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Protein

Alpha-(1,3)-fucosyltransferase 11

Gene

Fut11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable fucosyltransferase.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378

Protein family/group databases

CAZyiGT10 Glycosyltransferase Family 10

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,3)-fucosyltransferase 11 (EC:2.4.1.-)
Alternative name(s):
Fucosyltransferase XI
Short name:
Fuc-TXI
Short name:
FucT-XI
Galactoside 3-L-fucosyltransferase 11
Short name:
Fucosyltransferase 11
Gene namesi
Name:Fut11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi628731 Fut11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 24Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
Topological domaini25 – 494LumenalSequence analysisAdd BLAST470

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002990111 – 494Alpha-(1,3)-fucosyltransferase 11Add BLAST494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi99 ↔ 104By similarity
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi390 ↔ 393By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ68FV3
PRIDEiQ68FV3

PTM databases

PhosphoSitePlusiQ68FV3

Expressioni

Gene expression databases

BgeeiENSRNOG00000009274
GenevisibleiQ68FV3 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012300

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2619 Eukaryota
ENOG410ZIMX LUCA
GeneTreeiENSGT00680000099679
HOGENOMiHOG000006538
HOVERGENiHBG055521
InParanoidiQ68FV3
KOiK11257
OMAiGLFPHFP
OrthoDBiEOG091G064Z
PhylomeDBiQ68FV3
TreeFamiTF316348

Family and domain databases

Gene3Di3.40.50.11660, 1 hit
InterProiView protein in InterPro
IPR017176 Alpha-1_3-FUT_met
IPR031481 Glyco_tran_10_N
IPR001503 Glyco_trans_10
IPR038577 GT10-like_sf
PANTHERiPTHR11929 PTHR11929, 1 hit
PfamiView protein in Pfam
PF17039 Glyco_tran_10_N, 1 hit
PF00852 Glyco_transf_10, 1 hit
PIRSFiPIRSF037332 Alpha1_3FUT_met, 1 hit

Sequencei

Sequence statusi: Complete.

Q68FV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARYTEAVL AALGVLSVCS ASSSSGSGAS GKAGGEAEWA EPWDGAVFRP
60 70 80 90 100
PAALGAVGMT RGLGSPPPGN AETVDLPVLL WWSPGLFPHF PGDSERIECA
110 120 130 140 150
LGACVASRDR RARADPRTRA LLFYGTDFRA ADAPLPRLAH QSWALLHEES
160 170 180 190 200
PLNNFLLSHG PGIRLFNLTA TFSRHSDYPL PLQWLPGAAY LRRPAPPLRE
210 220 230 240 250
RAEWRRRGYA PLLYLQSHCD VPSDRDRYVR ELMRYIPVDS YGKCLQNREP
260 270 280 290 300
PTVRLQDTAT ATTEDPELMA FLSRYKFHLA MENAICNDYM TEKLWRPMHL
310 320 330 340 350
GAVPVYRGSP SVRDWMPNNH SVILIDDFES PQKLAEFIDF LDKNDEEYMK
360 370 380 390 400
YLAYKQPGGI TNQFLLDNLE HREWGVNDPM LPNYLNGFEC FVCDHELARL
410 420 430 440 450
DAEKAHESSP RDIPVLEPHI AQLSHMDCPV PTPGFGKVEE IPENDSWKEM
460 470 480 490
WLQDYWQGLY QGEALTAMIH NNETQQSKFW DYVHEIFMKR NKNL
Length:494
Mass (Da):56,000
Last modified:October 11, 2004 - v1
Checksum:i6EA3AB50641272D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41 – 42EP → A in CAD59737 (Ref. 1) Curated2
Sequence conflicti281 – 283MEN → LEK in CAD59737 (Ref. 1) Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ535753 mRNA Translation: CAD59737.1
BC079316 mRNA Translation: AAH79316.1
RefSeqiNP_775430.2, NM_173308.2
UniGeneiRn.24040

Genome annotation databases

EnsembliENSRNOT00000012300; ENSRNOP00000012300; ENSRNOG00000009274
GeneIDi286971
KEGGirno:286971
UCSCiRGD:628731 rat

Similar proteinsi

Entry informationi

Entry nameiFUT11_RAT
AccessioniPrimary (citable) accession number: Q68FV3
Secondary accession number(s): Q8CG40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health