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Q68FX1

- MPI_RAT

UniProt

Q68FX1 - MPI_RAT

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Protein

Mannose-6-phosphate isomerase

Gene
Mpi
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity.

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi110 – 1101Zinc By similarity
Metal bindingi112 – 1121Zinc By similarity
Metal bindingi137 – 1371Zinc By similarity
Metal bindingi276 – 2761Zinc By similarity
Active sitei295 – 2951 By similarity

GO - Molecular functioni

  1. mannose-6-phosphate isomerase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_196380. Synthesis of GDP-mannose.
SABIO-RKQ68FX1.
UniPathwayiUPA00126; UER00423.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Name:Mpi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi3107. Mpi.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 423422Mannose-6-phosphate isomerasePRO_0000194238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ68FX1.
PRIDEiQ68FX1.

PTM databases

PhosphoSiteiQ68FX1.

Expressioni

Gene expression databases

GenevestigatoriQ68FX1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025783.

Structurei

3D structure databases

ProteinModelPortaliQ68FX1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1482.
GeneTreeiENSGT00390000016075.
HOGENOMiHOG000241277.
HOVERGENiHBG000367.
InParanoidiQ68FX1.
KOiK01809.
OMAiFIDEFQP.
OrthoDBiEOG7GTT3M.
PhylomeDBiQ68FX1.
TreeFamiTF312831.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR10309. PTHR10309. 1 hit.
PfamiPF01238. PMI_typeI. 1 hit.
[Graphical view]
PIRSFiPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSiPR00714. MAN6PISMRASE.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR00218. manA. 1 hit.
PROSITEiPS00965. PMI_I_1. 1 hit.
PS00966. PMI_I_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68FX1-1 [UniParc]FASTAAdd to Basket

« Hide

MANPRVFPLS CVVQQYAWGK VGSKSEVACL LACSDPLTQI SEDKPYAELW    50
MGAHPRGDAK ILDNRISQKT LGQWIAENQN SLGQKVKDTF NGKLPFLFKV 100
LSVETALSIQ AHPNKELAEK LHLQAPEHYP DANHKPEMAI ALTPFQGLCG 150
FRPVEEIVTF LKKVPEFQSL IGEDATAQLK KSMNEGSGAM ASALKNCFSH 200
LMKSEKKVVV EQLNLLVKRI SQQISNGNSM DDICGELLLQ LHQQYPGDIG 250
CFAIYLLNLI TLKPGEAMFL EANVPHAYLK GDCVECMACS DNTVRAGLTP 300
KFIDVSTLCE MLDYTPSPSK DRLFAPTLSQ DDPYLSIYDP PVPDFTVMKI 350
EVPGSVTEYK VLTLDSASIL LLVQGTVTAI IPSVQGEIPL SRGGVLFIGA 400
NETVLLKLTV PKNLLIFRAC CLL 423
Length:423
Mass (Da):46,424
Last modified:October 11, 2004 - v1
Checksum:i69C6CE365535002B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC079111 mRNA. Translation: AAH79111.1.
RefSeqiNP_001004081.1. NM_001004081.1.
UniGeneiRn.229358.

Genome annotation databases

EnsembliENSRNOT00000025783; ENSRNOP00000025783; ENSRNOG00000018898.
GeneIDi300741.
KEGGirno:300741.
UCSCiRGD:3107. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC079111 mRNA. Translation: AAH79111.1 .
RefSeqi NP_001004081.1. NM_001004081.1.
UniGenei Rn.229358.

3D structure databases

ProteinModelPortali Q68FX1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000025783.

PTM databases

PhosphoSitei Q68FX1.

Proteomic databases

PaxDbi Q68FX1.
PRIDEi Q68FX1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000025783 ; ENSRNOP00000025783 ; ENSRNOG00000018898 .
GeneIDi 300741.
KEGGi rno:300741.
UCSCi RGD:3107. rat.

Organism-specific databases

CTDi 4351.
RGDi 3107. Mpi.

Phylogenomic databases

eggNOGi COG1482.
GeneTreei ENSGT00390000016075.
HOGENOMi HOG000241277.
HOVERGENi HBG000367.
InParanoidi Q68FX1.
KOi K01809.
OMAi FIDEFQP.
OrthoDBi EOG7GTT3M.
PhylomeDBi Q68FX1.
TreeFami TF312831.

Enzyme and pathway databases

UniPathwayi UPA00126 ; UER00423 .
Reactomei REACT_196380. Synthesis of GDP-mannose.
SABIO-RK Q68FX1.

Miscellaneous databases

NextBioi 647412.
PROi Q68FX1.

Gene expression databases

Genevestigatori Q68FX1.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR001250. Man6P_Isoase-1.
IPR016305. Mannose-6-P_Isomerase.
IPR018050. Pmannose_isomerase-type1_CS.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR10309. PTHR10309. 1 hit.
Pfami PF01238. PMI_typeI. 1 hit.
[Graphical view ]
PIRSFi PIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
PRINTSi PR00714. MAN6PISMRASE.
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR00218. manA. 1 hit.
PROSITEi PS00965. PMI_I_1. 1 hit.
PS00966. PMI_I_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiMPI_RAT
AccessioniPrimary (citable) accession number: Q68FX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: October 11, 2004
Last modified: September 3, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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