Q68J44 (DUPD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 72.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Dual specificity phosphatase DUPD1 EC=3.1.3.16 EC=3.1.3.48 Alternative name(s): Dual specificity phosphatase 27 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Reference proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 220 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Catalytic activity | Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate. |
| Subunit structure | Homodimer. Ref.3 |
| Subcellular location | |
| Tissue specificity | Skeletal muscle, liver and adipose tissue. Ref.1 |
| Sequence similarities | Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Coding sequence diversity | Polymorphism |
| Molecular function | Hydrolase Protein phosphatase |
| Technical term | 3D-structure Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC |
| Cellular_component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activityInferred from Biological aspect of Ancestor. Source: RefGenome |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||||||||||||||||||
Molecule processing | ||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 220 | 220 | Dual specificity phosphatase DUPD1 | PRO_0000295877 | ||||||||||||||||||||||||||||||||||
Regions | ||||||||||||||||||||||||||||||||||||||
| Domain | 54 – 201 | 148 | Tyrosine-protein phosphatase | |||||||||||||||||||||||||||||||||||
| Region | 146 – 153 | 8 | Substrate binding Probable | |||||||||||||||||||||||||||||||||||
Sites | ||||||||||||||||||||||||||||||||||||||
| Active site | 147 | 1 | Phosphocysteine intermediate By similarity | |||||||||||||||||||||||||||||||||||
Natural variations | ||||||||||||||||||||||||||||||||||||||
| Natural variant | 66 | 1 | D → N. Corresponds to variant rs11594934 [ dbSNP | Ensembl ]. | VAR_051757 | ||||||||||||||||||||||||||||||||||
| Natural variant | 137 | 1 | S → R. Corresponds to variant rs16931938 [ dbSNP | Ensembl ]. | VAR_033376 | ||||||||||||||||||||||||||||||||||
Secondary structure | ||||||||||||||||||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||||||||||||||||||
| Helix | 38 – 47 | 10 | ||||||||||||||||||||||||||||||||||||
| Beta strand | 54 – 59 | 6 | ||||||||||||||||||||||||||||||||||||
| Beta strand | 62 – 65 | 4 | ||||||||||||||||||||||||||||||||||||
| Helix | 67 – 71 | 5 | ||||||||||||||||||||||||||||||||||||
| Helix | 73 – 78 | 6 | ||||||||||||||||||||||||||||||||||||
| Beta strand | 83 – 86 | 4 | ||||||||||||||||||||||||||||||||||||
| Helix | 97 – 100 | 4 | ||||||||||||||||||||||||||||||||||||
| Turn | 101 – 103 | 3 | ||||||||||||||||||||||||||||||||||||
| Beta strand | 107 – 110 | 4 | ||||||||||||||||||||||||||||||||||||
| Helix | 121 – 124 | 4 | ||||||||||||||||||||||||||||||||||||
| Helix | 125 – 136 | 12 | ||||||||||||||||||||||||||||||||||||
| Beta strand | 143 – 146 | 4 | ||||||||||||||||||||||||||||||||||||
| Beta strand | 148 – 152 | 5 | ||||||||||||||||||||||||||||||||||||
| Helix | 153 – 165 | 13 | ||||||||||||||||||||||||||||||||||||
| Helix | 170 – 178 | 9 | ||||||||||||||||||||||||||||||||||||
| Helix | 187 – 205 | 19 | ||||||||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification and characterization of DUSP27, a novel dual-specific protein phosphatase." Friedberg I., Nika K., Tautz L., Saito K., Cerignoli F., Friedberg I., Godzik A., Mustelin T. FEBS Lett. 581:2527-2533(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "Structure of human dual-specificity phosphatase 27 at 2.38 A resolution." Lountos G.T., Tropea J.E., Waugh D.S. Acta Crystallogr. D 67:471-479(2011) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.38 ANGSTROMS) IN COMPLEX WITH SULFATE, SUBUNIT. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AY686755 mRNA. Translation: AAT94288.1. BC137321 mRNA. Translation: AAI37322.1. BC137322 mRNA. Translation: AAI37323.1. | ||||||||||||
| IPI | IPI00456156. | ||||||||||||
| RefSeq | NP_001003892.1. NM_001003892.1. | ||||||||||||
| UniGene | Hs.535090. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| ProteinModelPortal | Q68J44. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| STRING | 9606.ENSP00000340609. | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | Q68J44. | ||||||||||||
Polymorphism databases | |||||||||||||
| DMDM | 74748317. | ||||||||||||
Proteomic databases | |||||||||||||
| PaxDb | Q68J44. | ||||||||||||
| PRIDE | Q68J44. | ||||||||||||
Protocols and materials databases | |||||||||||||
| DNASU | 338599. | ||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000338487; ENSP00000340609; ENSG00000188716. | ||||||||||||
| GeneID | 338599. | ||||||||||||
| KEGG | hsa:338599. | ||||||||||||
| UCSC | uc001jwq.1. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 338599. | ||||||||||||
| GeneCards | GC10M076797. | ||||||||||||
| HGNC | HGNC:23481. DUPD1. | ||||||||||||
| HPA | HPA042964. | ||||||||||||
| neXtProt | NX_Q68J44. | ||||||||||||
| PharmGKB | PA134959776. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | COG2453. | ||||||||||||
| HOGENOM | HOG000233767. | ||||||||||||
| HOVERGEN | HBG001524. | ||||||||||||
| InParanoid | Q68J44. | ||||||||||||
| KO | K14165. | ||||||||||||
| OMA | MTVVDAI. | ||||||||||||
| OrthoDB | EOG4R23W1. | ||||||||||||
Gene expression databases | |||||||||||||
| Bgee | Q68J44. | ||||||||||||
| CleanEx | HS_DUPD1. HS_DUSP27. | ||||||||||||
| Genevestigator | Q68J44. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR020417. Atypical_DUSP. IPR020405. Atypical_DUSP_famA. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020422. Dual-sp_phosphatase_subgr_cat. IPR024950. DUSP. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. [Graphical view] | ||||||||||||
| PANTHER | PTHR10159. PTHR10159. 1 hit. | ||||||||||||
| Pfam | PF00782. DSPc. 1 hit. [Graphical view] | ||||||||||||
| PRINTS | PR01908. ADSPHPHTASE. PR01909. ADSPHPHTASEA. | ||||||||||||
| SMART | SM00195. DSPc. 1 hit. [Graphical view] | ||||||||||||
| PROSITE | PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other | |||||||||||||
| GenomeRNAi | 338599. | ||||||||||||
| NextBio | 97059. | ||||||||||||
Entry information
| Entry name | DUPD1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q68J44 Secondary accession number(s): B2RP93 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 10 Human chromosome 10: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with
