Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q68G74

- LHX8_HUMAN

UniProt

Q68G74 - LHX8_HUMAN

Protein

LIM/homeobox protein Lhx8

Gene

LHX8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcription factor involved in differentiation of certain neurons and mesenchymal cells.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi225 – 28460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. female gonad development Source: Ensembl
    2. forebrain neuron development Source: Ensembl
    3. learning or memory Source: Ensembl
    4. odontogenesis of dentin-containing tooth Source: Ensembl
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LIM/homeobox protein Lhx8
    Short name:
    LIM homeobox protein 8
    Gene namesi
    Name:LHX8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:28838. LHX8.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671553.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 356356LIM/homeobox protein Lhx8PRO_0000295810Add
    BLAST

    Proteomic databases

    PaxDbiQ68G74.
    PRIDEiQ68G74.

    PTM databases

    PhosphoSiteiQ68G74.

    Expressioni

    Gene expression databases

    ArrayExpressiQ68G74.
    BgeeiQ68G74.
    CleanExiHS_LHX8.
    GenevestigatoriQ68G74.

    Interactioni

    Protein-protein interaction databases

    BioGridi136112. 1 interaction.
    IntActiQ68G74. 1 interaction.
    MINTiMINT-8417689.
    STRINGi9606.ENSP00000294638.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68G74.
    SMRiQ68G74. Positions 75-186, 225-284.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini73 – 13361LIM zinc-binding 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini134 – 19663LIM zinc-binding 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox, LIM domain, Repeat

    Phylogenomic databases

    eggNOGiNOG264882.
    HOGENOMiHOG000038965.
    HOVERGENiHBG006261.
    InParanoidiQ68G74.
    KOiK09375.
    OMAiPGKCVCS.
    OrthoDBiEOG744T9J.
    PhylomeDBiQ68G74.
    TreeFamiTF315442.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    2.10.110.10. 2 hits.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR001781. Znf_LIM.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00412. LIM. 2 hits.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    SM00132. LIM. 2 hits.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q68G74-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQILSRCQGL MSEECGRTTA LAAGRTRKGA GEEGLVSPEG AGDEDSCSSS    50
    APLSPSSSPR SMASGSGCPP GKCVCNSCGL EIVDKYLLKV NDLCWHVRCL 100
    SCSVCRTSLG RHTSCYIKDK DIFCKLDYFR RYGTRCSRCG RHIHSTDWVR 150
    RAKGNVYHLA CFACFSCKRQ LSTGEEFALV EEKVLCRVHY DCMLDNLKRE 200
    VENGNGISVE GALLTEQDVN HPKPAKRART SFTADQLQVM QAQFAQDNNP 250
    DAQTLQKLAE RTGLSRRVIQ VWFQNCRARH KKHVSPNHSS STPVTAVPPS 300
    RLSPPMLEEM AYSAYVPQDG TMLTALHSYM DAHSPTTLGL QPLLPHSMTQ 350
    LPISHT 356
    Length:356
    Mass (Da):39,301
    Last modified:May 18, 2010 - v2
    Checksum:i9BA025D3ECADCD56
    GO
    Isoform 2 (identifier: Q68G74-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-10: Missing.

    Note: Gene prediction based on EST data.

    Show »
    Length:346
    Mass (Da):38,170
    Checksum:i989F0E991481A24F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti297 – 2971V → A in AAH40321. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1010Missing in isoform 2. CuratedVSP_047378

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC099786 Genomic DNA. No translation available.
    BC040321 mRNA. Translation: AAH40321.1.
    CCDSiCCDS30756.1. [Q68G74-1]
    CCDS58008.1. [Q68G74-2]
    RefSeqiNP_001001933.1. NM_001001933.1. [Q68G74-1]
    NP_001243043.1. NM_001256114.1. [Q68G74-2]
    UniGeneiHs.403934.

    Genome annotation databases

    EnsembliENST00000294638; ENSP00000294638; ENSG00000162624. [Q68G74-1]
    ENST00000356261; ENSP00000348597; ENSG00000162624. [Q68G74-2]
    GeneIDi431707.
    KEGGihsa:431707.
    UCSCiuc001dgo.3. human. [Q68G74-1]

    Polymorphism databases

    DMDMi296434566.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC099786 Genomic DNA. No translation available.
    BC040321 mRNA. Translation: AAH40321.1 .
    CCDSi CCDS30756.1. [Q68G74-1 ]
    CCDS58008.1. [Q68G74-2 ]
    RefSeqi NP_001001933.1. NM_001001933.1. [Q68G74-1 ]
    NP_001243043.1. NM_001256114.1. [Q68G74-2 ]
    UniGenei Hs.403934.

    3D structure databases

    ProteinModelPortali Q68G74.
    SMRi Q68G74. Positions 75-186, 225-284.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 136112. 1 interaction.
    IntActi Q68G74. 1 interaction.
    MINTi MINT-8417689.
    STRINGi 9606.ENSP00000294638.

    PTM databases

    PhosphoSitei Q68G74.

    Polymorphism databases

    DMDMi 296434566.

    Proteomic databases

    PaxDbi Q68G74.
    PRIDEi Q68G74.

    Protocols and materials databases

    DNASUi 431707.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000294638 ; ENSP00000294638 ; ENSG00000162624 . [Q68G74-1 ]
    ENST00000356261 ; ENSP00000348597 ; ENSG00000162624 . [Q68G74-2 ]
    GeneIDi 431707.
    KEGGi hsa:431707.
    UCSCi uc001dgo.3. human. [Q68G74-1 ]

    Organism-specific databases

    CTDi 431707.
    GeneCardsi GC01P075594.
    HGNCi HGNC:28838. LHX8.
    MIMi 604425. gene.
    neXtProti NX_Q68G74.
    PharmGKBi PA142671553.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG264882.
    HOGENOMi HOG000038965.
    HOVERGENi HBG006261.
    InParanoidi Q68G74.
    KOi K09375.
    OMAi PGKCVCS.
    OrthoDBi EOG744T9J.
    PhylomeDBi Q68G74.
    TreeFami TF315442.

    Miscellaneous databases

    GenomeRNAii 431707.
    NextBioi 108706.
    PROi Q68G74.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q68G74.
    Bgeei Q68G74.
    CleanExi HS_LHX8.
    Genevestigatori Q68G74.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    2.10.110.10. 2 hits.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR001781. Znf_LIM.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00412. LIM. 2 hits.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    SM00132. LIM. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.

    Entry informationi

    Entry nameiLHX8_HUMAN
    AccessioniPrimary (citable) accession number: Q68G74
    Secondary accession number(s): E9PGE3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3