766. 13 interactors.
    IntActiQ68J44. 13 interactors.
    STRINGi9606.ENSP00000340609.

    Structurei

    Secondary structure

    1220
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Helixi38 – 47Combined sources10
    Beta strandi54 – 59Combined sources6
    Beta strandi62 – 65Combined sources4
    Helixi67 – 71Combined sources5
    Helixi73 – 78Combined sources6
    Beta strandi83 – 86Combined sources4
    Helixi97 – 100Combined sources4
    Turni101 – 103Combined sources3
    Beta strandi107 – 110Combined sources4
    Helixi121 – 124Combined sources4
    Helixi125 – 136Combined sources12
    Beta strandi143 – 146Combined sources4
    Beta strandi148 – 152Combined sources5
    Helixi153 – 165Combined sources13
    Helixi170 – 178Combined sources9
    Helixi187 – 205Combined sources19

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2Y96X-ray2.38A/B2-220[»]
    ProteinModelPortaliQ68J44.
    SMRiQ68J44.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini54 – 201Tyrosine-protein phosphataseAdd BLAST148

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni146 – 153Substrate bindingCurated8

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiKOG1716. Eukaryota.
    COG2453. LUCA.
    GeneTreeiENSGT00760000118853.
    HOGENOMiHOG000233767.
    HOVERGENiHBG001524.
    InParanoidiQ68J44.
    KOiK14165.
    OMAiAKFIDSA.
    OrthoDBiEOG091G0249.
    PhylomeDBiQ68J44.
    TreeFamiTF105128.

    Family and domain databases

    CDDicd00127. DSPc. 1 hit.
    Gene3Di3.90.190.10. 1 hit.
    InterProiView protein in InterPro
    IPR020417. Atypical_DUSP.
    IPR020405. Atypical_DUSP_famA.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR016130. Tyr_Pase_AS.
    IPR000387. TYR_PHOSPHATASE_dom.
    IPR020422. TYR_PHOSPHATASE_DUAL_dom.
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiView protein in Pfam
    PF00782. DSPc. 1 hit.
    PRINTSiPR01908. ADSPHPHTASE.
    PR01909. ADSPHPHTASEA.
    SMARTiView protein in SMART
    SM00195. DSPc. 1 hit.
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiView protein in PROSITE
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q68J44-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MTSGEVKTSL KNAYSSAKRL SPKMEEEGEE EDYCTPGAFE LERLFWKGSP
    60 70 80 90 100
    QYTHVNEVWP KLYIGDEATA LDRYRLQKAG FTHVLNAAHG RWNVDTGPDY
    110 120 130 140 150
    YRDMDIQYHG VEADDLPTFD LSVFFYPAAA FIDRALSDDH SKILVHCVMG
    160 170 180 190 200
    RSRSATLVLA YLMIHKDMTL VDAIQQVAKN RCVLPNRGFL KQLRELDKQL
    210 220
    VQQRRRSQRQ DGEEEDGREL
    Length:220
    Mass (Da):25,336
    Last modified:October 11, 2004 - v1
    Checksum:iA4DA1E37FD39D5A3
    GO

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_05175766D → N. Corresponds to variant dbSNP:rs11594934Ensembl.1
    Natural variantiVAR_033376137S → R. Corresponds to variant dbSNP:rs16931938Ensembl.1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY686755 mRNA. Translation: AAT94288.1.
    BC137321 mRNA. Translation: AAI37322.1.
    BC137322 mRNA. Translation: AAI37323.1.
    CCDSiCCDS31223.1.
    RefSeqiNP_001003892.1. NM_001003892.1.
    XP_011538049.1. XM_011539747.2.
    UniGeneiHs.535090.

    Genome annotation databases

    EnsembliENST00000338487; ENSP00000340609; ENSG00000188716.
    ENST00000625469; ENSP00000487404; ENSG00000281660.
    GeneIDi338599.
    KEGGihsa:338599.
    UCSCiuc001jwq.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Similar proteinsi

    Entry informationi

    Entry nameiDUPD1_HUMAN
    AccessioniPrimary (citable) accession number: Q68J44
    Secondary accession number(s): B2RP93
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: October 11, 2004
    Last modified: October 25, 2017
    This is version 111 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families