Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome b-c1 complex subunit 1, mitochondrial

Gene

Uqcrc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1 (By similarity).By similarity

Caution

Does not seem to have a protease activity as it lack the zinc-binding site.Curated

GO - Molecular functioni

GO - Biological processi

  • aerobic respiration Source: GO_Central
  • mitochondrial electron transport, ubiquinol to cytochrome c Source: RGD
  • protein processing Source: GO_Central
  • response to activity Source: RGD
  • response to alkaloid Source: RGD

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-RNO-611105 Respiratory electron transport

Protein family/group databases

MEROPSiM16.975

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 1, mitochondrial
Alternative name(s):
Complex III subunit 1
Core protein I
Ubiquinol-cytochrome-c reductase complex core protein 1
Gene namesi
Name:Uqcrc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1303314 Uqcrc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34MitochondrionBy similarityAdd BLAST34
ChainiPRO_000027139835 – 480Cytochrome b-c1 complex subunit 1, mitochondrialAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei111N6-acetyllysineBy similarity1
Modified residuei138N6-acetyllysineBy similarity1
Modified residuei163N6-acetyllysine; alternateBy similarity1
Modified residuei163N6-succinyllysine; alternateBy similarity1
Modified residuei212PhosphoserineCombined sources1
Modified residuei214PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ68FY0
PRIDEiQ68FY0

2D gel databases

World-2DPAGEi0004:Q68FY0

PTM databases

CarbonylDBiQ68FY0
iPTMnetiQ68FY0
PhosphoSitePlusiQ68FY0

Expressioni

Gene expression databases

BgeeiENSRNOG00000032134
GenevisibleiQ68FY0 RN

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).By similarity

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ68FY0
IntActiQ68FY0, 1 interactor
STRINGi10116.ENSRNOP00000044696

Structurei

3D structure databases

ProteinModelPortaliQ68FY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0960 Eukaryota
COG0612 LUCA
GeneTreeiENSGT00550000074701
HOGENOMiHOG000242450
HOVERGENiHBG006393
InParanoidiQ68FY0
KOiK00414
OMAiFFLQGQW
OrthoDBiEOG091G05W9
PhylomeDBiQ68FY0
TreeFamiTF105032

Family and domain databases

InterProiView protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR011765 Pept_M16_N
IPR007863 Peptidase_M16_C
PfamiView protein in Pfam
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 1 hit
SUPFAMiSSF63411 SSF63411, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68FY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASAVCRAA CSGTQALLRT CRSPALLRLP ALRGTATFVQ ALQSVPETQV
60 70 80 90 100
SVLDNGLRVA SEQSSHPTCT VGVWIDVGSR YETEKNNGAG YFLEHLAFKG
110 120 130 140 150
TKNRPGNALE KEVESIGAHL NAYSTREHTA YLIKALSKDL PKVVELLADI
160 170 180 190 200
VQNISLEDSQ IEKERDVILR EMQENDASMQ NVVFDYLHAT AFQGTPLAQA
210 220 230 240 250
VEGPSENVRR LSRTDLTDYL SRHYKAPRMV LAAAGGVKHQ QLLDLAQDHF
260 270 280 290 300
SSVSQVYEED AVPSITPCRF TGSEIRHRDD ALPLAHVAIA VEGPGWANPD
310 320 330 340 350
NVALQVANAI IGHYDCTYGG GVHLSSPLAS VAVANKLCQS FQTFNISYSE
360 370 380 390 400
TGLLGAHFVC DAMSIDDMIF FLQGQWMRLC TSATESEVTR GKNILRNALI
410 420 430 440 450
SHLDGTTPVC EDIGRSLLTY GRRIPLAEWE SRIEEVDAQM VREVCSKYFY
460 470 480
DQCPAVAGYG PIEQLSDYNR IRSGMFWLRF
Length:480
Mass (Da):52,849
Last modified:October 11, 2004 - v1
Checksum:i140B7E886BD4D8C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078923 mRNA Translation: AAH78923.1
RefSeqiNP_001004250.1, NM_001004250.2
UniGeneiRn.3428

Genome annotation databases

EnsembliENSRNOT00000042114; ENSRNOP00000044696; ENSRNOG00000032134
GeneIDi301011
KEGGirno:301011
UCSCiRGD:1303314 rat

Similar proteinsi

Entry informationi

Entry nameiQCR1_RAT
AccessioniPrimary (citable) accession number: Q68FY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health