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Q68FW2 (CDCA3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell division cycle-associated protein 3
Alternative name(s):
Trigger of mitotic entry protein 1
Short name=TOME-1
Gene names
Name:Cdca3
Synonyms:Tome1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase By similarity.

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Interacts with SKP1. Part of a SCF (SKP1-cullin-F-box) protein ligase complex By similarity.

Subcellular location

Cytoplasmcytosol By similarity.

Domain

The KEN box is required for the association with the APC/C-Cdh1 complex By similarity.

Post-translational modification

Ubiquitinated and degraded by the APC/C-Cdh1 complex By similarity.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Mitosis
Ubl conjugation pathway
   Cellular componentCytoplasm
   PTMPhosphoprotein
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmitosis

Inferred from electronic annotation. Source: UniProtKB-KW

protein ubiquitination

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytosol

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 273273Cell division cycle-associated protein 3
PRO_0000287710

Regions

Region90 – 12435F-box-like
Motif263 – 2653KEN box

Amino acid modifications

Modified residue291Phosphoserine By similarity
Modified residue311Phosphoserine By similarity
Modified residue371Phosphothreonine By similarity
Modified residue441Phosphoserine By similarity
Modified residue671Phosphoserine By similarity
Modified residue751Phosphothreonine By similarity
Modified residue931Phosphoserine By similarity
Modified residue2041Phosphoserine By similarity
Modified residue2071Phosphothreonine By similarity
Modified residue2141Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q68FW2 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 2EB02AE5CFDFBDE1

FASTA27329,611
        10         20         30         40         50         60 
MGSTQSVSGT PARPLPRNKH VSRVADPRSP SAGIQRTPIQ VESSPQPNPP AEQLNSLKQA 

        70         80         90        100        110        120 
QDPDPRSPTL GIARTPMKIS GPDSQCPLVK ELSEVFETEV SETEVSESIS SPVLGLPQET 

       130        140        150        160        170        180 
PLSSELDLPP DPDPQVSLED QLLPWSQTEL NSKQVFAKEE AKQSTETMVS GQTSDKPSRD 

       190        200        210        220        230        240 
PETPQSSGSK RSRRKTNNKV LGRSPLTILQ DDNSPGTLTL RQGKRPSALS ENVKDLKEGV 

       250        260        270 
ILGTGRFLKA GGGAWEQNED HDKENQHFAL MES 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC079204 mRNA. Translation: AAH79204.1.
RefSeqNP_001007649.1. NM_001007648.1.
XP_006237401.1. XM_006237339.1.
XP_006237402.1. XM_006237340.1.
XP_006237403.1. XM_006237341.1.
UniGeneRn.129078.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000020803.

PTM databases

PhosphoSiteQ68FW2.

Proteomic databases

PaxDbQ68FW2.
PRIDEQ68FW2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000020803; ENSRNOP00000020803; ENSRNOG00000015529.
GeneID297594.
KEGGrno:297594.
UCSCRGD:1359093. rat.

Organism-specific databases

CTD83461.
RGD1359093. Cdca3.

Phylogenomic databases

eggNOGNOG46427.
GeneTreeENSGT00390000017343.
HOGENOMHOG000013100.
HOVERGENHBG053225.
InParanoidQ68FW2.
OMAKTGGRAW.
OrthoDBEOG7GJ6D8.
PhylomeDBQ68FW2.
TreeFamTF101068.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

GenevestigatorQ68FW2.

Family and domain databases

ProtoNetSearch...

Other

NextBio642465.
PROQ68FW2.

Entry information

Entry nameCDCA3_RAT
AccessionPrimary (citable) accession number: Q68FW2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2004
Last modified: April 16, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways