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Protein

LIM/homeobox protein Lhx8

Gene

LHX8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor involved in differentiation of certain neurons and mesenchymal cells.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi225 – 284HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM/homeobox protein Lhx8
Short name:
LIM homeobox protein 8
Gene namesi
Name:LHX8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28838. LHX8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi431707.
OpenTargetsiENSG00000162624.
PharmGKBiPA142671553.

Polymorphism and mutation databases

BioMutaiLHX8.
DMDMi296434566.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002958101 – 356LIM/homeobox protein Lhx8Add BLAST356

Proteomic databases

PaxDbiQ68G74.
PRIDEiQ68G74.

PTM databases

iPTMnetiQ68G74.

Expressioni

Gene expression databases

BgeeiENSG00000162624.
CleanExiHS_LHX8.
GenevisibleiQ68G74. HS.

Organism-specific databases

HPAiHPA071806.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KLF3P576823EBI-8474075,EBI-8472267
LDB1Q86U703EBI-8474075,EBI-677177
LDB1Q86U70-24EBI-8474075,EBI-11979761
NUTM1Q86Y263EBI-8474075,EBI-10178410
SCYL3Q8IZE33EBI-8474075,EBI-1380680

Protein-protein interaction databases

BioGridi136112. 8 interactors.
IntActiQ68G74. 15 interactors.
MINTiMINT-8417689.
STRINGi9606.ENSP00000294638.

Structurei

3D structure databases

ProteinModelPortaliQ68G74.
SMRiQ68G74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 133LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST61
Domaini134 – 196LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST63

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118921.
HOGENOMiHOG000038965.
HOVERGENiHBG006261.
InParanoidiQ68G74.
KOiK09375.
OMAiPGKCVCS.
OrthoDBiEOG091G0EXT.
PhylomeDBiQ68G74.
TreeFamiTF315442.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q68G74-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQILSRCQGL MSEECGRTTA LAAGRTRKGA GEEGLVSPEG AGDEDSCSSS
60 70 80 90 100
APLSPSSSPR SMASGSGCPP GKCVCNSCGL EIVDKYLLKV NDLCWHVRCL
110 120 130 140 150
SCSVCRTSLG RHTSCYIKDK DIFCKLDYFR RYGTRCSRCG RHIHSTDWVR
160 170 180 190 200
RAKGNVYHLA CFACFSCKRQ LSTGEEFALV EEKVLCRVHY DCMLDNLKRE
210 220 230 240 250
VENGNGISVE GALLTEQDVN HPKPAKRART SFTADQLQVM QAQFAQDNNP
260 270 280 290 300
DAQTLQKLAE RTGLSRRVIQ VWFQNCRARH KKHVSPNHSS STPVTAVPPS
310 320 330 340 350
RLSPPMLEEM AYSAYVPQDG TMLTALHSYM DAHSPTTLGL QPLLPHSMTQ

LPISHT
Length:356
Mass (Da):39,301
Last modified:May 18, 2010 - v2
Checksum:i9BA025D3ECADCD56
GO
Isoform 2 (identifier: Q68G74-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.

Note: Gene prediction based on EST data.
Show »
Length:346
Mass (Da):38,170
Checksum:i989F0E991481A24F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti297V → A in AAH40321 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0473781 – 10Missing in isoform 2. Curated10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC099786 Genomic DNA. No translation available.
BC040321 mRNA. Translation: AAH40321.1.
CCDSiCCDS30756.1. [Q68G74-1]
CCDS58008.1. [Q68G74-2]
RefSeqiNP_001001933.1. NM_001001933.1. [Q68G74-1]
NP_001243043.1. NM_001256114.1. [Q68G74-2]
UniGeneiHs.403934.

Genome annotation databases

EnsembliENST00000294638; ENSP00000294638; ENSG00000162624. [Q68G74-1]
ENST00000356261; ENSP00000348597; ENSG00000162624. [Q68G74-2]
GeneIDi431707.
KEGGihsa:431707.
UCSCiuc001dgo.3. human. [Q68G74-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC099786 Genomic DNA. No translation available.
BC040321 mRNA. Translation: AAH40321.1.
CCDSiCCDS30756.1. [Q68G74-1]
CCDS58008.1. [Q68G74-2]
RefSeqiNP_001001933.1. NM_001001933.1. [Q68G74-1]
NP_001243043.1. NM_001256114.1. [Q68G74-2]
UniGeneiHs.403934.

3D structure databases

ProteinModelPortaliQ68G74.
SMRiQ68G74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136112. 8 interactors.
IntActiQ68G74. 15 interactors.
MINTiMINT-8417689.
STRINGi9606.ENSP00000294638.

PTM databases

iPTMnetiQ68G74.

Polymorphism and mutation databases

BioMutaiLHX8.
DMDMi296434566.

Proteomic databases

PaxDbiQ68G74.
PRIDEiQ68G74.

Protocols and materials databases

DNASUi431707.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294638; ENSP00000294638; ENSG00000162624. [Q68G74-1]
ENST00000356261; ENSP00000348597; ENSG00000162624. [Q68G74-2]
GeneIDi431707.
KEGGihsa:431707.
UCSCiuc001dgo.3. human. [Q68G74-1]

Organism-specific databases

CTDi431707.
DisGeNETi431707.
GeneCardsiLHX8.
HGNCiHGNC:28838. LHX8.
HPAiHPA071806.
MIMi604425. gene.
neXtProtiNX_Q68G74.
OpenTargetsiENSG00000162624.
PharmGKBiPA142671553.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118921.
HOGENOMiHOG000038965.
HOVERGENiHBG006261.
InParanoidiQ68G74.
KOiK09375.
OMAiPGKCVCS.
OrthoDBiEOG091G0EXT.
PhylomeDBiQ68G74.
TreeFamiTF315442.

Miscellaneous databases

GenomeRNAii431707.
PROiQ68G74.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162624.
CleanExiHS_LHX8.
GenevisibleiQ68G74. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLHX8_HUMAN
AccessioniPrimary (citable) accession number: Q68G74
Secondary accession number(s): E9PGE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.