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Protein

LIM/homeobox protein Lhx8

Gene

LHX8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor involved in differentiation of certain neurons and mesenchymal cells.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi225 – 28460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. female gonad development Source: Ensembl
  2. forebrain neuron development Source: Ensembl
  3. learning or memory Source: Ensembl
  4. odontogenesis of dentin-containing tooth Source: Ensembl
  5. regulation of transcription, DNA-templated Source: UniProtKB-KW
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM/homeobox protein Lhx8
Short name:
LIM homeobox protein 8
Gene namesi
Name:LHX8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28838. LHX8.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. female germ cell nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671553.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356LIM/homeobox protein Lhx8PRO_0000295810Add
BLAST

Proteomic databases

PaxDbiQ68G74.
PRIDEiQ68G74.

PTM databases

PhosphoSiteiQ68G74.

Expressioni

Gene expression databases

BgeeiQ68G74.
CleanExiHS_LHX8.
ExpressionAtlasiQ68G74. baseline and differential.
GenevestigatoriQ68G74.

Interactioni

Protein-protein interaction databases

BioGridi136112. 6 interactions.
IntActiQ68G74. 1 interaction.
MINTiMINT-8417689.
STRINGi9606.ENSP00000294638.

Structurei

3D structure databases

ProteinModelPortaliQ68G74.
SMRiQ68G74. Positions 75-186, 225-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini73 – 13361LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini134 – 19663LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiNOG264882.
GeneTreeiENSGT00760000118921.
HOGENOMiHOG000038965.
HOVERGENiHBG006261.
InParanoidiQ68G74.
KOiK09375.
OMAiPGKCVCS.
OrthoDBiEOG744T9J.
PhylomeDBiQ68G74.
TreeFamiTF315442.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q68G74-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQILSRCQGL MSEECGRTTA LAAGRTRKGA GEEGLVSPEG AGDEDSCSSS
60 70 80 90 100
APLSPSSSPR SMASGSGCPP GKCVCNSCGL EIVDKYLLKV NDLCWHVRCL
110 120 130 140 150
SCSVCRTSLG RHTSCYIKDK DIFCKLDYFR RYGTRCSRCG RHIHSTDWVR
160 170 180 190 200
RAKGNVYHLA CFACFSCKRQ LSTGEEFALV EEKVLCRVHY DCMLDNLKRE
210 220 230 240 250
VENGNGISVE GALLTEQDVN HPKPAKRART SFTADQLQVM QAQFAQDNNP
260 270 280 290 300
DAQTLQKLAE RTGLSRRVIQ VWFQNCRARH KKHVSPNHSS STPVTAVPPS
310 320 330 340 350
RLSPPMLEEM AYSAYVPQDG TMLTALHSYM DAHSPTTLGL QPLLPHSMTQ

LPISHT
Length:356
Mass (Da):39,301
Last modified:May 17, 2010 - v2
Checksum:i9BA025D3ECADCD56
GO
Isoform 2 (identifier: Q68G74-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.

Note: Gene prediction based on EST data.

Show »
Length:346
Mass (Da):38,170
Checksum:i989F0E991481A24F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti297 – 2971V → A in AAH40321 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1010Missing in isoform 2. CuratedVSP_047378

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC099786 Genomic DNA. No translation available.
BC040321 mRNA. Translation: AAH40321.1.
CCDSiCCDS30756.1. [Q68G74-1]
CCDS58008.1. [Q68G74-2]
RefSeqiNP_001001933.1. NM_001001933.1. [Q68G74-1]
NP_001243043.1. NM_001256114.1. [Q68G74-2]
UniGeneiHs.403934.

Genome annotation databases

EnsembliENST00000294638; ENSP00000294638; ENSG00000162624. [Q68G74-1]
ENST00000356261; ENSP00000348597; ENSG00000162624. [Q68G74-2]
GeneIDi431707.
KEGGihsa:431707.
UCSCiuc001dgo.3. human. [Q68G74-1]

Polymorphism databases

DMDMi296434566.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC099786 Genomic DNA. No translation available.
BC040321 mRNA. Translation: AAH40321.1.
CCDSiCCDS30756.1. [Q68G74-1]
CCDS58008.1. [Q68G74-2]
RefSeqiNP_001001933.1. NM_001001933.1. [Q68G74-1]
NP_001243043.1. NM_001256114.1. [Q68G74-2]
UniGeneiHs.403934.

3D structure databases

ProteinModelPortaliQ68G74.
SMRiQ68G74. Positions 75-186, 225-284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136112. 6 interactions.
IntActiQ68G74. 1 interaction.
MINTiMINT-8417689.
STRINGi9606.ENSP00000294638.

PTM databases

PhosphoSiteiQ68G74.

Polymorphism databases

DMDMi296434566.

Proteomic databases

PaxDbiQ68G74.
PRIDEiQ68G74.

Protocols and materials databases

DNASUi431707.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294638; ENSP00000294638; ENSG00000162624. [Q68G74-1]
ENST00000356261; ENSP00000348597; ENSG00000162624. [Q68G74-2]
GeneIDi431707.
KEGGihsa:431707.
UCSCiuc001dgo.3. human. [Q68G74-1]

Organism-specific databases

CTDi431707.
GeneCardsiGC01P075594.
HGNCiHGNC:28838. LHX8.
MIMi604425. gene.
neXtProtiNX_Q68G74.
PharmGKBiPA142671553.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG264882.
GeneTreeiENSGT00760000118921.
HOGENOMiHOG000038965.
HOVERGENiHBG006261.
InParanoidiQ68G74.
KOiK09375.
OMAiPGKCVCS.
OrthoDBiEOG744T9J.
PhylomeDBiQ68G74.
TreeFamiTF315442.

Miscellaneous databases

GenomeRNAii431707.
NextBioi108706.
PROiQ68G74.
SOURCEiSearch...

Gene expression databases

BgeeiQ68G74.
CleanExiHS_LHX8.
ExpressionAtlasiQ68G74. baseline and differential.
GenevestigatoriQ68G74.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiLHX8_HUMAN
AccessioniPrimary (citable) accession number: Q68G74
Secondary accession number(s): E9PGE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 23, 2007
Last sequence update: May 17, 2010
Last modified: February 3, 2015
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.