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Reviewed, UniProtKB/Swiss-Prot Q68FX0 (IDH3B_RAT)

Last modified February 9, 2010. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
    EC=1.1.1.41
Alternative name(s):
    Isocitric dehydrogenase subunit beta
    NAD(+)-specific ICDH subunit beta
Gene names
Name: Idh3B
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length385 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Subunit structure

Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1 By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3434Mitochondrion By similarity
Chain35 – 385351Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
PRO_0000014447

Sites

Metal binding2511Magnesium or manganese By similarity
Binding site1331Substrate By similarity
Binding site1641Substrate By similarity
Binding site2511Substrate By similarity
Site1711Critical for catalysis By similarity
Site2181Critical for catalysis By similarity

Amino acid modifications

Modified residue1461N6-acetyllysine By similarity
Modified residue1991N6-acetyllysine By similarity
Modified residue3741N6-acetyllysine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q68FX0-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: DC91921B48EEED1E

FASTA38542,354
        10         20         30         40         50         60 
MAALSNVRWL TRAVLGARNS GAWRGLRTAA SAQAASQSQA QDVRVEGAFP VTMLPGDGVG 

        70         80         90        100        110        120 
PELMHAVKEV FKAAAVPVEF KEHHLSEVQN MASEEKLEQV LSSMKENKVA IIGKIYTPME 

       130        140        150        160        170        180 
YKGELASYDM QLRRKLDLFA NVVHVKSLPG YKTRHNNLDL VIIREQTEGE YSSLEHESAR 

       190        200        210        220        230        240 
GVIECLKIVT RTKSQRIAKF AFDYATKKGR SKVTAVHKAN IMKLGDGLFL QCCEEVAELY 

       250        260        270        280        290        300 
PKIKFETMII DNCCMQLVQN PYQFDVLVMP NLYGNIIDNL AAGLVGGAGV VPGESYSAEY 

       310        320        330        340        350        360 
AVFETGARHP FAQAVGRNIA NPTAMLLSAS NMLRHLNLEY HSSMIADAVK KVIKVGKVRT 

       370        380 
RDMGGYSTTT DFIKSVIGHL HPHGG

« Hide

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References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC079113 mRNA. Translation: AAH79113.1.
IPIIPI00357924.
RefSeqNP_446033.1.
UniGeneRn.1093

3D structure databases

SMRQ68FX0. Positions 47-381.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ68FX0.

PTM databases

PhosphoSiteQ68FX0.

Proteomic databases

PRIDEQ68FX0.

Genome annotation databases

EnsemblENSRNOT00000009681; ENSRNOP00000009681; ENSRNOG00000007316; Rattus norvegicus. [Genome view]
GeneID94173.
KEGGrno:94173.
NMPDRfig|10116.3.peg.19717.
UCSCNM_053581. rat.

Organism-specific databases

CTD94173.
RGD621881. Idh3B.

Phylogenomic databases

eggNOGroNOG15039.
HOVERGENQ68FX0.
InParanoidQ68FX0.
OMAFKAAAVP.
OrthoDBEOG9B2WGN.
PhylomeDBQ68FX0.

Enzyme and pathway databases

BRENDA1.1.1.41. 248.

Gene expression databases

ArrayExpressQ68FX0.
GenevestigatorQ68FX0.

Family and domain databases

InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD_mit.
[Graphical view]
Gene3DG3DSA:3.40.718.10. IDH_IMDH. 1 hit.
PANTHERPTHR11835. IDH_IMDH_dimeric. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR00175. mito_nad_idh. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio617826.

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Entry information

Entry nameIDH3B_RAT
AccessionPrimary (citable) accession number: Q68FX0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 11, 2004
Last modified: February 9, 2010
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents