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Q68G74 (LHX8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
LIM/homeobox protein Lhx8

Short name=LIM homeobox protein 8
Gene names
Name:LHX8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor involved in differentiation of certain neurons and mesenchymal cells By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Contains 1 homeobox DNA-binding domain.

Contains 2 LIM zinc-binding domains.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q68G74-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q68G74-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.
Note: Gene prediction based on EST data.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 356356LIM/homeobox protein Lhx8
PRO_0000295810

Regions

Domain73 – 13361LIM zinc-binding 1
Domain134 – 19663LIM zinc-binding 2
DNA binding225 – 28460Homeobox

Natural variations

Alternative sequence1 – 1010Missing in isoform 2.
VSP_047378

Experimental info

Sequence conflict2971V → A in AAH40321. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 9BA025D3ECADCD56

FASTA35639,301
        10         20         30         40         50         60 
MQILSRCQGL MSEECGRTTA LAAGRTRKGA GEEGLVSPEG AGDEDSCSSS APLSPSSSPR 

        70         80         90        100        110        120 
SMASGSGCPP GKCVCNSCGL EIVDKYLLKV NDLCWHVRCL SCSVCRTSLG RHTSCYIKDK 

       130        140        150        160        170        180 
DIFCKLDYFR RYGTRCSRCG RHIHSTDWVR RAKGNVYHLA CFACFSCKRQ LSTGEEFALV 

       190        200        210        220        230        240 
EEKVLCRVHY DCMLDNLKRE VENGNGISVE GALLTEQDVN HPKPAKRART SFTADQLQVM 

       250        260        270        280        290        300 
QAQFAQDNNP DAQTLQKLAE RTGLSRRVIQ VWFQNCRARH KKHVSPNHSS STPVTAVPPS 

       310        320        330        340        350 
RLSPPMLEEM AYSAYVPQDG TMLTALHSYM DAHSPTTLGL QPLLPHSMTQ LPISHT 

« Hide

Isoform 2 [UniParc].

Checksum: 989F0E991481A24F
Show »

FASTA34638,170

References

[1]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC099786 Genomic DNA. No translation available.
BC040321 mRNA. Translation: AAH40321.1.
CCDSCCDS30756.1. [Q68G74-1]
CCDS58008.1. [Q68G74-2]
RefSeqNP_001001933.1. NM_001001933.1. [Q68G74-1]
NP_001243043.1. NM_001256114.1. [Q68G74-2]
UniGeneHs.403934.

3D structure databases

ProteinModelPortalQ68G74.
SMRQ68G74. Positions 75-186, 225-284.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid136112. 1 interaction.
IntActQ68G74. 1 interaction.
MINTMINT-8417689.
STRING9606.ENSP00000294638.

PTM databases

PhosphoSiteQ68G74.

Polymorphism databases

DMDM296434566.

Proteomic databases

PaxDbQ68G74.
PRIDEQ68G74.

Protocols and materials databases

DNASU431707.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000294638; ENSP00000294638; ENSG00000162624. [Q68G74-1]
ENST00000356261; ENSP00000348597; ENSG00000162624. [Q68G74-2]
GeneID431707.
KEGGhsa:431707.
UCSCuc001dgo.3. human. [Q68G74-1]

Organism-specific databases

CTD431707.
GeneCardsGC01P075594.
HGNCHGNC:28838. LHX8.
MIM604425. gene.
neXtProtNX_Q68G74.
PharmGKBPA142671553.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG264882.
HOGENOMHOG000038965.
HOVERGENHBG006261.
InParanoidQ68G74.
KOK09375.
OMAPGKCVCS.
OrthoDBEOG744T9J.
PhylomeDBQ68G74.
TreeFamTF315442.

Gene expression databases

ArrayExpressQ68G74.
BgeeQ68G74.
CleanExHS_LHX8.
GenevestigatorQ68G74.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi431707.
NextBio108706.
PROQ68G74.
SOURCESearch...

Entry information

Entry nameLHX8_HUMAN
AccessionPrimary (citable) accession number: Q68G74
Secondary accession number(s): E9PGE3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM