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Q68FW2

- CDCA3_RAT

UniProt

Q68FW2 - CDCA3_RAT

Protein

Cell division cycle-associated protein 3

Gene

Cdca3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase By similarity.By similarity

    Pathwayi

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW
    2. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell division cycle-associated protein 3
    Alternative name(s):
    Trigger of mitotic entry protein 1
    Short name:
    TOME-1
    Gene namesi
    Name:Cdca3
    Synonyms:Tome1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi1359093. Cdca3.

    Subcellular locationi

    Cytoplasmcytosol By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 273273Cell division cycle-associated protein 3PRO_0000287710Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei29 – 291PhosphoserineBy similarity
    Modified residuei31 – 311PhosphoserineBy similarity
    Modified residuei37 – 371PhosphothreonineBy similarity
    Modified residuei44 – 441PhosphoserineBy similarity
    Modified residuei67 – 671PhosphoserineBy similarity
    Modified residuei75 – 751PhosphothreonineBy similarity
    Modified residuei93 – 931PhosphoserineBy similarity
    Modified residuei204 – 2041PhosphoserineBy similarity
    Modified residuei207 – 2071PhosphothreonineBy similarity
    Modified residuei214 – 2141PhosphoserineBy similarity

    Post-translational modificationi

    Ubiquitinated and degraded by the APC/C-Cdh1 complex.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ68FW2.
    PRIDEiQ68FW2.

    PTM databases

    PhosphoSiteiQ68FW2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ68FW2.

    Interactioni

    Subunit structurei

    Interacts with SKP1. Part of a SCF (SKP1-cullin-F-box) protein ligase complex By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000020803.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni90 – 12435F-box-likeAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi263 – 2653KEN box

    Domaini

    The KEN box is required for the association with the APC/C-Cdh1 complex.By similarity

    Phylogenomic databases

    eggNOGiNOG46427.
    GeneTreeiENSGT00390000017343.
    HOGENOMiHOG000013100.
    HOVERGENiHBG053225.
    InParanoidiQ68FW2.
    OMAiKTGGRAW.
    OrthoDBiEOG7GJ6D8.
    PhylomeDBiQ68FW2.
    TreeFamiTF101068.

    Sequencei

    Sequence statusi: Complete.

    Q68FW2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSTQSVSGT PARPLPRNKH VSRVADPRSP SAGIQRTPIQ VESSPQPNPP    50
    AEQLNSLKQA QDPDPRSPTL GIARTPMKIS GPDSQCPLVK ELSEVFETEV 100
    SETEVSESIS SPVLGLPQET PLSSELDLPP DPDPQVSLED QLLPWSQTEL 150
    NSKQVFAKEE AKQSTETMVS GQTSDKPSRD PETPQSSGSK RSRRKTNNKV 200
    LGRSPLTILQ DDNSPGTLTL RQGKRPSALS ENVKDLKEGV ILGTGRFLKA 250
    GGGAWEQNED HDKENQHFAL MES 273
    Length:273
    Mass (Da):29,611
    Last modified:October 11, 2004 - v1
    Checksum:i2EB02AE5CFDFBDE1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079204 mRNA. Translation: AAH79204.1.
    RefSeqiNP_001007649.1. NM_001007648.1.
    XP_006237401.1. XM_006237339.1.
    XP_006237402.1. XM_006237340.1.
    XP_006237403.1. XM_006237341.1.
    UniGeneiRn.129078.

    Genome annotation databases

    EnsembliENSRNOT00000020803; ENSRNOP00000020803; ENSRNOG00000015529.
    GeneIDi297594.
    KEGGirno:297594.
    UCSCiRGD:1359093. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC079204 mRNA. Translation: AAH79204.1 .
    RefSeqi NP_001007649.1. NM_001007648.1.
    XP_006237401.1. XM_006237339.1.
    XP_006237402.1. XM_006237340.1.
    XP_006237403.1. XM_006237341.1.
    UniGenei Rn.129078.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000020803.

    PTM databases

    PhosphoSitei Q68FW2.

    Proteomic databases

    PaxDbi Q68FW2.
    PRIDEi Q68FW2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000020803 ; ENSRNOP00000020803 ; ENSRNOG00000015529 .
    GeneIDi 297594.
    KEGGi rno:297594.
    UCSCi RGD:1359093. rat.

    Organism-specific databases

    CTDi 83461.
    RGDi 1359093. Cdca3.

    Phylogenomic databases

    eggNOGi NOG46427.
    GeneTreei ENSGT00390000017343.
    HOGENOMi HOG000013100.
    HOVERGENi HBG053225.
    InParanoidi Q68FW2.
    OMAi KTGGRAW.
    OrthoDBi EOG7GJ6D8.
    PhylomeDBi Q68FW2.
    TreeFami TF101068.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    NextBioi 642465.
    PROi Q68FW2.

    Gene expression databases

    Genevestigatori Q68FW2.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiCDCA3_RAT
    AccessioniPrimary (citable) accession number: Q68FW2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways

    External Data

    Dasty 3