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Q68FW2

- CDCA3_RAT

UniProt

Q68FW2 - CDCA3_RAT

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Protein

Cell division cycle-associated protein 3

Gene
Cdca3, Tome1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase By similarity.

Pathwayi

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
  2. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle-associated protein 3
Alternative name(s):
Trigger of mitotic entry protein 1
Short name:
TOME-1
Gene namesi
Name:Cdca3
Synonyms:Tome1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi1359093. Cdca3.

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273Cell division cycle-associated protein 3PRO_0000287710Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei29 – 291Phosphoserine By similarity
Modified residuei31 – 311Phosphoserine By similarity
Modified residuei37 – 371Phosphothreonine By similarity
Modified residuei44 – 441Phosphoserine By similarity
Modified residuei67 – 671Phosphoserine By similarity
Modified residuei75 – 751Phosphothreonine By similarity
Modified residuei93 – 931Phosphoserine By similarity
Modified residuei204 – 2041Phosphoserine By similarity
Modified residuei207 – 2071Phosphothreonine By similarity
Modified residuei214 – 2141Phosphoserine By similarity

Post-translational modificationi

Ubiquitinated and degraded by the APC/C-Cdh1 complex By similarity.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ68FW2.
PRIDEiQ68FW2.

PTM databases

PhosphoSiteiQ68FW2.

Expressioni

Gene expression databases

GenevestigatoriQ68FW2.

Interactioni

Subunit structurei

Interacts with SKP1. Part of a SCF (SKP1-cullin-F-box) protein ligase complex By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020803.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni90 – 12435F-box-likeAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi263 – 2653KEN box

Domaini

The KEN box is required for the association with the APC/C-Cdh1 complex By similarity.

Phylogenomic databases

eggNOGiNOG46427.
GeneTreeiENSGT00390000017343.
HOGENOMiHOG000013100.
HOVERGENiHBG053225.
InParanoidiQ68FW2.
OMAiKTGGRAW.
OrthoDBiEOG7GJ6D8.
PhylomeDBiQ68FW2.
TreeFamiTF101068.

Sequencei

Sequence statusi: Complete.

Q68FW2-1 [UniParc]FASTAAdd to Basket

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MGSTQSVSGT PARPLPRNKH VSRVADPRSP SAGIQRTPIQ VESSPQPNPP    50
AEQLNSLKQA QDPDPRSPTL GIARTPMKIS GPDSQCPLVK ELSEVFETEV 100
SETEVSESIS SPVLGLPQET PLSSELDLPP DPDPQVSLED QLLPWSQTEL 150
NSKQVFAKEE AKQSTETMVS GQTSDKPSRD PETPQSSGSK RSRRKTNNKV 200
LGRSPLTILQ DDNSPGTLTL RQGKRPSALS ENVKDLKEGV ILGTGRFLKA 250
GGGAWEQNED HDKENQHFAL MES 273
Length:273
Mass (Da):29,611
Last modified:October 11, 2004 - v1
Checksum:i2EB02AE5CFDFBDE1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC079204 mRNA. Translation: AAH79204.1.
RefSeqiNP_001007649.1. NM_001007648.1.
XP_006237401.1. XM_006237339.1.
XP_006237402.1. XM_006237340.1.
XP_006237403.1. XM_006237341.1.
UniGeneiRn.129078.

Genome annotation databases

EnsembliENSRNOT00000020803; ENSRNOP00000020803; ENSRNOG00000015529.
GeneIDi297594.
KEGGirno:297594.
UCSCiRGD:1359093. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC079204 mRNA. Translation: AAH79204.1 .
RefSeqi NP_001007649.1. NM_001007648.1.
XP_006237401.1. XM_006237339.1.
XP_006237402.1. XM_006237340.1.
XP_006237403.1. XM_006237341.1.
UniGenei Rn.129078.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000020803.

PTM databases

PhosphoSitei Q68FW2.

Proteomic databases

PaxDbi Q68FW2.
PRIDEi Q68FW2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000020803 ; ENSRNOP00000020803 ; ENSRNOG00000015529 .
GeneIDi 297594.
KEGGi rno:297594.
UCSCi RGD:1359093. rat.

Organism-specific databases

CTDi 83461.
RGDi 1359093. Cdca3.

Phylogenomic databases

eggNOGi NOG46427.
GeneTreei ENSGT00390000017343.
HOGENOMi HOG000013100.
HOVERGENi HBG053225.
InParanoidi Q68FW2.
OMAi KTGGRAW.
OrthoDBi EOG7GJ6D8.
PhylomeDBi Q68FW2.
TreeFami TF101068.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

NextBioi 642465.
PROi Q68FW2.

Gene expression databases

Genevestigatori Q68FW2.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiCDCA3_RAT
AccessioniPrimary (citable) accession number: Q68FW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2004
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

External Data

Dasty 3

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