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Protein

Nucleoporin NUP53

Gene

Nup35

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-RNO-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-RNO-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-RNO-191859. snRNP Assembly.
R-RNO-3108214. SUMOylation of DNA damage response and repair proteins.
R-RNO-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-RNO-3371453. Regulation of HSF1-mediated heat shock response.
R-RNO-4551638. SUMOylation of chromatin organization proteins.
R-RNO-4570464. SUMOylation of RNA binding proteins.
R-RNO-4615885. SUMOylation of DNA replication proteins.
R-RNO-5578749. Transcriptional regulation by small RNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin NUP53
Alternative name(s):
35 kDa nucleoporin
Nuclear pore complex protein Nup53
Nucleoporin Nup35
Gene namesi
Name:Nup35
Synonyms:Nup53
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1303069. Nup35.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002342961 – 325Nucleoporin NUP53Add BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53PhosphoserineBy similarity1
Modified residuei55PhosphoserineBy similarity1
Modified residuei66PhosphoserineBy similarity1
Modified residuei73PhosphoserineCombined sources1
Modified residuei99PhosphoserineBy similarity1
Modified residuei100PhosphoserineBy similarity1
Modified residuei106PhosphothreonineBy similarity1
Modified residuei121PhosphoserineBy similarity1
Modified residuei128PhosphothreonineBy similarity1
Modified residuei137PhosphoserineBy similarity1
Modified residuei251PhosphoserineBy similarity1
Modified residuei258PhosphoserineBy similarity1
Modified residuei264PhosphothreonineCombined sources1
Modified residuei272PhosphothreonineBy similarity1
Modified residuei274PhosphothreonineBy similarity1
Modified residuei278PhosphoserineBy similarity1
Modified residuei279PhosphothreonineBy similarity1
Modified residuei283PhosphoserineBy similarity1
Modified residuei307PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ68FY1.
PRIDEiQ68FY1.

PTM databases

iPTMnetiQ68FY1.
PhosphoSitePlusiQ68FY1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000009290.
GenevisibleiQ68FY1. RN.

Interactioni

Subunit structurei

Interacts with TMEM48/NDC1 (By similarity). Forms a complex with NUP93, NUP155, NUP205 and lamin B. The interaction with NUP93 is direct (By similarity).By similarity

Protein-protein interaction databases

CORUMiQ68FY1.
STRINGi10116.ENSRNOP00000012628.

Structurei

3D structure databases

ProteinModelPortaliQ68FY1.
SMRiQ68FY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 249RRM Nup35-typePROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Belongs to the Nup53 family.Curated

Phylogenomic databases

eggNOGiKOG4285. Eukaryota.
ENOG4111ARE. LUCA.
GeneTreeiENSGT00390000005923.
HOGENOMiHOG000231921.
HOVERGENiHBG060396.
InParanoidiQ68FY1.
KOiK14313.
OMAiAPQNGNW.
OrthoDBiEOG091G0DAQ.
PhylomeDBiQ68FY1.
TreeFamiTF325369.

Family and domain databases

InterProiView protein in InterPro
IPR017389. Nucleoporin_NUP53.
IPR000504. RRM_dom.
IPR007846. RRM_NUP35_dom.
PfamiView protein in Pfam
PF05172. Nup35_RRM. 1 hit.
PIRSFiPIRSF038119. Nucleoporin_NUP53. 1 hit.
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiView protein in PROSITE
PS51472. RRM_NUP35. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68FY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAFAVDPQA PTLGSEPMML GSPTSPKPGA NAQFLPGFLM GDLPAPVTPQ
60 70 80 90 100
PRSISGPSVG VMEMRSPLLA GGSPPQPVVP AHKDKSGAPP VRSIYDDISS
110 120 130 140 150
PGLGSTPLPS RRQANISVLQ SPLVGVTTPV TGQSMFSPAN IGQPRKTTLS
160 170 180 190 200
PAQLDPFYTQ GDSLTSEDHL DDTWVTVFGF PQASASYILL QFAQYGNILK
210 220 230 240 250
HVMSNTGNWM HIRYQSKLQA RKALSKDGRI FGESIMIGVK PCIDKNVMEN
260 270 280 290 300
SDRGVLSSPS LAFTPPIRTL GTPTQPGSTP RVSTMRPLAT AYKASTSDYQ
310 320
VISDRQTPKK DESLVSRAME YMFGW
Length:325
Mass (Da):34,802
Last modified:October 11, 2004 - v1
Checksum:i5EC3D9E5FE80B9FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078914 mRNA. Translation: AAH78914.1.
RefSeqiNP_001004229.1. NM_001004229.1.
UniGeneiRn.203627.

Genome annotation databases

EnsembliENSRNOT00000012628; ENSRNOP00000012628; ENSRNOG00000009290.
GeneIDi295692.
KEGGirno:295692.
UCSCiRGD:1303069. rat.

Similar proteinsi

Entry informationi

Entry nameiNUP53_RAT
AccessioniPrimary (citable) accession number: Q68FY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 11, 2004
Last modified: September 27, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families