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Q68FX0

- IDH3B_RAT

UniProt

Q68FX0 - IDH3B_RAT

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Protein

Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

Gene

Idh3B

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg(2+) or Mn(2+) ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei133 – 1331SubstrateBy similarity
Binding sitei164 – 1641SubstrateBy similarity
Sitei171 – 1711Critical for catalysisBy similarity
Sitei218 – 2181Critical for catalysisBy similarity
Metal bindingi251 – 2511Magnesium or manganeseBy similarity
Binding sitei251 – 2511SubstrateBy similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NAD+) activity Source: RGD
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. 2-oxoglutarate metabolic process Source: RGD
  2. isocitrate metabolic process Source: RGD
  3. NADH metabolic process Source: RGD
  4. tricarboxylic acid cycle Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NAD

Enzyme and pathway databases

ReactomeiREACT_216424. Citric acid cycle (TCA cycle).
SABIO-RKQ68FX0.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (EC:1.1.1.41)
Alternative name(s):
Isocitric dehydrogenase subunit beta
NAD(+)-specific ICDH subunit beta
Gene namesi
Name:Idh3B
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi621881. Idh3B.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrial isocitrate dehydrogenase complex (NAD+) Source: RGD
  2. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3434MitochondrionBy similarityAdd
BLAST
Chaini35 – 385351Isocitrate dehydrogenase [NAD] subunit beta, mitochondrialPRO_0000014447Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei199 – 1991N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ68FX0.
PRIDEiQ68FX0.

2D gel databases

World-2DPAGE0004:Q68FX0.

PTM databases

PhosphoSiteiQ68FX0.

Expressioni

Gene expression databases

ExpressionAtlasiQ68FX0. baseline and differential.
GenevestigatoriQ68FX0.

Interactioni

Subunit structurei

Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009681.

Structurei

3D structure databases

ProteinModelPortaliQ68FX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0473.
GeneTreeiENSGT00590000083091.
HOGENOMiHOG000021113.
HOVERGENiHBG052080.
InParanoidiQ68FX0.
KOiK00030.
OMAiILATPDY.
OrthoDBiEOG75B85R.
PhylomeDBiQ68FX0.
TreeFamiTF315033.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q68FX0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAALSNVRWL TRAVLGARNS GAWRGLRTAA SAQAASQSQA QDVRVEGAFP
60 70 80 90 100
VTMLPGDGVG PELMHAVKEV FKAAAVPVEF KEHHLSEVQN MASEEKLEQV
110 120 130 140 150
LSSMKENKVA IIGKIYTPME YKGELASYDM QLRRKLDLFA NVVHVKSLPG
160 170 180 190 200
YKTRHNNLDL VIIREQTEGE YSSLEHESAR GVIECLKIVT RTKSQRIAKF
210 220 230 240 250
AFDYATKKGR SKVTAVHKAN IMKLGDGLFL QCCEEVAELY PKIKFETMII
260 270 280 290 300
DNCCMQLVQN PYQFDVLVMP NLYGNIIDNL AAGLVGGAGV VPGESYSAEY
310 320 330 340 350
AVFETGARHP FAQAVGRNIA NPTAMLLSAS NMLRHLNLEY HSSMIADAVK
360 370 380
KVIKVGKVRT RDMGGYSTTT DFIKSVIGHL HPHGG
Length:385
Mass (Da):42,354
Last modified:October 11, 2004 - v1
Checksum:iDC91921B48EEED1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079113 mRNA. Translation: AAH79113.1.
RefSeqiNP_446033.1. NM_053581.1.
UniGeneiRn.1093.

Genome annotation databases

EnsembliENSRNOT00000009681; ENSRNOP00000009681; ENSRNOG00000007316.
GeneIDi94173.
KEGGirno:94173.
UCSCiRGD:621881. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079113 mRNA. Translation: AAH79113.1 .
RefSeqi NP_446033.1. NM_053581.1.
UniGenei Rn.1093.

3D structure databases

ProteinModelPortali Q68FX0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000009681.

PTM databases

PhosphoSitei Q68FX0.

2D gel databases

World-2DPAGE 0004:Q68FX0.

Proteomic databases

PaxDbi Q68FX0.
PRIDEi Q68FX0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000009681 ; ENSRNOP00000009681 ; ENSRNOG00000007316 .
GeneIDi 94173.
KEGGi rno:94173.
UCSCi RGD:621881. rat.

Organism-specific databases

CTDi 3420.
RGDi 621881. Idh3B.

Phylogenomic databases

eggNOGi COG0473.
GeneTreei ENSGT00590000083091.
HOGENOMi HOG000021113.
HOVERGENi HBG052080.
InParanoidi Q68FX0.
KOi K00030.
OMAi ILATPDY.
OrthoDBi EOG75B85R.
PhylomeDBi Q68FX0.
TreeFami TF315033.

Enzyme and pathway databases

Reactomei REACT_216424. Citric acid cycle (TCA cycle).
SABIO-RK Q68FX0.

Miscellaneous databases

NextBioi 617826.
PROi Q68FX0.

Gene expression databases

ExpressionAtlasi Q68FX0. baseline and differential.
Genevestigatori Q68FX0.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00175. mito_nad_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiIDH3B_RAT
AccessioniPrimary (citable) accession number: Q68FX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 11, 2004
Last modified: November 26, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3