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Protein

Syntaxin-18

Gene

Stx18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-18
Gene namesi
Name:Stx18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1310058. Stx18.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 308CytoplasmicSequence analysisAdd BLAST308
Transmembranei309 – 329Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini330 – 334VesicularSequence analysis5

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102341 – 334Syntaxin-18Add BLAST334

Proteomic databases

PaxDbiQ68FW4.
PRIDEiQ68FW4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000006139.
GenevisibleiQ68FW4. RN.

Interactioni

Subunit structurei

Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B. RINT1/TIP20L and ZW10 are associated with the complex through interaction with BNIP1/SEC20L. Interacts directly with USE1L and BNIP1/SEC20L (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ68FW4.
IntActiQ68FW4. 1 interactor.
STRINGi10116.ENSRNOP00000008410.

Structurei

3D structure databases

ProteinModelPortaliQ68FW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini242 – 304t-SNARE coiled-coil homologyAdd BLAST63

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3894. Eukaryota.
ENOG410XSGT. LUCA.
GeneTreeiENSGT00390000014853.
HOGENOMiHOG000007595.
HOVERGENiHBG054890.
InParanoidiQ68FW4.
KOiK08492.
OMAiLQHRKDY.
OrthoDBiEOG091G0FVR.
PhylomeDBiQ68FW4.
TreeFamiTF105868.

Family and domain databases

InterProiView protein in InterPro
IPR019529. Syntaxin-18_N.
IPR006012. Syntaxin/epimorphin_CS.
PfamiView protein in Pfam
PF10496. Syntaxin-18_N. 1 hit.
PROSITEiView protein in PROSITE
PS00914. SYNTAXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q68FW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVDITLLFR ASVKTVKTRN KALGVAVGGG ADGSRDELFR RSPRPKGDFS
60 70 80 90 100
SRAREVISHI GKLRDFLLEH RKEYINAYSH TMSEYGRMTD TERDQIDQDA
110 120 130 140 150
QIFMRTCKDA IQQLRTEAHK EIHSQQVKEH RTAVLDFVED YLKRVCKLYS
160 170 180 190 200
EQRAIRVKRV VDKKRLSKLE PEPHTKRKEP ASEKSSHNAS QDSEEKPAAE
210 220 230 240 250
DLPEKPLAES QPELGTWGDG KGEDELSPEE IQMFEQENQR LIGEMNSLFD
260 270 280 290 300
EVRQIEGKVV EISRLQEIFT EKVLQQETEI DSIHQLVVGA TENIKEGNED
310 320 330
IREAIKNNAG FRVWILFFLV MCSFSLLFLD WYDS
Length:334
Mass (Da):38,512
Last modified:October 11, 2004 - v1
Checksum:i98CB261E598BFF84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC079183 mRNA. Translation: AAH79183.1.
RefSeqiNP_001012151.1. NM_001012151.1.
UniGeneiRn.53006.

Genome annotation databases

EnsembliENSRNOT00000008410; ENSRNOP00000008410; ENSRNOG00000006139.
GeneIDi360953.
KEGGirno:360953.

Similar proteinsi

Entry informationi

Entry nameiSTX18_RAT
AccessioniPrimary (citable) accession number: Q68FW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 11, 2004
Last modified: September 27, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families