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Protein

Kinesin light chain 3

Gene

Klc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.

GO - Molecular functioni

  • microtubule motor activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin light chain 3
Alternative name(s):
Kinesin light chain KLCt
Gene namesi
Name:Klc3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621432. Klc3.

Subcellular locationi

GO - Cellular componenti

  • ciliary rootlet Source: Ensembl
  • cytoplasm Source: UniProtKB-KW
  • kinesin complex Source: RGD
  • microtubule Source: UniProtKB-KW
  • motile cilium Source: Ensembl
  • neuron projection Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002307881 – 505Kinesin light chain 3Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei173PhosphoserineBy similarity1
Modified residuei467PhosphoserineBy similarity1
Modified residuei499PhosphothreonineBy similarity1
Modified residuei503PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ68G30.
PRIDEiQ68G30.

PTM databases

iPTMnetiQ68G30.
PhosphoSitePlusiQ68G30.

Expressioni

Tissue specificityi

Expressed in postmeiotic male germ cells (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000018101.
GenevisibleiQ68G30. RN.

Interactioni

Subunit structurei

Oligomer composed of two heavy chains and two light chains. Associates with microtubulin in an ATP-dependent manner. Interacts with KIF5C and ODF1.2 Publications

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060483.

Structurei

3D structure databases

ProteinModelPortaliQ68G30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati207 – 240TPR 1Add BLAST34
Repeati249 – 282TPR 2Add BLAST34
Repeati291 – 324TPR 3Add BLAST34
Repeati333 – 366TPR 4Add BLAST34
Repeati375 – 408TPR 5Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili90 – 150Sequence analysisAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi181 – 184Poly-Glu4
Compositional biasi190 – 196Poly-Ala7

Domaini

The heptad repeat (HR) motif is sufficient for interaction with kinesin heavy (KHL) chains and ODF1. The TPR region is involved in mitochondrial binding.

Sequence similaritiesi

Belongs to the kinesin light chain family.Curated
Contains 5 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000006393.
HOGENOMiHOG000261663.
HOVERGENiHBG006217.
InParanoidiQ68G30.
KOiK10407.
OMAiCHPDVAT.
PhylomeDBiQ68G30.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR002151. Kinesin_light.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PRINTSiPR00381. KINESINLIGHT.
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q68G30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVQVAAPGS TGLGPERLNP EELVRQTRQV VQGLEALRAE HHSLAGHLAE
60 70 80 90 100
ALAGPGPVAG VELLEEKQQV VNHSLEAIEL GLGEAQVLLA LSAHVGVLEA
110 120 130 140 150
EKQRLRAQAR RLAQENTWLR EELEETQRRL RASEEAVAQL EEEKSHLQFL
160 170 180 190 200
GQLRQYDPPE ESQRPDSPPR RDSLASLFPS EEEEKKGPEA AGAAAAQQGG
210 220 230 240 250
YEIPARLRTL HNLVIQYASQ GRYEVAVPLC RQALEDLERS SGHCHPDVAT
260 270 280 290 300
MLNILALVYR DQNKYKEATE LLHDALQIRE QTLGPEHPAV AATLNNLAVL
310 320 330 340 350
YGKRGRYREA EPLCQRALEI REKVLGADHP DVAKQLNNLA LLCQNQGKFQ
360 370 380 390 400
DVERHYARAL SIYEALGGPQ DPNVAKTKNN LASAYLKQNK YQQAEELYKE
410 420 430 440 450
ILSQEALPAP LGAPQGGTAG EAQQQVLRRS SSFSKLRESI RRGSEKLVSR
460 470 480 490 500
LRGESMAGAA GMKRAMSLNM LNVDGPRAAR MQLSTQHLNE ASRTLSASTQ

DLSPR
Length:505
Mass (Da):55,655
Last modified:October 11, 2004 - v1
Checksum:iDA457FE4E82F6F37
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti205A → D in AAG15432 (PubMed:11319135).Curated1
Sequence conflicti213L → V in AAG15432 (PubMed:11319135).Curated1
Sequence conflicti220 – 221QG → HV in AAG15432 (PubMed:11319135).Curated2
Sequence conflicti227V → I in AAG15432 (PubMed:11319135).Curated1
Sequence conflicti238E → V in AAG15432 (PubMed:11319135).Curated1
Sequence conflicti244C → F in AAG15432 (PubMed:11319135).Curated1
Sequence conflicti249 – 254ATMLNI → PTMVDF in AAG15432 (PubMed:11319135).Curated6
Sequence conflicti271L → F in AAG15432 (PubMed:11319135).Curated1
Sequence conflicti377T → I in AAG15432 (PubMed:11319135).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF166267 mRNA. Translation: AAG15432.1.
BC078736 mRNA. Translation: AAH78736.1.
BC097284 mRNA. Translation: AAH97284.1.
RefSeqiNP_612529.1. NM_138520.1.
XP_006228440.2. XM_006228378.3.
XP_006228442.1. XM_006228380.3.
UniGeneiRn.161815.

Genome annotation databases

EnsembliENSRNOT00000068092; ENSRNOP00000060483; ENSRNOG00000018101.
ENSRNOT00000082928; ENSRNOP00000070496; ENSRNOG00000018101.
GeneIDi171549.
KEGGirno:171549.
UCSCiRGD:621432. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF166267 mRNA. Translation: AAG15432.1.
BC078736 mRNA. Translation: AAH78736.1.
BC097284 mRNA. Translation: AAH97284.1.
RefSeqiNP_612529.1. NM_138520.1.
XP_006228440.2. XM_006228378.3.
XP_006228442.1. XM_006228380.3.
UniGeneiRn.161815.

3D structure databases

ProteinModelPortaliQ68G30.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060483.

PTM databases

iPTMnetiQ68G30.
PhosphoSitePlusiQ68G30.

Proteomic databases

PaxDbiQ68G30.
PRIDEiQ68G30.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000068092; ENSRNOP00000060483; ENSRNOG00000018101.
ENSRNOT00000082928; ENSRNOP00000070496; ENSRNOG00000018101.
GeneIDi171549.
KEGGirno:171549.
UCSCiRGD:621432. rat.

Organism-specific databases

CTDi147700.
RGDi621432. Klc3.

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000006393.
HOGENOMiHOG000261663.
HOVERGENiHBG006217.
InParanoidiQ68G30.
KOiK10407.
OMAiCHPDVAT.
PhylomeDBiQ68G30.

Miscellaneous databases

PROiQ68G30.

Gene expression databases

BgeeiENSRNOG00000018101.
GenevisibleiQ68G30. RN.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR002151. Kinesin_light.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PRINTSiPR00381. KINESINLIGHT.
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLC3_RAT
AccessioniPrimary (citable) accession number: Q68G30
Secondary accession number(s): Q9ESH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.