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Protein

Mannose-6-phosphate isomerase

Gene

Mpi

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Mannose-6-phosphate isomerase (Mpi)
  2. Phosphomannomutase (Pmm1), Phosphomannomutase (Pmm2)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi110ZincBy similarity1
Metal bindingi112ZincBy similarity1
Metal bindingi137ZincBy similarity1
Metal bindingi276ZincBy similarity1
Active sitei295By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-446205 Synthesis of GDP-mannose
SABIO-RKQ68FX1
UniPathwayiUPA00126; UER00423

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Name:Mpi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi3107 Mpi

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001942382 – 423Mannose-6-phosphate isomeraseAdd BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei102PhosphoserineBy similarity1
Modified residuei108PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ68FX1
PRIDEiQ68FX1

PTM databases

iPTMnetiQ68FX1
PhosphoSitePlusiQ68FX1

Expressioni

Gene expression databases

BgeeiENSRNOG00000018898
GenevisibleiQ68FX1 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025783

Structurei

3D structure databases

ProteinModelPortaliQ68FX1
SMRiQ68FX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2757 Eukaryota
COG1482 LUCA
GeneTreeiENSGT00390000016075
HOGENOMiHOG000241277
HOVERGENiHBG000367
InParanoidiQ68FX1
KOiK01809
OMAiMGTHPSN
OrthoDBiEOG091G078D
PhylomeDBiQ68FX1
TreeFamiTF312831

Family and domain databases

Gene3Di2.60.120.10, 4 hits
InterProiView protein in InterPro
IPR001250 Man6P_Isoase-1
IPR016305 Mannose-6-P_Isomerase
IPR018050 Pmannose_isomerase-type1_CS
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR10309 PTHR10309, 1 hit
PfamiView protein in Pfam
PF01238 PMI_typeI, 1 hit
PIRSFiPIRSF001480 Mannose-6-phosphate_isomerase, 1 hit
PRINTSiPR00714 MAN6PISMRASE
SUPFAMiSSF51182 SSF51182, 1 hit
TIGRFAMsiTIGR00218 manA, 1 hit
PROSITEiView protein in PROSITE
PS00965 PMI_I_1, 1 hit
PS00966 PMI_I_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68FX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANPRVFPLS CVVQQYAWGK VGSKSEVACL LACSDPLTQI SEDKPYAELW
60 70 80 90 100
MGAHPRGDAK ILDNRISQKT LGQWIAENQN SLGQKVKDTF NGKLPFLFKV
110 120 130 140 150
LSVETALSIQ AHPNKELAEK LHLQAPEHYP DANHKPEMAI ALTPFQGLCG
160 170 180 190 200
FRPVEEIVTF LKKVPEFQSL IGEDATAQLK KSMNEGSGAM ASALKNCFSH
210 220 230 240 250
LMKSEKKVVV EQLNLLVKRI SQQISNGNSM DDICGELLLQ LHQQYPGDIG
260 270 280 290 300
CFAIYLLNLI TLKPGEAMFL EANVPHAYLK GDCVECMACS DNTVRAGLTP
310 320 330 340 350
KFIDVSTLCE MLDYTPSPSK DRLFAPTLSQ DDPYLSIYDP PVPDFTVMKI
360 370 380 390 400
EVPGSVTEYK VLTLDSASIL LLVQGTVTAI IPSVQGEIPL SRGGVLFIGA
410 420
NETVLLKLTV PKNLLIFRAC CLL
Length:423
Mass (Da):46,424
Last modified:October 11, 2004 - v1
Checksum:i69C6CE365535002B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079111 mRNA Translation: AAH79111.1
RefSeqiNP_001004081.1, NM_001004081.1
UniGeneiRn.229358

Genome annotation databases

EnsembliENSRNOT00000025783; ENSRNOP00000025783; ENSRNOG00000018898
GeneIDi300741
KEGGirno:300741
UCSCiRGD:3107 rat

Similar proteinsi

Entry informationi

Entry nameiMPI_RAT
AccessioniPrimary (citable) accession number: Q68FX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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