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Q68G12

- SIAT9_RAT

UniProt

Q68G12 - SIAT9_RAT

Protein

Lactosylceramide alpha-2,3-sialyltransferase

Gene

St3gal5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of ganglioside GM3 (alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide).By similarity

    Catalytic activityi

    CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.

    GO - Molecular functioni

    1. lactosylceramide alpha-2,3-sialyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. protein glycosylation Source: InterPro
    2. sialylation Source: GOC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_213723. Sialic acid metabolism.

    Protein family/group databases

    CAZyiGT29. Glycosyltransferase Family 29.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lactosylceramide alpha-2,3-sialyltransferase (EC:2.4.99.9)
    Alternative name(s):
    CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase
    Ganglioside GM3 synthase
    ST3Gal V
    Short name:
    ST3GalV
    Sialyltransferase 9
    Gene namesi
    Name:St3gal5
    Synonyms:Siat9
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi620875. St3gal5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of Golgi membrane Source: InterPro

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 387387Lactosylceramide alpha-2,3-sialyltransferasePRO_0000334618Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi167 ↔ 325By similarity
    Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ68G12.

    Expressioni

    Gene expression databases

    ArrayExpressiQ68G12.
    GenevestigatoriQ68G12.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini55 – 387333ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 29 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG257001.
    GeneTreeiENSGT00620000087815.
    HOGENOMiHOG000000682.
    HOVERGENiHBG056676.
    InParanoidiQ68G12.
    KOiK03370.
    OMAiFFWKQVA.
    OrthoDBiEOG76X609.
    PhylomeDBiQ68G12.

    Family and domain databases

    InterProiIPR001675. Glyco_trans_29.
    IPR012163. Sialyl_trans.
    [Graphical view]
    PfamiPF00777. Glyco_transf_29. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q68G12-1 [UniParc]FASTAAdd to Basket

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    MPNEFTSAKL RSDCSRTSLQ WYTQTQHKMR RPSLLLKDIL KCMLVVFGVW    50
    LLYILKLNYT AEECDMKKLN YVDPARIKRA HRNTQEVFQK ECRPGHAKKT 100
    MDLLFKGKYS MDLEPFVQKI PTASEAELKY DPPFGFRKFS SKVQSLLDML 150
    PEHDFPEHLR AKHCKRCVVI GNGGILHGLE LGHALNQFDV VIRLNSAPIE 200
    GYSEHVGNKT TIRMTYPEGA PLSDAEYYAN DLFVAVLFKS VDFKWLQAMV 250
    KNESLPFWIR LFFWKQVAEK IPLQPKHFRI LNPVIIKETA FDILQYSEPQ 300
    SRFWGHDKNI PTIGIIAIVL ATHLCDEVSL AGFGYDLSQP RTPLHYFDSQ 350
    CMGAMNWQVM HNVTTETQFL QKLIKEGVVQ DLSGGIH 387
    Length:387
    Mass (Da):44,640
    Last modified:October 11, 2004 - v1
    Checksum:iBF53342B7E8C06EA
    GO

    Sequence cautioni

    The sequence BAA33492.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018049 mRNA. Translation: BAA33492.1. Different initiation.
    BC078798 mRNA. Translation: AAH78798.1.
    RefSeqiNP_112627.2. NM_031337.2.
    XP_006236739.1. XM_006236677.1.
    XP_006236740.1. XM_006236678.1.
    XP_006236741.1. XM_006236679.1.
    UniGeneiRn.22706.

    Genome annotation databases

    EnsembliENSRNOT00000050249; ENSRNOP00000042426; ENSRNOG00000010284.
    GeneIDi83505.
    KEGGirno:83505.
    UCSCiRGD:620875. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018049 mRNA. Translation: BAA33492.1 . Different initiation.
    BC078798 mRNA. Translation: AAH78798.1 .
    RefSeqi NP_112627.2. NM_031337.2.
    XP_006236739.1. XM_006236677.1.
    XP_006236740.1. XM_006236678.1.
    XP_006236741.1. XM_006236679.1.
    UniGenei Rn.22706.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT29. Glycosyltransferase Family 29.

    Proteomic databases

    PRIDEi Q68G12.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000050249 ; ENSRNOP00000042426 ; ENSRNOG00000010284 .
    GeneIDi 83505.
    KEGGi rno:83505.
    UCSCi RGD:620875. rat.

    Organism-specific databases

    CTDi 8869.
    RGDi 620875. St3gal5.

    Phylogenomic databases

    eggNOGi NOG257001.
    GeneTreei ENSGT00620000087815.
    HOGENOMi HOG000000682.
    HOVERGENi HBG056676.
    InParanoidi Q68G12.
    KOi K03370.
    OMAi FFWKQVA.
    OrthoDBi EOG76X609.
    PhylomeDBi Q68G12.

    Enzyme and pathway databases

    Reactomei REACT_213723. Sialic acid metabolism.

    Miscellaneous databases

    NextBioi 615932.
    PROi Q68G12.

    Gene expression databases

    ArrayExpressi Q68G12.
    Genevestigatori Q68G12.

    Family and domain databases

    InterProi IPR001675. Glyco_trans_29.
    IPR012163. Sialyl_trans.
    [Graphical view ]
    Pfami PF00777. Glyco_transf_29. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005557. Sialyl_trans. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Rat GM3 synthase cDNA."
      Ishii A., Saito M.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiSIAT9_RAT
    AccessioniPrimary (citable) accession number: Q68G12
    Secondary accession number(s): O88830
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3