Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q68FX1

- MPI_RAT

UniProt

Q68FX1 - MPI_RAT

Protein

Mannose-6-phosphate isomerase

Gene

Mpi

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

    Catalytic activityi

    D-mannose 6-phosphate = D-fructose 6-phosphate.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi110 – 1101ZincBy similarity
    Metal bindingi112 – 1121ZincBy similarity
    Metal bindingi137 – 1371ZincBy similarity
    Metal bindingi276 – 2761ZincBy similarity
    Active sitei295 – 2951By similarity

    GO - Molecular functioni

    1. mannose-6-phosphate isomerase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_196380. Synthesis of GDP-mannose.
    SABIO-RKQ68FX1.
    UniPathwayiUPA00126; UER00423.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannose-6-phosphate isomerase (EC:5.3.1.8)
    Alternative name(s):
    Phosphohexomutase
    Phosphomannose isomerase
    Short name:
    PMI
    Gene namesi
    Name:Mpi
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi3107. Mpi.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 423422Mannose-6-phosphate isomerasePRO_0000194238Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ68FX1.
    PRIDEiQ68FX1.

    PTM databases

    PhosphoSiteiQ68FX1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ68FX1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000025783.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68FX1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1482.
    GeneTreeiENSGT00390000016075.
    HOGENOMiHOG000241277.
    HOVERGENiHBG000367.
    InParanoidiQ68FX1.
    KOiK01809.
    OMAiFIDEFQP.
    OrthoDBiEOG7GTT3M.
    PhylomeDBiQ68FX1.
    TreeFamiTF312831.

    Family and domain databases

    Gene3Di2.60.120.10. 3 hits.
    InterProiIPR001250. Man6P_Isoase-1.
    IPR016305. Mannose-6-P_Isomerase.
    IPR018050. Pmannose_isomerase-type1_CS.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR10309. PTHR10309. 1 hit.
    PfamiPF01238. PMI_typeI. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
    PRINTSiPR00714. MAN6PISMRASE.
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR00218. manA. 1 hit.
    PROSITEiPS00965. PMI_I_1. 1 hit.
    PS00966. PMI_I_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q68FX1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANPRVFPLS CVVQQYAWGK VGSKSEVACL LACSDPLTQI SEDKPYAELW    50
    MGAHPRGDAK ILDNRISQKT LGQWIAENQN SLGQKVKDTF NGKLPFLFKV 100
    LSVETALSIQ AHPNKELAEK LHLQAPEHYP DANHKPEMAI ALTPFQGLCG 150
    FRPVEEIVTF LKKVPEFQSL IGEDATAQLK KSMNEGSGAM ASALKNCFSH 200
    LMKSEKKVVV EQLNLLVKRI SQQISNGNSM DDICGELLLQ LHQQYPGDIG 250
    CFAIYLLNLI TLKPGEAMFL EANVPHAYLK GDCVECMACS DNTVRAGLTP 300
    KFIDVSTLCE MLDYTPSPSK DRLFAPTLSQ DDPYLSIYDP PVPDFTVMKI 350
    EVPGSVTEYK VLTLDSASIL LLVQGTVTAI IPSVQGEIPL SRGGVLFIGA 400
    NETVLLKLTV PKNLLIFRAC CLL 423
    Length:423
    Mass (Da):46,424
    Last modified:October 11, 2004 - v1
    Checksum:i69C6CE365535002B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079111 mRNA. Translation: AAH79111.1.
    RefSeqiNP_001004081.1. NM_001004081.1.
    UniGeneiRn.229358.

    Genome annotation databases

    EnsembliENSRNOT00000025783; ENSRNOP00000025783; ENSRNOG00000018898.
    GeneIDi300741.
    KEGGirno:300741.
    UCSCiRGD:3107. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079111 mRNA. Translation: AAH79111.1 .
    RefSeqi NP_001004081.1. NM_001004081.1.
    UniGenei Rn.229358.

    3D structure databases

    ProteinModelPortali Q68FX1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000025783.

    PTM databases

    PhosphoSitei Q68FX1.

    Proteomic databases

    PaxDbi Q68FX1.
    PRIDEi Q68FX1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000025783 ; ENSRNOP00000025783 ; ENSRNOG00000018898 .
    GeneIDi 300741.
    KEGGi rno:300741.
    UCSCi RGD:3107. rat.

    Organism-specific databases

    CTDi 4351.
    RGDi 3107. Mpi.

    Phylogenomic databases

    eggNOGi COG1482.
    GeneTreei ENSGT00390000016075.
    HOGENOMi HOG000241277.
    HOVERGENi HBG000367.
    InParanoidi Q68FX1.
    KOi K01809.
    OMAi FIDEFQP.
    OrthoDBi EOG7GTT3M.
    PhylomeDBi Q68FX1.
    TreeFami TF312831.

    Enzyme and pathway databases

    UniPathwayi UPA00126 ; UER00423 .
    Reactomei REACT_196380. Synthesis of GDP-mannose.
    SABIO-RK Q68FX1.

    Miscellaneous databases

    NextBioi 647412.
    PROi Q68FX1.

    Gene expression databases

    Genevestigatori Q68FX1.

    Family and domain databases

    Gene3Di 2.60.120.10. 3 hits.
    InterProi IPR001250. Man6P_Isoase-1.
    IPR016305. Mannose-6-P_Isomerase.
    IPR018050. Pmannose_isomerase-type1_CS.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR10309. PTHR10309. 1 hit.
    Pfami PF01238. PMI_typeI. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001480. Mannose-6-phosphate_isomerase. 1 hit.
    PRINTSi PR00714. MAN6PISMRASE.
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR00218. manA. 1 hit.
    PROSITEi PS00965. PMI_I_1. 1 hit.
    PS00966. PMI_I_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiMPI_RAT
    AccessioniPrimary (citable) accession number: Q68FX1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3