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Protein

Cytochrome b-c1 complex subunit 1, mitochondrial

Gene

Uqcrc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1 (By similarity).By similarity

GO - Molecular functioni

  • metalloendopeptidase activity Source: GO_Central
  • protein complex binding Source: RGD
  • zinc ion binding Source: GO_Central

GO - Biological processi

  • aerobic respiration Source: GO_Central
  • mitochondrial electron transport, ubiquinol to cytochrome c Source: GO_Central
  • protein processing Source: GO_Central
  • response to activity Source: RGD
  • response to alkaloid Source: RGD
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-RNO-611105. Respiratory electron transport.

Protein family/group databases

MEROPSiM16.975.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 1, mitochondrial
Alternative name(s):
Complex III subunit 1
Core protein I
Ubiquinol-cytochrome-c reductase complex core protein 1
Gene namesi
Name:Uqcrc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1303314. Uqcrc1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial respiratory chain complex III Source: RGD
  • mitochondrion Source: RGD
  • myelin sheath Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3434MitochondrionBy similarityAdd
BLAST
Chaini35 – 480446Cytochrome b-c1 complex subunit 1, mitochondrialPRO_0000271398Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei111 – 1111N6-acetyllysineBy similarity
Modified residuei138 – 1381N6-acetyllysineBy similarity
Modified residuei163 – 1631N6-acetyllysine; alternateBy similarity
Modified residuei163 – 1631N6-succinyllysine; alternateBy similarity
Modified residuei212 – 2121PhosphoserineCombined sources
Modified residuei214 – 2141PhosphothreonineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ68FY0.
PRIDEiQ68FY0.

2D gel databases

World-2DPAGE0004:Q68FY0.

PTM databases

iPTMnetiQ68FY0.
PhosphoSiteiQ68FY0.

Expressioni

Gene expression databases

GenevisibleiQ68FY0. RN.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).By similarity

GO - Molecular functioni

  • protein complex binding Source: RGD

Protein-protein interaction databases

IntActiQ68FY0. 1 interaction.
STRINGi10116.ENSRNOP00000044696.

Structurei

3D structure databases

ProteinModelPortaliQ68FY0.
SMRiQ68FY0. Positions 35-480.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0960. Eukaryota.
COG0612. LUCA.
GeneTreeiENSGT00550000074701.
HOGENOMiHOG000242450.
HOVERGENiHBG006393.
InParanoidiQ68FY0.
KOiK00414.
OMAiFFLQGQW.
OrthoDBiEOG74R1QJ.
PhylomeDBiQ68FY0.
TreeFamiTF105032.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR007863. Peptidase_M16_C.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68FY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASAVCRAA CSGTQALLRT CRSPALLRLP ALRGTATFVQ ALQSVPETQV
60 70 80 90 100
SVLDNGLRVA SEQSSHPTCT VGVWIDVGSR YETEKNNGAG YFLEHLAFKG
110 120 130 140 150
TKNRPGNALE KEVESIGAHL NAYSTREHTA YLIKALSKDL PKVVELLADI
160 170 180 190 200
VQNISLEDSQ IEKERDVILR EMQENDASMQ NVVFDYLHAT AFQGTPLAQA
210 220 230 240 250
VEGPSENVRR LSRTDLTDYL SRHYKAPRMV LAAAGGVKHQ QLLDLAQDHF
260 270 280 290 300
SSVSQVYEED AVPSITPCRF TGSEIRHRDD ALPLAHVAIA VEGPGWANPD
310 320 330 340 350
NVALQVANAI IGHYDCTYGG GVHLSSPLAS VAVANKLCQS FQTFNISYSE
360 370 380 390 400
TGLLGAHFVC DAMSIDDMIF FLQGQWMRLC TSATESEVTR GKNILRNALI
410 420 430 440 450
SHLDGTTPVC EDIGRSLLTY GRRIPLAEWE SRIEEVDAQM VREVCSKYFY
460 470 480
DQCPAVAGYG PIEQLSDYNR IRSGMFWLRF
Length:480
Mass (Da):52,849
Last modified:October 11, 2004 - v1
Checksum:i140B7E886BD4D8C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078923 mRNA. Translation: AAH78923.1.
RefSeqiNP_001004250.1. NM_001004250.2.
UniGeneiRn.3428.

Genome annotation databases

EnsembliENSRNOT00000042114; ENSRNOP00000044696; ENSRNOG00000032134.
GeneIDi301011.
KEGGirno:301011.
UCSCiRGD:1303314. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078923 mRNA. Translation: AAH78923.1.
RefSeqiNP_001004250.1. NM_001004250.2.
UniGeneiRn.3428.

3D structure databases

ProteinModelPortaliQ68FY0.
SMRiQ68FY0. Positions 35-480.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ68FY0. 1 interaction.
STRINGi10116.ENSRNOP00000044696.

Protein family/group databases

MEROPSiM16.975.

PTM databases

iPTMnetiQ68FY0.
PhosphoSiteiQ68FY0.

2D gel databases

World-2DPAGE0004:Q68FY0.

Proteomic databases

PaxDbiQ68FY0.
PRIDEiQ68FY0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000042114; ENSRNOP00000044696; ENSRNOG00000032134.
GeneIDi301011.
KEGGirno:301011.
UCSCiRGD:1303314. rat.

Organism-specific databases

CTDi7384.
RGDi1303314. Uqcrc1.

Phylogenomic databases

eggNOGiKOG0960. Eukaryota.
COG0612. LUCA.
GeneTreeiENSGT00550000074701.
HOGENOMiHOG000242450.
HOVERGENiHBG006393.
InParanoidiQ68FY0.
KOiK00414.
OMAiFFLQGQW.
OrthoDBiEOG74R1QJ.
PhylomeDBiQ68FY0.
TreeFamiTF105032.

Enzyme and pathway databases

ReactomeiR-RNO-611105. Respiratory electron transport.

Miscellaneous databases

PROiQ68FY0.

Gene expression databases

GenevisibleiQ68FY0. RN.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR007863. Peptidase_M16_C.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  2. Lubec G., Afjehi-Sadat L., Chen W.-Q.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 86-99; 112-126 AND 397-415, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus and Spinal cord.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-212 AND THR-214, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiQCR1_RAT
AccessioniPrimary (citable) accession number: Q68FY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 11, 2004
Last modified: July 6, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Does not seem to have a protease activity as it lack the zinc-binding site.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.