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Q68FX0

- IDH3B_RAT

UniProt

Q68FX0 - IDH3B_RAT

Protein

Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

Gene

Idh3B

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei133 – 1331SubstrateBy similarity
    Binding sitei164 – 1641SubstrateBy similarity
    Sitei171 – 1711Critical for catalysisBy similarity
    Sitei218 – 2181Critical for catalysisBy similarity
    Metal bindingi251 – 2511Magnesium or manganeseBy similarity
    Binding sitei251 – 2511SubstrateBy similarity

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NAD+) activity Source: RGD
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. 2-oxoglutarate metabolic process Source: RGD
    2. isocitrate metabolic process Source: RGD
    3. NADH metabolic process Source: RGD
    4. tricarboxylic acid cycle Source: RGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, NAD

    Enzyme and pathway databases

    ReactomeiREACT_216424. Citric acid cycle (TCA cycle).
    SABIO-RKQ68FX0.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (EC:1.1.1.41)
    Alternative name(s):
    Isocitric dehydrogenase subunit beta
    NAD(+)-specific ICDH subunit beta
    Gene namesi
    Name:Idh3B
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi621881. Idh3B.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrial isocitrate dehydrogenase complex (NAD+) Source: RGD

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3434MitochondrionBy similarityAdd
    BLAST
    Chaini35 – 385351Isocitrate dehydrogenase [NAD] subunit beta, mitochondrialPRO_0000014447Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei199 – 1991N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ68FX0.
    PRIDEiQ68FX0.

    2D gel databases

    World-2DPAGE0004:Q68FX0.

    PTM databases

    PhosphoSiteiQ68FX0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ68FX0.

    Interactioni

    Subunit structurei

    Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000009681.

    Structurei

    3D structure databases

    ProteinModelPortaliQ68FX0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0473.
    GeneTreeiENSGT00590000083091.
    HOGENOMiHOG000021113.
    HOVERGENiHBG052080.
    InParanoidiQ68FX0.
    KOiK00030.
    OMAiILATPDY.
    OrthoDBiEOG75B85R.
    PhylomeDBiQ68FX0.
    TreeFamiTF315033.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004434. Isocitrate_DH_NAD.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q68FX0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAALSNVRWL TRAVLGARNS GAWRGLRTAA SAQAASQSQA QDVRVEGAFP    50
    VTMLPGDGVG PELMHAVKEV FKAAAVPVEF KEHHLSEVQN MASEEKLEQV 100
    LSSMKENKVA IIGKIYTPME YKGELASYDM QLRRKLDLFA NVVHVKSLPG 150
    YKTRHNNLDL VIIREQTEGE YSSLEHESAR GVIECLKIVT RTKSQRIAKF 200
    AFDYATKKGR SKVTAVHKAN IMKLGDGLFL QCCEEVAELY PKIKFETMII 250
    DNCCMQLVQN PYQFDVLVMP NLYGNIIDNL AAGLVGGAGV VPGESYSAEY 300
    AVFETGARHP FAQAVGRNIA NPTAMLLSAS NMLRHLNLEY HSSMIADAVK 350
    KVIKVGKVRT RDMGGYSTTT DFIKSVIGHL HPHGG 385
    Length:385
    Mass (Da):42,354
    Last modified:October 11, 2004 - v1
    Checksum:iDC91921B48EEED1E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079113 mRNA. Translation: AAH79113.1.
    RefSeqiNP_446033.1. NM_053581.1.
    UniGeneiRn.1093.

    Genome annotation databases

    EnsembliENSRNOT00000009681; ENSRNOP00000009681; ENSRNOG00000007316.
    GeneIDi94173.
    KEGGirno:94173.
    UCSCiRGD:621881. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079113 mRNA. Translation: AAH79113.1 .
    RefSeqi NP_446033.1. NM_053581.1.
    UniGenei Rn.1093.

    3D structure databases

    ProteinModelPortali Q68FX0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000009681.

    PTM databases

    PhosphoSitei Q68FX0.

    2D gel databases

    World-2DPAGE 0004:Q68FX0.

    Proteomic databases

    PaxDbi Q68FX0.
    PRIDEi Q68FX0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000009681 ; ENSRNOP00000009681 ; ENSRNOG00000007316 .
    GeneIDi 94173.
    KEGGi rno:94173.
    UCSCi RGD:621881. rat.

    Organism-specific databases

    CTDi 3420.
    RGDi 621881. Idh3B.

    Phylogenomic databases

    eggNOGi COG0473.
    GeneTreei ENSGT00590000083091.
    HOGENOMi HOG000021113.
    HOVERGENi HBG052080.
    InParanoidi Q68FX0.
    KOi K00030.
    OMAi ILATPDY.
    OrthoDBi EOG75B85R.
    PhylomeDBi Q68FX0.
    TreeFami TF315033.

    Enzyme and pathway databases

    Reactomei REACT_216424. Citric acid cycle (TCA cycle).
    SABIO-RK Q68FX0.

    Miscellaneous databases

    NextBioi 617826.
    PROi Q68FX0.

    Gene expression databases

    Genevestigatori Q68FX0.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004434. Isocitrate_DH_NAD.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00175. mito_nad_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiIDH3B_RAT
    AccessioniPrimary (citable) accession number: Q68FX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3